Schuppan
Detlef Schuppan, Mainz DE
Patent application number | Description | Published |
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20120083458 | METHODS AND COMPOSITIONS FOR DETECTING AND TREATING INFLAMMATORY DISEASE - The invention features methods of diagnosing inflammatory disease based on the elevated presence microparticles (MP) expressing certain receptors. The invention also features methods of decreasing fibrosis in the liver by administering MP to subjects with liver fibrosis. | 04-05-2012 |
20130266584 | METHODS AND COMPOSITIONS FOR TREATING CELIAC DISEASE - The invention features the treatment of gastrointestinal disorders associated with an innate immune response tiggered by alpha amylase inhibitor CM3, alpha amylase inhibitor 0.19 (0.19), CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or alpha amylase inhibitor 0.53 (0.53). To this end, the invention features pharmaceutical compositions including neutralizing antibodies to CM3, 0.19, CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53, food products containing reduced levels of CM3, 0.19, CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53 protein, the use of oral TLR4 inhibitors to block the effect of said alpha-amylase inhibitors, assays for identifying CM3, 0.19, CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53 content in food products, and assays for diagnosing subjects with a disorder related to CM3, 0.19, CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53 triggered innate immune responses. | 10-10-2013 |
20140349314 | METHODS AND COMPOSITIONS FOR DETECTING AND TREATING INFLAMMATORY DISEASE - The invention features methods of diagnosing inflammatory disease based on the elevated presence microparticles (MP) expressing certain receptors. The invention also features methods of decreasing fibrosis in the liver by administering MP to subjects with liver fibrosis. | 11-27-2014 |
Detlef Bruno Igor Schuppan, Bubenreuth DE
Patent application number | Description | Published |
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20080267877 | Peptide-based carrier devices for stellate cells - A compound includes a carrier molecule wherein the carrier molecule is linked to a further molecule, wherein the further molecule is at least one cyclic peptide in which the cyclic peptide portion thereof contains at least one sequence encoding a cell receptor recognizing peptide (RRP) and with the proviso that the compound is not a naturally occurring receptor agonist or antagonist. Preferably, the RRP is a receptor specific for Hepatic Stellate Cells (HSC) or a receptor that is up-regulated on HSC during disease. The RFP may be chosen from among a PDGF receptor, a collagen type VI receptor, cytokine receptor(s) such as TGBβ, INFα and interleukinβ. The cyclic portion of the peptide can contain at least one amino acid sequence RGD or KPT. The compounds can be used as an active targeting ingredient for manufacturing a pharmaceutical composition for therapy, prophylaxis or diagnosis of a disease chosen from fibrotic disease, sclerotic disease, and chronic or acute inflammatory processes including glomeruloscherosis, interstitial fibrosis, lung fibrosis, atherosclerosis, rheumatoid arthritis, Crohns disease, colitis ulcerosa, glomerulonephritis and sepsis, and particularly for targeting HSC. Pharmaceutical compositions contain the above-compound(s). | 10-30-2008 |
Holger Schuppan, Bottrop DE
Patent application number | Description | Published |
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20080266609 | METHOD AND DEVICE FOR PROOFING RASTER PRINT DATA WHILE MAINTAINING THE RASTER INFORMATION - The screened printing data are subjected to a filtering method, the raster information being maintained. Intermediate tonal values are produced by the filtering method, using the binary tonal values, the intermediate tonal values being configured in such a way that, by means of a color space transformation, transformed tonal values and/or intermediate tonal values can be formed which represent a true-to-color proof. | 10-30-2008 |
20130107292 | DYNAMIC IMAGE GAMUT COMPRESSION | 05-02-2013 |
20140126001 | METHOD AND APPARATUS FOR AUTOMATED GENERATION OF A WHITE INK SEPARATION OUT OF CMYK DATA OR RGB PRINT DATA - Techniques are provided that include an algorithm and a computing device using such algorithm to compute a white ink separation channel from the CMYK or RGB data from a print pipeline as an input. This input originally corresponds to print data on a media with standard whiteness, e.g. standard whiteness corresponding to a diffuser used by the Comission Internationale de l'Eclairage (CIE) 1964 media whiteness formula. In an example implementation, the white ink channel computed by the computing device using such algorithm may be printed as a pre-coat on a colorimetrically different media which does not comply with definitions and formulae of CIE's whiteness and tint. | 05-08-2014 |