Santamaria
Angelo Santamaria, Kernen DE
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20110089359 | SPRING RETAINING SLEEVE - The invention relates to a spring retaining sleeve having a cylinder press-fit connection surface which has a press-fit diameter and a press-fit length. To enable cost-effective production of a stable press-fit assembly, at least one end of the cylinder press-fit connection surface, an optimized insertion chamfer for long press-fit assemblies is provided with a ratio of press-fit diameter to press-fit length of greater than thirty five percent. | 04-21-2011 |
Angelo Santamaria, Esslingen DE
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20080279707 | High-Pressure Pump, in Particular for a Fuel Injection Apparatus of an Internal Combustion Engine - The high-pressure pump has at least one pump element which has a pump plunger which is driven in a reciprocating motion and defines a pump working space into which fuel is drawn in from a fuel feed via an inlet valve during the suction stroke of the pump plunger and from which fuel is displaced into a high-pressure region via an outlet valve during the delivery stroke of the pump plunger. The inlet valve and/or the outlet valve has a valve member at least approximately in the shape of a ball which interacts by means of a sealing surface with a valve seat arranged in a valve housing. By means of the valve member, in the open state, when said valve member is lifted with its sealing surface from the valve seat, a first cross section of flow is cleared between the valve member and the valve seat, and downstream of the first cross section of flow, a second cross section of flow is formed between the valve member and the valve housing. In the direction of flow between the first cross section of flow and the second cross section of flow, a third cross section of flow is formed between the valve member and the valve housing, said third cross section of flow being larger than the first cross section of flow and the second cross section of flow. | 11-13-2008 |
Germán Solis Santamaria, Puebla MX
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20100094035 | AMORPHOUS ADSORBENT, METHOD OF OBTAINING THE SAME AND ITS USE IN THE BLEACHING OF FATS AND/OR OILS - The invention relates to a method for producing an adsorbent, in particular a bleaching earth, wherein a clay material having: a surface area of 180 to 300 m2/g; a total pore volume of 0.5 to 0.7 ml/l; wherein at least 60% of the total pore volume are provided by pores having a pore diameter of at least 140 A, at least 40% of the total pore volume is provided by pores having a pore diameter of less than 250 A and at least 15% of the total pore volume are provided by pores having a pore diameter of 140 to 250 A; and said clay material having an amorphous structure according to XRD data; is activated by an activation procedure. Further, the invention relates to an adsorbent as obtained by the method and a method for purification of oils, fats and biofuels. | 04-15-2010 |
Germán Solis Santamaria, Puebla MX
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20100094035 | AMORPHOUS ADSORBENT, METHOD OF OBTAINING THE SAME AND ITS USE IN THE BLEACHING OF FATS AND/OR OILS - The invention relates to a method for producing an adsorbent, in particular a bleaching earth, wherein a clay material having: a surface area of 180 to 300 m2/g; a total pore volume of 0.5 to 0.7 ml/l; wherein at least 60% of the total pore volume are provided by pores having a pore diameter of at least 140 A, at least 40% of the total pore volume is provided by pores having a pore diameter of less than 250 A and at least 15% of the total pore volume are provided by pores having a pore diameter of 140 to 250 A; and said clay material having an amorphous structure according to XRD data; is activated by an activation procedure. Further, the invention relates to an adsorbent as obtained by the method and a method for purification of oils, fats and biofuels. | 04-15-2010 |
Gorane Santamaria, Barcelona ES
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20160022197 | DETECTION OF BRCA CARRIERS IN BREAST TISSUE - A method and system for detecting the presence of BRCS carriers in breast tissue, comprises obtaining spectral data from breast tissue using a magnetic resonance spectroscopy device and producing spectral data by said device which provides chemical markers to enable detection of whether the breast tissue contains BRCA carriers. | 01-28-2016 |
Jose Alfonso Gonzalez Santamaria, Antiguo Cuscatlan SV
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20130000343 | Refrigerated Merchandise Display System - A refrigerated merchandise display system for storing and dispensing merchandise. The merchandise display system includes an outer housing, an inner support, a transparent front door, a refrigeration unit, a front door assembly, and a plurality of windows. The merchandise display system further includes a plurality of shelves for supporting merchandise within the display system. The refrigeration unit may be positioned at the top of the merchandise display system and may be removable. The outer housing of the refrigeration unit may be manufactured in a variety of colors. Each of the colors may be indicative a type of merchandise stored within the merchandise display system. | 01-03-2013 |
Julie Santamaria, Paris FR
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20100100978 | RNAi MEDIATED EXPRESSION INHIBITION OF A CHOLINERGIC PROTEIN - The present invention relates to nucleic acid sequences producing at least one functional miRNA, at least one functional shRNA and/or at least one functional siRNA, said miRNA, shRNA or siRNA being designed to silence the expression of a gene that encodes a cholinergic protein. The present invention further relates to compositions and kits comprising such nucleic acid sequences as well as to uses thereof. | 04-22-2010 |
Manuel Jane Santamaria, Palau Solita I Plegamans (barcelona) ES
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20090139805 | BRAKE DEVICE FOR PRAMS - This device is actuated by a single control ( | 06-04-2009 |
Pedro Santamaria, Calgary CA
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20090155292 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS - The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases. | 06-18-2009 |
20110059121 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS - The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases. | 03-10-2011 |
20120093934 | METHODS FOR TREATING AUTOIMMUNE DISEASE USING BIOCOMPATIBLE BIOABSORBABLE NANOSPHERES - The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells using biocompatible bioabsorbable nanospheres. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases. | 04-19-2012 |
20120121649 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER - Conventional cancer immunotherapy falls short at efficiently expanding T cells that specifically target cancerous cells in numbers sufficient to significantly reduce the tumor size or cancerous cell number in vivo. To overcome this limitation, provided herein are nanoparticles coated with MHC class I and/or class II molecules presenting tumor-specific antigens and co-stimulatory molecules and their use to expand antigen-specific anti-tumorigenic T cells to levels not achieved in current immunotherapeutic techniques. These antigen-specific anti-tumorigenic T cells include cytotoxic T cells, effector T cells, memory T cells, and helper T cells that are necessary to initiate and maintain a substantial immune response against metastatic or non-metastatic cancerous, pre-cancerous, or neoplastic cells in vivo. The present invention describes a systemic approach to targeting cancerous or pre-cancerous cells that are circulating cells, as in lymphomas, migratory metastatic cells, and solid tumors. | 05-17-2012 |
20130302421 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS - The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases. | 11-14-2013 |
20130330414 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION - This disclosure provides therapeutic compositions and methods for inducing an anti-inflammatory response and/or treating inflammation in the gastrointestinal tract and/or accumulating gut microbial antigen-specific anti-inflammatory T cells in a patient in need thereof. | 12-12-2013 |
20140105980 | METHODS AND COMPOSITIONS FOR TREATING MULTIPLE SCLEROSIS AND RELATED DISORDERS - This disclosure provides therapeutic compositions and methods for treating multiple sclerosis or a multiple sclerosis-related disorder in a subject in need thereof comprising administering an effective amount of an antigen-MHC-nanoparticle complex to the subject, wherein the antigen is a multiple sclerosis-related antigen. | 04-17-2014 |
20150125536 | METHODS AND COMPOSITIONS FOR SUSTAINED IMMUNOTHERAPY - This disclosure provides compositions and methods for promoting the formation, expansion and recruitment of TR1 cells and/or Breg cells in an antigen-specific manner and treating autoimmune diseases and disorders in a subject in need thereof. | 05-07-2015 |
20150209446 | METHODS AND COMPOSITIONS FOR TREATING MULTIPLE SCLEROSIS AND RELATED DISORDERS - This disclosure provides therapeutic compositions and methods for treating multiple sclerosis or a multiple sclerosis-related disorder in a subject in need thereof comprising administering an effective amount of an antigen-MHC-nanoparticle complex to the subject, wherein the antigen is a multiple sclerosis-related antigen. | 07-30-2015 |
20150250871 | METHODS AND COMPOSITIONS FOR TREATING MULTIPLE SCLEROSIS AND RELATED DISORDERS - This disclosure provides therapeutic compositions and methods for treating multiple sclerosis or a multiple sclerosis-related disorder in a subject in need thereof comprising administering an effective amount of an antigen-MHC-nanoparticle complex to the subject, wherein the antigen is a multiple sclerosis-related antigen. | 09-10-2015 |
Romain Santamaria, Compiegne FR
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20150266203 | APPARATUS AND METHOD FOR MANUFACTURING A THERMAL AND/OR ACOUSTIC INSULATION PRODUCT - An apparatus for manufacturing a thermal and/or acoustic insulation product based on mineral wool, including: a first line for production of first mineral fibers, including at least one fiberizing member; a second line for production of second mineral fibers, including at least one fiberizing member and a cross-lapping device; and a cross-lapping device configured to deposit the second mineral fibers onto the first mineral fibers by cross-lapping. The apparatus can manufacture a thermal and/or acoustic insulation product with improved thermal and/or acoustic properties. | 09-24-2015 |