Patent application number | Description | Published |
20100216858 | BENDAMUSTINE CYCLOPOLYSACCHARIDE COMPOSITIONS - The present invention is directed to pharmaceutical compositions comprising: (a) bendamustine, (b) a charged cyclopolysaccharide, and (c) a stabilizing agent having a charge opposite to that of the cyclopolysaccharide. Such composition provides unexpectedly desirable stability in reactive environments such as plasma, coupled with unexpectedly desirable anticancer activity. Such compositions are suitable for injection or infusion into patients in need for treatment with bendamustine. | 08-26-2010 |
20110015244 | BENDAMUSTINE AMPHIPHILIC ANIONIC COMPOSITIONS - The present invention is directed to pharmaceutical compositions comprising bendamustine and one or more amphiphilic anionic compounds and self assembled aggregates, which aggregates exhibit enhanced stability in aqueous solutions, including plasma, are disclosed. The unexpectedly enhanced stability afforded by such aggregates permits patients to be treated with bendamustine in lower and/or with less frequent dosages or to improve its therapeutic effect while using the same as presently used treatment protocol. | 01-20-2011 |
20110015245 | BENDAMUSTINE AMPHIPHILIC CATIONIC COMPOSITIONS - The present invention is directed to pharmaceutical compositions comprising bendamustine and one or more amphiphilic cationic compounds, which self assemble to form aggregates. The exhibiting enhanced stability in aqueous solutions, including plasma. The unexpectedly enhanced stability afforded by such aggregates permits patients to be treated with bendamustine in lower and/or with less frequent dosages or to improve its therapeutic effect while using the same as presently used treatment protocol. | 01-20-2011 |
20110207760 | SN-38 COMPOSITIONS - In one aspect, the present invention is directed to a stable aqueous composition including (a) SN-38; (b) a sulfoalkyl derivative of a cyclodextrin; and (c) water; in which the concentration of SN-38 in the composition is at least about 0.13 mg/g of the composition. In another aspect, this invention is directed to a process for making the composition which process comprises mixing SN-38 and a sulfoalkyl derivative of a cyclodextrin in an aqueous medium wherein the water content of the mixture is less than about 60% by weight. | 08-25-2011 |
20110207764 | CYCLOPOLYSACCHARIDE COMPOSITIONS - The present invention is directed to a composition including: (a) an active ingredient other than bendamustine; (b) a charged cyclopolysaccharide comprising at least one charged group; and (c) a stabilizing agent comprising at least one charged group having a charge opposite to that of the cyclopolysaccharide. The composition provides unexpectedly desirable stability in reactive environments such as plasma which contain entities (such as enzymes, other proteins and the like) and/or conditions which can decompose or deactivate the active ingredient. | 08-25-2011 |
20120015995 | BENDAMUSTINE ANIONIC-CATIOINIC CYCLOPOLYSACCHARIDE COMPOSITIONS - The present invention is directed to pharmaceutical compositions including: (a) bendamustine, (b) a first charged cyclopolysaccharide, and (c) a stabilizing agent which is a second charged cyclopolysaccharide having a charge opposite to that of the first charged cyclopolysaccharide. The composition provides unexpectedly desirable stability in reactive environments such as plasma, coupled with unexpectedly desirable anticancer activity. The compositions are suitable for injection or infusion into patients in need for treatment with bendamustine. | 01-19-2012 |
20130150311 | MIXED POLOXAMER EXCIPIENTS - In one aspect, the present invention is directed to a dry, flowable and compressible composition, useful as a pharmaceutical excipient, which composition comprises a mixture of hydrophobic and hydrophilic poly(ethylene oxide)-polypropylene oxide)-poly(ethylene oxide) block copolymers, and which possesses a Carr index of less than about 20. In other aspects, the present invention is directed a pharmaceutical composition comprising such adjuvant and a pharmaceutically active ingredient; as well as to a method of making the compositions. | 06-13-2013 |
20130150397 | RAPAMYCIN COMPOSITION - In one aspect, the present invention is directed to a dry, flowable and compressible rapamycin composition comprising a specific mixture of hydrophobic and hydrophilic poly(ethylene oxide)-polypropylene oxide)-poly(ethylene oxide) block copolymers. In other aspects, the present invention is directed to a method of making the composition. | 06-13-2013 |
Patent application number | Description | Published |
20120018334 | CONJUGATED ANTIMICROBIAL AGENTS - Provided herein are antimicrobial conjugates of two antibiotic agents, exhibiting improved activity also against resistant bacteria, compared to each of the agents separately or their mixture, and having substantially no resistance emerged thereagainst, as well as processes for preparation the same, compositions containing the same, and uses thereof in medical treatments against pathogenic microorganisms. The disclosed antimicrobial conjugates are composed of aminoglycosides and non-ribosomal active antibiotics. Some of the antimicrobial conjugates are prepared via “click” chemistry. | 01-26-2012 |
20130237489 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS - A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5″ position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: | 09-12-2013 |
20140357590 | AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS - A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5″ position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: | 12-04-2014 |
20140357591 | CONJUGATED ANTIMICROBIAL AGENTS - Provided herein are antimicrobial conjugates of two antibiotic agents, exhibiting improved activity also against resistant bacteria, compared to each of the agents separately or their mixture, and having substantially no resistance emerged thereagainst, as well as processes for preparation the same, compositions containing the same, and uses thereof in medical treatments against pathogenic microorganisms. The disclosed antimicrobial conjugates are composed of aminoglycosides and non-ribosomal active antibiotics. Some of the antimicrobial conjugates are prepared via “click” chemistry. | 12-04-2014 |
Patent application number | Description | Published |
20120097144 | EXPLOSIVE DECOMPRESSION PROPULSION SYSTEM - A projectile propulsion system includes a launch tube, multiphase material, and a membrane. The launch tube has an interior cavity, the multiphase material disposed therein. The launch tube also has an opening to receive the multiphase material. The membrane seals the opening while the multiphase material is disposed in the interior cavity of the launch tube so as to allow the launch tube to be pressurized. When the membrane is broken, a supersonic wave thrusts the contents of the interior cavity, such as a projectile, outwards with a high velocity and force. | 04-26-2012 |
20120204709 | PROJECTILE PROPULSION SYSTEM - A projectile propulsion system includes a launch tube, multiphase material, and a pressure barrier member. The launch tube has an interior cavity, the multiphase material disposed therein. The launch tube also has an opening to receive the multiphase material. The pressure barrier member seals the opening while the multiphase material is disposed in the interior cavity of the launch tube so as to allow the launch tube to be pressurized. When the pressure barrier member is broken, a shock wave allows the contents of the interior cavity, such as a projectile, to be expelled from the tube with a high velocity and force. | 08-16-2012 |
Patent application number | Description | Published |
20090012578 | Neurostimulation Catheter - The conductor is composed of at least one layer ( | 01-08-2009 |
20090277460 | Operating Drapes with a Window - The invention relates to an operating drape formed by an impermeable web that has a window ( | 11-12-2009 |
20100030163 | Connector For A Establlshing A Fluid Communication Controlled By A Valve Essentially Used In The Field Of Medicine - According to the invention, the spring-effect deformation capacity of the valve ( | 02-04-2010 |
20100179484 | Device For Introducing A Catheter Guide Wire Into A Vessel - A device for introducing a catheter guide wire into a vessel of a patient has a connector and a straightener for a J-shaped end of the guide wire, the connector having an axial bore, and its distal end and proximal end permitting a connection of the Luer type to a needle and to a syringe, respectively. The connector supports, on its inside, a sealing valve equipped with a slit, and the axial bore has, in its portion between the sealing valve and the distal end of the connector, a leaktight mating surface, the shape of which is such that it permits liquid-tight mating with the outer surface of the distal end of the straightener, when the latter is introduced into the connector via the sealing valve. | 07-15-2010 |
Patent application number | Description | Published |
20100154570 | ATOMCHIP DEVICE - An AtomChip device and a method for trapping, manipulating and measuring atoms in ultra high vacuum chamber, and for increasing the lifetime of the trapped atoms, the AtomChip device including at least one conductive element, made of metal, wherein at least part of the metal is a dilute alloy metal, and wherein the at least one conductive element has a low working temperature. | 06-24-2010 |
20100320995 | ATOM CHIP DEVICE - Ultra-cold (nano-Kelvin) neutral atoms can be trapped, manipulated, and measured, using integrated current carrying micro-structures on a nearby surface (Atom Chips). This can be utilized for the realization of ultra-sensitive sensors and quantum computation devices based on the quantum mechanical properties of the trapped atoms. However, harmful processes arise from the interactions between the atoms and the nearby surface. According to the present invention these harmful processes can be highly suppressed by using electrically anisotropic materials. It is shown that time-independent trapping potential corrugation leading to fragmentation of the trapped atom cloud can be suppressed, and that time dependent noise processes arising from the coupling of atoms to the nearby surface, and leading to loss of atoms from the trap, heating and loss of coherence can be significantly reduced. | 12-23-2010 |
Patent application number | Description | Published |
20090242388 | Stress adjustment in reactive sputtering - In a dual cathode magnetron, an adjustment circuit is provided between a pair of sputter targets having a coaxial (preferably frusto-conical) relationship to modify the distribution of ion and electron currents flowing from the plasma discharge to a substrate residing within a sputter chamber. A stress adjustment circuit is used to modify the ion bombardment of the growing films on the substrate resulting in a mechanism for control of the stress in the deposited films. In a preferred embodiment, the adjustment circuit comprises a variable resistor disposed between an internal shield that acts as a passive anode and a target. The value of the variable resistor influences the plasma discharge current distribution between the split sputter targets and the internal shields, and can effectively be used to adjust the properties of the deposited films. | 10-01-2009 |
20090242392 | Stress adjustment in reactive sputtering - In a dual cathode magnetron, an adjustment circuit is provided between a pair of sputter targets having a coaxial (preferably frusto-conical) relationship to modify the distribution of ion and electron currents flowing from the plasma discharge to a substrate residing within a sputter chamber. A stress adjustment circuit is used to modify the ion bombardment of the growing films on the substrate resulting in a mechanism for control of the stress in the deposited films. In a preferred embodiment, the adjustment circuit comprises a variable resistor disposed between an internal shield that acts as a passive anode and a target. The value of the variable resistor influences the plasma discharge current distribution between the split sputter targets and the internal shields, and can effectively be used to adjust the properties of the deposited films. | 10-01-2009 |
20090246385 | Control of crystal orientation and stress in sputter deposited thin films - A two step thin film deposition process is disclosed to provide for the simultaneous achievement of controlled stress and the achievement of preferred crystalline orientation in sputter-deposited thin films. In a preferred embodiment, a first relatively short deposition step is performed without substrate bias to establish the crystalline orientation of the deposited film followed by a second, typically relatively longer deposition step with an applied rf bias to provide for low or no stress conditions in the growing film. Sputter deposition without substrate bias has been found to provide good crystal orientation and can be influenced through the crystalline orientation of the underlying layers and through the introduction of intentionally oriented seed layers to promote preferred crystalline orientation. Conversely, sputter deposition with substrate bias has been found to provide a means for producing stress control in growing films. | 10-01-2009 |
Patent application number | Description | Published |
20090189083 | Ion-beam source - An ion-beam source comprising: a plasma-generation unit for generating plasma and an ion-extraction unit for extraction and acceleration of ions from the aforementioned plasma, where the ion-extraction unit is made in the form of at least one grid under a negative potential. The plasma generating unit consists of a working chamber having a deeply immersed antenna cell. The cell contains a ferromagnetic core, a heat conductor with a heat sink, at least one inductive coil wound onto the ferromagnetic core, and a cap made from a dielectric material that sealingly covers the ferromagnetic core and the inductive coil. | 07-30-2009 |
20100136262 | INDUCTIVE PLASMA SOURCE WITH HIGH COUPLING EFFICIENCY - A method and apparatus are provided for processing a substrate with a radiofrequency inductive plasma in the manufacture of a device. The inductive plasma is maintained with an inductive plasma applicator having one or more inductive coupling elements. There are thin windows between the inductive coupling elements and the interior of the processing chamber. Various embodiments have magnetic flux concentrators in the inductive coupling elements and feed gas holes interspersed among the inductive coupling elements. The thin windows, magnetic flux concentrators, and interspersed feed gas holes are useful to effectuate uniform processing, high power transfer efficiency, and a high degree of coupling between the applicator and plasma. In some embodiments, capacitive current is suppressed using balanced voltage to power an inductive coupling element. | 06-03-2010 |
20100283399 | Symmetrical RF Power Supply for Inductively Coupled Electrodeless Lamps - A radio frequency (RF) power supply for an electrodeless lamp includes a pair of DC rails, an RF inverter having power input terminals connected between the rails, a first inductor arranged to inductively couple with an electrodeless lamp, first and second resonance capacitors that each connects a respective one of two input terminals of the first inductor to a same first rail of the pair of DC rails, and a second (ballasting) inductor connecting an output of the RF inverter to one of the two input terminals of the first inductor. Thus, the first inductor is connected in a symmetrical π-filter and supplied by two equal but phase-opposite voltages whose sum is the lamp voltage. The inductance of the ballasting inductor is significantly reduced so that the RF efficiency of the power supply is 96%. | 11-11-2010 |
20120074855 | Power Splitter Circuit For Electrodeless Lamp - A lamp assembly adapted to operate as one of a total number of lamp assemblies that are connected together in series and connected to a ballast. The lamp assembly comprises an electrodeless, closed-loop, tubular lamp envelope enclosing mercury vapor and a buffer gas, and a transformer core disposed around a portion of the lamp envelope. An input winding is disposed on the transformer core so that it has a particular number of turns, N | 03-29-2012 |
Patent application number | Description | Published |
20080244534 | SYSTEM AND METHOD FOR TROUBLESHOOTING SOFTWARE CONFIGURATION PROBLEMS USING APPLICATION TRACING - A software system is disclosed which facilitates the process of tracing the execution paths of a program, called a client or application. Trace data corresponding to selected system resources that interact with the execution of the application is collected during the tracing operation and stored in an application signature. A computer system user can generate trace options, trace the application, and compare the application signature to a known software configuration. The application signature is compared to a reference signature created by tracing the execution of the application on a system with the known software configuration. In another embodiment, the application signature is compared to a static configuration of a reference computer. | 10-02-2008 |
20100088683 | SYSTEM AND METHOD FOR SOFTWARE DIAGNOSTICS USING A COMBINATION OF VISUAL AND DYNAMIC TRACING - A software system is disclosed that provides remote troubleshooting and tracing of the execution of computer programs. The software system allows a remote software developer or help desk person to troubleshoot computer environment and installation problems such as missing or corrupted environment variables, files, DLLs, registry entries, and the like. In one embodiment the software system includes an information-gathering module that gathers run-time information about program execution, program interaction with the operating system and the system resources. The information-gathering module also monitors user actions and captures screen output. The information-gathering module passes the gathered information to an information-display module. The information-display module allows a support technician (e.g., a software developer, a help desk person, etc.) to see the user interactions with the program and corresponding reactions of the system. In one embodiment, the information-display module allows the support technician to remotely view environment variables, file access operations, system interactions, and user interactions that occur on the user's computer and locate failed operations that cause execution problems | 04-08-2010 |
20140245268 | SYSTEM AND METHOD FOR TROUBLESHOOTING SOFTWARE CONFIGURATION PROBLEMS USING APPLICATION TRACING - In a general aspect, a tracer is configured to instrument an application by injecting at least one interrupt instruction at a function entry point in a memory image of the application such that executable code of the application is not modified. The tracer is configured to collect information relating to execution of the application when the inserted at least one interrupt instruction is triggered during runtime of the application including tracing at least one operating system function used by the application at the function entry point. The tracer is configured to create an application signature based on the collected information. The application signature provides information about at least one system object accessed by the at least one operating system function. | 08-28-2014 |
Patent application number | Description | Published |
20110258005 | SYSTEM AND METHOD FOR ANCILLARY TRAVEL VENDOR FEE EXPENSE MANAGEMENT - A computer-implemented method and system for ancillary travel vendor fee expense management comprising: receiving, by at least one expense management application, travel expense transaction data, said travel expense transaction data further comprising at least one expense transaction attribute; generating, by the at least one expense management application, at least one travel expense transaction record, wherein said at least one travel expense transaction record includes said expense transaction data, and storing said at least one expense transaction record in an expense transaction database; determining, by at least one ancillary fee module which analyzes the at least one expense transaction attribute, whether the at least one expense transaction corresponds to a travel event, a fee for an ancillary good or service offered by a travel vendor, or a fee for an ancillary good or service offered by a travel agency; presenting the at least one expense transaction record on a computerized user interface contained within at least one expense management application, wherein it is indicated whether the at least one expense transaction is at least one ancillary fee; and, adding the at least one expense transaction record to an expense report. | 10-20-2011 |
20130218615 | SYSTEM AND METHOD FOR INTEGRATED TRAVEL AND EXPENSE MANGEMENT AND DETECTING DUPLICATE TRAVEL PATH INFORMATION - Methods and systems may retrieve travel data records corresponding to travel requests; retrieve expense data records reflecting expense transactions, compare the expense data records to the travel data records, and determine a likelihood that the expense data records match the travel data records. Methods and systems may also detect possible duplicate travel path information by obtaining a set of travel paths with at least two travel paths, breaking each travel path into at least one segment comprising a single unit of travel with an origin and a destination, comparing each leg in each travel path to each leg in every other travel path to determine whether any travel paths are duplicates, and listing any segment paths that are possible duplicates. | 08-22-2013 |
Patent application number | Description | Published |
20080208628 | System and Method for Targeted Healthcare Messaging - A system and method for targeted healthcare messaging is provided. The system includes a central targeted messaging server for receiving targeted advertisements or messages, such as information about one or more clinical trials, from a plurality of data sources, a notification database for storing the targeted messages and associated, pre-defined criteria, and a web server which can communicate with a plurality of message requesters to receive requests for targeted messages and to convey same to the plurality of message requesters. A customized web site could be provided for allowing vendors (e.g., pharmaceutical companies, etc.) to upload targeted message text files and/or voice files to the system of the present invention. In response to prescription-related activity, requests for targeted messages are transmitted by the plurality of message requesters to the system of the present invention. The targeted messaging server queries the notification database to identify a matching targeted message, and responds with the location of a matching targeted message text and/or voice file. The matching targeted message can then be transmitted and conveyed to the recipient. | 08-28-2008 |
20080208986 | System and method for targeted healthcare messaging - A system and method for targeted pharmaceutical messaging is provided. The system includes a central targeted messaging server for receiving targeted advertisements or messages from a plurality of data sources, a notification database for storing the targeted messages and associated, pre-defined criteria, and a web server which can communicate with a plurality of message requesters to receive requests for targeted messages and to convey same to the plurality of message requesters. A customized web site could be provided for allowing vendors (e.g., pharmaceutical companies, etc.) to upload targeted message text files and/or voice files to the system of the present invention. In response to prescription-related activity, requests for targeted messages are transmitted by the plurality of message requesters to the system of the present invention. The targeted messaging server queries the notification database to identify a matching targeted message, and responds with the location of a matching targeted message text and/or voice file. The matching targeted message can then be transmitted and conveyed to the recipient. | 08-28-2008 |
20100239075 | System and Method for Providing Local Interactive Voice Response Services - A system and method for providing local interactive voice response (IVR) services is provided. A local computer system having associated telephony equipment and installed at a local facility (e.g., a retail store of a chain, etc.) receives telephone calls to the local facility. The local computer system generates IVR prompts locally, and is controlled by a central IVR server. Reduced bandwidth is required between the local computer system and the central IVR server since no voice traffic is communicated between the central IVR server and the local computer system. | 09-23-2010 |
20110082705 | Remote Prescription Refill System - A prescription refill system having interactive text messaging capabilities is provided. A computer system remote from a pharmacy receives a text message from a customer cellular phone relating to a prescription refill request. The computer system sends another text message back to the customer's cellular telephone, prompting the customer to select a pharmacy from a plurality of pharmacies, at which the customer desires to have the prescription refilled. The customer sends a text message selecting the desired pharmacy, and the system transmits the prescription refill request to the desired pharmacy for subsequent filling. The system could also transmit a text message to the customer's cellular telephone regarding the status of the prescription refill request. | 04-07-2011 |
20120330678 | System and Method for Targeted Healthcare Messaging Using Mobile Communication Devices - Systems and methods are provided for targeted healthcare messaging using mobile communication devices. A targeted messaging server is provided and is in communication with a plurality of data sources and a mobile communication device remote from the targeted messaging system. The system detects prescription-related activity occurring at the mobile communication device and automatically generates a request for a targeted healthcare message in response to a prescription-related activity detected by the system. The targeted messaging server receives the request, queries a database to identify a link to a matching targeted healthcare message, and transmits the link to the mobile communication device. The link is accessed at the mobile communication device and to convey the targeted healthcare message to the user. | 12-27-2012 |
Patent application number | Description | Published |
20110081494 | Organoclay-Polyurea Nanocomposites - A nanocomposite having a nanomaterial dispersed into a polymer matrix, in one embodiment exfoliated nanoclay dispersed in a polyurea matrix. A method of making PU-nanocomposites for coatings for improved mechanical properties, in one embodiment the method comprises obtaining and treating a nanomaterial, dispersing the nanomaterial into a pre-polymer matrix, mixing the pre-polymer matrix under heating to form a coating; and depositing the coating on a substrate. | 04-07-2011 |
20140187449 | FUNCTIONALIZED SILICATE NANOPARTICLE COMPOSITION, REMOVING AND EXFOLIATING ASPHALTENES WITH SAME - Removing an asphaltene particle from a substrate includes contacting a silicate nanoparticle with a chemical group to form a functionalized silicate nanoparticle, the chemical group includes a first portion; and a second portion comprising an aromatic moiety, the first portion being bonded to the silicate nanoparticle; contacting the asphaltene particle with the functionalized silicate nanoparticle, the asphaltene particle being disposed on the substrate; interposing the functionalized silicate nanoparticle between the asphaltene particle and the substrate; and separating the asphaltene particle from the substrate with the functionalized silicate nanoparticle to remove the asphaltene particle. A composition includes a functionalized silicate nanoparticle comprising a reaction product of a silicate nanoparticle and an aromatic compound; and a fluid. The aromatic compound includes a chemical group that includes a first portion, the first portion being directly bonded to the silicate nanoparticle in the functionalized silicate nanoparticle; and a second portion including an aromatic moiety. | 07-03-2014 |
20140374267 | METHOD TO PRODUCE METAL MATRIX NANOCOMPOSITE - A method for coating a substrate includes disposing a deposition composition in a container. The deposition composition includes a plurality of nanosheets and a metal material. The method also includes disposing a substrate in the container, contacting the substrate with the deposition composition, applying a voltage to the substrate, electrodepositing, on the substrate, a coating that includes a metal from metal ions and the nanosheets in response to biasing the substrate at the first potential. | 12-25-2014 |
Patent application number | Description | Published |
20090035308 | Methods for using and identifying modulators of Delta-like 4 - In certain embodiments, this present invention provides methods of identifying and using agonists and antagonists of Delta-like 4 (Dll4) signaling. | 02-05-2009 |
20090155251 | Polypeptide compounds for inhibiting angiogenesis and tumor growth - In certain embodiments, this present invention provides polypeptide compositions, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases. | 06-18-2009 |
20090196880 | Cancer treatment using humanized antibodies that bind to EphB4 - In certain embodiments, this application provides humanized antibodies that bind to the EphB4 protein as well as uses of the antibodies for therapeutic purposes. | 08-06-2009 |
20100261653 | Polypeptide compounds for inhibiting angiogenesis and tumor growth - In certain embodiments, this present invention provides polypeptide compositions, including compositions containing a modified polypeptide, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases. | 10-14-2010 |
20110213127 | METHODS FOR USING AND IDENTIFYING MODULATORS OF DELTA-LIKE 4 - In certain embodiments, this present invention provides antibodies that act as either agonists or antagonists of Delta-like 4 (Dll4) signaling. | 09-01-2011 |
20120277162 | POLYPEPTIDE COMPOUNDS FOR INHIBITING ANGIOGENESIS AND TUMOR GROWTH - In certain embodiments, this present invention provides polypeptide compositions, including compositions containing a modified polypeptide, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases. | 11-01-2012 |
20130344075 | POLYPEPTIDE COMPOUNDS FOR INHIBITING ANGIOGENESIS AND TUMOR GROWTH - In certain embodiments, this present invention provides polypeptide compositions (e.g., antibodies and antigen binding portions thereof that bind to EphB4), and methods for inhibiting EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases. | 12-26-2013 |
20140107030 | POLYPEPTIDE COMPOUNDS FOR INHIBITING ANGIOGENESIS AND TUMOR GROWTH - In certain embodiments, this present invention provides polypeptide compositions, including compositions containing a modified polypeptide, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases. | 04-17-2014 |
Patent application number | Description | Published |
20080311105 | Reversibly Inactivated Acidified Plasmin - The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. | 12-18-2008 |
20100047228 | RECOMBINANTLY MODIFIED PLASMIN - Methods of using polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided, including methods related to vitrectomy or vitreolysis. The plasmin(ogen) molecule has a single kringel domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme. | 02-25-2010 |
20100304465 | Recombinantly Modified Plasmin - Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme. | 12-02-2010 |
20110003332 | RECOMBINANTLY MODIFIED PLASMIN - Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that no foreign sequences are present, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme. | 01-06-2011 |
20110318812 | Recombinantly Modified Plasmin - Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme. | 12-29-2011 |
20120093799 | RECOMBINANTLY MODIFIED PLASMIN - Polynucleotides and polypeptides relating to a recombinantly modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that no foreign sequences are present, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme | 04-19-2012 |
20120276611 | RECOMBINANTLY MODIFIED PLASMIN - Polynucleotides and polypeptides relating to a recombinantly modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that no foreign sequences are present, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme | 11-01-2012 |
20130164273 | REVERSIBLY INACTIVATED ACIDIFIED PLASMIN COMPOSITION - The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. | 06-27-2013 |
20130164815 | PROCESS FOR THE PRODUCTION OF A REVERSIBLY INACTIVE ACIDIFIED PLASMIN COMPOSITION - Disclosed is both a process for producing a reversibly inactive acidified plasmin by activating plasminogen and a process for producing a purified plasminogen. The produced plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantially stable formulation. The purified plasminogen is typically purified from a fraction obtained in the separation of immunoglobulin from Fraction II+III chromatographic process and eluded at a low pH. The reversibly inactive acidified plasmin may be used in the administration of a thrombolytic therapy. | 06-27-2013 |
20130289528 | THERAPEUTIC DELIVERY DEVICES, SYSTEMS, AND METHODS - Devices, systems, and methods for delivery of therapeutics, in particular thrombolytic agents, in particular plasmin, are provided. The devices, systems, and methods also provide for occlusion of a vessel or graft distal and/or proximal to a treatment zone. Also provided are devices, systems, and methods that trap emboli. | 10-31-2013 |
Patent application number | Description | Published |
20110184510 | TRICUSPID VALVE REPAIR USING TENSION - A method is provided, including implanting at least a first tissue-engaging element in a first portion of tissue in a vicinity of a heart valve of a patient, implanting at least a second tissue-engaging element in a portion of a blood vessel that is in contact with an atrium of a heart of the patient, and drawing at least a first leaflet of the valve toward at least a second leaflet of the valve by adjusting a distance between the portion of the blood vessel and the first portion of tissue in the vicinity of the heart valve of the patient. Other applications are also described. | 07-28-2011 |
20120035712 | METHOD AND APPARATUS FOR TRICUSPID VALVE REPAIR USING TENSION - Apparatus is provided, including a radially-expandable percutaneous implant, a tissue anchor, and a connecting element shaped so as to provide an annular loop surrounding a proximal portion of the tissue anchor in a manner which enables rotation of the anchor about a central longitudinal axis thereof when surrounded by the annular loop. The apparatus also includes a flexible longitudinal member coupled at a first portion thereof to at least a portion of the percutaneous implant and at a second portion to the connecting element. The annular loop of the connecting element facilitates rotation of the tissue anchor about the central longitudinal axis such that the anchor can rotate about the central longitudinal axis with respect to the annular loop, the flexible longitudinal member, and the percutaneous implant. Other applications are also described. | 02-09-2012 |
20120221081 | PHASE-CHANGE AND SHAPE-CHANGE MATERIALS - Apparatus and methods are described for killing cancer cells ( | 08-30-2012 |
20130018459 | METHOD AND APPARATUS FOR TRICUSPID VALVE REPAIR USING TENSION - Apparatus is provided including a first tissue-engaging element, a first flexible longitudinal member coupled at a first end portion thereof to at least a portion of the first tissue-engaging element, and a first flexible-longitudinal-member-coupling element coupled to the first flexible longitudinal member at a second end portion of the first flexible longitudinal member. Apparatus includes a second tissue-engaging element, a second flexible longitudinal member coupled at a first end portion thereof to at least a portion of the second tissue-engaging element, and a second flexible-longitudinal-member-coupling element coupled to the second flexible longitudinal member at a second end portion of the second flexible longitudinal member, the first and second flexible-longitudinal-member-coupling elements being couplable to couple together the first and second flexible longitudinal elements. Other applications are also described. | 01-17-2013 |
20130046380 | TRICUSPID VALVE REPAIR USING TENSION - Apparatus is provided including a stent, which is configured to assume compressed and expanded states. The stent includes one or more elongated members, and two or more rings, which are coupled together by the one or more elongated members and by no other elements of the stent. The rings define respective planes that are generally perpendicular to the elongated members when the stent is in its expanded state. A longitudinal member, having a proximal end and a distal end, is coupled to the stent at the proximal end of the longitudinal member. A tissue anchor is coupled to the distal end of the longitudinal member. Other applications are also described. | 02-21-2013 |
Patent application number | Description | Published |
20090190223 | OPTICAL SECURITY MARKING COMPONENT, METHOD OF MANUFACTURING SUCH A COMPONENT, SYSTEM COMPRISING SUCH A COMPONENT, AND READER FOR CHECKING SUCH A COMPONENT - The present invention relates to an optical security marking component producing a first visible configuration when observed through a polarizer oriented in a first orientation, and a second configuration, separate from the first, visible when observed through the polarizer oriented in a second orientation, the optical component comprising a stamped film for forming at least two diffraction gratings having different orientations, characterized in that each of said gratings has a period of less than 550 nm and a modulation between 0.25 and 0.5 relative to a reference plane. | 07-30-2009 |
20130052373 | OPTICAL AUTHENTICATION COMPONENT AND METHOD OF FABRICATING SAID COMPONENT - An optical authentication component visible in reflection having a structure imprinted on a substrate of index n | 02-28-2013 |
20130252008 | SECURE PRODUCT AND METHOD OF PRODUCING SAID SECURE PRODUCT - A secure product, and a production method, comprising a first reflective layer, a second layer and a third layer including readable information, the first layer being enclosed between the second and the third layers, in which the first and second layers are transparent, at least a first part of the internal surface of the second layer comprises a diffusing microstructure, and the diffusing microstructure is positioned so as to cover a predetermined part of the readable information. | 09-26-2013 |
20140028012 | OPTICAL SAFETY COMPONENT HAVING A TRANSMISSIVE EFFECT, MANUFACTURE OF SUCH A COMPONENT, AND SECURE DOCUMENT PROVIDED WITH SUCH A COMPONENT - According to one aspect, the invention relates to an optical safety component having a plasmonic effect intended to be observed by transmission, including two layers ( | 01-30-2014 |
20140239627 | OPTICAL SECURITY COMPONENT, PRODUCTION OF SUCH A COMPONENT AND SECURE PRODUCT PROVIDED WITH SUCH A COMPONENT - One aspect of the invention relates to an optical security component ( | 08-28-2014 |
20140285892 | OPTICAL SECURITY COMPONENT HAVING A REFLECTIVE EFFECT, MANUFACTURE OF SAID COMPONENT, AND SECURED DOCUMENT PROVIDED WITH SUCH A COMPONENT - According to one aspect, the invention relates to an optical security component ( | 09-25-2014 |
20150084327 | OPTICAL SECURITY COMPONENT, FABRICATION OF SUCH A COMPONENT AND SECURE PRODUCT EQUIPPED WITH SUCH A COMPONENT - An optical security component intended to be checked in reflection in a checking spectral band includes a layer that is reflective in the checking spectral band. The layer exhibits a structured zone that includes microstructures distributed spatially in a uniform manner over a whole of the structured zone so as to form an optical structure that is at least partially scattering in the checking spectral band. The microstructures have heights that are distributed according to a random function, modulated over the structured zone by a modulation function so as to form, after illumination of the optical security component at a given angle, an image identifiable by observation in reflection. | 03-26-2015 |
Patent application number | Description | Published |
20120055744 | HYBRID BRAKE CONTROL - A method to control a vehicle including control of regenerative brakes and friction brakes includes monitoring a desired corner force and moment distribution, monitoring real-time actuator constraints including a braking torque limit of each of the regenerative brake, determining a regenerative braking torque for each of the regenerative brakes based upon the desired corner force and moment distribution and the real-time actuator constraints, determining a friction braking torque for each of the friction brakes based upon the desired corner force and moment distribution and the determined regenerative braking torque for each of the regenerative brakes, and controlling the vehicle based upon the determined regenerative braking torques and the determined friction braking torques. | 03-08-2012 |
20120059547 | OPTIMAL CORNER CONTROL FOR VEHICLES - A method to control a vehicle having a plurality of wheels includes monitoring desired vehicle dynamics, determining a desired corner force and moment distribution based upon the desired vehicle dynamics and a real-time closed form dynamics optimization solution, and controlling the vehicle based upon the desired corner force and moment distribution. The real-time closed form dynamics optimization solution is based upon a minimized center of gravity force error component, a minimized control energy component, and a maximized tire force reserve component. | 03-08-2012 |
20120197469 | REAL-TIME ALLOCATION OF ACTUATOR TORQUE IN A VEHICLE - A method for allocating forces among the corners of a vehicle having a redundant actuator suite includes determining a set of desired forces at the center of gravity of the vehicle, and allocating the set of desired forces among the corners of the vehicle as virtual control commands using a controller. The method also includes mapping the virtual control commands at the corners to actual or true control commands at the corners, and controlling a plurality of actuators at the corners using the actual or true control commands. The actuators may include friction brakes and wheel motors. Mapping the virtual control commands may include using a Least Squares formulation. Control of the actuators may be prioritized with respect to each other using weighting matrices. A vehicle includes a controller having actuators and a controller configured for executing the above method. | 08-02-2012 |
Patent application number | Description | Published |
20090104248 | Lacrimal implants and related methods - Lacrimal implants for treating diseases or disorders are disclosed. More particularly, lacrimal implants, methods of making such implants, and methods of treating ocular, respiration, inner ear or other diseases or disorders using such implants are disclosed. | 04-23-2009 |
20090105749 | Insertion and extraction tools for lacrimal implants - Insertion and extraction tool, systems, and methods for use with lacrimal implants. An insertion tool is disclosed that includes a proximal end, a distal end, and a tool body therebetween. The distal end includes a mechanical coupling to receive a cartridge preloaded with a lacrimal implant, and a plunger configured to dispense the lacrimal implant from a preloaded cartridge. | 04-23-2009 |
20100056982 | Photodynamic therapy for the treatment of acne - The present method involves the photodynamic treatment of acne vulgaris. The method involves the topical administration of a photosensitizer composition comprising hydrophobic green porphyrins such as lemuteporfin, polyethylene glycol and skin penetration enhancers such as oleyl alcohol and TRANSCUTOL™ to acne-affected skin and subsequent exposure of that skin to energy of a wavelength of activating the photosensitizer. | 03-04-2010 |
20100274204 | LACRIMAL IMPLANTS AND RELATED METHODS - Lacrimal implants and related methods providing secure, wedgable retention within a lacrimal punctum and associated canaliculus of an eye are disclosed. The lacrimal implants can comprise an implant body configured for at least partial insertion through the lacrimal punctum and into the canaliculus. The implant body can include first and second portions, and can extend from a proximal end of the first portion defining a longitudinal proximal axis to a distal end of the second portion defining a longitudinal distal axis. The implant body can be configured such that, when implanted using an integral dilator, an angled intersection exists between the proximal and distal axes. In this way, at least a portion of the implant body can be biased against at least a portion of the lacrimal canaliculus located at or more distal to a canalicular curvature, thereby retaining an implanted position of the lacrimal implant using anatomical structures. | 10-28-2010 |
20120318281 | LACRIMAL IMPLANTS AND RELATED METHODS - Lacrimal implants for treating diseases or disorders are disclosed. More particularly, lacrimal implants, methods of making such implants, and methods of treating ocular, respiration, inner ear or other diseases or disorders using such implants are disclosed. | 12-20-2012 |
20130053794 | SUSTAINED RELEASE DELIVERY OF ACTIVE AGENTS TO TREAT GLAUCOMA AND OCULAR HYPERTENSION - A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through a firsts punctum and into a first lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent. | 02-28-2013 |
20130253411 | PHOTODYNAMIC THERAPY LASER - A laser system including: a laser source operable to emit a first and a second laser beam having first and second operating wavelengths, respectively; a fiber optic cable to guide and homogenize the laser beams; an expander to increase the diameter of the laser beams; a cylinder to guide the laser beams and limit respective diameters of the first and second laser beams, wherein the cylinder is positioned after the expander on an optical path of the laser beam; a first optical system to collimate the laser beams, wherein the optical system is positioned after the cylinder on the optical path of the laser beams; a spot-size selector comprising a plurality of apertures, wherein the spot-size selector is positioned after the first optical system on the optical path of the laser beams; and a second optical system to focus the laser beams on a tissue of the patient. | 09-26-2013 |
20140180253 | LACRIMAL IMPLANTS AND RELATED METHODS - Lacrimal implants for treating diseases or disorders are disclosed. More particularly, lacrimal implants, methods of making such implants, and methods of treating ocular, respiration, inner ear or other diseases or disorders using such implants are disclosed. | 06-26-2014 |
Patent application number | Description | Published |
20090116522 | Enhanced efficiency laterally-coupled distributed feedback laser - The invention describes the method and apparatus for enhanced efficiency in a laterally-coupled distributed feedback (LC-DFB) laser. In a device featuring the effective ridge design, lateral confinement of the guided optical modes is provided by a surface etched grating, which also serves as a DFB element of the laser. Coupling and quantum efficiency of such a LC-DFB laser both improve with an increase of the lateral mode order. In accordance with this invention, a dramatic enhancement of the laser efficiency is achievable by designing it to operate in one of the higher order modes, notably the first order mode, while all the other lateral modes, including the zero order mode, are suppressed through gain-loss discrimination. In the exemplary embodiment of the invention, this enhanced efficiency technique is applied to the design of a single-mode LC-DFB laser suitable for a monolithic integration with other active and passive functional elements of photonic integrated circuits fabricated by using one-step epitaxial growth. | 05-07-2009 |
20090136173 | Integrated lateral mode converter - The invention describes method and apparatus for a mode converter enabling an adiabatic transfer of a higher order mode into a lower order optical mode within a photonic integrated circuit exploiting integrated semiconductor ridge waveguide techniques. As disclosed by the invention, such a mode conversion is achievable by using an asymmetric coupler methodology. In an exemplary embodiment of the invention, the invention is used to provide a low insertion loss optical connection between laterally-coupled DFB laser operating in first order mode and passive waveguide operating in the zero order optical mode. The integrated arrangement fabricated by using one-step epitaxial growth allows for a launch of the laser's light into the waveguide circuitry operating in the zero order lateral mode or efficiently coupling it to single-mode fiber, an otherwise high loss interface due to the difference in laser and optical fiber modes. | 05-28-2009 |
20110135314 | Waveguide Optically Pre-Amplified Detector with Passband Wavelength Filtering - The invention describes an integrated-photonics arrangement, implementable in a multi-guide vertical integration (MGVI) structure composed from III-V semiconductors and grown in one epitaxial growth run, allowing for the integration of semiconductor optical amplifier (SOA) and PIN photodetector (PIN) structures within a common wavelength-designated waveguide of the plurality of the vertically integrated wavelength-designated waveguides forming the MGVI structure. The integration includes a wavelength filter integrated between the SOA and PIN to reduce noise within the PIN arising from ASE generated by the SOA. In exemplary embodiments of the invention, the wavelength filter is integrated into MGVI structure either within a common wavelength designated waveguide or within the wavelength-designated waveguide. Further in other embodiments the wavelength filter is provided by a thin-film filter abutting a facet of the integrated-photonics arrangement wherein optical signals are coupled by optical waveguides and/or additional optical elements such as a multimode interference device. | 06-09-2011 |
20120106583 | VERTICALLY-COUPLED SURFACE-ETCHED GRATING DFB LASER - A VCSEG-DFB laser, fully compatible with MGVI design and manufacturing methodologies, for single growth monolithic integration in multi-functional PICs is presented. It comprises a laser PIN structure, in mesa form, etched from upper emitter layer top surface through the active, presumably MQW, gain region, down to the top surface of the lower emitter. Lower electrical contacts sit adjacent the mesa disposed on the lower emitter layer with upper strip contacts disposed atop the upper emitter layer on the mesa top. An SEG is defined/etched from mesa top surface, between the upper strip contacts, through upper emitter layer down to or into the SCH layers. Vertical confinement is provided by the SCH structure and the lateral profile in the bottom portion of the mesa provides lateral confinement. The guided mode interacts with the SEG by the vertical tail penetrating the SEG and evanescent field coupling to the SEG. | 05-03-2012 |
Patent application number | Description | Published |
20090106716 | VARIOUS METHODS AND APPARATUSES FOR MEMORY MODELING USING A STRUCTURAL PRIMITIVE VERIFICATION FOR MEMORY COMPILERS - A structural primitive verification tool for memory compilers is described. A first set of memory structural primitives are supplied by a designer by filling in fields of a presented user interface. The first set of structural primitives describe certain physical layout features of a proposed memory array in an integrated circuit. A first model of a memory instance derived from the first set of memory structural primitives supplied by the designer is compared to a second model of a memory instance derived from a memory layout file from a memory compiler under-test. The first model is verified against the second model to verify to an integrity of the first set of memory structural primitives supplied by the designer compared to the memory layout file derived from a second set of memory structural primitives configuring that memory instance from the memory compiler. | 04-23-2009 |
20100050135 | VARIOUS METHODS AND APPARATUSES FOR EFFECTIVE YIELD ENHANCEMENT OF GOOD CHIP DIES HAVING MEMORIES PER WAFER - A method and apparatus are described in which an optimal configuration of memory instances is determined. The optimal configuration of memory instances to be fabricated with built-in repair capacity and memory instances that are non-repairable may provide a maximum number of good chip dies per wafer. An amount of memory instances to be fabricated with built-in repair capacity as well as a remaining amount of memory instances to be fabricated without any built-in repair components in the integrated circuit design is determined relative to achieving the maximum number of good chip dies per wafer for a given defect density and wafer area. The amount of good dies produced per fabricated wafer for a populated amount of memories with built-in repair components is determined to be between an amount established by a minimum limit for the die area up to the amount established by a maximum limit for the die area. | 02-25-2010 |
20130019130 | TESTING ELECTRONIC MEMORIES BASED ON FAULT AND TEST ALGORITHM PERIODICITYAANM HAKHUMYAN; AramAACI YerevanAACO AMAAGP HAKHUMYAN; Aram Yerevan AMAANM Harutyunyan; GurgenAACI AbovyanAACO AMAAGP Harutyunyan; Gurgen Abovyan AMAANM Shoukourian; SamvelAACI YerevanAACO AMAAGP Shoukourian; Samvel Yerevan AMAANM Vardanian; ValeryAACI YerevanAACO AMAAGP Vardanian; Valery Yerevan AMAANM Zorian; YervantAACI Santa ClaraAAST CAAACO USAAGP Zorian; Yervant Santa Clara CA US - Testing electronic memories based on fault and test algorithm periodicity. A processor unit for testing an electronic memory includes a built-in self-test (BIST) finite state machine, an address generator, a data generator, a test algorithm generation unit, a programmable test algorithm register, and a test algorithm register control unit. A memory wrapper unit for testing an electronic memory includes an operation decoder, a data comparator, and an electronic memory under test. The method includes constructing a fault periodic table having columns corresponding with test mechanisms, and rows corresponding with fault families. A first March test sequence and second March test sequence are selected according to respective fault families and test mechanisms, and applied to an electronic memory. The electronic memory under test is determined to be one of acceptable and unacceptable based on results of the first March test sequence and the second March test sequence. | 01-17-2013 |
20130019132 | DETECTING RANDOM TELEGRAPH NOISE INDUCED FAILURES IN AN ELECTRONIC MEMORYAANM AMIRKHANYAN; KarenAACI YerevanAACO AMAAGP AMIRKHANYAN; Karen Yerevan AMAANM Grigoryan; HaykAACI YerevanAACO AMAAGP Grigoryan; Hayk Yerevan AMAANM Harutyunyan; GurgenAACI AbovyanAACO AMAAGP Harutyunyan; Gurgen Abovyan AMAANM Melkumyan; TatevikAACI YerevanAACO AMAAGP Melkumyan; Tatevik Yerevan AMAANM Shoukourian; SamvelAACI YerevanAACO AMAAGP Shoukourian; Samvel Yerevan AMAANM Shubat; AlexAACI Los Altos HillsAAST CAAACO USAAGP Shubat; Alex Los Altos Hills CA USAANM Vardanian; ValeryAACI YerevanAACO AMAAGP Vardanian; Valery Yerevan AMAANM Zorian; YervantAACI Santa ClaraAAST CAAACO USAAGP Zorian; Yervant Santa Clara CA US - A method and system for testing an electronic memory. The method includes subjecting the electronic memory to a first test condition of a predetermined set of test conditions. The method also includes testing functionality of the electronic memory, a first plurality of times, for the first test condition using a predetermined test algorithm. The method further includes checking availability of a second test condition from the predetermined set of test conditions if the functionality of the electronic memory is satisfactory. Further, the method includes testing the functionality of the electronic memory, a second plurality of times, for the second test condition using the predetermined test algorithm if the second test condition is available. Moreover, the method includes accepting the electronic memory for use in a product if the functionality of the electronic memory is satisfactory. | 01-17-2013 |
20130145119 | Determining A Desirable Number Of Segments For A Multi-Segment Single Error Correcting Coding Scheme - A desirable number of segments for a multi-segment single error correcting (SEC) coding scheme is determined based on scrambling information for a memory. The desirable number of segments can be the minimum number of segments required to satisfy a masked write segmentation requirement and a multi-bit upset size requirement. In one aspect, the memory scrambling information can specify the different scrambling techniques employed by the memory (e.g., Input-Output (IO) cell scrambling, column scrambling, column twisting, strap distribution, etc.). Based on the scrambling information, a mapping between the logical structure and physical layout for the memory can be derived. The mapping can be used to determine the least number of segments needed to satisfy the masked write requirement and the multi-bit upset size requirement. | 06-06-2013 |
20130346056 | Generation of Memory Structural Model Based on Memory Layout - A memory structural model is generated directly from memory configuration information and memory layout information in an efficient manner. Information on strap distribution is generated by analyzing configuration information of the memory and the corresponding memory layout. Information on scrambling of addresses in the memory layout is generated by programming the memory layout with physical bit patterns, extracting corresponding logical bit patterns and then analyzing the discrepancy between the physical bit patterns and the logical bit patterns. The strap distribution information and the address scrambling information are combined into the memory structural model used for designing an efficient test and repair engine. | 12-26-2013 |
Patent application number | Description | Published |
20110070157 | RADIOMETAL-LABELED AMINO ACID ANALOGS, IMAGING AND THERAPEUTIC AGENTS INCORPORATING THE SAME, AND METHODS USING THE SAME - An amino acid analog is provided, in syn-stereoisomeric form, anti-stereoisomeric form, or a combination thereof. The amino acid analog includes a cyclobutane ring with at least one of an amine group and a carboxyl group attached to one carbon node of the cyclobutane ring. A chain of moieties X, Y, and Z attached to one of remaining three carbon nodes of the cyclobutane ring. X is a chelating agent selected from a group comprising DCTA, DOTA, DTPA, EDTA, NOTA, PCTA, and TETA. Y is a linking moiety selected from a group comprising —NH—CO— and —NH-p-CHSN-Bn- where the linking moiety facilitates incorporation of the chelating agent into the amino acid analog. Z is a metal radioisotope selected from a group comprising Cu-60, Cu-61, Cu-62, Cu-64, Cu-67, Ga-67, Ga-68, Y-86, Y-88, Y-90, Sr-85, Sr-89, Gd-153, Gd-157, Sm-153, Lu-177, W-185, Re-186, Re-188, and Ir-192. | 03-24-2011 |