Van Es, NL
Andries Johannes Jozef Van Es, Dorst NL
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20080274957 | RGD-ENRICHED GELATINE-LIKE PROTEINS WITH ENHANCED CELL BINDING - The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems. | 11-06-2008 |
20090182063 | RGD-ENRICHED GELATINE-LIKE PROTEINS WITH ENHANCED CELL BINDING - The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems. | 07-16-2009 |
20100048477 | METHOD FOR PREVENTION OF PLATELET AGGREGATION EMPLOYING AN RGD-ENRICHED GELATINE-LIKE PROTEINS - The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems. | 02-25-2010 |
20100222264 | USE OF RGD-ENRICHED GELATINE-LIKE PROTEINS FOR INHIBITION OF CANCER METASTASIS - The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines arc prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems. | 09-02-2010 |
Arthur Van Es, Eindhoven NL
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20080276370 | Trolley For Transporting a Patient and a Patient Handling System - A trolley for transporting a lying patient comprising a transferable table-top ( | 11-13-2008 |
Arthur R. Van Es, Eindhoven NL
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20120325334 | MANIFOLD FOR A FLUIDIC CARTRIDGE - A manifold system is provided that includes a manifold housing and a manifold core. The manifold housing is configured to receive the manifold core. The manifold housing includes an oblique inner surface and at least one fluidic channel. The fluidic channel ends with one of its ends at the oblique inner surface. The manifold housing together with the at least one fluidic channel has no undercut. | 12-27-2012 |
Arthur Robert Van Es, Eindhoven NL
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20080201849 | Patient Handling System Whereby a patient Table Top Can Move Over a Table Base - A patient handling system comprising a table top ( | 08-28-2008 |
20120085078 | GUIDANCE CHAIN FOR GUIDING CABLES OR OTHER LINES IN A MEDICAL DIAGNOSTIC APPARATUS - The invention relates to a guidance chain ( | 04-12-2012 |
20130066412 | ELECTRODE ASSEMBLY WITH MAGNETIC CONNECTION - An electrode assembly that includes an electrode configured to provide electrical contact with a subject's skin through a subject contact surface. The electrode includes an electrode base pad having a first contact surface on a side of the electrode opposite the subject contact surface. The electrode also includes a connector assembly configured to electrically connect the electrode to an external electrical apparatus to transfer electrical signals between the subject's skin and the external electrical apparatus. The connector assembly includes a housing having a second contact surface. The second contact surface is configured to be magnetically and electrically coupled to the first contact surface of the electrode base pad. The connector assembly also includes an electrical connector configured to connect the second contact surface to the external electrical apparatus. | 03-14-2013 |
20140191592 | Electro-mechanical energy harvesting switch - An electro-mechanical energy harvesting switch configured to provide at least two different control signals comprises: a generator activating member ( | 07-10-2014 |
20140353135 | Self-powered energy harvesting switch and method for harvesting energy - A switch device ( | 12-04-2014 |
20150084440 | ENERGY HARVESTING DEVICE - Energyharvesting device The present invention relates to a very simple and robust wireless batteryless device ( | 03-26-2015 |
20150192287 | LIGHTING DEVICE COMPRISING A HEAT SINK STRUCTURE - A lighting device ( | 07-09-2015 |
20150233533 | LED BASED LINE ILLUMINATION LUMINAIRE AND SYSTEM - LED luminaire ( | 08-20-2015 |
Daniel Stephan Van Es, Pb Wageningen NL
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20140371472 | METHOD OF MAKING ISOIDIDE - Disclosed is a process for the preparation of isoidide from isosorbide. An aqueous solution of isosorbide is subjected to epimerization in the presence of hydrogen under the influence of a catalyst comprising ruthenium on a support, preferably a carbon support. The process of the invention can be conducted using a relatively low hydrogen pressure, and leads to a desired distribution of epimers, favoring isoidide over isomannide and isosorbide. | 12-18-2014 |
Daniël Stephan Van Es, Bennekom NL
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20160107967 | METHOD FOR THE DEPOLYMERIZATION OF LIGNIN - A catalytic method is disclosed for the valorization of lignin. The method comprises subjecting lignin to a catalyzed hydrothermal conversion reaction, said reaction being conducted in the presence of water at an alkaline pH>8 and a temperature of 200° C.-300° C., under the influence of a noble metal catalyst comprising a carbon support. The same reaction can also be applied to subsequently defunctionalize one or more phenolic compounds, notably guaiacol, so as to produce six-membered cyclic hydrocarbons, such as phenol. | 04-21-2016 |
Daniël Stephan Van Es, Bennekom NL
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20120178961 | BIO-DERIVED OLEFIN SYNTHESIS - Disclosed is a method for the combined synthesis of at least two vinylic monomers, at least one of which being an acrylic compound, comprising subjecting a monoconjugated alkene-1-carboxylic compound to reaction with a C | 07-12-2012 |
Daniël Stephan Van Es, Wageningen NL
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20150065749 | CATALYTIC OXIDATION OF URONIC ACIDS TO ALDARIC ACIDS - Disclosed is the oxidation of uronic acids, such as galacturonic acid, to the corresponding aldaric acids (characterized by the formula HOOC—(CHOH)n-COOH, with n being an integer of from 1 to 5) such as galactaric acids. The starting material comprising the uronic acid is subjected to oxygen under the influence of a supported gold catalyst and in the presence of a base. The oxidation occurs in good selectivity and yield, under unexpectedly mild conditions. A source of galacturonic acids is pectin, such as that derived from sugar beet pulp. | 03-05-2015 |
20160075672 | PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF FURAN-2,5-DICARBOXYLIC ACID OR DERIVATIVES THEREOF - Disclosed is a method of making 5-formyl-2-furoic acid and furan-2,5-dicarboxylic acid. The method involves the use of 5-keto-aldonic acids as intermediates, as these can be subjected to ring formation by a cyclodehydration reaction under mild conditions. The 5-formyl-2-furoic acid or carboxylic derivative thereof is subjected to oxidation so as to form furan-2,5-dicarboxylic acid. The 5-keto-aldonic acid intermediates can be obtained by isomerization of uronic acids which can be obtained from sugar beet pulp, chicory pulp, fruit peals including orange peels, or non-terrestrial sources like seaweeds. A preferred source is sugar beet pulp. | 03-17-2016 |
Helmuth H.g. Van Es, Haarlem NL
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20100087514 | METHOD AND MEANS FOR TREATMENT OF OSTEOARTHRITIS - The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject. | 04-08-2010 |
20120190727 | METHOD AND MEANS FOR TREATMENT OF OSTEOARTHRITIS - The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject. | 07-26-2012 |
20140107181 | METHODS AND MEANS FOR TREATMENT OF OSTEOARTHRITIS - The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject. | 04-17-2014 |
Jan Robert Van Es, Zoelen NL
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20150211201 | Vibrator System - A vibrator-system for sinking an object into the ground by means of vibration, comprising a suspension yoke, a carter or carters mounted to the suspension yoke and equipped with a rotatable eccentric weight or weights for the generation of the vibration, and clamping means connected at a side of the carter or carters that is opposite to the suspension yoke for clamping the object, wherein the vibrator system is convertible between a first configuration and a second configuration, wherein in the first configuration a single carter is mounted to the suspension yoke and the clamping means are mounted to the single carter, and that in the second configuration two carters, each equipped with a rotatable eccentric weight or weights, are mounted between the suspension yoke and the clamping means. | 07-30-2015 |
Johannes Van Es, Zwolle NL
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20100245791 | LITHOGRAPHIC APPARATUS AND DEVICE MANUFACTURING METHOD - Methods and apparatus for maintaining the thermal equilibrium of a substrate and an immersion lithographic apparatus are disclosed using or having a timetable comprising information regarding the position, speed and/or acceleration of the substrate; and an evaporation controller and/or condensation controller acting to decrease localized evaporation and/or increase localized condensation in response to the information in the timetable. Evaporation of liquid from the surface of the substrate cools it down, while condensing liquid on its bottom surface heats the substrate locally. | 09-30-2010 |
20110232878 | HEAT PIPE, LITHOGRAPHIC APPARATUS AND DEVICE MANUFACTURING METHOD - A heat pipe to maintain an object at a substantially uniform temperature is disclosed. The heat pipe includes a chamber containing a liquid reservoir and a vapor space, part of the chamber being defined by a condensing surface, and a liquid transporter to apply a force additional to gravity to liquid to transport liquid away from the condensing surface towards the reservoir, wherein the condensing surface is shaped such that condensed liquid moves along it towards the liquid transporter. | 09-29-2011 |
20140318169 | SYSTEM FOR FAST AND ACCURATE FILLING OF A TWO-PHASE COOLING DEVICE, NOTABLY A HEAT PIPE, ADAPTED FOR USE IN AN AUTOMATED PROCESS - The current invention relates to a system for fast and accurate filling of a two-phase cooling device, comprising a binding device ( | 10-30-2014 |
20150292497 | Piezo pump and pressurized circuit provided therewith - A piezo pump for use in a pressurized circuit includes a pump chamber with an inlet provided with a one way inlet valve, for connection to a feeding line of the pressurized circuit and an outlet provided with a one way outlet valve, for connection to a discharge line of the pressurized circuit and a piezo pump diaphragm closing one end of the pump chamber. A pressure chamber, which can function as a second pump chamber if desired, is defined at the side of the piezo pump diaphragm facing away from the pump chamber, wherein said pressure chamber is connected to a pressure source, which may be the feeding line. | 10-15-2015 |
Johannes Hendrikus Van Es, Maarsen NL
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20090306049 | Treatment of Barrett's Esophagus - The invention relates to the field of biochemistry and medicine. More specifically, the invention relates to the treatment of epithelial changes in the esophagus. Even more specific, the invention relates to the treatment of Barrett's esophagus. The invention provides a method for at least in part decreasing Barrett's esophagus present in an animal comprising at least in part inhibiting Notch pathway activation in said animal. Preferably, said inhibition of Notch pathway activation is accomplished via a g-secretase inhibitor. | 12-10-2009 |
Johannes Hendrikus Van Es, Maarssen NL
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20100292165 | Treatment of an intestinal adenoma and/or adenocarcinoma by inhibition of notch pathway activation - The invention relates to the field of biochemistry and medicine. More specifically, the invention relates to methods and pharmaceuticals for the treatment of intestinal neoplasia. The invention discloses the surprising finding that inhibitors of Notch pathway activation (for example, γ-secretase inhibitors) are extremely useful in the treatment of intestinal adenoma and/or adenocarcinoma. | 11-18-2010 |
Martin Antonius Van Es, Brunssum NL
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20090126060 | PROCESS FOR THE PRODUCTION OF A MONOLAYER COMPOSITE ARTICLE, THE MONOLAYER COMPOSITE ARTICLE AND A BALLISTIC-RESISTANT ARTICLE - Process for the production of a monolayer composite article comprising an unidirectional array of high performance polyolefin fibers, the process comprising the steps of positioning of the fibers in a coplanar, parallel fashion consolidation of the fibers to obtain the monolayer composite article, the process comprises after the step of position of the fibers and before or after the step of consolidation of the fibers, a step in which the fibers are stretched. | 05-21-2009 |
20100050310 | BALLISTIC RESISTANT SHEET AND BALLISTIC RESISTANT ARTICLE - The present invention relates to a ballistic resistant sheet comprising a stack of at least 2 monolayers with on top hereof a polymeric film, each monolayer containing nidirectionally oriented reinforcing fibers or yarns with a tensile strength of between 3.5 an 4.5 GPa, and at most 20 mass % of a matrix material, the areal density of a monolayer is between 10 and 80 g/m | 03-04-2010 |
20100170021 | BALLISTIC-RESISTANT MOULDED ARTICLE AND PROCESS FOR OBTAINING SUCH ARTICLE - The invention relates to a process for the manufacture of a moulded article comprising the steps of forming a stack by stacking (2) or more sheets comprising monolayers of unidirectional fibers and optionally a binder; providing isostatic pressurizing means; placing the stack in the isostatic pressurizing means; and consolidating the stack under temperature and isostatic pressure into a moulded article. The invention furthermore relates to products obtainable with said process, which are very suitable for use in anti-ballistic applications and include e.g. helmets, curved panels, cones and domes. | 07-08-2010 |
20120085224 | STACK OF FIRST AND SECOND LAYERS, A PANEL AND A BALLISTIC RESISTANT ARTICLE COMPRISING THE STACK OR PANEL - The invention relates to a stack comprising a stack of first and second layers. The first layers comprise drawn polymeric fibers and optionally a binder, and the second layers comprise drawn polymeric tapes. The invention also relates to a panel comprising a consolidated stack and to a ballistic resistant article comprising the stack or the panel. | 04-12-2012 |
Martin Antonius Van Es, Landgraaf NL
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20130284006 | PROCESS FOR COMPACTING POLYMERIC POWDERS - The invention relates to a process for compacting a polymeric powder in a press, wherein the polymeric powder is supported during compaction by a powder carrier, characterized in that said powder carrier comprises a layer of thickness (T), said layer comprising a material with a static coefficient of friction (COF), and wherein TχCOF is at least 10 μm. The invention also relates to a compacted polymeric powder obtainable with the above process. | 10-31-2013 |
20130291712 | MULTI-BALLISTIC-IMPACT RESISTANT ARTICLE - The invention relates to a multi-ballistic-impact resistant article comprising a plurality of stacked monolayers ( | 11-07-2013 |
Michel Van Es, Eindhoven NL
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20130220136 | TEA MAKER WITH LUMINOUS BREWING PROGRESS INDICATOR - A tea maker ( | 08-29-2013 |
Paul Emile Van Es, Helvoirt NL
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20080277244 | Conveyor Segment And Assembly For Use In High Wall Mining, And Coupling And Releasing Methods - The invention relates to a conveyor segment ( | 11-13-2008 |
20090039695 | GUIDE FRAME FOR GUIDING CONVEYOR SEGMENTS IN HIGH WALL MINING - The invention relates to a guide frame for use in high wall mining to be located between a launching apparatus and the entrance of a shaft ( | 02-12-2009 |
Rene Van Es, Utrecht NL
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20150065855 | CARDIAC IMAGING PROCESSING FOR INTERVENTIONS - A method of processing an image includes determining a local disease severity measure based on a 3D dataset. The method further includes determining a target region for a treatment, based on the local disease severity measure, wherein the target region corresponds to a transition region between a first region and a second region, wherein the first region has values of the local disease severity measure which are substantially distinct from the values of the local disease severity measure in the second region. The method further includes registering at least the target region with an interventional image modality. For example, the local disease severity measure is indicative of a measure of a local disease severity at a location along a surface of a myocardium. | 03-05-2015 |
Roland Arthur Van Es, Waalre NL
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20080244630 | Cooling and Selective Dust Shielding of Optical Pick-Up Unit in Dvd Disc Drive - A DVD data drive ( | 10-02-2008 |
Thomas Van Es, Voorschoen NL
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20160054304 | MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF FIBROTIC DISEASES - The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic conditions. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of fibrotic conditions. The invention further provides in vitro methods for reduction or inhibition of macrophage differentiation into alternatively-activated macrophages (M2). | 02-25-2016 |