Jenkins, MA
Adam Jenkins, Marlborough,, MA US
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20130219226 | DISTRIBUTED TESTING WITHIN A SERIAL TESTING INFRASTRUCTURE - A serial testing infrastructure includes the capability to execute a distributed test on multiple virtual processors. A test executable may be stored in a library and the test description, including the name of the test, the test library, and other test characteristics, may be stored in a separate test data file. The serial testing infrastructure initiates multiple distributed test executors that each launch an instance of the distributed test as a process that runs concurrently with other instances of the distributed test. Each distributed test executor monitors execution of it corresponding process until completion or timeout. | 08-22-2013 |
Adam P. Jenkins, Marlborough, MA US
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20130132783 | REPRESENTATION AND MANIPULATION OF ERRORS IN NUMERIC ARRAYS - In an embodiment, a computer system accesses various different data entries in dense data array, where at least one of those data entries in the dense data array is invalid. The computer system creates an associated sparse data array that includes multiple data entries with zero values as well as data entries with non-zero values. The non-zero data entries are configured to store location information and data values for each of the invalid data entries in the dense array. The zero-value data entries are inferred from the location information of the non-zero data entries. The computer system stores the location information and data values of the non-zero data entries in the sparse data array. Those data values stored in the sparse array are proportional to the number of invalid values in the dense array. | 05-23-2013 |
20140006473 | PARTITIONED ARRAY OBJECTS IN A DISTRIBUTED RUNTIME | 01-02-2014 |
20140007060 | IMPLEMENTATION OF DISTRIBUTED METHODS THAT SUPPORT GENERIC FUNCTIONS | 01-02-2014 |
20140282614 | PROVIDING DISTRIBUTED ARRAY CONTAINERS FOR PROGRAMMING OBJECTS - Embodiments are directed to establishing registration objects for distributed processes, to managing memory on worker processes of a distributed software application and to using object serialization to communicate references to shim objects. In one scenario, a computer system accesses distributed process instances in a distributed runtime and creates a registration object for each of the process instances in the distributed runtime. The registration object includes a key value pair, where the key includes a unique identifier (ID) that identifies a distributed array instance associated with the distributed process, and the value includes a reference to a local portion of the distributed array instance. The computer system then maintains a mapping between the unique ID and the distributed array instance using the registration object. As such, the key value refers to the local portion of the same distributed array instance on each distributed process of the distributed runtime. | 09-18-2014 |
20150040141 | PROVIDING DISTRIBUTED ARRAY CONTAINERS FOR PROGRAMMING OBJECTS - Embodiments are directed to establishing registration objects for distributed processes, to managing memory on worker processes of a distributed software application and to using object serialization to communicate references to shim objects. In one scenario, a computer system accesses distributed process instances in a distributed runtime and creates a registration object for each of the process instances in the distributed runtime. The registration object includes a key value pair, where the key includes a unique identifier (ID) that identifies a distributed array instance associated with the distributed process, and the value includes a reference to a local portion of the distributed array instance. The computer system then maintains a mapping between the unique ID and the distributed array instance using the registration object. As such, the key value refers to the local portion of the same distributed array instance on each distributed process of the distributed runtime. | 02-05-2015 |
Alexander James Jenkins, Brookline, MA US
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20130204940 | SYSTEM AND METHOD FOR DETERMINING RELEVANCE OF SOCIAL CONTENT - A method, computer program product, and computer system for receiving, at a computing device, information associated with an entity from one or more social media sites. One or more attributes for the information associated with the entity is identified. A relevance profile associated with the one or more attributes is generated. A plurality of posts from the one or more social media sites is identified, wherein at least a portion of the plurality of posts includes at least a portion of the one or more attributes for the information associated with the entity. At least the portion of the plurality of posts is ordered on a display based upon, at least in part, the relevance profile associated with the one or more attributes. | 08-08-2013 |
Alexander James Jenkins, Boston, MA US
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20110072034 | PRIVACY-SENSITIVE COOPERATIVE LOCATION NAMING - A location database may be configured to store a set of subjective, arbitrary, and/or ephemeral names assigned to a location by various users. When a user of a device arrives at a particular location, the device may retrieve and present to the user the set of names assigned to the location. Moreover, the names may be associated with a privacy designation, which may permit an author of a location name to indicate whether the name of a location should be shared with the public or restricted to access by the user (or to a specified group of users, etc.) Other access criteria may also be specified, e.g., read-only access to a name for the public and read/write access to a particular group of users. Within the set of names of a location, particular names may be designated as authoritative, and may be presented to users with emphasis. | 03-24-2011 |
Anthony Jenkins, North Reading, MA US
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20090161824 | SYSTEMS FOR THE DETECTION OF TRACE VAPORS AND PARTICLES IN AIR - A detector for the detection for trace vapors and particles in the air that includes a housing; a well formed in the housing; a heated filter positioned across the well; a source delivering sampled air substantially perpendicular to the open end of the well on a first side of the filter; a source to supply dry air across the first side of the filter; a detector line in communication with the at least one well on a second side of the filter; and a second dry air source for supplying air to the second side of the filter at a pressure below atmospheric pressure. An automatic inspection station that includes a vibrator for vibrating articles to be inspected. An automatic inspection station that includes a heating element positioned below an upper surface of the floor and an inlet positioned above the floor. | 06-25-2009 |
Bruce Jenkins, Belmont, MA US
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20090030618 | SYSTEM, METHOD AND SOFTWARE ARRANGEMENT FOR ANALYZING AND CORRELATING MOLECULAR PROFILES ASSOCIATED WITH ANATOMICAL STRUCTURES - A system, method and software arrangement according to exemplary embodiments of the present invention are provided which can use molecular profiles obtained from unaltered human tissue specimens for clinical purposes including disease diagnoses and treatment evaluations. For example, spatial distributions of chemical species including metabolites within the tissue may be obtained using radiological techniques such as magnetic resonance spectroscopy imaging. Disease-specific profiles may be obtained by comparing the distributions of chemical species obtained in ex vivo tissues with pathological observations made on them using statistical analysis. The disease-specific profiles may then be correlated with in vivo or ex vivo molecular profiles to obtain spatial maps that can provide a more sensitive and accurate detection of diseased tissue. Thus, such exemplary systems, methods and software arrangements can include the ability to receive information relating to the distribution of at least three chemical species in the tissue of interest, compare this information statistically to a predetermined profile and, based on the statistical correlation between the information and the profile, determine certain characteristics of the tissue of interest such as, e.g., the presence or absence of diseased tissue. | 01-29-2009 |
Christopher W. Jenkins, Stow, MA US
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20120271651 | Systems, Methods, And Media Providing An Integrated Timecard, Quality Assurance, And Claim Submission Service - An integrated timecard, quality assurance, and claim submission service helps manage and ensure that a care recipient is receiving care from a caregiver in accordance with a pre-established plan of care and that claim submissions are generated and transmitted to an insurance company or other payer(s) completely, accurately, and compatibly for straight-through processing. The service automatically verifies the hours and days worked and the activities performed by a caregiver, identifies any discrepancies, and adheres to the claim submission requirements of the care recipient's insurance company and/or other payer(s). In some embodiments, a payroll preparation process is also provided to help manage payments to caregivers. | 10-25-2012 |
David Jenkins, Carlisle, MA US
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20130064823 | COMPOSITIONS AND METHODS OF USE FOR THERAPEUTIC LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) MULTIVALENT ANTIBODIES - The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding do mains for two different binding sites of LRP6 and compositions and methods of use thereof. | 03-14-2013 |
20140050725 | LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) - HALF LIFE EXTENDER CONSTRUCTS - The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit. | 02-20-2014 |
20140056912 | METHODS OF TREATING SQUAMOUS CELL CARCINOMA - The disclosure relates to methods for treating a sclerostin-expressing cancer, e.g., a squamous cell carcinoma (SCC), e.g., SCC of the upper aerodigestive tract, esophagus, or lung, employing a therapeutically effective amount of at least one sclerostin antagonist, e.g., an anti-sclerostin antibody, such as Antibody 1, 2, 3, 4 or 5. | 02-27-2014 |
20140301946 | ANTIBODY DRUG CONJUGATES - The present invention relates to anti-FGFR2 and FGFR4 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer. | 10-09-2014 |
20140308201 | ANTIBODY DRUG CONJUGATES - The present invention relates to anti-FGFR2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer. | 10-16-2014 |
20150030617 | LOW DENSITY LIPOPROTEIN - RELATED PROTEIN 6 (LRP6) - HALF LIFE EXTENDER CONSTRUCTS - The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit. | 01-29-2015 |
David Jenkins, Waltham, MA US
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20100196385 | TARGETED BINDING AGENTS DIRECTED TO DLL4 AND USES THEREOF 524 - The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of DLL4 and as diagnostics. | 08-05-2010 |
20100196388 | TARGETED BINDING AGENTS DIRECTED TO SONIC HEDGEHOG HOMOLOG AND USES THEREOF - The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics. | 08-05-2010 |
20120195905 | TARGETED BINDING AGENTS DIRECTED TO DLL4 AND USES THEREOF 524 - The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of DLL-4 and as diagnostics. | 08-02-2012 |
20120328625 | TARGETED BINDING AGENTS DIRECTED TO SONIC HEDGEHOG HOMOLOG AND USES THEREOF - The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics. | 12-27-2012 |
Garth Jenkins, Belmont, MA US
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20080267181 | Selective Multicasting of Sensor Data for Reliable Delivery - Described is a method for reliable transmission of sensor data and sensor commands. The method is particularly useful for shared packet networks and lossy wireless networks where the rate of packet drops can be significant. A network access node receives a data packet that includes the sensor data and multicasts the data packet towards an aggregation node. Each data packet preferably is transmitted over a unique network path. The number of multicast data packets is determined according to one or more network parameters such as network congestion, packet drop probability, the priority and class of service of the data packet, and the number of unique network paths between the network access node and an aggregation node. The first data packet to arrive at the aggregation node is forwarded to the application node and subsequently received data packets with identical sensor data are discarded. | 10-30-2008 |
20090222541 | DYNAMIC SENSOR NETWORK REGISTRY - A scalable network architecture adapted to interface with various sensor types and sensor access mechanisms while providing real-time access to sensor data for distributed applications and organizations is described. A centralized sensor network service manages the registration, capabilities, near real-time status of the sensors and their current network connections. New sensors are discovered automatically through messaging between network access nodes and the sensor registry. The registry service can be made available to distributed sensor applications and sensor middleware, and facilitates the sharing of sensors across organizations. The sensor registry is automatically updated by network software and does not require manual configuration or reconfiguration each time a sensor is added to or relocated within the network. Authentication and authorization policies can be implemented to ensure that only authorized applications can query and view the registry. The registry can be implemented for multi-vendor sensor networks and can accommodate multiple addressing schemes. | 09-03-2009 |
Geoffrey H. Jenkins, Wayland, MA US
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20110306929 | Fluid Delivery Device Needle Retraction Mechanisms, Cartridges and Expandable Hydraulic Fluid Seals - A fluid delivery device includes an automatic needle retraction mechanism configured to automatically retract a delivery end of a needle into a housing. In one embodiment, the needle assembly is configured to automatically withdraw the delivery end of the needle into the housing upon an actuator moving from the first position to the second position. In one embodiment, the needle assembly is configured to automatically withdraw the delivery end of the needle into the housing upon decoupling a bottom surface of the housing from a skin surface. | 12-15-2011 |
20140236086 | Fluid Delivery Device Needle Retraction Mechanisms, Cartridges and Expandable Hydraulic Fluid Seals - A fluid delivery device includes an automatic needle retraction mechanism configured to automatically retract a delivery end of a needle into a housing. In one embodiment, the needle assembly is configured to automatically withdraw the delivery end of the needle into the housing upon an actuator moving from the first position to the second position. In one embodiment, the needle assembly is configured to automatically withdraw the delivery end of the needle into the housing upon decoupling a bottom surface of the housing from a skin surface. | 08-21-2014 |
Jeremy Lee Jenkins, Watertown, MA US
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20080207718 | Use of Fused Imidazole Derivatives to Mediate Ccr3 Related Conditions - The use of compound of formula I in the preparation of a medicament, e.g. for the treatment of condition mediated by CCR3. | 08-28-2008 |
John Jenkins, Tyngsboro, MA US
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20130058462 | INDEPENDENTLY ROTATABLE DETECTOR PLATE FOR MEDICAL IMAGING DEVICE - A real-time fluoroscopic imaging system includes a collimator and a detector which are rotationally movable independent of the support assembly, e.g., c-arm, to which they are mounted. Rotational movement of the collimator and the detector are coordinated such that the orientation of the detector with respect to the collimator does not change. The collimator may include a geared flange member to facilitate rotation, and may be a single molded piece formed of a plastic such as tungsten polymer material. The system may also include a plurality of interchangeable collimators characterized by different shapes. A display is provided to present an image to an operator, and image orientation logic displays a target anatomy in a selected orientation regardless of orientation of the target anatomy relative to the detector, and regardless of rotation of the detector. | 03-07-2013 |
Kevin Jenkins, Blackstone, MA US
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20090039024 | APPARATUS AND METHODS FOR PERFORMING STEPS OF A MULTI-STEP PROCESS IN PARALLEL - Embodiments of the present invention feature a device ( | 02-12-2009 |
Kristina Yim Jenkins, Hudson, MA US
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20130217954 | ADJUSTABLE MEDICAL ASSEMBLY FOR IMPLANT TENSION ADJUSTMENT - The present invention discloses a medical assembly and method to deliver and place a bodily implant inside a patient's body. The medical assembly includes an insertion tool such that a portion of the insertion tool defines a lumen. The medical assembly further includes a carrier configured to be coupled to the insertion tool and including a passageway. The medical assembly also includes a flexible elongate member configured to pass through the passageway of the carrier and the lumen. The elongate member is also configured to be coupled to the bodily implant such that a portion of the elongate member between the bodily implant and the carrier defines a length. | 08-22-2013 |
Lyle J. Jenkins, Scituate, MA US
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20110132088 | FLEXURE ASSEMBLIES AND METHODS FOR MANUFACTURING AND USING THE SAME - In one embodiment, an accelerometer includes a suspension frame, a proof mass, and a plurality of flexures suspending the proof mass from the suspension frame. The flexures allow the proof mass to deflect in response to an acceleration along a sensitive axis of the accelerometer. Each flexure exhibits an initial spring rate along the sensitive axis of substantially zero. | 06-09-2011 |
Scott A. Jenkins, Charlestown, MA US
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20150238505 | INJECTABLE NANOPARTICULATE OLANZAPINE FORMULATIONS - Described are injectable formulations of particulate olanzapine that produce a prolonged duration of action upon administration, and methods of making and using such formulations. The injectable formulations comprise particulate olanzapine. | 08-27-2015 |
Tracy Jenkins, Cambridge, MA US
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20160002265 | MACROCYCLIC COMPOUNDS AS IRAK4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES - Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein i.a. Ring A is phenylene or 5- to 6-membered heteroarylene; Ring B is phenylene, 5- to 6-membered heterocycloalkylene or 5- to 6-membered heteroarylen; R | 01-07-2016 |
Tracy J. Jenkins, Belmont, MA US
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20090275556 | Aryl sulfonamides useful as inhibitors of chemokine receptor activity - The present invention provides compounds of general formula I: | 11-05-2009 |
20120157442 | HETEROARYL BTK INHIBITORS - The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same. | 06-21-2012 |
20120157443 | BRUTON'S TYROSINE KINASE INHIBITORS - The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same. | 06-21-2012 |
20130345192 | HETEROCYCLIC TYROSINE KINASE INHIBITORS - The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same. | 12-26-2013 |
20140309212 | BRUTON'S TYROSINE KINASE INHIBITORS - The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same. | 10-16-2014 |
Tracy J. Jenkins, Watertown, MA US
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20150126528 | INHIBITORS OF BRUTON'S TYROSINE KINASE - The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms. | 05-07-2015 |
20150158843 | PYRIMIDINYL TYROSINE KINASE INHIBITORS - The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. | 06-11-2015 |