Herman, MD
Andrew L. Herman, Columbia, MD US
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20090183149 | DATA IMAGING SYSTEM AND METHODS - A method performed by a network device may include receiving index information from a second network device identifying an updated application, querying a third network device for the identified updated application, receiving the identified updated application from the third network device, storing the identified updated application received from the third network device and applying stored application user settings from memory to the stored updated application. | 07-16-2009 |
20120331531 | CUSTOM DATA IMAGE BUILDING - A first server is configured to receive an image from a first client device. The image may include an instruction to provide a second client device with a computer file. The first server is further configured to store the image, receive a task query from the first client device, and provide a task query response to the first client device based on receiving the task query. The task query response may include an indication that the first server is storing a task associated with the second client device. The first server is further configured to receive an image request from the second client device, communicate with a second server to identify whether the second client device is authorized to receive the image, and provide, to the second client device, the computer file associated with the image based on identifying that the second client device is authorized to receive the image. | 12-27-2012 |
Andrew L. Herman, Silver Spring, MD US
Cila Herman, Towson, MD US
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20110230942 | HIGH-RESOLUTION INFRARED IMAGING FOR ENHANCED DETECTION, DIAGNOSIS, AND TREATMENT OF CUTANEOUS LESIONS - A medical diagnosis system, comprising: a thermal stimulator; an infrared detection system constructed and arranged to detect infrared radiation from at least a portion of a subject under observation to provide an output signal from the portion of the subject after undergoing thermal stimulation from said thermal stimulator; and a signal processor in communication with the infrared detection system to receive the output signal from the infrared detection system, wherein the signal processor determines a measured thermal response of the portion of the subject to the thermal stimulation and compares the measured thermal response to an expected thermal response to determine a presence of an abnormality. | 09-22-2011 |
20130116573 | THREE-DIMENSIONAL THERMAL IMAGING FOR THE DETECTION OF SKIN LESIONS AND OTHER NATURAL AND ABNORMAL CONDITIONS - A thermal imaging system includes a data processing system and a geometrical scanning system constructed to communicate with the data processing system. The geometrical scanning system is adapted to scan at least a section of a surface of a subject under observation. The thermal imaging system also includes an infrared imaging system constructed to communicate with the data processing system. The infrared imaging system is adapted to image at least a portion of the section of the surface of the subject under observation. The data processing system is configured to receive data from the geometrical scanning system and to construct a surface map of the section of the surface of the subject under observation and to identify geometrical markers on the surface map based on the data from the geometrical scanning system. The data processing system is also configured to receive data from the infrared imaging system and to construct a thermal map of the portion of the section of the surface, to identify thermal markers on the thermal map based on the data from the infrared imaging system, and to register the thermal map to the surface map based on a correspondence between at least some of the geometrical and thermal markers. The data processor is configured to correct temperatures of the thermal map based on the surface map subsequent to the registering. | 05-09-2013 |
James Herman, Baltimore, MD US
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20110117551 | DETECTION AND PROGNOSIS OF LUNG CANCER - Methods and tools are provided for detecting and predicting lung cancer. The methods and tools are based on epigenetic modification due to methylation of genes in lung cancer or pre-lung cancer. The tools can be assembled into kits or can be used seperately. Genes found to be epigentically silenced in association with lung cancer include ACSL6, ALS2CL, APC2, ART-S1, BEX1, BMP7, BNIP3, CBR3, CD248, CD44, CHD5, DLK1, DPYSL4, DSC2, EDNRB, EPB41L3, EPHB6, ERBB3, FBLN2, FBN2, FOXL2, GNAS, GSTP1, HS3ST2, HPN, IGFBP7, IRF7, JAM3, LOX, LY6D, LY6K, MACF1, MCAM, NCBP1, NEFH, NID2, PCDHB15, PCDHGA12, PFKP, PGRMC1, PHACTR3, PHKA2, POMC, PRKCA, PSEN1, RASSF1A, RASSF2, RBP1, RRAD, SFRP1, SGK, SOD3, SOX17, SULF2, TIMP3, TJP2, TRPV2, UCHL1, WDR69, ZFP42, ZNF442, and ZNF655. | 05-19-2011 |
James Herman, Lutherville, MD US
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20090099037 | Genomic Screen for Epigenetically Silenced Genes Associated With Cancer - A method of identifying epigenetically silenced genes, e.g., methylation silenced genes, in cancer cells is provided. In addition, methods of identifying a cancer by detecting epigenetic silencing of gene expression are provided, as are methods of treating a subject having such a cancer, for example, a colorectal cancer and/or gastric cancer. Reagents for practicing such methods also are provided. | 04-16-2009 |
James Herman, Bltimore, MD US
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20150105342 | IN VITRO METHOD FOR PREDICTING DISEASE OUTCOME IN STAGE II COLORECTAL CANCER - The present invention relates to a method for determining the likelihood of disease outcome of a patient diagnosed with microsatellite stable, stage II colorectal cancer. More in particular, the present invention relates to a method for determining the prognosis of a patient diagnosed with microsatellite stable, stage II colorectal cancer wherein the CpG island methylation status of the promoter of the CHFR gene is determined and wherein methylation of the promoter is indicative of a poor prognosis. | 04-16-2015 |
James G. Herman, Timontown, MD US
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20100112593 | Method of Predicting the Clinical Response to Chemotherapeutic Treatment with Alkylating Agents - The present invention provides methods relating to chemotherapeutic treatment of a cell proliferative disorder. In particular, a method is provided for predicting the clinical response to certain types of chemotherapeutic agents. Alkylating agents, used for the treatment of certain types of tumors including tumors of the nervous system and lymph system, are efficacious agents when the damage they do to tumor cell DNA is not repaired by cellular DNA repair mechanisms. The present invention provides a method for determining the activity of a gene encoding a DNA repair enzyme, thus providing a prediction of the clinical response to alkylating agents. | 05-06-2010 |
James G. Herman, Lutherville, MD US
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20080213782 | SOCS-1 Gene Methylation in Cancer - Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In addition, methods of treating a cancer patient, wherein cancer cells in the patient exhibit methylation-silenced transcription of SOCS/CIS gene such as a SOCS-1 gene, are provided, as are reagents for practicing such methods. | 09-04-2008 |
20090092976 | Hypermethylation of GATA-4 and GATA-5 Transcription Factor Genes in Cancer - Methods are provided for identifying the presence of cancer cells in a sample by detecting hypermethylation of the promoter region of a GATA-4 transcription factor gene, a GATA-5 transcription factor gene, or both. Methods for ameliorating a cancer by effecting expression of a hypermethylation silenced GATA-4 and/or GATA-5 transcription also are provided. | 04-09-2009 |
20100297655 | SOCS-1 GENE METHYLATION IN CANCER - Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In addition, methods of treating a cancer patient, wherein cancer cells in the patient exhibit methylation-silenced transcription of SOCS/CIS gene such as a SOCS-1 gene, are provided, as are reagents for practicing such methods. | 11-25-2010 |
20110159504 | METHYLATION MARKERS FOR SENSITIVITY TO MICROTUBE BASED THERAPIES AND METHODS OF USE - The present invention relates to the use of nucleic acid methylation and methylation profiles to detect predict sensitivity of cells to cytotoxic chemotherapies, and in particular to microtubule based therapies, for example taxanes. The invention relates to methods for identifying a methylation profile of the checkpoint with forkhead and ring finger domains gene (CHFR) that is associated with a sensitivity to agents directed at the microtubule. | 06-30-2011 |
20130288241 | COMPOSITIONS AND METHODS FOR DETECTING A NEOPLASIA - The invention provides compositions and methods for detecting a neoplasia (e.g., pancreatic cancer, lung cancer, colon cancer) in a subject sample (e.g., serum, blood, plasma, tissue). In particular embodiments, the invention provides methods for detecting BNC1 and ADAMTS1 promoter methylation in circulating DNA in serum. | 10-31-2013 |
20150031022 | DNA METHYLATION MARKERS AND METHODS OF USE - The present invention provides methods for identifying metastases by detecting nucleic acid hypermethylation of one or more genes in one or more samples, and in particular in the lymph nodes. The invention further relates to DNA methylation as a predictor of disease recurrence and patient prognosis, specifically in the field of cancer biology. | 01-29-2015 |
James Gordon Herman, Lutherville, MD US
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20100278772 | DNA METHYLATION MARKERS AND METHODS OF USE - The present invention provides methods for identifying metastases by detecting nucleic acid hypermethylation of one or more genes in one or more samples, and in particular in the lymph nodes. The invention further relates to DNA methylation as a predictor of disease recurrence and patient prognosis, specifically in the field of cancer biology. | 11-04-2010 |
20100297067 | METHYLATION MARKERS FOR PROSTATE CANCER AND METHODS OF USE - The present invention provides methods for identifying prostate cancer by detecting nucleic acid methylation of one or more genes in one or more samples. The invention further relates to DNA methylation as a predictor of prostate cancer recurrence and patient prognosis. | 11-25-2010 |
20110165565 | COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE EXTRACTION AND METHYLATION DETECTION - The present invention features methods and compositions for methylation detection, as well as a novel method for polynucleotide extraction and sodium bisulfite treatment. | 07-07-2011 |
Joel Duane Herman, Thurmont, MD US
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20140008596 | RAILING SUPPORT POST WITH THREADED RECEIVERS - A railing support post with threaded holes or receivers for receiving threaded hardware, such as might be used for tensioned cable railing. A decorative sleeve or post cover may be used to at least partially enclose the railing support post. The railing support post may be manufactured, for example, by providing an elongated member of a prescribed length, drilling a plurality of holes spaced along the length of the elongated member, and tapping the plurality of holes to form a plurality of threaded receivers. The threaded receivers are configured to receiver rail fittings or other fittings. | 01-09-2014 |
20140008597 | RAILING SYSTEM AND TENSIONED POSTS USED THEREIN - One or more posts of a railing system are held securely in place by a hidden tensioning cable that extends through a cavity of the post along a longitudinal axis and is tensioned to securely fasten the post securely to a surface of a structure. Placement of the tensioning cable through the cavity allows cable receivers to be placed at desired spacing in one or more receiver channels of the post, the cable receivers operable to receive cable rails of the railing system. The receiver channels are oriented transverse the longitudinal axis of the post and are each configured to receive a receiver in to which a cable assembly may be placed. This abstract is not to be considered limiting. | 01-09-2014 |
20140299829 | RAILING SUPPORT POST WITH THREADED RECEIVERS - A railing support post with threaded holes or receivers for receiving threaded hardware, such as might be used for tensioned cable railing. A decorative sleeve or post cover may be used to at least partially enclose the railing support post. The railing support post may be manufactured, for example, by providing an elongated member of a prescribed length, drilling a plurality of holes spaced along the length of the elongated member, and tapping the plurality of holes to form a plurality of threaded receivers. The threaded receivers are configured to receive rail fittings or other fittings. | 10-09-2014 |
20150308148 | RAILING SUPPORT POST WITH THREADED RECEIVERS - A railing support post with threaded holes or receivers for receiving threaded hardware, such as might be used for tensioned cable railing. A decorative sleeve or post cover may be used to at least partially enclose the railing support post. The railing support post may be manufactured, for example, by providing an elongated member of a prescribed length, drilling a plurality of holes spaced along the length of the elongated member, and tapping the plurality of holes to form a plurality of threaded receivers. The threaded receivers are configured to receive rail fittings or other fittings. | 10-29-2015 |
John M. Herman, Elkton, MD US
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20090240267 | Soft Tissue Defect Repair Device - An inguinal hernia repair device in the form of an implantable plug that is affixed at one end to the center region of a sheet of implantable material. The plug takes the form of a plurality of hollow members, arranged so as to be in substantially parallel relationship when implanted into a defect. The hollow members are preferably tubular members and are preferably bundled together by various means, such as bonding or wrapping a band or strand about the plurality of hollow members to maintain them in adjacent and contacting relationship during insertion into a defect. The device is provided with a base member for anchorage made of a composite material having a non-bioabsorable component and a bioabsorbable component. | 09-24-2009 |
20120035644 | Tissue Plug - Tissue plugs for occlusion of hollow anatomical structures and methods for their use are provided. | 02-09-2012 |
20120232505 | Medical Device for use with a Stoma - An device including a proximal portion adapted for placement intermediately within a hollow body cavity to capture and divert contents; the proximal portion being expandable from an initial state with an initial diameter, into an expanded state with a diameter greater than the initial diameter for engaging the proximal portion with an inner wall of the hollow body cavity; and a distal portion, connected to the proximal portion, adapted to extend through the abdominal wall or into the intestine to conduct the hollow body cavity contents out of the proximal portion. | 09-13-2012 |
Joshua Herman, Potomac, MD US
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20150088649 | Quick Audience Search and Recommendation Apparatus and Method - A system and method for facilitating searching and recommendation for reaching a particular consumer audience with a marketing message operates across multiple media channels. Syndicated survey data for consumer behaviors is combined with consumer segmentation schema to create a subset of segments best associated with the product or service that is the subject of the marketing message. An average propensity index is calculated for that subset of best segments, and displayed for a user along with the total number of consumers in that subset of segments across multiple possible media channels. | 03-26-2015 |
Warren N. Herman, Laurel, MD US
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20120268338 | CONDUCTING POLYMER ANTENNA - An apparatus for receiving and transmitting electromagnetic signals. In one aspect, the apparatus is an antenna. The antenna comprises a dielectric substrate and a non-metallic conducting layer substantially overlying the substrate. In one aspect, the non-metallic conducting layer is an intrinsic conducting polymer (“ICP”). In one exemplary method of manufacturing the antenna, the desired outline of the antenna may be first printed out on a substantially flexible substrate. In one example, a substrate made from polyethylene terephthalate may be used. | 10-25-2012 |