Charest, US
Alain Charest, Boston, MA US
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20100100974 | Models of Malignant Brain Cancer, and Therapeutic siRNAs Against Oncogenic Signaling Pathways, and Methods and Kits for Uses Therefor - Methods for screening compounds to treat an oncological disorder regulated through a tumor-inducing pathway are provided. The compounds are administered to non-human animal subjects having a disease model, so that the subjects display pathology symptoms that correspond to the oncological disorder in humans. The subjects carry a regulatable transgene expression, of which is associated with tumor formation, and further carry regulatable genes for suppression of tumor formation. The disease-pathology symptoms are induced using a site-specific recombination system to induce expression of the transgene associated with tumor formation and negatively regulate or eliminate the genes for suppression of the tumor formation. The methods further involve analyzing tumor formation in subjects administered the compound and comparing appearance and amount of tumors in the subjects administered the compound with control subjects not administered the compound. Also included are a vector for engineering a disease model and a kit for its use. | 04-22-2010 |
20140243229 | METHODS AND PRODUCTS RELATED TO GENOTYPING AND DNA ANALYSIS - The invention encompasses methods and products related to genotyping. The method of genotyping of the invention is based on the use of single nucleotide polymorphisms (SNPs) to perform high throughput genome scans. The high throughput method can be performed by hybridizing SNP allele-specific oligonucleotides and a reduced complexity genome (RCG). The invention also relates to methods of preparing the SNP specific oligonucleotides and RCGs, methods of fingerprinting, determining allele frequency for a SNP, characterizing tumors, generating a genomic classification code for a genome, identifying previously unknown SNPs, and related compositions and kits. | 08-28-2014 |
Alain Charest US
Patent application number | Description | Published |
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20090098551 | METHODS AND PRODUCTS RELATED TO GENOTYPING AND DNA ANALYSIS - The invention encompasses methods and products related to genotyping. The method of genotyping of the invention is based on the use of single nucleotide polymorphisms (SNPs) to perform high throughput genome scans. The high throughput method can be performed by hybridizing SNP allele-specific oligonucleotides and a reduced complexity genome (RCG). The invention also relates to methods of preparing the SNP specific oligonucleotides and RCGs, methods of fingerprinting, determining allele frequency for a SNP, characterizing tumors, generating a genomic classification code for a genome, identifying previously unknown SNPs, and related compositions and kits. | 04-16-2009 |
Glenn Patrick Charest, San Jose, CA US
Patent application number | Description | Published |
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20120219413 | CONFIGURABLE FAN UNIT - In order to increase the flexibility of the positioning of a stacked computer system within a data center, a removable fan unit is positioned within the stacked computer system. The removable fan unit includes a housing and a fan housing rotatably attached to the housing. The fan housing supports a fan that is electrically connected to a connector on a side of the housing of the removable fan unit. The connector of the removable fan unit may be electrically connected to a computer system-side connector. The fan housing may be rotated into at least two different orientations relative to the housing of the removable fan unit, such that the removable fan unit moves air through the stacked computer system in at least two corresponding directions. | 08-30-2012 |
20160058188 | SYSTEMS AND METHODS FOR DAMPING A STORAGE SYSTEM - In an embodiment, an apparatus (e.g., for damping a motion of a drawer in a storage system) comprises a plate to pivotally attach to a first wall of a drawer, the plate comprising a pivot point about which the plate can pivot; a damped gear coupled to the plate, the damped gear having a plurality of gear teeth; and a spring to facilitate pivoting the plate about the pivot point to engage at least one of the plurality of gear teeth with at least one tooth on a rack. In some embodiments, the spring is to pivot the plate from a first configuration to an angular position relative the wall in a second configuration, wherein the at least one of the plurality of gear teeth and the at least one tooth on the rack are fully engaged with one another in both the first configuration and the second configuration. | 03-03-2016 |
Joal Annette Charest, Allen, TX US
Patent application number | Description | Published |
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20140137312 | Removable Headwear Extension - An easily removable headwear extension that will attach to a wide variety of headwear utilizing the headwear's structural band. It is for multiple purposes including but not limited to, fashion design; protection from environmental elements (weather, insects, overspray); and/or advertising and promotional expression. The fabric will vary based on artistic and environmental requirements. The extension utilizes a unique attachment method that allows the headwear extension to slide over the any exposed structural band without any mating parts, destructive mounting or permanency. | 05-22-2014 |
Joe Charest, Cambridge, MA US
Patent application number | Description | Published |
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20140061115 | COMPACT HYDRAULIC MANIFOLD STRUCTURE FOR SHEAR SENSITIVE FLUIDS - An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device. | 03-06-2014 |
John A. Charest, Colchester, CT US
Patent application number | Description | Published |
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20130248042 | METHODS AND APPARATUSES FOR REPAIRING A CONDUIT - Methods and apparatuses relate to repairing a conduit having a defect and providing the conduit with structural support. A support member may be positioned along the inner surface of a conduit covering a defect. A sealing member may be disposed along a periphery of the support member so as to provide an obstruction to fluid flow between an outer surface of the support member and the inner surface of the conduit. One or more retaining members may apply a suitable pressure to the sealing member and support member to maintain obstruction to fluid flow between the interior and the exterior of the conduit. The support member may provide the repaired conduit with a greater degree of structural integrity and strength at the site of the defect than would otherwise be available. | 09-26-2013 |
Joseph Charest, Cambridge, MA US
Patent application number | Description | Published |
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20110082563 | MICROSCALE MULTIPLE-FLUID-STREAM BIOREACTOR FOR CELL CULTURE - Microfluidic bioreactor devices may feature intercommunicating microchannels defined in two polymer layers separated by a membrane. A geometric parameter associated with the microchannels in one layer may vary along a length of those channels. | 04-07-2011 |
Joseph I. Charest, Cambridge, MA US
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20150108056 | MICROFLUIDIC DEVICE FOR BLOOD DIALYSIS - The invention provides microfluidic devices and methods of using such devices for filtering solutions, such as blood. | 04-23-2015 |
Joseph L. Charest, Cambridge, MA US
Patent application number | Description | Published |
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20110155667 | Microfluidic Device for Blood Dialysis - The invention provides microfluidic devices and methods of using such devices for filtering solutions, such as blood. | 06-30-2011 |
20110158847 | Microfluidic Device Facilitating Gas Exchange, and Methods of Use and Manufacture Thereof - The invention provides systems and methods for exchanging gas in a microfluidic device, and methods for preparing such microfluidic devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient. | 06-30-2011 |
20110186165 | THREE-DIMENSIONAL MICROFLUIDIC PLATFORMS AND METHODS OF USE AND MANUFACTURE THEREOF - Microfluidic devices may be fabricated from thermoplastics using, for example, hot embossing techniques. In some embodiments, the devices feature non-uniform surface modifications. | 08-04-2011 |
20110290113 | MICROFABRICATED ARTIFICIAL LUNG ASSIST DEVICE, AND METHODS OF USE AND MANUFACTURE THEREOF - The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient. | 12-01-2011 |
20120182609 | MEMBRANE-INTEGRATED MICROFLUIDIC DEVICE FOR IMAGING CELLS - The invention provides microfluidic devices, methods for imaging cells, and methods for preparing such microfluidic devices. The microfluidic devices are contemplated to provide advantages for use in imaging of cells and subcellular compartments in an environment that mimics in vivo conditions. The microfluidic devices can used with a microscope equipped with an oil emersion objective lens. | 07-19-2012 |
20120318726 | SYSTEMS, METHODS, AND DEVICES RELATING TO A BIOMIMETIC CELLULARIZED NEPHRON UNIT - Disclosed herein are systems and devices for culturing cells in a biomimetic environment of a cellularized nephron unit, and methods for fabricating and using the cellularized nephron unit. | 12-20-2012 |
20120322097 | DEVICE AND METHOD FOR CULTURING CELLS IN A BIOMIMETIC ENVIRONMENT - Devices and methods are disclosed herein for a biomimetic flow apparatus. The biomimetic flow apparatus includes a microfluidic flow channel and an inlet in fluid connection with the flow channel for allowing fluid to flow into the flow channel. The flow channel has at least one surface with a topography formed therein. The topography of the at least one surface of the flow channel is selected to cause cells in a cell layer above the surface to achieve an arrangement, behavior, or morphology. The cell arrangement, behavior, or morphology is determined at least in part by the topography of the at least one surface. | 12-20-2012 |
20130144266 | METHODS FOR REDUCING THE BLOOD PRIMING VOLUME AND MEMBRANE SURFACE AREA IN MICROFLUIDIC LUNG ASSIST DEVICES - A device and method for oxygenating blood is disclosed herein. The device includes a plurality of passive mixing elements that causes a fluid to mix as it flows through the device. The passive mixing elements continually expose new red blood cells to the portion of the flow channel where oxygenation can occur. Accordingly, in some implementations, the device and method uses less blood to prime the device and allows for the oxygenation of blood with a substantial shorter flow channel when compared to conventional oxygenation methods and devices. | 06-06-2013 |
20130230911 | POROUS STRUCTURE WITH INDEPENDENTLY CONTROLLED SURFACE PATTERNS - Disclosed herein are systems and methods for manufacturing and using a cell culture support device. The device includes a plurality of polymer layers, each with at least one flow chamber defined therethrough. The device also includes a cross channel interface between the channels of different polymer layers. The cross channel interface includes a plurality of pores and a topographical pattern that is selected independent of the plurality of pores. Furthermore, the formation of the topographical pattern preservers the pores. | 09-05-2013 |
20140190884 | COMPACT HYDRAULIC MANIFOLD STRUCTURE FOR SHEAR SENSITIVE FLUIDS - An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device. | 07-10-2014 |
20140193799 | MICROFABRICATED ARTIFICIAL LUNG ASSIST DEVICE, AND METHODS OF USE AND MANUFACTURE THEREOF - The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient. | 07-10-2014 |
20140197101 | SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE - A microfluidic device for increasing convective clearance of particles from a liquid is provided. A network of first channels can be separated from a network of second channels by a membrane. The network of second channels can include a pressurizing feature to create a high pressure at an upstream portion of the second channels and a low pressure at a downstream portion of the second channels. Liquid containing an analyte can be introduced in the network of first channels. Filtrate can be flowed through the pressurizing feature in the second channels, such that the pressure difference in between the first and second channels causes at least some of the analyte in the first liquid is transported into the second channels through the membrane. | 07-17-2014 |
20140197105 | SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE - A microfluidic device for increasing convective clearance of particles from a fluid is provided. A network of first channels can be separated from a network of second channels by a first membrane. The network of first channels can also be separated from a network of third channels by a second membrane. Fluid containing an analyte can be introduced in the network of first channels. Infusate can be introduced into the network of second channels, and waste-collecting fluid can be introduced into the network of third channels. A pressure gradient can be applied in a direction perpendicular to the direction of fluid flow in the network of first channels, such that the analyte is transported from the network of first channels into the network of third channels through the second membrane. | 07-17-2014 |
20150076067 | MICROFLUIDIC ORGAN ASSIST DEVICE INCORPORATING BOUNDARY LAYER DISRUPTERS - The general disclosure discusses a system and method for improving the efficacy of blood filtration treatments such as hemodialysis, hemofiltration, and hemodiafiltration. More particularly, the disclosure discusses a microfluidic device that includes first and second channels separated by a permeable membrane. One of the channels is configured for blood flow and includes a protein gel disruption layer. The protein gel disruption layer includes a plurality of elements at least partially extending across the blood flow channel that reduce the formation of a boundary layer or gel layer at the blood-membrane interface. | 03-19-2015 |
20150096936 | SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE - A microfluidic device for increasing convective clearance of particles from a fluid is provided. A network of first channels can be separated from a network of second channels by a first membrane. The network of first channels can also be separated from a network of third channels by a second membrane. Fluid containing an analyte can be introduced in the network of first channels. Infusate can be introduced into the network of second channels, and waste-collecting fluid can be introduced into the network of third channels. A pressure gradient can be applied in a direction perpendicular to the direction of fluid flow in the network of first channels, such that the analyte is transported from the network of first channels into the network of third channels through the second membrane. | 04-09-2015 |
20150233512 | MICROFLUIDIC MANIFOLD FOR SHEAR SENSITIVE FLUIDS - A microfluidic device is provided. A manifold having a first channel, a second channel, and a third channel configured to transport blood can be coupled to a substrate defining an artificial vasculature. The first channel can be configured to carry blood in a first direction. Each of the second and third channels can couple to the first channel at a first junction and can be configured to receive blood from the first channel. The second channel can be configured to carry blood in a second direction away from the first direction. The third channel can be configured to carry blood in a third direction away from the second direction. The first, second, and third channels can be non-coplanar. | 08-20-2015 |
20150301027 | MICROFLUIDIC TISSUE MODEL - The present disclosure describes systems and methods for mimicking body tissue and the function thereof. The mimicked body tissue can include kidney tissue, the blood brain barrier, and other tissues. In some implementations, the systems described herein are used to test the impact of controlled factors on the tissue. The controlled factors can include flow rates, shear rates, and test chemicals (e.g., therapeutics and toxins). In some implementations, the system and methods are used to test pharmaceutical and biological therapies, characterize healthy or diseased tissue, and observe phenomena of the tissue in vitro. | 10-22-2015 |
20150306296 | BLOOD OXYGENATOR - The present disclosure describes a blood oxygenator that includes a checkerboard layout of fluid (e.g., blood) and gas (e.g., oxygen) channels. When viewed as a cross-section through each of the channels of the oxygenator, the checkerboard configuration includes alternating gas and fluid channels in both the x-axis (e.g., in-plane) and in the y-axis (e.g., out-of-plane) directions. The oxygenator described herein reduces manufacturing complexity by using first, second, and third polymer layers that include asymmetrical channel designs. The channel designs include “open” gas channels, which are exposed to the ambient atmosphere. The oxygenator is placed within a pressure vessel to drive gas into each of the open gas channels, which in some implementations, negates the need for a gas manifold. | 10-29-2015 |
20160045655 | SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE - A microfluidic device for increasing convective clearance of particles from a fluid is provided. In some implementations, described herein the microfluidic device includes multiple layers that each define infusate, blood, and filtrate channels. Each of the channels have a pressure profile. The device can also include one or more pressure control features. The pressure control feature controls a difference between the pressure profiles along a length of the device. For example, the pressure control feature can control the difference between the pressure profile of the filtrate channel and the pressure profile of the blood channel. In some implementations, the pressure control feature controls the pressure difference between two channels such that the difference varies along the length of the channels by less than 50% of the pressure difference between the channels at the channels' inlets. | 02-18-2016 |
Josh Charest, Lewiston, ME US
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20160067062 | PROSTHESIS COOLING LINER SYSTEM - The present invention is directed to a prosthetic cooling liner system for reducing heat and sweat for an individual's residual limb. The prosthetic cooling liner system uses fluid conduit with a prosthetic silicone liner. The fluid conduit allows for cooling fluid to flow across the residual limb, cooling the skin's surface and thereby reducing sweat produced. The cooling fluid is contained in a reservoir in a small backpack worn by the individual. A peristaltic pump is used to pump the cooling fluid from the reservoir through the embedded tubes. Such a system allows the individual to maintain a high level of activity as well as comfort, while wearing the prosthetic. | 03-10-2016 |
Leonard Charest, Redmond, WA US
Patent application number | Description | Published |
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20100241603 | POLICY PROCESSOR FOR CONFIGURATION MANAGEMENT - A policy processor is described that may be used to implement a system for managing the configuration of assets in a distributed computing network, such as an enterprise network. The policy processor resides on a managed node in the distributed computing network and operates to receive, evaluate and enact policies issued by one or more policy authorities in the distributed computing network. The policy processor utilizes a conflict resolution model to determine which policy rules included within the policies should be put into effect and which should not. | 09-23-2010 |
20120102182 | POLICY PROCESSOR FOR CONFIGURATION MANAGEMENT - A policy processor is described that may be used to implement a system for managing the configuration of assets in a distributed computing network, such as an enterprise network. The policy processor resides on a managed node in the distributed computing network and operates to receive, evaluate and enact policies issued by one or more policy authorities in the distributed computing network. The policy processor utilizes a conflict resolution model to determine which policy rules included within the policies should be put into effect and which should not. | 04-26-2012 |
20140279352 | SYSTEM AND METHODS OF PROVIDING A FUNGIBLE CONSUMER SERVICES MARKETPLACE - The invention generally pertains to computer software and methods, and more generally pertains a system for, and methods of providing, a fungible services marketplace. The system and methods are useful in providing markets for consumer services. | 09-18-2014 |
Mark G. Charest, Belle Mead, NJ US
Patent application number | Description | Published |
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20110009371 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF - The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals. | 01-13-2011 |
20140163238 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF - The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals. | 06-12-2014 |
Mark G. Charest, Cambridge, MA US
Patent application number | Description | Published |
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20080242658 | Inhibitors of Iap - Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I | 10-02-2008 |
20110015232 | Pyrrolydine Derivatives as IAP Inhibitors - The present invention relates to novel IAP inhibitor compounds of: Formula (I). | 01-20-2011 |
20110065726 | Organic Compounds - The present invention is directed to a compound of the formula: | 03-17-2011 |
20110281875 | Inhibitors of IAP - Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I). | 11-17-2011 |
20120207769 | Inhibitors of IAP - Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I). | 08-16-2012 |
20130005663 | SMAC PEPTIDOMETICS USEFUL AS IAP INHIBITORS - The present invention is directed to a compound of the formula: | 01-03-2013 |
20140004101 | SMAC PEPTIDOMETICS USEFUL AS IAP INHIBITORS | 01-02-2014 |
Pascale Charest, San Diego, CA US
Patent application number | Description | Published |
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20090123953 | Double brilliance beta-arrestin: a biosensor for monitoring the activity of receptors and signalling molecules, and method of using same - An intramolecular bioluminescence resonance energy transfer (BRET), biosensor for monitoring receptor activity and signalling cascades is disclosed. The “double-brilliance” biosensor sandwiches β-arrestin (β-arr) between Renilla | 05-14-2009 |
20110275134 | Arrestin Biosensor - The present invention relates to a novel biosensor. A resonance energy transfter (RET) biosensor comprising a beta(β)-arrestin tagged with a first and a second chromophore, wherein said first chromophore is a fluorophore and said second chromophore is a fluorophore or a bioluminophore is described. | 11-10-2011 |
Robert Charest, Orlando, FL US
Patent application number | Description | Published |
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20110125593 | ONLINE MARKETING PAYMENT MONITORING METHOD AND SYSTEM - A method of collecting and correlating information about user interactions with a plurality of websites including adding a first cookie from a first website, the first cookie recording information concerning interactions of a user with the first website; adding a second cookie from a second website, the second cookie recording information concerning interactions of the user with the second website; initiating a tracking pixel on a third website; capturing information from the first and second cookie; and determining a first contribution of the first website and a second contribution of the second website to interests in the third website. | 05-26-2011 |
Ross Thomas Charest, Allen, TX US
Patent application number | Description | Published |
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20140137312 | Removable Headwear Extension - An easily removable headwear extension that will attach to a wide variety of headwear utilizing the headwear's structural band. It is for multiple purposes including but not limited to, fashion design; protection from environmental elements (weather, insects, overspray); and/or advertising and promotional expression. The fabric will vary based on artistic and environmental requirements. The extension utilizes a unique attachment method that allows the headwear extension to slide over the any exposed structural band without any mating parts, destructive mounting or permanency. | 05-22-2014 |