Alving
Carl Alving, Bethesda, MD US
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20080233142 | Use of penetration enhancers and barrier disruption methods to enhance the immune response of an antigen - A transcutaneous immunization system where the topical application of an adjuvant and an antigen or nucleic acid encoding for an antigen, to intact skin induces a systemic or mucosol antibody response. The immune response so elicited can be enhanced by physical or chemical skin penetration enhancement. | 09-25-2008 |
20140220107 | TRUNCATED HIV ENVELOPE PROTEINS (ENV), METHODS AND COMPOSITIONS RELATED THERETO - The instant application provides methods and related compositions pertaining to novel HIV envelope proteins. In some embodiments, the invention relates to methods and compositions for the preparation, production, and administration of isolated novel HIV envelope nucleic acid and protein sequences suitable, for example, as vaccines against HIV. | 08-07-2014 |
Carl R. Alving, Bethesda, MD US
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20080274533 | T4 BACTERIOPHAGE BOUND TO A SUBSTRATE - T4 bacteriophages are bound to substrates such as liposomes using a binder. | 11-06-2008 |
20090081244 | Dry Formulation for Transcutaneous Immunization - A transcutaneous immunization system delivers antigen to immune cells through the skin, and induces an immune response in an animal or human. For example, skin-active adjuvant (e.g., an ADP-ribosylating exotoxin) can be used to induce an antigen-specific immune response (e.g., humoral and/or cellular effectors) after transcutaneous application of a dry formulation containing antigen and adjuvant to skin of the animal or human. The dry formulation may be a powder or a unit-dose patch. Use of adjuvant is not required if the antigen is sufficiently antigenic. Transcutaneous immunization may be induced with or without penetration enhancement | 03-26-2009 |
20110243979 | Method of Transcutaneous Immunization Using Antigen - Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response. Use of skin-active adjuvants is preferred. Although perforation of intact skin is not required, superficial penetration or micropenetration of the skin can act as an enhancer; similarly, hydration may enhance the immune response. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigen and adjuvant. The formulation may initiate processes such as antigen uptake, processing, and presentation; Langerhans cell activation, migration from the skin to other immune organs, and differentiation to mature dendritic cells; contacting antigen with lymphocytes bearing cognate antigen receptors on the cell surface and their stimulation; and combinations thereof. Systemic and/or regional immunity may be induced; immune responses that result in prophylaxis and/or therapeutic treatments are preferred. Antigen and adjuvant activities in the formulation may be found in the same molecule, two or more different molecules dissociated from each other, or multiple molecules in a complex formed by covalent or non-covalent bonds. For antigens and adjuvants which are proteinaceous, they may be provided in the formulation as a polynucleotide for transcutaneous genetic immunization. Besides simple application of a liquid formulation, patches or other medical devices may be used to deliver antigen for immunization. | 10-06-2011 |
20120201845 | TRANSCUTANEOUS IMMUNIZATION WITHOUT HETEROLOGOUS ADJUVANT - Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response without the use of a heterologous adjuvant. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigens Immune responses that provide prophylactic and/or therapeutic treatments are preferred. Antigenic activities in the formulation may be found in the same molecule, two or more different molecules dissociated from each other, or multiple molecules in a complex formed by covalent or non-covalent bonds. For antigens which are proteinaceous, they may be provided in the formulation as a polynucleotide for transcutaneous genetic immunization. Besides simple application of a dry or liquid formulation to the skin, patches and other medical devices may be used to deliver antigen for immunization. | 08-09-2012 |
Kim Alving, Rockville, MD US
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20080219992 | Pancreatic cancer secreted targets and uses thereof - The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAST) and antibodies binds to PCAST. The present invention provides that PCAST is used as targets for screening agents that modulates the PCAST activities. Further the present invention provides methods for treating diseases associated with pancreas. | 09-11-2008 |
Kjell Alving, Uppsala SE
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20150025407 | DEVICES AND METHODS FOR GENERATING AN ARTIFICIAL EXHALATION PROFILE - Methods and devices for creating an artificial exhalation profile, for example for use in the sampling of exhaled breath or air from the nasal cavity from a mammal, wherein said mammal exhales into a device comprising a flow channel, a pressure sensor, a flow sensor, a control unit, and means for creating an exhalation flow, wherein said means for creating an exhalation flow maintain an exhalation flow at one or more pre-determined flow rate (rates), within a predetermined interval, substantially independent of exhalation pressure. | 01-22-2015 |
Lex Alving, Mierlo NL
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20110108735 | HIGH DYNAMIC RANGE X-RAY DETECTOR WITH IMPROVED SIGNAL TO NOISE RATIO - An x-ray detector and its pixel circuit are described, that allow to cover a large dynamic range with automatic selection of the sensitivity setting in each pixel, thus providing improved signal to noise ratio with all exposure levels. X-ray detectors are required to cover a large dynamic range. The largest exposure determines the required pixel capacitance. However, a large pixel capacitance gives a bad signal to noise ratio with small exposures e.g. in the dark parts of the image. This invention disclosure describes several approaches to provide automatic sensitivity selection in the pixels. This ensures that low signals are stored in a small capacitor or read out with a high sensitivity with corresponding good signal to noise ratio, while larger signals are stored in larger capacitors or are read out with lower sensitivity so that no information is lost. | 05-12-2011 |
20120080606 | PROCESSING CIRCUIT FOR AN X-RAY SENSOR - A processing circuit for an X-ray sensor for collecting at least a first pixel information of a first pixel and a second pixel information of a second pixel is provided. The processing circuit comprises an amplifier ( | 04-05-2012 |