Williams, MA
Adrian D. Williams, Bridghton, MA US
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20140061861 | PLANARIZATION OF GaN BY PHOTORESIST TECHNIQUE USING AN INDUCTIVELY COUPLEDPLASMA - Films of III-nitride for semiconductor device growth are planarized using an etch-back method. The method includes coating a III-nitride surface having surface roughness features in the micron range with a sacrificial planarization material such as an appropriately chosen photoresist. The sacrificial planarization material is then etched together with the III-nitride roughness features using dry etch methods such as inductively coupled plasma reactive ion etching. By closely matching the etch rates of the sacrificial planarization material and the III-nitride material, a planarized III-nitride surface is achieved. The etch-back process together with a high temperature annealing process yields a planarized III-nitride surface with surface roughness features reduced to the nm range. Planarized III-nitride, e.g., GaN, substrates and devices containing them are also provided. | 03-06-2014 |
Adrian D. Williams, Brighton, MA US
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20090236693 | Planarization of Gan by Photoresist Technique Using an Inductively Coupled Plasma - Films of III-nitride for semiconductor device growth are planarized using an etch-back method. The method includes coating a III-nitride surface having surface roughness features in the micron range with a sacrificial planarization material such as an appropriately chose photoresist. The sacrificial planarization material is then etched together with the III-nitride roughness features using dry etch methods such as inductivel coupled plasma reactive ion etching. By closely matching the etch rates of the sacrificial planarization material and the III-nitride material, a planarized III-nitride surface is achieved. The etch-back process together with a high temperature annealing process yields a planarize III-nitride surface with surface roughness features reduced to the nm range. Planarized III-nitride, e.g., GaN, substrates and devices containing them are also provided. | 09-24-2009 |
Amy Casey Williams, Groton, MA US
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20110070596 | AGENTS AND METHODS FOR ANALYZING PROTEIN INTERACTIONS - Agents and methods for qualitative and quantitative analysis a protein complex or protein complexes using isotope-labeled symmetrical bifunctional crosslinkers and mass spectrometry are provided. Targeting moieties, cell permeability moieties, or affinity moieties, may be appended to the bifunctional crosslinkers. The isotope-labeled symmetrical bifunctional crosslinkers may be used in a kit or as a library. | 03-24-2011 |
Archibald Williams, Wareham, MA US
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20080226499 | Automated microsampling dissolution test system - An automated MicroSampling dissolution testing system that is constructed of a base; a plurality of vessels mounted on an invertible, temperature controlled bath manifold; a cleaning manifold; a stirring and sampling assembly for each vessel; an integrated image capture device, a plurality of hydrodynamic, nonresident sampling probes; a non-resident dispensing manifold; a novel fluid handling system; a MicroSampler; a sample transfer mechanism; and a sample and filter storage apparatus. | 09-18-2008 |
Arthur Robert Williams, Princeton, MA US
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20130269333 | FULL-WATER-COLUMN SURGE-TYPE WAVE-ENERGY CONVERTER - A wave-energy converter (WEC) designed to capture the predominantly horizontal (surge) water motion in near-shore waves is called a Surge-type WEC. A Surge-type WEC comprises a moveable paddle that faces and resists the wave motion, in a way that converts the energy of the wave motion into a more useful form, such as electricity. The challenge addressed by the present invention is the efficient capture of the energy contained in the entire water column, from the seabed to the surface. This is a challenge because the height of the water column (depth) varies both within waves and with the tide. Capture of the full water column is accomplished using a floating paddle. The top of the paddle is pinned to the water surface by buoyancy. The lower portion of the water column is captured differently in different embodiments. | 10-17-2013 |
Benjamin Scott Williams, Norwood, MA US
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20110048252 | SHELF LIFE EXTENDING CONTAINER FOR FRUITS AND VEGETABLES - The Shelf Life Extending Container for fruits and vegetables extends the shelf life of various fresh fruits and vegetables and vase life of fresh cut flowers by changing the atmosphere in which these living products are stored and respires. The Shelf Life Extending Container does this by utilizing a Gas Permeable Non-Woven Fabric Based Film. The high oxygen and carbon dioxide permeability of the Gas Permeable Non-Woven Fabric Based Film establishes an ideal atmosphere for the multiple perishable items stored within the Shelf life Extending Container, and therefore extends their shelf life. The establishment of lower oxygen and carbon dioxide atmospheres within the Shelf Life Extending Container using the Gas Permeable Non-Woven Fabric Based Film, also leads to a reduction in the respiration rate of the perishable items stored. The reduction in the respiration rate of the perishable items prevents loss of moisture, production of metabolic heat, yellowing, browning, and reduces the production levels of ethylene by the perishable items. Therefore, the created atmosphere is able to extend shelf life, maintain high quality, and preserve nutrients of fresh produce items by naturally regulating respiration of said produce/flowers. | 03-03-2011 |
Benjamin Scott Williams, East Walpole, MA US
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20130341236 | Breathable Container for Fruits and Vegteables - The Breathable Container for fruits and vegetables extends the shelf life of various fresh fruits and vegetables and vase life of fresh cut flowers by changing the atmosphere in which these living products are stored and respires. The Breathable Container does this by utilizing a Gas Permeable Non-Woven Fabric Based Film. The high oxygen and carbon dioxide permeability of the Gas Permeable Non-Woven Fabric Based Film establishes an ideal atmosphere for the perishable items stored within the Breathable Container, and therefore extends their shelf life. The establishment of lower oxygen and carbon dioxide atmospheres within the Breathable Container using the Gas Permeable Film, also leads to a reduction in the respiration rate of the perishable items stored. The reduction in the respiration rate of the perishable items prevents loss of moisture, production of metabolic heat, yellowing, browning, and reduces the production levels of ethylene by the perishable items. Therefore, the created atmosphere is able to extend shelf life, maintain high quality, and preserve nutrients of fresh produce items by naturally regulating respiration of said produce. | 12-26-2013 |
Betsey S. Williams, Auburndale, MA US
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20100049448 | MULTIDIMENSIONAL MORPHOLOGICAL RECONSTRUCTION OF GENOME EXPRESSION ACTIVITY - A method of morphological reconstruction of biological activity in a tissue sample maps biological data resulting from analysis of tissue samples onto a 3-D morphological rendering of the biological sample. Each slice in a set of histological slices, indexed by a first index, is micro dissected into micro samples indexed by a pair of first and second indices. The indices are utilized to spatially map biological data to the 3-D rendering. | 02-25-2010 |
20110196663 | MULTIDIMENSIONAL MORPHOLOGICAL RECONSTRUCTION OF GENOME EXPRESSION ACTIVITY - A method of morphological reconstruction of biological activity in a tissue sample maps biological data resulting from analysis of tissue samples onto a 3-D morphological rendering of the biological sample. Each slice in a set of histological slices, indexed by a first index, is micro dissected into micro samples indexed by a pair of first and second indices. The indices are utilized to spatially map biological data to the 3-D rendering. | 08-11-2011 |
Brandon Williams, Revere, MA US
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20130304809 | Reducing TCP connection establishment time in an overlay network - Applications that run on an overlay network-based managed service achieve high performance gains using a set of TCP optimizations. In a first optimization, a typical single TCP connection between a client and an origin server is broken into preferably three (3) separate TCP connections. These connections are: an edge-to-client connection, an edge-to-edge connection, and edge-to-origin connection. A second optimization replicates TCP state along the connection to increase fault tolerance. In this approach, preferably a given TCP connection is maintained on two servers. When a packet is received by one server, called the primary, its state is updated and then passed to a second server, called the backup. Only when the backup sends an acknowledgement back to the primary can it then send a TCP acknowledgement back to the host that originally sent the packet. Another optimization reduces connection establishment latency. | 11-14-2013 |
Brandon S. Williams, Revere, MA US
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20100211885 | QUICK DESIGN USER PROFILES FOR IMPROVING DESIGN TIME OF PERSONALIZED PRODUCTS - QuickDesign User Profiles allowing users to store personalized information for auto-population of template designs when the user visits a website to design personalized products. | 08-19-2010 |
Brown Williams, Jamaica Plain, MA US
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20110023952 | PHOTOVOLTAIC CELL WITH SEMICONDUCTOR FINGERS - A photovoltaic cell has a semiconductor substrate formed from semiconductor material doped by a first dopant type, and a doped region over at least a portion of the substrate. The doped region is doped by a second dopant type that is opposite to that of the first dopant type to form an emitter. Moreover, the doped region is doped to a region dopant level. In addition to the substrate and emitter, the cell also has a plurality of semiconductor fingers formed on the emitter, a plurality of busbars formed from a conductor and intersecting the plurality of semiconductor fingers, and a plurality of tabs soldered to the busbars. The fingers are doped by the second dopant type to have a second dopant level, which is greater than the region dopant level. | 02-03-2011 |
Brown Williams, Boston, MA US
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20090145479 | Shaped Tab Conductors for a Photovoltaic Cell - A shaped tab conductor configured to allow more incident light to strike a cell substrate, improving the photovoltaic efficiency of the cell. The shaped tab conductor is configured to reduce the amount of incident light that is blocked by the tab from reaching the surface of the cell substrate. The tab may also be configured to redirect light reflected from the cell surface back to the cell surface. The cross-section of the tab conductor may be polygonal, such as a rhombus, with at least one generally planar surface that forms an acute angle with the substrate. | 06-11-2009 |
20090159114 | Photovoltaic Panel and Cell with Fine Fingers and Method of Manufacture of the Same - A photovoltaic cell has a photosensitive substrate and a plurality of fingers in ohmic contact with the substrate. At least one of the fingers has an average width of less than about 95 microns. The cell also has a plurality of busbars in ohmic contact with the fingers. At least two of the busbars that are spaced less than about 38 millimeters apart intersect the at least one finger (i.e., the finger(s) having an average width of less than about 95 microns). | 06-25-2009 |
20130065347 | SHAPED TAB CONDUCTORS FOR A PHOTOVOLTAIC CELL - A shaped tab conductor configured to allow more incident light to strike a cell substrate, improving the photovoltaic efficiency of the cell. The shaped tab conductor is configured to reduce the amount of incident light that is blocked by the tab from reaching the surface of the cell substrate. The tab may also be configured to redirect light reflected from the cell surface back to the cell surface. The cross-section of the tab conductor may be polygonal, such as a rhombus, with at least one generally planar surface that forms an acute angle with the substrate. | 03-14-2013 |
Bruce A. Williams, South Boston, MA US
Patent application number | Description | Published |
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20090148639 | High strength ribbon-woven disposable bag for containing refuse - An ultra-strong tear resistant, cut resistant, puncture resistant bag having a high shear strength or modulus is provided by weaving ribbons of flat polypropylene sheet into a bag. The bag is formed by weaving a cylindrically shaped object, cutting the object transversely and sealing up one end to form the bag. The physical properties of the ribbon-woven bag easily accommodate holding refuse including bricks, wood with nails, glass and other refuse in a lightweight disposable bag. In an alternative embodiment, the ribbon-woven bag is overlain with sheets laminated to the exterior of the bag to provide a fluid-tight container. | 06-11-2009 |
Cara Williams, Methuen, MA US
Patent application number | Description | Published |
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20080247955 | Inflammation treatment, detection and monitoring via TREM-1 - The present invention provides methods of treating inflammatory diseases/disorders in a subject by inhibiting/antagonizing TREM-1 expression/activity/signal transduction and/or DAP12/TyroBP expression and/or activity. Methods of detecting the presence of inflammatory disease in a subject by detecting TREM-1 and/or DAP12/TyroBP expression and/or activity in the subject or a sample obtained therefrom, wherein increased expression or activity is indicative of the inflammatory disease are also included. The present invention further provides methods for assessing the efficacy of a TREM-1-modulating agent administered to a patient by detecting levels of secreted phosphoprotein 1 (SPP1) and/or one or more other biomarkers in the patient or in a sample from the patient. | 10-09-2008 |
20090156537 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING ASTHMA OR OTHER ALLERGIC OR INFLAMMATORY DISEASES - The present invention provides compositions and methods useful for detecting or treating asthma or other allergic or inflammatory diseases. In one aspect, the methods of the present invention include inhibiting the activity or expression of a component of an arginine metabolic pathway in tissues affected by asthma or other allergic or inflammatory diseases. In many embodiments, the component being inhibited is a cationic amino acid transporter, an arginase, or a component downstream of the arginase. In many other embodiments, the activity or expression of the component is inhibited by an agent that binds to the component. In still many other embodiments, the activity or expression of the component is inhibited by an agent that binds a polynucleotide encoding the component. | 06-18-2009 |
20100022536 | Inhibitors of Cytosolic Phospholipase A2 - This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A | 01-28-2010 |
20100029645 | Inhibitors of Cytosolic Phospholipase A2 - This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A | 02-04-2010 |
Cara Margaret May Williams, Methuen, MA US
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20110105509 | INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS - Disclosed are compounds of Formula (I): | 05-05-2011 |
Cheryl Ann Williams, Malden, MA US
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20120291718 | SCRATCHING POST FOR HOUSEHOLD PETS - This invention provides a cat scratching post with removable and/or interchangeable panels. The cat scratching post has a base, a column to house scratching panels, and a top cover. The top cover and the base are attached to the column by a nut and screw. The areas used for scratching may be exchanged as needed by simply removing the top and sliding the panel up and out and then turning it around to expose the other side. The panels may also be clipped together and attached to the column. Additional panels are stored inside the column. The panels may have different materials, colors and themes. The top cover serves a bed, which is removable for easy cleaning and is also reversible. There are also four corner pieces, which have hard plastic bumps so that the cat may rub and scratch its body. The corner pieces are also removable. | 11-22-2012 |
Chester Smith Williams, Lexington, MA US
Patent application number | Description | Published |
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20110284315 | RECONFIGURABLE LOUDSPEAKER ENCLOSURE - A reconfigurable loudspeaker enclosure. A loudspeaker enclosure, includes a first section that includes a mounting location for an acoustic driver. The mounting location includes a first section mating surface and first section walls, a second section that includes an exit for an acoustic element from which acoustic energy can be radiated. The second section includes a second section mating surface and second section walls. The first section mating surface and the second section are rotatably coupled so that in a first configuration the first section walls and the second section walls are substantially continuous, and so that in a second configuration, the walls of the two sections are substantially non-continuous or perpendicular or both and so that in both the first configuration and the second configuration the two sections are coupled acoustically. | 11-24-2011 |
20130213628 | Convective Airflow Using a Passive Radiator - Systems and methods to remove heat from an acoustic enclosure are provided. An apparatus for reproducing acoustic signals includes an acoustic enclosure comprising an acoustic volume. A heat producing element is coupled to the acoustic enclosure, and a thermally conductive structure is thermally coupled to the heat producing element. The thermally conductive structure includes a first surface. A first passive radiator includes a first diaphragm. The first diaphragm extends over at least a portion of the first surface and moves in response to pressure variations within the acoustic volume. Movement of the first diaphragm causes air to flow over the first surface, to facilitate heat removal from the thermally conductive structure. | 08-22-2013 |
20130213730 | ACOUSTIC PORTS ALIGNED TO CREATE FREE CONVECTIVE AIRFLOW - Systems and methods to remove heat from an acoustic enclosure are provided. An apparatus includes an enclosure and a free convection passage located within the enclosure. The convection passage includes a non-horizontal convection inlet acoustic port having an inlet opening to the ambient environment and a non-horizontal convection outlet acoustic port having an outlet opening to the ambient environment. At least one heat producing element is coupled to an acoustic port of the free convection passage via a low thermal resistance conduction path. Heat produced by the heat producing element initiates a unidirectional free convective airflow in a direction corresponding to a path between the convection inlet acoustic port and the convection outlet acoustic port. | 08-22-2013 |
Christopher John Williams, Manchester By The Sea, MA US
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20130083701 | Flexible Radix Switch - A system and method for interconnecting nodes and routing data packets in high radix networks includes constructing or redefining a network structure to provide improved performance. Computation and data storage nodes are connected to a network of switching nodes that provide near optimum bandwidth and latency for networks of any size. Specialized interconnection patterns and addressing methods ensure reliable data delivery in very large networks with high data traffic volume. | 04-04-2013 |
Daniel Williams, Norwell, MA US
Patent application number | Description | Published |
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20110246945 | SYSTEMS AND METHODS FOR MULTIMEDIA CONTENT SHARING WITH REMOVEABLY COUPLED HEADLESS COMPUTING AND/OR COMMUNICATIONS NODES - The invention provides, in one aspect, a multimedia content sharing system that includes (i) a shared content server which stores items of content (such as still, moving images and audio) and (ii) a plurality of nodes, each of which is in communications with the shared content server via cellular telephone and/or other data networks. One or more of those nodes can be a headless communications device, such as a modem, that can be removeably coupled with a host for purposes of displaying such items of content. Other nodes can be mobile phones, personal digital assistants, network-enabled digital picture frames, personal computers, with integral or other attendant displays for those items. The shared content server transmits items of content to a first set of the nodes “automatically,” e.g., without requests by users of those nodes for the items. At least one node in that first set displays the content of received items (e.g., on an LCD screen) and accepts user feedback in regard to those items. That feedback—which may be, for example, a command to copy an item into an “album”, to rotate an item on the display, to block another node from displaying the items, and/or to block a sender (or creator) of the item from sending further items of content from presenting—is transmitted back to the shared content server for distribution to other nodes, which alter their own respective displays of the items accordingly. | 10-06-2011 |
Daniel L. Williams, Norwell, MA US
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20110092835 | WIRELESS ECG SYSTEM - A wireless monitoring system and, more particularly, a wireless monitoring system for detecting and transmitting physiological data. The present invention detects physiological data relating to a patient's cardiac activity and respiration rate and transmits the data to a remote base station via telemetry. The base station processes the data so that the data can be display by an ECG monitor. | 04-21-2011 |
20110160604 | WIRELESS ECG SYSTEM - A wireless monitoring system and, more particularly, a wireless monitoring system for detecting and transmitting physiological data. The present invention detects physiological data relating to a patient's cardiac activity and respiration rate and transmits the data to a remote base station via telemetry. The base station processes the data so that the data can be display by an ECG monitor. | 06-30-2011 |
Darryl S. Williams, Groton, MA US
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20100084852 | LUMINESCENT COMPOSITIONS, METHODS FOR MAKING LUMINESCENT COMPOSITIONS AND INKS INCORPORATING THE SAME - A particulate luminescent composition is disclosed that, when excited by electromagnetic radiation at a first frequency, emits electromagnetic radiation at a second frequency equal to or within 1500 cm | 04-08-2010 |
20110207860 | Inkjet Ink Compositions Comprising Polymeric Dispersants Having Attached Chromophore Groups - The present invention relates to an inkjet ink composition comprising a liquid vehicle, a pigment, and a polymeric dispersant. In one embodiment, the pigment comprises a colorant having the formula A-(B) | 08-25-2011 |
20120105559 | Metallic Dispersions for Inkjet Printing - A dispersion of silver particles and a method of making the dispersion and ink are described. The dispersion or ink may be an aqueous dispersion or ink and may produce silver images having improved properties such as an improvement in gloss. | 05-03-2012 |
David C. Williams, Medford, MA US
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20080289475 | FOSTER EXTENSION FOR FLUTES - A flute attachment which improves and enhances the harmonic capability of a flute by lengthening the resonant chamber of the standing wave. The instant invention ‘fine tunes’ the harmonic range of the flute by taking into account the end point of the fundamental length of the sounding oscillations of an air column without negating the frequency which has been predetermined by the original terminus of the physical scale length of the flute. The sound wave length within a flute terminates slightly beyond the physical length of the flute tube and this difference in length is known as the ‘end correction’. The instant invention captures the node which extends beyond the flute tubing and balances and reinforces the propagation of upper partials throughout the sounding range of the instrument. | 11-27-2008 |
David R. Williams, Carlisle, MA US
Douglas Williams, Acton, MA US
Patent application number | Description | Published |
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20110060480 | MOBILE DEVICE APPLICATION FOR COMMUNICATING WITH VEHICLES - Methods, systems, and devices for reserving a reservable asset using a mobile device. A mobile device communicates directly with a vehicle-associated control module or through a reservation server using either a TCP/IP communications channel or near-field communications. A member enters a request using the user interface provided by the mobile-device application. The identity of the member is validated the vehicle-associated control module executes the request by sending a signal to a computer or sensor in the vehicle through the vehicle wiring or the vehicle CANbus. The request can be a function, such as unlocking the vehicle doors, illuminating the interior or exterior lights, honking the horn, or activating a panic alarm. | 03-10-2011 |
Elizabeth Williams, Hopkinton, MA US
Patent application number | Description | Published |
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20080307861 | Method For Screening Mobile Phases In Chromatography Systems - A method and system of screening or selecting a mobile phase eluent for a chromatography column is provided. A sample for chromatographic analysis or purification is combined with a solvent and passed through a membrane. A pressure measurement is taken of the sample/solvent combination in the system prior to the membrane. The pressure measurement may be compared to a second pressure and an appropriate solvent may be selected based on the relationship between the first measured pressure and the second pressure. | 12-18-2008 |
Gail I. Williams, Medford, MA US
Patent application number | Description | Published |
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20080289475 | FOSTER EXTENSION FOR FLUTES - A flute attachment which improves and enhances the harmonic capability of a flute by lengthening the resonant chamber of the standing wave. The instant invention ‘fine tunes’ the harmonic range of the flute by taking into account the end point of the fundamental length of the sounding oscillations of an air column without negating the frequency which has been predetermined by the original terminus of the physical scale length of the flute. The sound wave length within a flute terminates slightly beyond the physical length of the flute tube and this difference in length is known as the ‘end correction’. The instant invention captures the node which extends beyond the flute tubing and balances and reinforces the propagation of upper partials throughout the sounding range of the instrument. | 11-27-2008 |
Gethin Williams, Newton, MA US
Patent application number | Description | Published |
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20080319315 | Method of reducing interferences in positron emission tomography - Methods and compositions are disclosed that lower the uptake of the radiopharmaceutical FDG, a glucose analog, by brown adipose tissue and the myocardium in FDG-PET/CT scans. The composition is substantially carbohydrate free and includes high levels of lipids. The method uses the composition and doses at particular times before the scan. The method has an advantage over fasting methods since it reduces the uptake by brown adipose tissue and/or myocardium that can be mistaken for cancer on FDG-PET or PET//CT scans or obscures sites of cancer adjacent to the heart. In addition, this permits the identification, monitoring and treatment of coronary artery disease on PET or PET/CT scans. | 12-25-2008 |
Grace L. Williams, Waltham, MA US
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20110319277 | PRPK-TPRKB MODULATORS AND USES THEREOF - The present invention provides methods of identifying an agent that modulates PRPK, TPRKB, OSGEP, LAGE3 and its homologs, PRPK/TPRKB complex, and/or KEOPS complex. The present invention also provides compositions of such agents and methods of treating a disease, disorder, or condition associated with PRPK, TPRKB, OSGEP, LAGE3 and its homologs family (CT antigens), PRPK/TPRKB complex, and/or KEOPS complex using such an agent or composition. | 12-29-2011 |
Gregory Williams, Marblehead, MA US
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20130262148 | DATA-DRIVEN CONCEPTS FOR PROCESSING CLAIMS - Systems, methods, apparatus, and computer program products are provided for processing claims. In various embodiments, claims can be processed in accordance with a data-driven approach that limits changes to existing claims processing rules. | 10-03-2013 |
20130262149 | DATA-DRIVEN CONCEPTS FOR PROCESSING CLAIMS - Systems, methods, apparatus, and computer program products are provided for processing claims. In various embodiments, claims can be processed in accordance with a data-driven approach that limits changes to existing claims processing rules. | 10-03-2013 |
20130262150 | DATA-DRIVEN CONCEPTS FOR PROCESSING CLAIMS - Systems, methods, apparatus, and computer program products are provided for processing claims. In various embodiments, claims can be processed in accordance with a data-driven approach that limits changes to existing claims processing rules. | 10-03-2013 |
James Benjamin Williams, Sherborn, MA US
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20100293082 | Methods for creating, issuing, managing and redeeming annuity-based retirement funding instruments - A method for administering an annuity-based retirement funding in which an investor's funds or current income is used to make incremental purchases of immediate annuity benefits at market rates, with the annuity payments received from previous purchases being applied purchase additional annuity benefits. The investor allocates a first allocated portion of each received benefit into an account and the reinvested funds are thereafter available in combination with new investment payments from the investor for the purchase of additional immediate annuity benefits. At the direction of the investor, typically after retirement, all or part of the received annuity payments can be received for the use of the investor. | 11-18-2010 |
James O. Williams, Marlborough, MA US
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20130036796 | ENCLOSURE FOR LEAK DETECTOR - A leak detection structure for attachment to a fire hydrant includes an enclosure, the enclosure defining a cavity internal to the enclosure and a leak detection subassembly located in the cavity, the leak detection subassembly including at least one leak detection sensor and at least one circuit. | 02-14-2013 |
20130049968 | FIRE HYDRANT LEAK DETECTOR - A leak detection system includes a housing for installation within a hydrant; at least one leak detection sensor within the housing; and a transmitter circuit in communication with the at least one leak detection sensor for communicating leak detection data. | 02-28-2013 |
James Ola Williams, Marlborough, MA US
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20120090697 | NON-INTERRUPT METER CHANGE OUT - Disclosed is a non-interrupt meter change out device including a clamp assembly, at least one case assembly, and at least one collar, the clamp assembly including a frame and a distance adjuster. | 04-19-2012 |
20120241020 | NOZZEL CHECK VALVE - A protection system for protecting a fire hydrant is disclosed having an interior, the protection system including a nozzle having a first end to be secured to the hydrant and a second end configured to engage a fire hose coupling, the nozzle defining a bore that is in fluid communication with the interior of the fire hydrant, wherein the nozzle defines a seat disposed in the bore; and a disc disposed within the bore and configured to move axially and rotationally from a normally closed position to an open position in response to an increase in pressure within the interior of the fire hydrant. | 09-27-2012 |
20130192348 | SENSOR-ENABLED GATE VALVE - Methods, systems, and apparatus for a gate valve including a body and a sensing bore. A subassembly includes a body with a sensing bore; a bonnet contacting the body; and at least one of a vein and a plug in the sensing bore. | 08-01-2013 |
20130192350 | SENSOR-ENABLED GATE VALVE - Methods, systems, and apparatus for a gate valve including a body, a stem, and a sensing bore. A subassembly includes a body, a stem, and a sensing bore; a bonnet contacting the body; and at least one of a vein and a plug in the sensing bore. | 08-01-2013 |
20130199625 | FLUSHING HYDRANT - A device for flushing a hydrant includes a stem connected to a valve of the hydrant; and an actuation system including a biased translational system coupled to the stem. An actuation system for flushing a hydrant includes a fluid; a piston assembly movable by the fluid; and a biasing element at least indirectly biasing the piston assembly towards a stop position. A method of flushing a hydrant includes operating an actuation system coupled to the hydrant, the actuation system including a stored energy device, a piston assembly coupled to a stem of the hydrant; and a biasing element coupled to the stem, the stem connected to a valve of the hydrant; and opening the valve of the hydrant by releasing energy from the stored energy device against a piston plate of the piston assembly. | 08-08-2013 |
20130206241 | FLUSHING HYDRANT WITH FAIL-SAFE - A device for flushing a hydrant includes a stem connected to a fluid valve of the hydrant and an actuation system including a biased translational system coupled to the stem, a compressed gas, and a normally-open gas discharge valve. An actuation system for flushing a hydrant includes a fluid, a piston assembly movable by the fluid, a manual bleed valve in communication with the fluid, and a biasing element at least indirectly biasing the piston assembly towards a stop position. | 08-15-2013 |
20130281008 | RELAY MODULES FOR COMMUNICATION WITHIN A MESH NETWORK - The present disclosure relates to devices, systems, and methods for relaying data. An exemplary device includes a relay module comprising: a mast having an inner surface and an outer surface, the inner surface defining a cavity; an antenna disposed within the cavity; and a mounting device coupled to the mast and engageable with a utility structure. | 10-24-2013 |
20130281009 | TAMPER-RESISTANT RELAY MODULES FOR COMMUNICATION WITHIN A MESH NETWORK - The present disclosure relates to devices, systems, and methods for relaying data. An exemplary device includes a mast having an inner surface and an outer surface, the inner surface defining a cavity; an antenna disposed within the cavity; and a radio housing engageable with a utility structure by a mounting bracket fastened to the radio housing. | 10-24-2013 |
James R. Williams, Cambridge, MA US
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20110089404 | Microfabrication of Carbon-based Devices Such as Gate-Controlled Graphene Devices - A graphene device includes a graphene layer and a back gate electrode connected to apply a global electrical bias to the graphene from a first surface of the graphene. At least two graphene device electrodes are each connected to a corresponding and distinct region of the graphene at a second graphene surface. A dielectric layer blanket-coats the second graphene surface and the device electrodes. At least one top gate electrode is disposed on the dielectric layer and extends over a distinct one of the device electrodes and at least a portion of a corresponding graphene region. Each top gate electrode is connected to apply an electrical charge carrier bias to the graphene region over which that top gate electrode extends to produce a selected charge carrier type in that graphene region. Such a carbon structure can be exposed to a beam of electrons to compensate for extrinsic doping of the carbon. | 04-21-2011 |
Jeffrey Williams, Plainville, MA US
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20080208202 | ADAPTABLE TOOL REMOVAL DEVICE AND METHOD - The present invention may provide for an adaptable medical tool removal device and method for removing medical instruments seized in vivo. The removal tool may comprise a clamping mechanism. The clamping mechanism may comprise a locking member, a pivotal clamp member, and a connector clamp member. The pivotal clamp member may be pivotally attached to the connector clamp member. The pivotal clamp member may pivot between an opened and a closed position. The locking member may lock the pivotal clamp member in a closed position around a tool adaptor device. The tool adaptor device may attach to a seized medical instrument. The removal tool may further comprise a sliding weight able to impart an impact force to the seized medical instrument through the tool adaptor device. An embodiment of the tool adaptor device may comprise hooks to connect to a t-shaped handle of a seized medical instrument. | 08-28-2008 |
John D. Williams, Worcester, MA US
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20110098323 | INHIBITORS OF BACTERIAL BIOFILM FORMATION - Organic compounds are described for use in inhibiting or preventing formation of bacterial biofilms. | 04-28-2011 |
20120114633 | Inhibitors Of Bacterial Type III Secretion System - Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as | 05-10-2012 |
20120189614 | INHIBITORS OF FILOVIRUS ENTRY INTO HOST CELLS - Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains. | 07-26-2012 |
John D. Williams, Sherborn, MA US
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20140219995 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM - Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as | 08-07-2014 |
John D. Williams, Watertown, MA US
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20130331456 | INHIBITORS OF VIRAL ENTRY INTO MAMMALIAN CELLS - The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell. | 12-12-2013 |
20140142134 | INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM - Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as | 05-22-2014 |
John M. Williams, Hopkinton, MA US
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20100233158 | INDUCTION OF IMMUNE TOLERANCE - Methods of inducing immune tolerance by administering an immunosuppressive agent and a compound represented by Formula (I) are disclosed: | 09-16-2010 |
20130310388 | Modulators of TNF-Alpha Signaling - The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas: | 11-21-2013 |
Jon Williams, Cambridge, MA US
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20120116714 | Digital Data Processing Systems and Methods for Skateboarding and Other Social Sporting Activities - Systems and methods for social and other sporting activities. A system according to one such aspect of the invention comprises a sensing device that is attached to an object, such as a skateboard (by way of non-limiting example), for measuring characteristics thereof. It communicates those characteristics wirelessly, e.g., via bluetooth, to a mobile device, such as a cell phone, personal digital assistant, or the like (by way of non-limiting example). That device can log and/or display those characteristics, graphically, for study or analysis by the operator (e.g., the skateboard enthusiast) or others. | 05-10-2012 |
20130083941 | Devices, Systems, and Methods for Games, Sports, Entertainment And Other Activities of Engagement - Devices, systems, and methods according to one such aspect of the invention comprises (i) a sensing device that is attached (or otherwise coupled) to a skateboard and that measures a physical characteristic of it and/or of its environment, (ii) an audio output device, and (iii) a digital data processor that is communicatively coupled to the audio output device and the sensor. The digital data processor drives the audio output device to effect one or more selected sounds (e.g., to prompt the user to perform a selected action). The digital data processor, further, and monitors the sensing device to identify user actions in response to those sounds and drives the audio output device to effect still further sounds based on those actions. | 04-04-2013 |
20130085713 | SIGNATURE-BASED TRICK DETERMINATION SYSTEMS AND METHODS FOR SKATEBOARDING AND OTHER ACTIVITIES OF MOTION - The invention provides improved devices, systems and methods for skateboarding (and other sporting activities) that monitor motion of a skateboard to identify tricks performed on it by a user. A system according to one aspect of the invention includes (i) a sensing device that is attached (or otherwise coupled) to the skateboard and that measures a physical characteristic of it, and (ii) a data processor that identifies the feat or trick (or other action) performed by or on the skateboard based, at least in part, on correspondence between physical characteristics of motion and/or of the environment measured by the sensing device(s) and a unique signature associated with each of one or more possible tricks. | 04-04-2013 |
Jon Austen Williams, Cambridge, MA US
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20110087454 | Tap Detection - Methodology and circuitry for determining if a device, such as a cellular phone or personal digital assistant has been tapped is disclosed. The device includes an accelerometer and in response to an acceleration, the accelerometer outputs an acceleration signal. The accelerometer may continuously output an acceleration signal even if no acceleration occurs. A tap detection device receives the temporally sampled acceleration signal and takes the first derivative of the temporally sampled acceleration signal producing one or more derivative values. The tap detection system compares each derivative value to a threshold value and if the derivative value exceeds the threshold a tap is detected. By taking the derivative of the acceleration signal, the noise floor for the acceleration signal is reduced leading to more accurate results with less false positives and less positive negatives. | 04-14-2011 |
Kara Williams, Saugus, MA US
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20110067715 | REDUCTION OF CONSTITUENTS IN TOBACCO - Methods of selectively reducing constituents in tobacco as well as the tobacco obtained by such methods are disclosed. Subcritical fluids, e.g., liquid carbon dioxide, serve as the reduction media. | 03-24-2011 |
20140041675 | REDUCTION OF CONSTITUENTS IN TOBACCO - Methods of selectively reducing constituents in tobacco as well as the tobacco obtained by such methods are disclosed. Subcritical fluids, e.g., liquid carbon dioxide, serve as the reduction media. | 02-13-2014 |
Kendrick Barry A. Williams, Duxbury, MA US
Patent application number | Description | Published |
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20100090663 | ENERGY STORAGE MODULE - An energy storage module for providing backup power to electronic systems includes one or more capacitor banks, each including one or more capacitors for storing energy. The energy storage module also includes a first voltage regulator that may, during a normal mode of operation, provide a regulated direct current (DC) voltage to charge the one or more capacitors of each capacitor bank. In addition, each of the capacitor banks may include a voltage leveling circuit that may maintain a specific voltage on the capacitors. Further, the energy storage module includes an output circuit that may, during a backup mode of operation, provide an output voltage derived from an output of each of the one or more capacitor banks. The output circuit includes a control unit configured to regulate and combine the output of each of the one or more capacitor banks. | 04-15-2010 |
Kenneth C. Williams, Newburyport, MA US
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20130244965 | ASSAYS AND METHODS FOR DETERMINING RISK OF A MACROPHAGE-MEDIATED DISEASE DEVELOPMENT IN A SUBJECT INFECTED WITH HIV - The invention is generally related to assays and methods for determining the risk of an HIV+ individual for developing a macrophage-mediated disease using measurement of soluble CD163 levels in a biological sample. The invention also provides assays and methods for monitoring efficacy of a treatment or a drug for a macrophage-mediated disease, and assays and methods for screening for agents to treat a macrophage-mediated disease in an HIV+ individual by monitoring soluble CD163 levels. | 09-19-2013 |
Kevin J. Williams, Lexington, MA US
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20130218625 | UTILIZING HISTORIC PROJECTS TO ESTIMATE A NEW PROJECT SCHEDULE BASED ON USER PROVIDED HIGH LEVEL PARAMETERS - A data warehouse for historic projects can be maintained and can include different artifacts per project, human and organizational resources consumed, intra-artifact temporal dependencies, and timelines. A set of parameters for a new project can be received which can define a scope of the new project at a level of abstraction above an artifact level. Key artifacts and stages needed for completing the project can be established which can be consistent with the set of parameters. Two or more historic projects can be determined to have artifacts/stages similar to the key artifacts/stages of the project. A data driven heuristic algorithms can estimate timelines for producing the key artifacts and the stages based on artifact level data for the historic projects can be executed. A schedule for the project can be generated which can break down the project by the stages and the key artifacts and provide the estimated timelines. | 08-22-2013 |
20130218626 | UTILIZING HISTORIC PROJECTS TO ESTIMATE A NEW PROJECT SCHEDULE BASED ON USER PROVIDED HIGH LEVEL PARAMETERS - A data warehouse for historic projects can be maintained and can include different artifacts per project, human and organizational resources consumed, intra-artifact temporal dependencies, and timelines. A set of parameters for a new project can be received which can define a scope of the new project at a level of abstraction above an artifact level. Key artifacts and stages needed for completing the project can be established which can be consistent with the set of parameters. Two or more historic projects can be determined to have artifacts/stages similar to the key artifacts/stages of the project. A data driven heuristic algorithms can estimate timelines for producing the key artifacts and the stages based on artifact level data for the historic projects can be executed. A schedule for the project can be generated which can break down the project by the stages and the key artifacts and provide the estimated timelines. | 08-22-2013 |
Kevin P. Williams, Natick, MA US
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20090286265 | Cripto Blocking Antibodies And Uses Thereof - The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4 are provided. Antibodies which bind Cripto and modulate tumor growth are also provided. Antibodies which bind Cripto, modulate signaling, and modulate tumor growth are also provided. Antibodies which bind Cripto, block the interaction between Cripto and ALK4 and modulate tumor growth are provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research applications. | 11-19-2009 |
20100202962 | Cripto blocking antibodies and uses thereof - The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4 are provided. Antibodies which bind Cripto and modulate tumor growth are also provided. Antibodies which bind Cripto, modulate signaling, and modulate tumor growth are also provided. Antibodies which bind Cripto, block the interaction between Cripto and ALK4 and modulate tumor growth are provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research applications. | 08-12-2010 |
20120195912 | Cripto Blocking Antibodies and Uses Thereof - The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4 are provided. Antibodies which bind Cripto and modulate tumor growth are also provided. Antibodies which bind Cripto, modulate signaling, and modulate tumor growth are also provided. Antibodies which bind Cripto, block the interaction between Cripto and ALK4 and modulate tumor growth are provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research applications. | 08-02-2012 |
Louise Williams, Reading, MA US
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20130096009 | METHODS OF IDENTIFYING INTERACTIONS BETWEEN GENOMIC LOCI - The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci. | 04-18-2013 |
Marcus R. Williams, Medford, MA US
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20080276408 | AUTONOMOUS COVERAGE ROBOT - A surface treatment robot includes a chassis having forward and rear ends and a drive system carried by the chassis. The drive system includes right and left driven wheels and is configured to maneuver the robot over a cleaning surface. The robot includes a vacuum assembly, a collection volume, a supply volume, an applicator, and a wetting element, each carried by the chassis. The wetting element engages the cleaning surface to distribute a cleaning liquid applied to the surface by the applicator. The wetting element distributes the cleaning liquid along at least a portion of the cleaning surface when the robot is driven in a forward direction. The wetting element is arranged substantially forward of a transverse axis defined by the right and left driven wheels, and the wetting element slidably supports at least about ten percent of the mass of the robot above the cleaning surface. | 11-13-2008 |
20080281470 | AUTONOMOUS COVERAGE ROBOT SENSING - An autonomous coverage robot detection system includes an emitter configured to emit a directed beam, a detector configured to detect the directed beam and a controller configured to direct the robot in response to a signal detected by the detector. In some examples, the detection system detects a stasis condition of the robot. In some examples, the detection system detects a wall and can follow the wall in response to the detected signal. | 11-13-2008 |
20120265343 | AUTONOMOUS COVERAGE ROBOT SENSING - An autonomous coverage robot detection system includes an emitter configured to emit a directed beam, a detector configured to detect the directed beam and a controller configured to direct the robot in response to a signal detected by the detector. In some examples, the detection system detects a stasis condition of the robot. In some examples, the detection system detects a wall and can follow the wall in response to the detected signal. | 10-18-2012 |
20120265346 | AUTONOMOUS COVERAGE ROBOT SENSING - An autonomous coverage robot detection system includes an emitter configured to emit a directed beam, a detector configured to detect the directed beam and a controller configured to direct the robot in response to a signal detected by the detector. In some examples, the detection system detects a stasis condition of the robot. In some examples, the detection system detects a wall and can follow the wall in response to the detected signal. | 10-18-2012 |
20140215735 | AUTONOMOUS COVERAGE ROBOT - A surface treatment robot includes a chassis having forward and rear ends and a drive system carried by the chassis. The drive system includes right and left driven wheels and is configured to maneuver the robot over a cleaning surface. The robot includes a vacuum assembly, a collection volume, a supply volume, an applicator, and a wetting element, each carried by the chassis. The wetting element engages the cleaning surface to distribute a cleaning liquid applied to the surface by the applicator. The wetting element distributes the cleaning liquid along at least a portion of the cleaning surface when the robot is driven in a forward direction. The wetting element is arranged substantially forward of a transverse axis defined by the right and left driven wheels, and the wetting element slidably supports at least about ten percent of the mass of the robot above the cleaning surface. | 08-07-2014 |
Mark K. Williams, Revere, MA US
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20090281353 | Use of dimethyl disulfide for methionine production in microoragnisms - The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of | 11-12-2009 |
Melissa Kiriaki Williams, Boston, MA US
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20090106004 | Systems and methods for evaluating interventions - A system and method for evaluating one or more interventions having a direct or indirect impact on a disease identification or a disease progression incorporating a causal framework to establish relationships among the disease, complications, and comorbidities. The system and method determines population groups and risk factors for the disease, complications, and comorbidities. The system and method structures and calibrates a simulation model of the relationships, population groups, and risk factors and characterizes interventions. The system and method analyzes the characterized interventions to determine the direct or indirect impact of the interventions on the disease identification or progression using the simulation model. An indication of the impact of the interventions is provided on an electronic display or to a memory device. | 04-23-2009 |
Michael L. Williams, Melrose, MA US
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20100262023 | POWER APPROACH TO BIOMEDICAL SIGNAL ANALYSIS - A consideration of electromagnetic energy transfer following from Poynting's theorem leads to a power signal that facilitates the detection of biomedical pulses. This power signal is derived from and is complementary to the measured biomedical voltage signals. The method may be applied to F-wave signals obtained from nerve conduction studies as well as other biomedical signals. Among other things, this power signal is useful in latency determination. | 10-14-2010 |
Michael L. Williams, Newburyport, MA US
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20120236611 | POWER LINE CURRENT FED POWER SUPPLIES PRODUCING STABLE LOAD CURRENTS AND RELATED METHODS - Power line current fed power supplies producing stable load currents and related methods are described. The power supplies may include a current transformer coupled to an inductive network. In some embodiments, the current transformer operates in saturation mode. In some embodiments, a substantially constant DC current is generated having a magnitude that remains substantially constant despite variations of the magnitude of AC current in the power line. | 09-20-2012 |
20130306355 | Electrical Insulator Apparatus and Methods of Retaining an Electrical Conductor with an Electrical Insulator Apparatus - An electrical insulator apparatus and methods of using the same are provided. The apparatus includes an insulator body formed about a central axis, the insulator body having a plurality of spaced fins positioned along an exterior of the insulator body. A first jaw portion is positioned on an upper portion of the insulator body. A second jaw portion is positioned proximate to the first jaw portion and is movable with respect to the first jaw portion. At least one fastener is connected between the first and second jaw portions. A jaw platform is positioned at least partially between the first and second jaw portions, wherein the first and second jaw portions and the jaw platform form a notch sized to receive an electrical conductor, wherein the jaw platform substantially lies within a first plane angled substantially between 6° and 184° with respect to the central axis of the insulator body. | 11-21-2013 |
Mortimer Williams, Sturbridge, MA US
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20130081438 | HYBRID HYDRODYNAMIC AND HYDROSTATIC BEARING BUSHING AND LUBRICATION SYSTEM FOR ROLLING MILL - Rolling mill bearings incorporate bearing bushings with pluralities of hydrostatic pad recesses, that are preferably in conjunction hydrodynamic bearings also formed within the bushing. Each recess has an isolated lubricant passage that is adapted for coupling to a separate isolated source of pressurized lubricant. In some embodiments herein, the isolated pressurized lubricant source is supplied by a dedicated outlet of a pressure pump. In this manner each hydrostatic pad recess has a dedicated pressurized lubricant supply that is not interrupted by loss of lubricant pressure events in other bearing pads or elsewhere within the rolling mill lubrication system. | 04-04-2013 |
Mortimer Daniel Williams, Sturbridge, MA US
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20140076441 | CHOCK DRAIN CONNECTOR - A connector attaches a hose to a port from which oil is drained from the chock of an oil film bearing. The connector comprises a conduit having a first leg adapted to be connected to the chock in communication with the port, and a second leg adapted to be connected to the hose. A latching mechanism coacts with the first leg to releasably secure the conduit to the chock. | 03-20-2014 |
Mortimer Daniel Williams, Stubridge, MA US
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20110108408 | VACUUM DEHYDRATOR - A vacuum dehydrator for processing an oil containing entrained contaminants such as water, air, and particulates comprises a tower enclosing upper and lower chambers. A random packing is contained in the upper chamber. The oil is preheated to a temperature above the boiling point of water and is introduced into the upper chamber for downward flow through the random packing into the lower chamber. Entrained air and water is retained as water vapor in the upper chamber, and particulates are retained in the random packing. Heated ambient air is introduced into the lower chamber for upward flow through the random packing into the upper chamber, and the upper chamber is cooled to condense the water vapor. Oil and condensed water are pumped respectively from the lower and upper chambers. | 05-12-2011 |
Nathan L. Williams, Boston, MA US
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20110320929 | Construction and analysis of markup language document representing computing architecture having computing elements - A markup language document representing computing elements of a computing architecture, such as data storage elements of a data storage architecture, is constructed and analyzed. A first computing element contained by a second computing element is represented; a first tag of the document corresponding to the first computing element is nested within a second tag of the markup language document corresponding to the second computing element. A non-containing/contained relationship from the first computing element to a third computing element is also represented; a pointer tag of the document corresponding to the data access path is nested within the first tag, and references a third tag of the document corresponding to the third computing element. Get-pointer-node and get-child-node application programming interfaces for the markup language are called to traverse among containing/contained relationships. Pointer tags are followed to traverse among non-containing/contained relationships. Redundant attributes among the relationships can thus be detected. | 12-29-2011 |
Peter J. Williams, Dover, MA US
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20110136867 | Treatment of Synucleinopathies - Methods and compositions useful in the treatment or prevention of synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease, and Multiple System Atrophy, or other neurodegenerative diseases are provided. The treatment including administering to a subject a farnesyl transferase inhibitor compound. | 06-09-2011 |
Peter Russell Williams, Wayland, MA US
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20120192106 | MULTIMEDIA AUTHORING TOOL - An apparatus and method of producing multiple panels for display on a single display device receives first and second data through a user interface. The first data relates to a first panel having first visual indicia and a first timeline, while, in a similar manner, the second data relates to a second panel having second visual indicia and a second timeline. The apparatus and method select a given time in both the first and second timelines, and coordinate, at least in part in a computer process, the first data with the second data to produce a multi-panel presentation. The multi-panel presentation has at least one instruction that causes at least a portion of at least one of the first panel and second panel to change size at the given time when displayed on a single display device. | 07-26-2012 |
Ricky N. Williams, Pittsfield, MA US
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20080290109 | Selectably Lockable Case - A lockable container includes a lockable case and an insert. The insert can be stored in the lockable case. The lockable case and the insert can each have one or more engaging elements and receiving elements, with reciprocal elements for engaging or receiving being included in the case or insert. The engaging elements, the receiving elements, or both, can be made removable to provide selective removal of the locking feature of the lockable container. For example, the engaging elements can be a removable post that can be selectively removed from the lockable case. | 11-27-2008 |
Roger Williams, Acton, MA US
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20090147524 | POINT LIGHT SOURCE WITH ACCURATE POSITIONING - A lamp system that has two opposed electrodes for forming an arc with end cap connection has an electrode and a connector made from a unitary conductor as opposed to two parts that need to be connected and positioned after connection. The lamp assembly is particularly useful in cases in which accurate positioning of the arc is useful or even critical such as an application's used to provide light for an optical fiber or other small target. | 06-11-2009 |
20100223843 | INCREASING VITAMIN D CONTENT OF MUSHROOMS WITH UV LIGHT - The vitamin D content of a mushroom can be increased by exposing the mushroom to a lamp that emits UVA and UVB, but not UVC radiation. The need for ozone ventilation is eliminated by utilizing a lamp that does not emit the shorter UVC wavelengths. | 09-09-2010 |
20120017829 | REDUCTION OF STRAY LIGHT DURING SINTERINIG - A conductive particle sintering system has light blocking coating, aperture, or shutter to allow energy from a radiant source, such as a flash lamp, to reach a desired portion of a workpiece to be sintered, while blocking stray light from reaching other workpieces and/or other portions of a workpiece being processed to prevent stray light from partially sintering the other workpieces and/or other portions of a workpiece. | 01-26-2012 |
20130043221 | Sintering Process and Apparatus - A two-step pulse lamp sintering process using a series of low energy light pulses to pre-treat the target before applying one or more higher energy pulses to sinter the metallic nanoparticles. The pulses can be provided so that nanoparticles are not sintered by the low energy pulse(s), but are sintered by the high energy pulse(s). | 02-21-2013 |
Samuel C. Williams, Acton, MA US
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20090242173 | TEMPERATURE CONTROL SYSTEM - An improved system and method for controlling the temperature of fluids during a mixing procedure or a chemical, pharmaceutical, or biological process is disclosed. One embodiment of the system comprises: a first collapsible bag including | 10-01-2009 |
Simon Williams, Sherborn, MA US
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20120283666 | DRUG ELUTING COCHLEAR IMPLANTS - Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance. | 11-08-2012 |
Simon F. Williams, Sherborn, MA US
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20090012604 | POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS - Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation. | 01-08-2009 |
20090093872 | POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS - Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally polylactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation. | 04-09-2009 |
20090162276 | MEDICAL DEVICES CONTAINING MELT-BLOWN NON-WOVENS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF - Continuous processing methods for making absorbable polymeric non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 1 μm to 50 μm, and thickness from 10 μm to 50 mm, have been developed. Improved fiber cohesion is made possible by allowing the fibers of the non-woven to initially remain molten during web collection. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a non-woven of poly-4-hydroxybutyrate or copolymer thereof, wherein the non-woven has a burst strength greater than 0.1 Kgf, wherein the non-woven is derived by a continuous melt-blown process. The non-wovens can be used for a variety of purposes including fabrication of medical devices. | 06-25-2009 |
20110135707 | POLYHYDROXYALKANOATES FOR IN VIVO APPLICATIONS - Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. PHAs are provided which are suitable for use in in vivo applications such as in tissue coatings, stents, sutures, tubing, bone and other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses. Properties which are selected for include degradability, elasticity, inclusion of functional groups or derivatized groups, which can in turn be used to attach targeting agents, and bioadhesion. | 06-09-2011 |
20110189475 | MEDICAL DEVICES CONTAINING ORIENTED FILMS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS - Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm | 08-04-2011 |
20110190866 | POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS - Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation. | 08-04-2011 |
20110318395 | POLYHYDROXYALKANOATE MEDICAL TEXTILES AND FIBERS - Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties. | 12-29-2011 |
20120328523 | POLYHYDROXYALKANOATES FOR IN VIVO APPLICATIONS - Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. The PHAs are suitable for use in in vivo applications such as in tissue coatings, stents, sutures, tubing, bone, other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses. | 12-27-2012 |
20130300018 | Polyhydroxyalkanoate Medical Textiles and Fibers - Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties. | 11-14-2013 |
20130309166 | Injection Molding of Poly-4-Hydroxybutyrate - Compositions of P4HB and processes to injection mold these compositions have been developed. These compositions are prepared from P4HB polymers and blends having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g, moisture contents of less than 0.5% by weight, and more preferably less than 0.05% by weight, and using a polymer melt temperature during molding of at least 150° C. A preferred embodiment comprises a P4HB molding with an intrinsic viscosity of less than 3.2 dl/g that degrades rapidly in vivo. | 11-21-2013 |
20140246802 | Polyhydroxyalkanoate Medical Textiles and Fibers - Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or nomopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally he combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties. | 09-04-2014 |
20140248331 | Polyhydroxyalkanoate Medical Textiles and Fibers - Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties. | 09-04-2014 |
20140275325 | Compositions and Devices of Poly-4-Hydroxybutyrate - Compositions of P4HB with high purity have been developed. The compositions are prepared by washing P4HB biomass prior to solvent extraction, and precipitating P4HB from solution. The same solvent is preferably used to wash the P4HB biomass, and as a non-solvent to precipitate the polymer from a P4HB solvent solution. The highly pure P4HB compositions are suitable for preparing implants. The implants may be used for the repair of soft and hard tissues. | 09-18-2014 |
20140277572 | Ultrafine Electrospun Fibers of Poly-4-Hydroxybutyrate and Copolymers Thereof - Methods to produce structures containing ultrafine fibers with average diameters from 10 nm to 10 μm and more preferably from 50 nm to 5 μm, have been developed. These methods produce ultrafine fibers without substantial loss of the polymer's weight average molecular weight. The ultrafine electrospun fibers have an unexpectedly higher degree of molecular orientation, and higher melt temperature than fibers derived by dry spinning. In the preferred embodiment, the polymer comprises 4-hydroxybutyrate. The ultrafine fibers are preferably derived by electrospinning. A solution of the polymer is dissolved in a solvent, pumped through a spinneret, subjected to an electric field, and ultrafine fibers with a high degree of molecular orientation are collected. These structures of ultrafine fibers can be used for a variety of purposes including fabrication of medical devices. | 09-18-2014 |
20150018878 | SOFT SUTURE ANCHOR - Compositions and materials for making soft suture anchors comprising materials that improve osteointegration have been developed. These compositions and materials comprise bioceramics, resorbable materials, and combinations thereof. A preferred embodiment comprises a soft suture anchor comprising a resorbable ceramic and a resorbable suture. | 01-15-2015 |
20150056131 | THERMOFORMED POLY-4-HYDROXYBUTYRATE MEDICAL IMPLANTS - Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150° C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh. | 02-26-2015 |
20150057368 | CLOSED CELL FOAMS INCLUDING POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF - Methods to produce substantially closed cell foams with densities less than 0.75 g/cm | 02-26-2015 |
20150073444 | Polyhydroxyalkanoate Medical Textiles and Fibers - Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties. | 03-12-2015 |
Thomas D. Williams, Shutesbury, MA US
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20130307714 | Passive Millimeter Wave Imaging System with Environmental Control for Concealed Object Detection - Embodiments of the present innovation relate to a system and technique for passive millimeter wave imaging for concealed object detection. In one arrangement, millimeter wave imaging is provided in conjunction with an environment which is, radiometrically, at a lower temperature than the human subject. In one arrangement, the environment is configured as part of a system wherein the subject may easily pass into the system for scanning and then out of the system. Size of the overall system is minimized. Furthermore, the system includes a structure configured with sufficient strength to withstand reasonable abuse but, at the same time, is substantially transparent to the radiometric wavelengths being employed. | 11-21-2013 |
Tong Li Williams, Shrewsbury, MA US
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20090136558 | Anti-Restenosis Coatings and Uses Thereof - The present invention provides coatings or coating compositions for implantable or insertable medical devices containing one or more polymers and a combination of an immunosuppressant agent and an anti-neoplastic agent. In some embodiments, the coatings or coating compositions of the invention control sustained-release of the immunosuppressant agent and the anti-neoplastic agent for at least about 4 weeks. The present invention also provides implantable or insertable medical devices and other drug delivery or eluting systems containing a coating or coating composition of the invention and uses thereof. | 05-28-2009 |
William Williams, Ipswich, MA US
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20080262016 | ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF - The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described. | 10-23-2008 |
20100113386 | N-BENZYL SUBSTITUTED PYRIDYL PORPHYRIN COMPOUNDS AND METHODS OF USE THEREOF - The present invention relates to N-Benzyl-Substituted Pyridyl Porphyrin Compounds, compositions comprising an effective amount of an N-Benzyl-Substituted Pyridyl Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction, urinary incontinence, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, and methods for prolonging the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of an N-Benzyl-Substituted Pyridyl Porphyrin Compound. | 05-06-2010 |
William R. Williams, Reading, MA US
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20090163637 | Filler system including densed fumed metal oxide - A curable coating composition includes a polymer precursor and at least 6% by weight of a densed fumed metal oxide having a DBP number of at least 65% of the DBP number of an undensed fumed metal oxide of the same composition, surface area, and surface chemistry. The curable coating composition is at most 70% as viscous as a composition having the same components and the same weight fraction of the undensed fumed metal oxide. | 06-25-2009 |
20130129597 | SURFACE-TREATED METAL OXIDE PARTICLES - The invention provides metal oxide particles surface-treated with at least one alkoxysilane compound, methods of making such, and toners comprising same. | 05-23-2013 |
20130230432 | Method And Apparatus For Reducing NOx Emissions In The Incineration Of Tail Gas - Methods for control of NO | 09-05-2013 |
Zev Williams, Brookline, MA US
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20100217299 | SURGICAL REMOVAL OF INTERNAL TISSUE - Methods and devices are provided for macerating and removing tissue. In general, a maceration device is provided that can be distally advanced into a body in a minimally invasive surgical procedure and positioned proximate to tissue desirable for removal from the body. The maceration device can include an elongate shaft having a cutting element positioned on the shaft's side (i.e., not located on a distal tip of the elongate shaft). The cutting element can rotate to macerate tissue. When being introduced to the body, an elongate axis of the elongate shaft and a longitudinal axis of the cutting element can be substantially parallel to each other. When the cutting element rotates, the elongate axis of the elongate shaft and longitudinal axis of the cutting element can not be parallel during at least a portion of the cutting element's rotation. | 08-26-2010 |