Patent application number | Description | Published |
20110112160 | TABLET COMPRISING EPROSARTAN MESYLATE - A tablet comprising eprosartan mesylate in only one form of either anhydrous or dihydrate form is described. In another aspect, a tablet is disclosed comprising eprosartan mesylate obtainable by direct compression, wherein eprosartan mesylate is provided in one primary form of being either anhydrous or dihydrate to the extent that the eprosartan mesylate shows a dissolution profile with a variability of dissolution from the different tablet samples of a set of below 30%, preferably below 20% and more preferably below 10% relative standard deviation at all time during dissolution, measured using USP apparatus 2, placing the tablets in 1000 ml 0.1 M hydrochloric acid at 37±0.5° C. with paddle speed of 50 rpm. Further described is a set of samples of tablets, wherein each comprises eprosartan mesylate as an active ingredient, wherein the eprosartan mesylate shows a dissolution profile with a variability of dissolution from different tablet samples of the set of below 30%, preferably below 20% and more preferably below 10% relative standard deviation at all time during dissolution. A tablet can be prepared by using a process, comprising providing eprosartan mesylate in only one primary form of being either anhydrous or dihydrate, optionally subjecting eprosartan mesylate to dry granulation process, and a direct compression while maintaining said only one primary form; or by process comprising mixing eprosartan mesylate in particulate form with excipients or additives, wherein the prepared whole dry formulation or granulation of eprosartan mesylate has a water activity of less than 0.62, preferably less than 0.60 and more preferably less than 0.50, respectively determined at room temperature, and subsequently tabletting. Suitable prophylactic and/or therapeutic uses are also described. | 05-12-2011 |
20110135738 | SINGLE DOSAGE PHARMACEUTICAL FORMULATION COMPRISING EPROSARTAN MESYLATE - A dry formulation or granulation of eprosartan mesylate is described which comprises eprosartan mesylate in particulate form with a particle size, wherein at least 65 v/v % eprosartan mesylate particles fall in a particle size range of from 2 to 27 μm. In another aspect, a dry formulation or granulation of eprosartan mesylate comprises eprosartan mesylate combined with an excipient which at least comprises a PEG having molecular weight in the range of 400 to 20000 and mannitol. Further described is a single dosage pharmaceutical formulation such as tablet obtained from such a dry formulation or granulation of eprosartan mesylate by direct compression or dry granulation. A dry formulation or granulation of eprosartan mesylate, or a process for the preparation thereof is also described, which comprising eprosartan mesylate in particulate form mixed with one or more excipients or additives in a way that a limited water activity is obtained. The dry formulation or granulation of eprosartan mesylate can be directly compressed or processed by dry granulation, while maintaining the eprosartan mesylate in only one stable form. Suitable prophylactic and/or therapeutic uses are also described. | 06-09-2011 |
20110136883 | GRANULATION OF ACTIVE PHARMACEUTICAL INGREDIENTS - The present invention discloses a dry formulation or granulation comprising, in admixture, more than 50 wt. % of active pharmaceutical ingredient and from 1 to 10 wt. % of each of any nonaqueous excipient selected from liquid substances. In a preferred embodiment no water or lower alcohol has been added in any step of the preparation of the dry formulation or granulation, and the nonaqueous excipient selected from liquid substances is adsorbed to dryness by the active pharmaceutical ingredient and/or by a further solid excipient. Pharmaceutical formulations based on such dry formulation or granulation, and processes for the preparation thereof, are described as well. The dry formulations or granulations reliably and effectively further processed under dry conditions without requiring active drying, including e.g. briquetting, slugging, sieving, milling, tabletting, further fine granulating, direct compression, and the like. | 06-09-2011 |
20110262497 | NOVEL EZETIMIBE FORMULATIONS - Formulations of ezetimibe are described, wherein attention is paid, alternatively or optionally in combination, to (i) the existence of ezetimibe in the form of primary particles, which when blended with a suitable hydrophilic excipient in particulate form are allowed adsorb on the surface of particles of the hydrophilic excipient; (ii) a selection of specific types of excipients; and/or (iii) a careful control of how the formulation of ezetimibe is obtained. | 10-27-2011 |
Patent application number | Description | Published |
20130227934 | AFTERTREATMENT BURNER AIR SUPPLY SYSTEM - A system and method for efficient regeneration of a diesel particulate filter used in the exhaust system of a diesel engine, is disclosed. In various systems, a burner is incorporated into the exhaust stream, and prior to the diesel particulate filter. Because the burner requires precise amounts of fuel and air to operate properly, an air flow delivery device, such as a positive displacement pump or blower is incorporated into the system to channel boost air to the burner. Alternatively, a bypass line may be used in conjunction with a pressure regulator, wherein the bypass line diverts the boost air from the pump or blower, while the pressure regulator controls the final pressure to the burner. | 09-05-2013 |
20140208720 | CATALYTIC BURNER SYSTEM FOR DPF REGENERATION - A system and method of effective regeneration of a diesel particulate filter used in the exhaust system of a diesel engine during low engine operating temperatures, is disclosed. Generally speaking, a catalytic burner system and method used in filter regeneration on a diesel engine comprises a burner diesel oxidation catalyst (BDOC) coupled to an exhaust flow of the diesel engine, a mixer fluidly coupled to the BDOC, a diesel oxidation catalyst (DOC) fluidly coupled to the mixer, and a diesel particulate filter (DPF) fluidly coupled to the DOC, wherein the BDOC directs the exhaust flow through the mixer, the DOC and the DPF during a regeneration cycle of the DPF under low engine temperature operating conditions. | 07-31-2014 |
20150020503 | CONTROL OF PASSIVE SOOT OXIDATION - A system and method for controlling passive soot oxidation in a diesel particulate filter that includes sensing the temperature of exhaust gases upstream and downstream of the diesel particulate filter. The sensed temperatures are used by a control unit to predict whether the temperature of the exhaust gas within the diesel particulate is within a predetermined temperature range for passive oxidation of soot in the diesel particulate filter. If the temperatures are below passive oxidation temperatures, an auxiliary component is activated that increases the temperature of exhaust gas delivered to the diesel particulate filter. When the exhaust gas temperature within the DPF is predicted to be within passive oxidation levels but below active regeneration temperatures, the auxiliary component is deactivated. | 01-22-2015 |
20150020504 | EXHAUST FLOW ESTIMATION - The present technology provides systems for monitoring particulate matter buildup on a filter installed in the engine exhaust stream of a vehicle. A filter differential pressure sensor monitors a pressure differential across the filter. A downstream differential pressure sensor monitors a pressure differential across an exhaust stream outlet. A processor monitors a particulate buildup value based at least in part on the pressure differential across the filter and the pressure differential across the exhaust stream outlet. A method for monitoring particulate buildup is also provided. The method monitors a pressure differential across the filter, and determines a downstream exhaust flow rate based on a pressure differential between a filter outlet housing and an exit pipe, where the diameter of the filter outlet housing is greater than the diameter of the exhaust exit pipe. | 01-22-2015 |
20150083096 | TURBOCHARGER TURBINE BOOSTER - A method of operating the turbine booster to improve engine operating response and to increase the effectiveness of emission control devices is disclosed. A turbocharger turbine booster for a turbo charged internal combustion engine provides pressurized air to the turbocharger turbine and increases the oxygen in engine exhaust without increasing the engine combustion oxygen content. | 03-26-2015 |