Clark, NJ
Andrew C. Clark, Succasunna, NJ US
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20080304462 | SESSION INITIATION PROTOCOL/INTERNET PROTOCOL MULTIMEDIA SUBSYSTEM BASED ARCHITECTURE FOR SUPPORTING 3G1x VOICE/DATA - A core network architecture for supporting an internet protocol based network is disclosed. The system includes a base station which is configured to convert a signal from a first network to an internet protocol network signal and send the converted signal through the internet protocol base network. The network also includes a gateway which is configured to receive the converted signal and deploy the converted signal through the internet protocol base network. In this sense, the internet protocol base network manages the call mobility and delivery of the signal. The base station in this disclosure may be a femto base station and the first network may be a code division multi-access (CDMA) network. | 12-11-2008 |
Andy J. Clark, East Hanover, NJ US
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20160122109 | RESEALABLE PACKAGE WITH SEGMENTED OPENING - A flexible film package having a resealable opening is provided. The package is comprised of a flexible film with at least a first film layer and a second film layer with a resealable adhesive disposed between portions of the first and second film layer. The flexible film defines at least a portion of an interior cavity where contents, such as discrete food articles, can be stored and a package opening provides access to the discrete food articles. Further, the package has a segmented opening with a plurality of opening windows separated by at least one cross tie that extends from one side of the opening to another side. | 05-05-2016 |
Anthony Clark, West Windsor, NJ US
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20090155874 | METHOD FOR PRODUCING TERPENES AND MEP-TRANSFORMED MICROORGANISMS THEREFORE - The present invention relates to a microorganism capable of producing a terpene of choice. The microorganism expresses a heterologous pathway for the formation of isoprene units and, preferably, a heterologous terpene synthase. In this way, high amounts of terpene can be isolated from the medium of the microorganism. | 06-18-2009 |
Athony Clark, West Windsor, NJ US
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20080201796 | Transformed plants accumulating mono-and/or sesquiterpenes - The present invention relates to plant expressing transgenes and to plants transformed to comprise additional copies of genes, said genes encoding at least a HMGR-CoA reductase and a terpene synthase. The invention further claims methods for preparing the plants, and a method for producing terpenes. The present thus provides a reliable and cost effective platform for generating any terpene, in particular any mono- and/or sesquiterpene of interest. For example, the skilled person may use any gene encoding a sesquiterpene synthase for accumulating the respective sesquiterpene in the plant of the present invention. | 08-21-2008 |
20090123984 | Transformed plants accumulating terpenes - The present invention relates to transformed plants with an altered terpene content, preferably over-accumulating a mono- or sesqui-terpene. By transformation of plants with genes encoding terpene synthases (TS), and prenyl transferases (PRT), plants accumulating at least 1000 ng/per g of fresh leaf of a specific terpene were obtained. The present invention provides an advantageous system for production of terpenes in that any desired mono- or sesqui-terpene at the choice of the skilled person can be produced in plants. Preferably, the transformed plants contain at least one recombinant plastid targeted TS and PRT. | 05-14-2009 |
Charles G. Clark, Cherry Hill, NJ US
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20080221197 | INDOLE ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS - The present invention provides indole compounds of Formula (I) or (II): | 09-11-2008 |
20080280905 | UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS - The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y | 11-13-2008 |
20140163002 | CYCLIC P1 LINKERS AS FACTOR XIA INHIBITORS - The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same. | 06-12-2014 |
20150057262 | CYCLIC P1 LINKERS AS FACTOR XIA INHIBITORS - The present invention provides compounds of Formula (Ia): | 02-26-2015 |
20150259358 | GUANIDINE SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS - The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments. | 09-17-2015 |
20150274671 | GUANIDINE AND AMINE SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS - The present invention provides compounds of Formula (I): (Formula (I)) or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments. | 10-01-2015 |
Christine Clark, Howell, NJ US
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20130013071 | Osteoimplants and Methods for their Manufacture - An osteoimplant is made up of a coherent aggregate of elongate bone particles. | 01-10-2013 |
Christine Yu-Sha Chou Clark, Matawan, NJ US
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20130010946 | METHOD AND APPARATUS FOR SELF-LEARNING OF CALL ROUTING INFORMATION - The present invention is directed to a method and apparatus for learning call routing information in a communication system. A switching architecture is presented. The switch may be implemented in a centralized architecture or a distributed architecture. In addition, the switch may be implemented in a variety of networks such as a circuit-switched network or a packet-switched network. The switch includes a policy server and a self-learning application server. The policy server includes routing information for routing calls across the switch. The routes for incoming and outgoing calls are analyzed as they pass through the switch. The self-learning application server uses artificial intelligence techniques and caching algorithms to learn new more-efficient routing paths or initial routing paths based on the incoming and outgoing calls. The self-learning application server then updates the policy server with the new learned routes. | 01-10-2013 |
Doug Clark, Mendham, NJ US
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20140035693 | METHOD AND APPARATUS FOR IMPLEMENTING HIGH-ORDER MODULATION SCHEMES USING LOW-ORDER MODULATORS - A processing device includes a plurality of modulators, the plurality of modulators performing modulation according to a first modulation scheme, a combiner configured to combine outputs from the plurality of modulators, and a signal processor configured to receive a bit stream and convert the bit stream into a plurality of input signals for the plurality of modulators such that the combiner generates a modulated output according to a second modulation scheme. The plurality of modulators may be low order modulators and a modulation schemes of the modulated output may include, for example, rotated quadrature phase shift keying (QPSK), pulse amplitude modulation (PAM), high order quadrature amplitude modulation (QAM), and multi-resolution high order quadrature amplitude modulation (M-QAM). | 02-06-2014 |
Edwin Clark, Pennington, NJ US
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20100009358 | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer - The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of newly identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of breast cancer. | 01-14-2010 |
20110104306 | NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS - The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent. | 05-05-2011 |
20120141604 | NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS - The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent. | 06-07-2012 |
Edwin A. Clark, Pennington, NJ US
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20080318228 | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents - Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone. | 12-25-2008 |
20090170866 | MOESIN, CAVEOLIN 1 AND YES ASSOCIATED PROTEIN 1 AS PREDICTIVE MARKERS OF RESPONSE TO DASATINIB IN BREAST CANCERS - The invention described herein relates to methods and compositions useful in the diagnosis, treatment and management of cancers that express particular genes, including the moesin, caveolin 1, and/or yes-associated protein 1 genes. | 07-02-2009 |
20100120788 | IDENTIFICATION OF POLYNUCLEOTIDES FOR PREDICTING ACTIVITY OF COMPOUNDS THAT INTERACT WITH AND/OR MODULATE PROTEIN TYROSINE KINASES AND/OR PROTEIN TYROSINE KINASE PATHWAYS IN PROSTATE CELLS - The present invention describes polynucleotides that have been discovered to correlate to the relative intrinsic sensitivity or resistance of cells, e.g., prostate cell lines, to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, such as, for example, members of the Src family of tyrosine kinases, e.g., Src, Fgr, Fyn, Yes, Blk, Hck, Lck and Lyn, as well as other protein tyrosine kinases, including, Bcr-abl, Jak, PDGFR, c-kit and Eph receptors. These polynucleotides have been shown to have utility in predicting the resistance and sensitivity of prostate cell lines to the compounds. The expression level or phosphorylation status of some polynucleotides is regulated by treatment with a particular protein tyrosine kinase inhibitor compound, thus indicating that these polynucleotides are involved in the protein tyrosine kinase signal transduction pathway, e.g., Src tyrosine kinase. Such polynucleotides, whose expression levels correlate highly with drug sensitivity or resistance and which are modulated by treatment with the compounds, comprise polynucleotide predictor or marker sets useful in methods of predicting drug response, and as prognostic or diagnostic indicators in disease management, particularly in those disease areas, e.g., prostate cancer, in which signaling through the protein tyrosine kinase pathway, such as the Src tyrosine kinase pathway, is involved with the disease process. | 05-13-2010 |
20100190150 | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators - EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing the mammal to the EGFR modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer. | 07-29-2010 |
20100221754 | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators - EGFR biomarkers useful in a method for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) measuring in the mammal the level of at least one biomarker selected from epiregulin and amphiregulin, (b) exposing a biological sample from the mammal to the EGFR modulator, and (c) following the exposing of step (b), measuring in the biological sample the level of the at least one biomarker, wherein an increase in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates an increased likelihood that the mammal will respond therapeutically to the method of treating cancer. | 09-02-2010 |
20110166154 | IDENTIFICATION OF PREDICTIVE MARKERS OF RESPONSE TO DASATINIB IN HUMAN COLON CANCER - Methods and compositions are provided useful in the diagnosis, treatment and management of cancers wherein cancer cells express certain polynucleotides and/or polypeptides that are differentially expressed in colon cancer subtypes that are sensitive to therapy with abl kinase inhibitors and src kinase inhibitors. In particular, PTK-7, PLK-2 and PLK-3 could be identified as markers for determining the responsiveness of cancer to dasatinib. | 07-07-2011 |
Elizabeth Clark, Jersey City, NJ US
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20150150681 | TISSUE REPAIR DEVICES AND SCAFFOLDS - The present invention relates to multiphasic, three-dimensionally printed, tissue repair devices or scaffolds useful for promoting bone growth and treating bone fracture, defect or deficiency, methods for making the same and methods for promoting bone growth and treating bone fracture, defect or deficiency using the same. The scaffold has a porous bone ingrowth area containing interconnected struts surrounded by a microporous shell. At the ends of the scaffold, the shell may be extended as a guide flange to stabilize the scaffold between ends of bone. The center of the scaffold may be empty and may serve as a potential marrow space. The porous ingrowth structure may be infiltrated with a soluble filler or carrier, such as, for example calcium sulfate which may be infiltrated with one or more of an antibiotic, a growth factor, a differentiation factors, a cytokine, a drug, or a combination of these agents. | 06-04-2015 |
Janet E. Clark, Matawan, NJ US
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20100040552 | METHODS TO EVALUATE GLUCOCORTICOID RECEPTOR AGONISTS AND ANTAGONISTS FOR EFFECTS ON NEURON-LIKE CELLS - The present invention provides methods for identifying a modulator of glucocorticoid receptor activity. In one embodiment, the methods include the steps of (a) contacting neuron-like cells, in vitro, with a chemical agent; (b) measuring the expression of a member, or group of members, of a group of genes (as defined herein) in the neuron-like cells contacted with the chemical agent; and (c) determining whether the chemical agent significantly alters the expression of the member, or group of members, of the group of genes, thereby determining whether the chemical agent is likely to be a modulator of glucocorticoid receptor activity. In another embodiment, an in vivo method for identifying a modulator of glucocorticoid receptor activity is provided. | 02-18-2010 |
John M. Clark, Little Silver, NJ US
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20090222506 | System and method for metering and analyzing usage and performance data of a virtualized compute and network infrastructure - A method and system for metering and analyzing usage and performance data of virtualized compute and network infrastructures is disclosed. The processing functions of the metered data are divided into “processing units” that are configured to execute on a server (or plurality of interconnected servers). Each processing unit receives input from an upstream processing unit, and processes the metered data to produce output for a downstream processing unit. The types of processing units, as well as the order of the processing units is user-configurable (e.g. via XML file), thus eliminating the need to modify source code of the data processing application itself, thereby saving considerable time, money, and development resources required to manage the virtualized compute and network infrastructure. | 09-03-2009 |
Kerri Clark, Whippany, NJ US
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20150089902 | METHOD OF MAKING A MAGNETIC STRUCTURE - A method is provided for making a magnetic structure. The method includes forming a composition of magnetizable ferrites in a carrier on a substrate at a first location. The method further includes magnetizing the composition on the substrate at a second location different from the first location. More specifically, the substrate may be formed into a packaging housing at the second location and filled with consumable products. | 04-02-2015 |
Kerri Clark, Morristown, NJ US
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20090283581 | PACKAGING AND DISPLAY TRAY FORMED FROM INTERLOCKED BLANKS - The present invention provides a tray for accommodating and dispensing a stacked plurality of consumable product packages and a method for forming the tray. The tray includes a housing having a bottom wall, opposed front and back walls, and opposed side walls extending upwardly from the bottom wall. The housing defines an open upper end. The side walls include an undulating upper extent defined by space apart upwardly opening recesses. The recesses extend below the stacked packages for permitting manual grasping of the individual stacked packages through the side walls. | 11-19-2009 |
20110233097 | PACKAGING ASSEMBLY INCLUDING A BLISTER CARD HAVING A VAPOR BARRIER - A package assembly ( | 09-29-2011 |
20130327820 | RELEASABLY CLOSABLE PRODUCT ACCOMMODATING PACKAGE - A releasable closure provides for the opening and closing of a package assembly which accommodates a plurality of elongate consumable products. The assembly includes a package housing for supporting the products. The package housing includes a first product accommodating compartment and a second product accommodating compartment separated by a hinge. Each of the product accommodating compartments has an open end adjacent the hinge. The product accommodating compartments are foldable about the hinge in a book-like fashion. The releasable closure is applied to each compartment and positioned to be in aligned facing relationship for mutual engagement upon closably folding the compartments about the hinge. | 12-12-2013 |
20140008258 | MAGNETICALLY CLOSABLE PRODUCT ACCOMMODATING PACKAGE - A package for containing and dispensing contents includes a magnetic closure. The package defines a package interior for accommodating the contents. A pair of package portions defines an opening for accessing the package interior. The magnetic closure includes magnetic material which is placed on at least one of the packaging portions for permitting reopenable closure of the packaging portions. | 01-09-2014 |
20150076154 | RELEASABLY CLOSABLE PRODUCT ACCOMMODATING PACKAGE - A releasable closure provides for the opening and closing of a package assembly which accommodates a plurality of elongate consumable products. The assembly includes a package housing for supporting the products. The package housing includes a first product accommodating compartment and a second product accommodating compartment separated by a hinge. Each of the product accommodating compartments has an open end adjacent the hinge. The product accommodating compartments are foldable about the hinge in a book-like fashion. The releasable closure is applied to each compartment and positioned to be in aligned facing relationship for mutual engagement upon closably folding the compartments about the hinge. | 03-19-2015 |
Kerri Kim Clark, Morristown, NJ US
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20110210163 | Package Having An Adhesive-Based Reclosable Fastener And Methods Therefor - A reclosable package for a plurality of products is described herein. The reclosable package includes an adhesive-based fastener that utilizes a low tack adhesive and pivotably connected first and second compartments, each compartment configured to receive the plurality of products therein. The adhesive-based fastener includes opposing portions of resealable adhesive on interior surfaces of the first and second compartments respectively, so that the interior surfaces can be pivoted together to close the reclosable package. | 09-01-2011 |
20110211778 | Reclosable Fasteners, Packages Having Reclosable Fasteners, and Methods for Creating Reclosable Fasteners - A UV-curable pressure sensitive adhesive, a package having an adhesive-based reclosable fastener including the pressure sensitive adhesive, and a method of forming the package is described herein. The package includes a cavity and opposing panels configured to cover an opening to the cavity. The reclosable fastener is a UV-cured pressure sensitive adhesive comprised of one or more UV-curable acrylic oligomers, one or more tack control components, and, optionally, an elastomeric material. An adhesive component ratio defines an effective ratio made up of the weight percent of the UV-curable acrylic oligomer relative to the sum of the weight percents of the tack control component and elastomeric component, where the ratio provides a fastener with a first peel adhesion and subsequent peel adhesions effective to form the adhesive-based fastener into a reclosable fastener. | 09-01-2011 |
Lee M. Clark, Ewing, NJ US
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20110112685 | System and method for the management and design of complex production processes - An apparatus, system and method for line management. The apparatus, system and method includes data indicative of a plurality of items to pass through the line, a plurality of available processes, and a plurality of available streams. Ones of the plurality of available processes are corresponded to obtain at least one outcome. Computing code, when executed by at least one computing processor, effects a presentation of at least one graphical user interface, wherein the at least one outcome is obtained in accordance with at least one input to the graphical user interface related to ones of the items, ones of the processes, and ones of the streams, and wherein the presentation of the at least one graphical user interface optionally comprises a remote presentation via at least one network | 05-12-2011 |
Michael Clark, Freehold, NJ US
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20140132417 | GENERATOR COUPLING KIT AND METHODS THEREOF - A generator coupling kit is provided. In exemplary embodiments, the generator coupling kit may comprise a wire adapted to couple with a generator on a first end, the wire adapted to couple with an outdoor box on a second end; the outdoor box adapted to couple with the wire; an indoor electrical panel adapted to couple with the outdoor box via a generator breaker; and the generator breaker adapted to couple with indoor electrical panel, the generator breaker adapted to couple with the outdoor box via internal wiring, the generator breaker comprising a circuit breaker. | 05-15-2014 |
Nigel Thornton Clark, Princeton, NJ US
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20130073443 | METHOD FOR AUTOMATED TRADING BASED ON INFORMATION IN A PRESS RELEASE - A method for automated trading based on information in a press release is disclosed. A programmed computer receives a press release from a wire service. The programmed computer scans each word of the press release sequentially. The programmed computer employs a scanned word as an index into a pre-processed table of reduced-encoded, negative sentiment and positive sentiment words, where sentiment is measured on a log-scale. The programmed computer fetches a word from the table based on the index. The programmed computer renders at least one trading decision based on the fetched word. The programmed computer delivers the at least one trading decision to at least one trading system. | 03-21-2013 |
Ralph Howard Clark, Palmyra, NJ US
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20090226669 | POLYMERIC ARTICLES HAVING A TEXTURED SURFACE AND FROSTED APPEARANCE - Disclosed is a polymeric article having a frosted and/or surface textured finish made from a polymeric resin comprised of a polymeric matrix and polymeric particles which are substantially spherical, highly crosslinked, have a mean particle size of between 15 and 70 micrometers and have a particle size distribution between 10-110 micrometers. | 09-10-2009 |
Shawn Clark, Hamilton, NJ US
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20100245594 | CAMERA CALIBRATION TOOL - In one embodiment, the present invention is a camera calibration tool. One embodiment of a three-dimensional test target for calibrating an image capturing device includes a first planar face exhibiting a first color, a second planar face exhibiting a two-toned pattern of a second color and a third color, and a third planar face exhibiting the two-toned pattern of the second color and the third color, wherein the first planar face, the second planar face, and the third planar face meet at a first right-angle convex vertex. | 09-30-2010 |
20120206612 | TEST TARGET FOR COLOR CALIBRATING A CAMERA AND LENS COMBINATION - In one embodiment, the present invention is a test target for color calibrating a camera and lens combination. One embodiment of a test target for use in color calibrating a camera and lens combination includes a first substantially flat plane, the first substantially flat plane including a first magnetic support surface, a second substantially flat plane, the second substantially flat plane including a second magnetic support surface, and a hinge connecting the first substantially flat plane to the second substantially flat plane. | 08-16-2012 |
20130016350 | Method for Securing a Display Diagnostic Device to a DisplayAANM Park; TaeyoungAACI PrincetonAAST NJAACO USAAGP Park; Taeyoung Princeton NJ USAANM Tobie; DavidAACI Mount VernonAAST MEAACO USAAGP Tobie; David Mount Vernon ME USAANM Clark; ShawnAACI HamiltonAAST NJAACO USAAGP Clark; Shawn Hamilton NJ US - An apparatus for securing a diagnostic tool proximate to and in front of a display device between the corners thereof. A harness is adapted to releasably hold the diagnostic tool, a restraining bracket extends from the harness, and there is at least one elastic cord having a first end, an intermediate portion and a second end. The cord is threaded through the restraining bracket and is sized so as to impart elastic tension to the corners of the display device while concomitantly protecting the front surface from pressure due to the position of the harness and diagnostic tool. | 01-17-2013 |
Whitney Edna Cameron Clark, Ridgewood, NJ US
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20090239689 | LACROSSE STICK SHAFT HAVING A PLURALITY OF CAVITIES THEREIN - A shaft for sporting equipment comprises an elongate outer wall with a longitudinal bore extending between its first and second ends. An X-shaped web is disposed within the bore and extends along the entire length thereof. The web has four legs that radiate outwardly from a central core and connect to the outer wall. At least one longitudinal opening is defined in the outer wall. The outer wall and web define at least one closed cavity in the shaft. The outer wall, web and opening further define at least one open cavity in the shaft. | 09-24-2009 |
William A. Clark, Matawan, NJ US
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20090092581 | Interferons of rhesus and cynomolgus origin and uses thereof - Disclosed are interferons of Rhesus and Cynomolgus origin and methods of production and use thereof. | 04-09-2009 |