Patent application number | Description | Published |
20120101256 | MULTISPECIFIC PEPTIDES - The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions. | 04-26-2012 |
20120172235 | PEPTIDE LIBRARIES - The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive groups, to produce a second repertoire of polypeptide ligands, comprising assembling said second repertoire from the polypeptides and structural scaffold of said first repertoire, incorporating one of the following alterations: (a) altering at least one reactive group; or (b) altering the nature of the molecular scaffold; or (c) altering the bond between at least one reactive group and the molecular scaffold; or (d) any combination of (a), (b) or (c). | 07-05-2012 |
20140163201 | MULTISPECIFIC PEPTIDES - The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions. | 06-12-2014 |
Patent application number | Description | Published |
20100314461 | VOLATILE COMPOSITION DISPENSER - A volatile composition dispenser comprises a volatile composition container comprising at least one volatile composition therein. A rupture element is positioned proximate to the volatile composition container. The volatile composition container comprises a cam comprising a camming surface. The camming surface is configured to move at least a portion of the rupture element toward the volatile composition container to puncture the volatile composition container and release at least a portion of the volatile composition from the volatile composition container such that the portion of the volatile composition evaporates and exits the volatile composition dispenser. | 12-16-2010 |
20130047358 | CLEANING DEVICE HAVING ONBOARD REPLACEABLE CLEANING PAD AND ONBOARD REPLACEABLE CLEANING SOLUTION - A device for cleaning debris from a target surface. The device has a sole plate with permanent cleaning material, such as bristles, and a removable/replaceable pad. The device also has a replaceable, on-board supply of cleaning solution. The pad/cleaning solution may be replaced when depleted and replaced with a new pad/cleaning solution or may simply be replaced with a new pad/cleaning solution when that pad/cleaning solution is more suitable for a particular cleaning task. | 02-28-2013 |
20150013350 | Cryogenic Fluid Cylinder - A cryogenic fluid cylinder includes an inner vessel for holding cryogenic fluid, a cylindrically shaped outer vessel having a vertical longitudinal axis surrounds the inner vessel and forms an insulating space there between, and operating controls located on a top of the outer vessel. Customer or end user operating controls include a liquid-use valve for selectively dispensing liquid cryogen, a pressure-building valve for selectively controlling a pressure building circuit, and a gas-use valve for selectively dispensing cryogen gas. Supplier or maintenance personnel operating controls include an economizer regulator for selectively setting at least one desired pressure of the inner vessel, a vent valve for selectively venting cryogen fluid, and a vacuum pressure port for indicating vacuum pressure between the vessels. The end user controls are located on a front side of the outer vessel while the supplier controls are located on a rear side of the outer vessel. | 01-15-2015 |