Eldrup
Ann B. Eldrup, Newtown, CT US
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20160053261 | COMPOSITIONS COMPRISING ALTERNATING 2'-MODIFIED NUCLEOSIDES FOR USE IN GENE MODULATION - The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression. | 02-25-2016 |
Anne B. Eldrup, Encinitas, CA US
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20120165515 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase - The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention. | 06-28-2012 |
Anne B. Eldrup, Newtown, CT US
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20160076031 | PHOSPHOROUS-LINKED OLIGOMERIC COMPOUNDS AND THEIR USE IN GENE MODULATION - Oligonucleotide compositions comprising first and second oligonucleotides are provided wherein at least a portion of the first oligonucleotide is capable of hybridizing with at least a portion of the second oligonucleotide, at least a portion of the first oligonucleotide is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligonucleotides includes at least one nucleotide having a modified phosphorous-containing internucleoside linkage. Oligonucleotide/protein compositions are also provided comprising an oligonucleotide complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligonucleotide has a modified phosphorous-containing internucleoside linkage. | 03-17-2016 |
Anne Bettina Eldrup, Danbury, CT US
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20080280904 | N-Substituted Pyridinone or Pyrimidinone Compounds Useful as Soluble Epoxide Hydrolase Inhibitors - Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same. | 11-13-2008 |
20090099184 | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors - Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same. | 04-16-2009 |
20090111791 | Soluble Epoxide Hydrolase Inhibitors and Methods of Using Same - Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same. | 04-30-2009 |
20100121051 | UROTENSIN II RECEPTOR ANTAGONISTS - Compounds of the formula (I) | 05-13-2010 |
Anne Bettina Eldrup, Newtown, CT US
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20110118262 | Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors - Disclosed are compounds of formula (I) and compositions of the present invention which are inhibitors of the sodium proton exchanger isoform-1 (NHE-I). Also disclosed are methods of using and making the same. | 05-19-2011 |
Nils Henrik Eldrup, Stathelle NO
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20120174784 | METHOD AND APPARATUS FOR CO2 CAPTURE - Disclosed is a method for capturing C02 from a gas stream ( | 07-12-2012 |