Grogan, US
Aaron Grogan, Scotts Valley, CA US
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20130035537 | ROBOTIC SYSTEMS AND METHODS FOR TREATING TISSUE - A method of manipulating an elongate member in at least two degrees of freedom includes holding an elongate member between two rotary members that define respective rotational axes, the elongate member having a flexible proximal portion, a distal rigid needle attached to the proximal portion, and an operative element for delivering energy, the needle having a distal port, actuating at least one of the rotary members in a rotational direction about its rotational axis to generate a corresponding linear motion of the elongate member along a longitudinal axis of the elongate member, and actuating at least one of the rotary members in a linear direction along its rotational axis to generate a corresponding rotational motion of the elongate member about the longitudinal axis of the elongate member. | 02-07-2013 |
20130072787 | SYSTEM AND METHOD FOR VIRTUALLY TRACKING A SURGICAL TOOL ON A MOVABLE DISPLAY - The invention comprises a virtual window system that creates a visual coherency between the image of the patient and his or her anatomy and the patient by aligning the image of the patient anatomy on the display to the patient and presenting the image to the user that feels is if the user is looking directly into the patient through the display. The invention is designed to also display medical devices, such as a minimally invasive tool. The system substantially unifies the coordinate systems of the patient, the medical device, the display, and the physician's hands. The invention creates a visual coherency between the motion of the medical device in the image and the motion of the physician's hands manipulating the device. This invention also creates a visual coherency between the motion of the image in the display and display. | 03-21-2013 |
20140357984 | SYSTEM AND METHOD FOR DISPLAYING ANATOMY AND DEVICES ON A MOVABLE DISPLAY - An image display system is provided comprised of a virtual window system that creates a visual coherency between the patient's anatomical images and the actual patient by aligning the image on the display to the patient and then presenting the image to the user in a way that feels as if the user is looking directly into the patient through the display. The image shown within the image display system is dependent upon the position of the image display apparatus and the position of the user so that the display orientation of the image may be biased slightly toward the user to improve ergonomics and usability. | 12-04-2014 |
Alison Grogan, The Woodlands, TX US
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20150152712 | METHOD AND APPARATUS FOR TREATING A WELLBORE - The present invention generally concerns the treatment of hydrocarbon-bearing formations adjacent a wellbore. In one embodiment, fracturing jobs are performed through the use of subs disposed in a casing string having profiles that interact with profiles formed on retractable keys of a tool. | 06-04-2015 |
20150152714 | METHOD AND APPARATUS FOR TREATING A WELLBORE - The present invention generally concerns the treatment of hydrocarbon-bearing formations adjacent a wellbore. In one embodiment, fracturing jobs are performed through the use of subs disposed in a casing string having profiles that interact with profiles formed on retractable keys of a tool. | 06-04-2015 |
Aloysius Grogan, Middle Village, NY US
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20140311766 | WIRE SECURITY DEVICE AND METHOD FOR PROTECTING A WIRE IN A CONDUIT - A wire security device is provided or the protection of conduit body of a conduit for a wire. Also provided is a method of enclosing a conduit body with a wire security device such that only authorized persons can unlock the wire security device and access the conduit body. | 10-23-2014 |
Eugene Stuart Grogan, Lexington, NC US
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20150241364 | Inspecting Radiology Shields Using Passive RFID - A method for locating/identifying and inspecting radiology shields to facilitate the safe use thereof is carried out by providing a set of radiology shields, each of the radiology shields having a unique identifier, and each of the radiology shields carrying a passive RFID tag, the passive RFID tag associated with the unique identifier; providing a central database, the database comprising common data and individual shield data; transmitting the common data and individual shield data for at least shields to be inspected to a portable RFID reader; identifying, with the portable RFID reader, shields to be inspected based on the inspection time interval and the data of last inspection; entering a determination of pass or fail inspection into the portable RFID reader for each of the shields to be inspected; and updating the central database individual shield data for each of the shields to be inspected from the portable RFID reader. | 08-27-2015 |
George W. Grogan, Dallas, TX US
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20130243993 | STRIPABLE UNIFORM FILM COATING COMPOSITION WITH LOW RESIDUALS - A method of preparing a coating composition. The method comprises preparing a mixture that includes a releasing agent, thickening agents, and vinyl acetate-acrylic copolymer. Another embodiment is a method of forming a film, comprising, providing the coating composition and applying the coating composition to a surface. Another embodiment is a protective coating comprising a film, that includes the coating composition, applied to a surface of a manufactured product. | 09-19-2013 |
20150368497 | STRIPABLE UNIFORM FILM COATING COMPOSITION WITH LOW RESIDUALS - A coating mixture is presented herein. In one aspect, the coating mixture is an aqueous mixture of water and a first thickening/releasing agent of poly(ethylene oxide), an aqueous dispersion mixture of vinyl acetate-acrylic copolymer, including a second thickening agent of a mixture of acrylate ester and methacrylic acid mixture; a third thickening agent of polyacrylate; and a second releasing agent of phosphate ester salt. | 12-24-2015 |
Jack Grogan, Blissfield, MI US
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20140147522 | GASTRIC HEALTH SUPPLEMENT AND METHODS THEREOF - The invention provides novel compositions that can be used as a supplement (e.g. feed supplement) to animals such as, horses. In certain embodiments, the composition comprises an effective amount of a preparation obtained from sea buckthorn and an effective amount of an amino acid. In other embodiments, the composition includes specific combinations of components selected from the group of a preparation obtained from sea buckthorn, glutamine, aloe vera extract, pectin, and lecithin. The invention also provides methods and uses of the composition for alleviating, treating or preventing an ulcer-related condition in a subject identified in need thereof. | 05-29-2014 |
Jane Grogan, San Francisco, CA US
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20090258013 | NOVEL COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES - The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases. | 10-15-2009 |
20110263451 | BIOLOGICAL MARKERS PREDICTIVE OF RHEUMATOID ARTHRITIS RESPONSE TO LYMPHOTOXIN ANTAGONISTS - The present invention relates to a soluble lymphotoxin (solLT) and methods of using the solLT as a biomarker in the treatment of autoimmune disease. More particularly, the present invention relates to soluble lymphotoxin alpha-beta (solLTαβ) and methods of using this solLTαβ as a biomarker in the treatment of rheumatoid arthritis (RA). | 10-27-2011 |
20130251720 | NOVEL COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES - The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases. | 09-26-2013 |
20150216970 | METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS - The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection. | 08-06-2015 |
Jane L. Grogan, San Francisco, CA US
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20090285830 | ANTIBODIES TO LYMPHOTOXIN-ALPHA - The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies. | 11-19-2009 |
20110150865 | ANTIBODIES TO LYMPHOTOXIN-ALPHA - The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies. | 06-23-2011 |
20110208673 | ANTIBODIES TO LYMPHOTOXIN-ALPHA - The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies. | 08-25-2011 |
20130011412 | ANTIBODIES TO LYMPHOTOXIN-ALPHA - The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for example, an autoimmune disorder. The antibodies include murine, chimeric, and humanized antibodies. | 01-10-2013 |
Jay G. Grogan, Tucson, AZ US
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20130336752 | SYSTEM AND METHOD FOR TRANSFERRING A WHEELED LOAD INTO A TRANSPORT VEHICLE - A simple, adjustable lift system to load a cot bearing a patient into and out of an ambulance and a method of transferring a load on a transport into a vehicle is provided. More specifically, the lift system provides a pair of rails that may be adjusted to accommodate any cot currently in use by an ambulance. The rail system is extendable and is operated by a linear actuator to couple to a cot or other transport and lift the cot or other transport to a height from which the cot may be laterally inserted into the ambulance without undue strain on the EMT, firefighter, or other user. | 12-19-2013 |
Jennifer L. Grogan, Edison, NJ US
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20150305571 | Food storage container and strainer device - A container with strainer divider is appointed to filter liquid from a food product to maintain freshness. The container has a bottom wall and side walls with securing means to secure the liquid strainer divider, which is formed with a main body portion terminating at a perimeter. The perimeter has a perimeter rim and is composed of a flat sheet with at least two opposing fold lines forming wall sections terminating at edges and a centrally located aperture. The perimeter rim is adapted to be received within the securing means. When inserted within the securing means, the sheet is forced to form a shallow cone shape with sloping side walls having a slope angle θ. In its non-compressed form, as when it is removed from the container, the liquid strainer divider is generally a flat sheet with fold lines and wall sections lying separated or non-overlapping in relation to one another. | 10-29-2015 |
Joseph Grogan, Port Washington, NY US
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20100137884 | METHOD AND DEVICE FOR THE CONTROLLED DELIVERY AND PLACEMENT OF SECURING ELEMENTS IN A BODY | 06-03-2010 |
Joseph Grogan, San Antonio, TX US
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20080243321 | Event sensor - An automatic timing measurement system that provides a measure of time of passage of a watercraft through a prescribed course. Algorithms based on inertial or other estimates augmented by GPS speed/position measurements are used to track position of a watercraft. Said position estimates are used to allow the locations of prescribed courses to be mapped and memorized. Algorithms are then used to allow the apparatus to automatically detect passage of a watercraft through mapped courses for the purpose of measuring and reporting time of passage of said watercraft past key points in said course, and for modifying the behavior of the speed control portion of the apparatus if necessary at certain points in the mapped course. A measure of accuracy of driver steering can be provided along with the ability to automatically steer the watercraft through the course if “steer-by-wire” mechanism is available. GPS speed control is augmented with a secondary velocity measurement device that measures speed over water resulting in an optional user selectable real-time compensation for water current. Furthermore, GPS is used as the key input to produce boat speed-based pull-up profiles. | 10-02-2008 |
20090209152 | WATERCRAFT SPEED CONTROL DEVICE - An automatic speed control system that provides desired watercraft velocity over land. The coupled algorithms correct engine speed and torque using inertia based measurements, GPS, and tachometer measurements, and the corrections are augmented and enhanced by velocity/speed and torque/speed relationships that are dynamically and adaptively programmed with real-time data collected during replicated operations of the watercraft in specified conditions. | 08-20-2009 |
20090209153 | WATERCRAFT SPEED CONTROL DEVICE - An automatic speed control system that provides desired watercraft velocity over land. The coupled algorithms correct engine speed and torque using inertia based measurements, GPS, and tachometer measurements, and the corrections are augmented and enhanced by velocity/speed and torque/speed relationships that are dynamically and adaptively programmed with real-time data collected during replicated operations of the watercraft in specified conditions. | 08-20-2009 |
20130333671 | Highly Accurate Continuous-Flow Vaporized Fuel Supply for Large Dynamic Power Ranges - Methods and systems for accurate and precise fuel supply control for continuous-flow of gaseous fuel to an internal combustion engine over a large dynamic power range, including a dual-stage valve that allows optimal control—a first stage in the form of a voice-coil driven electronic pressure regulator, and a second stage in the form of a voice-coil-driven choked-flow valve; monitoring the pressure of the fuel intermediate the two stages and making appropriate adjustments to the first stage via a pressure actuator loop; feeding the gaseous fuel mixture through a unitary block assembly into the second stage; monitoring the pressure of the air/fuel mixture and making appropriate adjustments to the second stage via a valve actuator control loop. | 12-19-2013 |
Joseph Grogan, Lakewood, CO US
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20150259766 | DECOATING OF COATED MATERIALS - A system and method for decoating a scrap coated metal in a leach solution uses direct measuring of the corrosion potential of the scrap metal in the system to determine the progress of the decoating process and end the process when the scrap is decoated. Corrosion potential measurements are made using a working electrode comprising more than one piece of scrap coated-metal within the system. The decoating system and method may include a system for recycling leach solution. | 09-17-2015 |
Joseph M. Grogan, Philadelphia, PA US
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20120298883 | Flow Cells for Electron Microscope Imaging With Multiple Flow Streams - Provided are flow cell devices—referred to as nanoaquariums—that are microfabricated devices featuring a sample chamber having a controllable height in the range of nanometers to micrometers. The cells are sealed so as to withstand the vacuum environment of an electron microscope without fluid loss. The cells allow for the concurrent flow of multiple sample streams and may be equipped with electrodes, heaters, and thermistors for measurement and other analysis devices. | 11-29-2012 |
Mark Grogan, Cleveland, OH US
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20160031013 | Heterogeneous Composite Bodies With Isolated Cermet Regions Formed By High Temperature, Rapid Consolidation - A heterogeneous composite consisting of near-nano ceramic clusters dispersed within a ductile matrix. The composite is formed through the high temperature compaction of a starting powder consisting of a core of ceramic nanoparticles held together with metallic binder. This core is clad with a ductile metal such that when the final powder is consolidated, the ductile metal forms a tough, near-zero contiguity matrix. The material is consolidated using any means that will maintain its heterogeneous structure. | 02-04-2016 |
Mark V. Grogan, Cleveland, OH US
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20140231695 | Syntactic Insulator with Co-Shrinking Fillers - A syntactic foam insulator with co-shrinkage in the form of an insulating material formed by the inclusion of microballoons in a matrix material such that the microballoons and the matrix material exhibit co-shrinkage upon processing. The syntactic foam insulator can be formed by a variety of microballoon-matrix material combinations such as polymer microballoons in a preceramic matrix material. The matrix materials generally contain fine, rigid fillers. | 08-21-2014 |
Michael Grogan, Winchester, MA US
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20100093719 | PHARMACOKINETICALLY IMPROVED COMPOUNDS - A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: | 04-15-2010 |
20100324037 | PHARMACOKINETICALLY IMPROVED COMPOUNDS - A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: | 12-23-2010 |
20110172422 | Methods of Making Pharmacokinetically Improved Compounds Comprising Functional Residues or Groups and Pharmaceutical Compositions Comprising Said Compounds - The present invention relates to methods of modulating the pharmacokinetic and/or pharmacodynamic properties of a compound by attaching at least one functional unit or group to the compound, thereby improving its non-specific binding characteristics and/or pharmacokinetic properties. Compounds comprising at least one functional residue are provided, as are pharmaceutical compositions comprising said compounds. | 07-14-2011 |
20130096114 | PHARMACOKINETICALLY IMPROVED COMPOUNDS - A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: | 04-18-2013 |
Michael L. Grogan, Winchester, MA US
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20120088738 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z | 04-12-2012 |
Richard M. Grogan, Queensbury, NY US
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20130146547 | SCREEN BASKET HAVING DIAGONAL SLOTS FOR TOP SEPARATOR OF A DIGESTER - A screen basket in a top separator for a cellulosic material treatment vessel, the screen basket includes: a cylindrical plate having a vertical joint connecting opposite edges of the plate, rows of slots extending through the plate, and each slot has a curved or chamfered inlet corner edge adjacent an inside surface of the plate and is oblique to a vertical axis of the basket. | 06-13-2013 |
20130206346 | FLASH TANK WITH ADJUSTABLE INLET AND METHOD FOR ADJUSTING INLET FLOW TO A FLASH TANK - A flash tank including: a closed interior chamber; a gas exhaust port coupled to an upper portion of the chamber; a liquid discharge port coupled to a lower portion of the chamber; an inlet nozzle attached to an inlet port of the chamber, wherein the inlet nozzle includes a flow passage, and a movable valve plate in the flow passage, wherein the valve plate has a first position which defines a first throat in the flow passage and a second position which defines a second throat having a smaller cross-sectional area than the first throat. | 08-15-2013 |
20140007908 | VAPOR RELIEF SCREEN BASKET CLEANING BRUSH AND METHOD - A brush for dislodging impurities on steam relief screen basket within an operating vessel including at least one brush that includes an elongated support column with a brush attached to a first end of the elongated support column extends out of a seal located on a removable vessel cover of the vessel. The steps using the brush to dislodge impurities on steam relief screen basket include locating the brush comprised of a plurality of bristles adjacent to the steam relief screen basket, contacting the brush with the screen basket, extending the elongated support column through the seal, closing the removable vessel cover of the vessel to avoid pressure drop inside the vessel, and moving the brush from a first location on the screen basket to a second location on the screen basket to dislodge impurities attached to the screen basket. | 01-09-2014 |
20140034260 | FLASH TANK WITH COMPACT STEAM DISCHARGE ASSEMBLY - A flash tank for concentrating fluids including a wall defining a rounded interior chamber bounded by a top elliptical head opposite to a bottom elliptical head; an inlet nozzle of the chamber; a steam chamber operatively engaged to the top elliptical head, wherein the steam chamber includes baffles and a conduit that directs condensate from the steam chamber to the level of liquid condensate; a gas discharge port operatively engaged to the steam chamber; and a liquid discharge port engaged to the bottom elliptical head below a vortex breaker. Changes to the flow passage of the steam chamber have been made by extending the baffles further into the internal chambers of the steam chamber. | 02-06-2014 |
20140352900 | FLASH TANK WITH FLARED INLET INSERT AND METHOD FOR INTRODUCING FLOW INTO A FLASH TANK - A flash tank including: an interior chamber having a interior surface formed by a sidewall of the flash tank; a vapor exhaust port coupled to an upper portion of the chamber; a liquid discharge port coupled to a lower portion of the chamber; an insert inlet tube having an insert outlet and inserted into an inlet port of the chamber, wherein the insert inlet tube extends inward of the sidewall and the insert outlet has an elongated cross-sectional shape oriented substantially parallel to a center vertical axis of the flash tank and substantially perpendicular to a radial line of the flash tank, such that the insert outlet is substantially tangential to the sidewall. | 12-04-2014 |
20150284909 | FLASH TANK WITH ADJUSTABLE INLET AND METHOD FOR ADJUSTING INLET FLOW TO A FLASH TANK - A flash tank including: a closed interior chamber; a gas exhaust port coupled to an upper portion of the chamber; a liquid discharge port coupled to a lower portion of the chamber; an inlet nozzle attached to an inlet port of the chamber, wherein the inlet nozzle includes a flow passage, and a movable valve plate in the flow passage, wherein the valve plate has a first position which defines a first throat in the flow passage and a second position which defines a second throat having a smaller cross-sectional area than the first throat. | 10-08-2015 |
20150315745 | FLARED INLET INSERT FOR INTRODUCING FLOW INTO A FLASH TANK - An insert inlet tube assembly for a flash tank including a sidewall and an insert inlet port has been conceived, the insert inlet tube assembly may comprise: a tubular section configured to be inserted into the inlet port and fixed to the inlet port, and an insert outlet of the tubular section, and inserted into an inlet port of the chamber, wherein the insert inlet tube extends inward of the sidewall and the insert outlet has an elongated cross-sectional shape oriented substantially parallel to a center vertical axis of the flash tank and substantially perpendicular to a radial line of the flash tank, such that the insert outlet is substantially tangential to the sidewall. | 11-05-2015 |
Ronald Grogan, Spokane, WA US
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20090038650 | Compositions and substrate cleaning methods - Compositions are provided that can include a fatty acid ester such as canolates, and essential oils such as borneol. Example compositions can include a canolate and lime oil. Methods for cleaning substrates are also provided that can include exposing the substrate to a mixture including a fatty acid ester and an essential oil. Methods for dissolving a primarily organic substance are also provided that can include exposing the substance to a mixture including a fatty acid ester and an essential oil. Particular methods are provided for cleaning painting equipment that can include exposing the painting equipment to a composition comprising a fatty acid ester and an essential oil. | 02-12-2009 |
20090269499 | Mixtures, Compositions, and Methods of Using and Preparing Same - Mixtures are provided that can include at least one polyhydric alcohol; at least one acrylic compound; and at least one polyhydric ester. Compositions are provided that can include a particle at least partially coated with a mixture can include at least one polyhydric alcohol and a carbonyl compound. Methods for limiting particulate distribution during road use are provided that can include providing a mixture to the surface of the road, the mixture including at least one polyhydric alcohol and a carbonyl compound. Methods for limiting particulate distribution are provided that can include providing a mixture comprising at least one polyhydric alcohol and a carbonyl compound to a surface prior to agitating the surface. | 10-29-2009 |
Shawn Patrick Grogan, Oceanside, CA US
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20120214217 | IN SITU TISSUE ENGINEERING USING MAGNETICALLY GUIDED THREE DIMENSIONAL CELL PATTERNING - Methods are provided for the three dimensional manipulation of cells, and for the formation of an organized engineered cell tissue. Also provided are the organized engineered cell tissues produced by the methods. In one method, a plurality of magnetically labeled cells are mixed with a cross-linkable hydrogel to form a cell-hydrogel mixture, the at least a portion of the plurality of magnetically labeled cells are manipulated with a magnetic field to arrange the magnetically labeled cells into a specific cellular arrangement, and the hydrogel is crosslinked to form the organized engineered cell tissue. The approach presented herein offers a means to circumvent the deficiencies in the field of regenerative medicine, and allows for the production of organized tissues in situ with specific cellular organizations that mimic the native tissue. | 08-23-2012 |
Thomas Grogan, Tucson, AZ US
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20110136130 | METHOD FOR CHROMOGENIC DETECTION OF TWO OR MORE TARGET MOLECULES IN A SINGLE SAMPLE - The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule. | 06-09-2011 |
20120225793 | METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS - Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject. | 09-06-2012 |
20130034853 | TWO-COLOR CHROMOGENIC IN SITU HYBRIDIZATION - The present invention relates to systems and processes for chromogenic in situ hybridization (CISH), and in particular to methods that prevent interference between two or more color detection systems in a single assay. The present invention also relates to processes for scoring assays utilizing break-apart probes. | 02-07-2013 |
20130273540 | METHOD FOR CHROMOGENIC DETECTION OF TWO OR MORE TARGET MOLECULES IN A SINGLE SAMPLE - The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule. | 10-17-2013 |
20150346206 | Method of Identifying Treatment Responsive Non-Small Cell Lung Cancer Using Anaplastic Lymphoma Kinase (ALK) as a Marker - Disclosed herein are methods for identifying a subject as having NSCLC that is predicted or is likely to respond to treatment with an ALK inhibitor, for example crizotinib. The methods include identifying a sample including NSCLC tumor cells as ALK-positive or ALK-negative using immunohistochemistry (IBC) and scoring methods disclosed herein. A subject is identified as having NSCLC likely to respond to treatment with an ALK inhibitor if the sample is identified as ALK-positive and is identified as having NSCLC not likely to respond to treatment with an ALK inhibitor if the sample is identified as ALK-negative. According to certain embodiments of the methods, subjects predicted to respond to an ALK inhibitor may then be treated with an ALK inhibitor such as crizotinib. | 12-03-2015 |
Thomas Grogan, Folsom, CA US
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20080259269 | Decorative magnetic attachments to enhance eyewear - Decorative elements magnetically attachable to, removable from and/or interchangeable with eyewear frames comprise decorative element mounting means having a recess for receiving a magnet and cooperating with a recess on the eyewear frame which receives the mounting means. The two recesses are generally opposed in direction such that the recess on the mounting means and the magnet therein are both received internally by the recess on the eyewear frame with the magnet being sufficiently close to the internal metal or wire reinforcement of the frame to be attracted thereto. | 10-23-2008 |
Thomas M. Grogan, Tucson, AZ US
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20080286386 | Na+, K+-Atpase Expression in Cervical Dysplasia and Cancer - The present disclosure provides methods of diagnosing cervical dysplasia and cervical cancer by detecting Na | 11-20-2008 |
20080299555 | Multicolor chromogenic detection of biomarkers - The present invention provides compositions, kits, assembles of articles and methodology for detecting multiple target molecules in a sample, such as in a tissue sample. In particular, site-specific deposition of elemental metal is used in conjunction with other means of detection, such as other chromogenic, radioactive, chemiluminescent and fluorescent labeling, to simultaneously detect multiple targets, such a gene, a protein, and a chromosome, in a biological sample. More particularly the multiple targets may be labeled with the specifically deposited metal and other chromogenic labels to allow chromogenic immunohistochemical (IHC) detection in situ by using bright field light microscope. | 12-04-2008 |
Timothy W. Grogan, Rochester Hills, MI US
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20080224524 | MOTOR VEHICLE SEAT ASSEMBLY - According to one embodiment of a seat assembly for a motor vehicle a seat back pivots about a hip axis, a seat bottom pivots about a knee axis, and at least one seat bottom leg is pivots about an ankle axis, so that the seat back folds down against the seat bottom and the seat bottom kneels on the floor to at least partially define a seating load floor. According to another embodiment; a seat bottom and a seat back are articulatable in a forward direction to fold the seat bottom and back down toward a floor of the vehicle to at least partially define a seating load floor. | 09-18-2008 |
20110148163 | MOTOR VEHICLE SEAT ASSEMBLY - According to one embodiment of a seat assembly for a motor vehicle a seat back pivots about a hip axis, a seat bottom pivots about a knee axis, and at least one seat bottom leg is pivots about an ankle axis, so that the seat back folds down against the seat bottom and the seat bottom kneels on the floor to at least partially define a seating load floor. According to another embodiment, a seat bottom and a seat back are articulatable in a forward direction to fold the seat bottom and back down toward a floor of the vehicle to at least partially define a seating load floor. | 06-23-2011 |
Tom Grogan, Tucson, AZ US
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20120237930 | METHOD OF ANALYZING CHROMOSOMAL TRANSLOCATIONS AND A SYSTEM THEREFORE - The present disclosure relates to systems and methods for analyzing chromosomal translocations, and in particular to analysis of chromosomal translocation by in situ hybridization. | 09-20-2012 |