Jens Hoffmann
Jens Hoffmann, Muehlenbeck DE
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20100168179 | 6-ALKENYL-, 6-ALKINYL- AND 6-EPOXY-EPOTHILONE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE IN PHARMACEUTICAL PREPARATIONS - This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R | 07-01-2010 |
Jens Hoffmann, Muhlenbeck DE
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20080261929 | COMBINATION OF PROGESTERONE-RECEPTOR ANTAGONIST TOGETHER WITH AN AROMATASE INHIBITOR FOR USE IN BRCA MEDIATED DISEASES - The present invention relates to the combination of the progesterone-receptor antagonist 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof, together with at least one aromatase inhibitor and to the use of said combination for the prophylaxis and treatment of BRCA1- or BRCA2-mediated diseases. Aromatase inhibitors which can be combined together with the compound 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2 pentafluoroethyl)-estra-4,9-dien-3-one are for example aminoglutethimide, fadrozole, anastrozole, letrozole, vorozole, formestane, exemestane and atamestane. | 10-23-2008 |
20080261933 | COMBINATION OF PROGESTERONE-RECEPTOR ANTAGONIST TOGETHER WITH A LUTEIN-HORMONE-RELEASING HORMONE AGONIST AND ANTAGONIST FOR USE IN BRCA MEDIATED DISEASES - The present invention relates to the combination of the progesterone-receptor antagonist 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof, together with at least one lutein-hormone-releasing hormone agonist or antagonist and to the use of said combination for the prophylaxis and treatment of BRCA1- or BRCA2-mediated diseases. Lutein-hormone-releasing hormone agonists and antagonists, which can be combined together with the compound 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2 pentafluoroethyl)-estra-4,9-dien-3-one are for example gonadorelin, goserelin, triptorelin, buserelin, nafarelin, deslorelin, histrelin, antide, ramorelix, cetrorelix, antarelix, ORG30850, abarelix, ganirelix and leuprolin. | 10-23-2008 |
20080268041 | COMBINATION OF PROGESTERONE-RECEPTOR ANTAGONIST TOGETHER WITH NONE-STEROIDAL ANTIESTROGEN FOR USE IN BRCA MEDIATED DISEASES - The present invention relates to the combination of the progesterone-receptor antagonist 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof, together with at least one none-steroidal antiestrogen and to the use of said combination for the prophylaxis and treatment of BRCA1- or BRCA2-mediated diseases. None-steroidal antiestrogens which can be combined together with the progesterone-receptor antagonist 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one are for example is tamoxifen, raloxifene, droloxifen, toremifen, lasofoxifen, arzoxifen, GW5638, EM-800, idoxifen and basedoxifene. | 10-30-2008 |
20090029954 | PROGESTERONE-RECEPTOR ANTAGONIST FOR USE IN BRCA ALONE OR AS COMBINATION WITH ANTIESTROGEN - The present invention relates to the single use of the progesterone-receptor antagonist 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof for the prophylaxis and treatment of BRCA1- or BRCA2-mediated breast cancer, as well as to a combination comprising the progesterone-receptor antagonist 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof, together with at least one pure antiestrogen, for the prophylaxis and treatment of BRCA1- or BRCA2-mediated breast cancer, ovarian cancer endometrial cancer, gastric cancer, colorectal cancer, endometriosis, myeloma, myoma and meningioma. | 01-29-2009 |
20090076098 | METHODS, KITS, AND COMPOUNDS FOR DETERMINING RESPONSIVENESS TO TREATMENT OF A PATHOLOGICAL DISORDER BY EPOTHILONES - The invention provides methods, kits and compounds for determining the potential responsiveness of a subject suffering from a pathological disorder, including non-small cell lung cancer (NSCLC), to treatment with an epothilone by analyzing the gene expression profile and/or certain molecular markers in a sample obtained from said subject. The invention further relates to methods, compounds and uses of said compounds for treating subjects suffering from said pathologic disorder, optionally in combination with other therapeutic agents. Also provided are genes and/or proteins encoded by them whose expression level have been determined to differ between epothilone responders and epothilone non-responders. | 03-19-2009 |
20090163450 | COMBINATIONS COMPRISING A PROSTAGLANDIN AND USES THEREOF - The invention relates to a combination comprising (a) a compound selected from the class of prostaglandins and (b) a compound selected from the class of tubulin/microtubule interfering agents and/or (c) a compound selected from the class of cyclooxygenase inhibitors. | 06-25-2009 |
20120157421 | 17Beta-Alkyl-17Alpha-oxy-estratrienes - The invention relates to 17β-alkyl-17α-oxy-oestratrienes of the formula (I), to processes for their preparation, to the use of the 17β-alkyl-17α-oxy-oestratrienes for preparing pharmaceuticals and to pharmaceutical preparations comprising these compounds. | 06-21-2012 |
Jens Hoffmann, Mannheim DE
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20090147993 | HEAD-TRACKING SYSTEM - A head-tracking system and a method for operating a head-tracking system in which a stationary reference point is detected are provided. A detector for detecting the position of a head is calibrated based on the detected stationary reference point. In one example implementation, the detection of the stationary reference point is used to determine the position of the head. | 06-11-2009 |
Jens Hoffmann, Olching DE
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20120205899 | PASSENGER FRONT AIRBAG - A front passenger airbag ( | 08-16-2012 |
Jens Hoffmann, Stuttgart DE
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20120306479 | POSITION SENSOR - A position sensor has at least one guide rail for a guide housing having a magnetic component. On the guide housing, an encapsulation is accommodated which electrically insulates and/or fixes a lead frame assembly and/or a circuit trace assembly. It forms a retainer for the magnetic component. | 12-06-2012 |
Jens Hoffmann, Darmstadt DE
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20140020997 | DRUM BRAKE MODULE WHICH CAN BE OPERATED BY ELECTRIC MOTOR - A drum brake module for motor vehicles operable by electric motor and performs at least one parking brake function, having an electromechanical actuator mounted on one side of the armature plate and a rotational-translational movement converter converting a rotational drive rotational movement into a translational activation movement of brake shoes arranged on a side of the armature plate facing away from the actuator in a brake drum, and including at least one supporting device between the brake shoes such that the latter can carry out an activation movement in the direction of the brake drum. A drive nut is supported by the rotational-translational movement converter in an axially secure and rotatable fashion on the armature plate to assist the braking force. The drive nut drives a spindle arrangement mounted in a rotationally fixed and axially displaceable fashion and engages with an activation cable on at least one brake shoe. | 01-23-2014 |
Jens Hoffmann, Penzberg DE
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20140051121 | FEED MIXING DEVICE AND ITS USE - Herein is reported a feed mixing device for adding feed solutions with a non-physiologically pH value to a cell cultivation vessel comprising a chamber for mixing the feed solutions prior to their addition to the cell cultivation vessel as well as its use. With the feed mixing device as reported herein feed components can be provided in solution at a pH value at which they have good solubility and/or good stability whereby the pH value can be clearly different from the pH value of the cultivation medium, i.e. different from the physiological pH value. This allows performing the cultivation with more flexibility compared to a cultivation in which the pH value of the feed solution is limited to a small range around the pH value of the cultivation. | 02-20-2014 |
Jens Hoffmann, Meerbusch DE
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20140290813 | TREAD PROFILE OF A PNEUMATIC VEHICLE TIRE WITH AN INDICATOR FOR REGROOVING THE PROFILE - A regroovable treat profile of a pneumatic vehicle tire includes a regrooving indicator formed with an additional indent in the base of the depression in the form of a blind hole lying transversely in relation to the main direction of extent (U) of the groove and having a length of extent (A | 10-02-2014 |
20150251500 | PNEUMATIC VEHICLE TIRE - A vehicle tire has outer shoulders and two tread halves. The vehicle tire includes a tire tread having six block rows and a plurality of circumferential grooves. Mutually adjacent ones of the block rows are separated from each other by a corresponding one of the plurality of circumferential grooves. Each of the block rows has a plurality of individual blocks and the individual blocks of each of the block rows are separated from each other by mutually parallel essentially straight transverse grooves running at an angle to the axial direction of the tire. The circumferential grooves includes first circumferential grooves having a maximum profile depth and second circumferential grooves. The block rows are arranged such that each tread profile half has two pairs of block rows. The pairs of block rows of each tread profile half are separated from each other by a corresponding one of the first circumferential grooves. The block rows of each of the pairs of block rows are separated from each other by a corresponding one of the second circumferential grooves. The second circumferential grooves have a second profile depth less than the maximum profile depth. A first portion of the transverse grooves defines first outlet locations to the first circumferential grooves and a second portion of the transverse grooves has first outlet locations to the outer shoulders. The transverse grooves have a depth approximately corresponding to the maximum profile depth at the first outlet locations. The transverse grooves define second outlet locations to a corresponding one of the second circumferential grooves. The transverse grooves have a depth corresponding to the second profile depth at the second outlet locations. | 09-10-2015 |
Jens Hoffmann, Essen DE
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20150052717 | METHOD AND DEVICE FOR DESCALING A SCALED METAL STRIP - The invention relates to a method for descaling a scaled metal strip, in particular a hot-rolled metal strip with a thickness of more than 1 mm, for example 1.2 mm to 16 mm. The strip is guided around at least two straightening rollers which are arranged one behind the other in the strip running direction and undergoes an alternating bending in the process. At least one of the straightening rollers can be positioned transversely to the strip running direction. The method is characterized in that the strip is unstressed or is under a low tensile stress of less than 10% of the yield strength of the strip on the inlet side upstream of the straightening rollers, and the diameter of the straightening rollers, the spacing between same in the strip running direction, and the positioning of the rollers transverse to the strip running direction are selected while taking into consideration the strip properties such that expansions and compressions of at least 2%, preferably at least 3%, are produced in the course of a first plastic bending process and a second plastic bending process on the strip upper face and on the strip lower face for the purpose of descaling. | 02-26-2015 |
Jens Hoffmann, Aschaffenburg DE
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20150239424 | Airbag Module With an Adaptive Influencing Device - An airbag module having a first shell ( | 08-27-2015 |
Jens Hoffmann, Aschffenburg DE
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20150314747 | Airbag Module With an Adaptive Ventilation Device - An airbag module having a first nozzle ( | 11-05-2015 |