Patent application number | Description | Published |
20110300205 | SELF REPLICATING RNA MOLECULES AND USES THEREOF - This application discloses self-replicating RNA molecules that contain modified nucleotides, compositions that contain the self-replicating RNA molecules, and methods for using the self-replicating RNA molecules, for example, to raise an immune response. | 12-08-2011 |
20130177639 | DELIVERY OF RNA TO TRIGGER MULTIPLE IMMUNE PATHWAYS - RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection. | 07-11-2013 |
20130177640 | DELIVERY OF RNA TO DIFFERENT CELL TYPES - RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection. | 07-11-2013 |
20130195968 | VIRION-LIKE DELIVERY PARTICLES FOR SELF-REPLICATING RNA MOLECULES - Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non-virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases. | 08-01-2013 |
Patent application number | Description | Published |
20110108002 | IGNITION MODULE HAVING A BUS LINE - The invention relates to a portable hand-guided work apparatus having an internal combustion engine ( | 05-12-2011 |
20130112180 | IGNITION DEVICE FOR A TWO-STROKE ENGINE - The invention relates to an ignition device for triggering an ignition spark at a spark plug by way of an ignition generator. The latter includes a magnet wheel, which has two permanent magnets arranged at a spacing from each other in the peripheral direction and a magnetic yoke. The magnetic yoke carries a charging coil which charges an ignition capacitor, a primary coil and a secondary coil, connected, to the spark plug. During every passing of a permanent magnet, a voltage is induced in the coils, wherein, in order to trigger the ignition spark, the ignition capacitor is discharged via a switch element. In order to avoid an unwanted ignition at the bottom dead center of the piston, a device for reducing the voltage that occurs at the spark plug is provided. | 05-09-2013 |
20140028332 | ARRANGEMENT FOR IDENTIFYING A SWITCHING POSITION OF A SWITCH ON AN INTERNAL COMBUSTION ENGINE IN A HANDHELD WORK APPARATUS - The invention relates to an arrangement for identifying a switching position of a switch (on an internal combustion engine in a handheld work apparatus. An energy source for supplying power to an inductive electrical load is provided, it being possible to connect the load to the energy source in order to be switched on and off via a controller. The switch is arranged in a voltage branch which is connected in parallel with the inductive load and in which a zener diode is also connected. The zener diode is activated or inactivated via the switch as a function of the switching position of the switch. The amplitude of the switch-off voltage, which is induced when the inductive load is disconnected, is limited by the zener diode, so that it is possible to read from the magnitude of the amplitude whether the switch is closed or open. | 01-30-2014 |
Patent application number | Description | Published |
20140286369 | OPTOELECTRONIC COMPONENT - An optoelectronic device having an active layer that includes a multiplicity of structural elements spaced apart from one another laterally, wherein the structural elements each have a quantum well structure including at least one barrier layer composed of In | 09-25-2014 |
20140339577 | OPTOELECTRONIC SEMICONDUCTOR CHIP - An optoelectronic semiconductor chip includes a multiplicity of active regions, arranged at a distance from one another, and a reflective layer arranged at an underside of the multiplicity of active regions, wherein at least one of the active regions has a main extension direction, one of the active regions has a core region formed with a first semiconductor material, the active region has an active layer, covering the core region at least in directions transversely with respect to the main extension direction of the active region, the active region has a cover layer formed with a second semiconductor material and covers the active layer at least in directions transversely with respect to the main extension direction of the active region, and the reflective layer reflects electromagnetic radiation generated during operation in the active layer. | 11-20-2014 |
20140353581 | LIGHT-EMITTING DIODE CHIP - A light-emitting diode chip comprising:—a semiconductor body ( | 12-04-2014 |
20150021636 | Optoelectronic Semiconductor Chip - An optoelectronic semiconductor chip includes a number active regions that are arranged at a distance from each other and a substrate that is arranged on an underside of the active regions. One of the active regions has a main extension direction. The active region has a core region that is formed using a first semiconductor material. The active region has an active layer that covers the core region at least in directions perpendicular to the main extension direction of the active region. The active region has a cover layer that is formed using a second semiconductor material and covers the active layer at least in directions perpendicular to the main extension direction of the active region. | 01-22-2015 |
20150207043 | METHOD OF PRODUCING A MULTICOLOR LED DISPLAY - A method produces a multicolor LED display, the display including an LED luminous unit having a multiplicity of pixels. First subpixels, second subpixel and third subpixels contain an LED chip that emits radiation of a first color, wherein a first conversion layer that converts the radiation into a second color is arranged at least above the second subpixels and a second conversion layer that converts the radiation into a third color is arranged above the third subpixels. At least one process step is carried out in which the first or second conversion layer is applied or removed in at least one defined region above the pixels, wherein a portion of the LED chips is electrically operated, and wherein the region is defined by the radiation generated by the operated LED chips, generated heat or a generated electric field. | 07-23-2015 |
20150279902 | METHOD FOR PRODUCING A LIGHT-EMITTING DIODE DISPLAY AND LIGHT-EMITTING DIODE DISPLAY - In at least one embodiment, the method is designed for producing a light-emitting diode display ( | 10-01-2015 |
20150279903 | METHOD FOR PRODUCING AN OPTOELECTRONIC SEMICONDUCTOR COMPONENT, AND OPTOELECTRONIC SEMICONDUCTOR COMPONENT - In at least one embodiment of the method, said method includes the following steps: A) producing radiation-active islands ( | 10-01-2015 |
20160087150 | LIGHT-EMITTING ASSEMBLY HAVING A SEMICONDUCTOR LAYER SEQUENCE HAVING AN ACTIVE ZONE ON A COLUMNAR STRUCTURE - An assembly has a columnar structure arranged with one end on a substrate, wherein the structure is at least partly covered with a semiconductor layer structure having an active zone that generates electromagnetic radiation, the active zone has a band gap for a radiative recombination, and the band gap decreases along a longitudinal axis of the structure in a direction of a free end of the structure such that a diffusion of charge carriers in the direction of the free end of the structure and a radiative recombination of charge carrier pairs in the region of the free end of the structure are supported. | 03-24-2016 |
Patent application number | Description | Published |
20080213302 | Methods for treating cancer with MVA - The invention relates to compositions, kits, and methods for cancer therapy using recombinant MVA viruses encoding a tumor-associated antigen, such as HER-2, particularly in combination with taxanes. The taxanes can be administered prior to, at the same time as, or after the recombinant MVA virus. | 09-04-2008 |
20090104225 | USE OF MVA TO TREAT PROSTATE CANCER - The invention relates to compositions, kits, and methods for cancer prophylaxis and therapy using recombinant MVA viruses encoding tumor-associated antigens, such as PSA and PAP. The recombinant MVA viruses can induce B- and T-cell responses. The recombinant MVA viruses can be administered prior to, at the same time as, or after a taxane. | 04-23-2009 |
20110008294 | METHODS FOR TREATING CANCER WITH MVA - The invention relates to compositions, kits, and methods for cancer therapy using recombinant MVA viruses encoding a tumor-associated antigen, such as HER-2, particularly in combination with taxanes. The taxanes can be administered prior to, at the same time as, or after the recombinant MVA virus. | 01-13-2011 |
20110008386 | USE OF MVA TO TREAT PROSTATE CANCER - The invention relates to compositions, kits, and methods for cancer prophylaxis and therapy using recombinant MVA viruses encoding tumor-associated antigens, such as PSA and PAP. The recombinant MVA viruses can induce B- and T-cell responses. The recombinant MVA viruses can be administered prior to, at the same time as, or after a taxane. | 01-13-2011 |
20150283220 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER - Provided herein are vaccine compositions having potent adjuvant activity. Such compositions are capable of increasing anti-gen-specific antibody responses and increased frequency of Her-2-specific CD4+ T-cells, have improved anti-tumor efficacy, and are useful in methods of treating cancer. | 10-08-2015 |