Patent application number | Description | Published |
20110065610 | Synthetic Polypeptide Libraries and Methods for Generating Naturally Diversified Polypeptide Variants - The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence. | 03-17-2011 |
20110118149 | Synthetic Polypeptide Libraries and Methods for Generating Naturally Diversified Polypeptide Variants - The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence. | 05-19-2011 |
20120184716 | Methods for the Generation of Multispecific and Multivalent Antibodies - The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody. | 07-19-2012 |
20140179547 | Methods For The Generation Of Multispecific And Multivalent Antibodies - The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody. | 06-26-2014 |
Patent application number | Description | Published |
20080261056 | Photocatalytic Substrate Active Under a Visible Light - The invention relates to a substrate provided with a mechanically resistant, long-lasting coating, and suitable for being handled by a user. Said substrate is characterised in that the coating comprises a first photocatalytic compound which is intimately associated with a second compound containing an energy jump between the upper level of the valence band thereof and the lower level of the conductive band thereof, corresponding to a wavelength in the visible field. The invention also relates to a glazing comprising said substrate, to the applications of the inventive substrate, and to the methods for the production thereof. | 10-23-2008 |
20090110918 | Microbicidal Substrate - The invention relates to a substrate comprising at least one photocatalytic compound active under the conditions of illuminating an interior of a building or transport vehicle, intended to neutralize the microorganisms with which it comes into contact, and also to its preparation processes and its uses as glazing or another substrate for disinfection, filtration, ventilation, etc. | 04-30-2009 |
20090175026 | Self-cleaning lighting device - The invention relates to a self-cleaning lighting device comprising a light source and a wall, which permits a portion of at least the radiation emitted by said source to pass therethrough and which is covered, over a portion of at least one of its two faces, by a photocatalytically active layer. The invention is characterized in that under the weakest illumination conditions, the photocatalytic activity of said layer is high enough for degrading and reducing organic soilings into easily eliminable particles that do not adhere to said layer, and/or for conferring a hydrophilic character to this layer. The invention also relates to a method for producing the aforementioned device, a translucent wall provided for this device, and to the use of the device for lighting tunnels, public lighting, airport runway lighting, indoor lighting or for headlamps or indicator lights of transportation vehicles. | 07-09-2009 |
20100303875 | BIOCIDAL GRANULE, IN PARTICULAR FOR MAKING ASPHALT SHINGLE - The invention relates to biocidal granules composed of a mineral core coated with at least one porous inorganic layer including at least one organic compound capable of limiting or preventing the growth of microorganisms, in particular of algae. | 12-02-2010 |