Manoj Kumar Singh
Manoj Kumar Singh, Gurgaon IN
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20110082458 | Dynamic External Fixator And Methods For Use - An external fixation system and method for realigning, compressing or distracting broken bones has a planar ring element with an adjustable device having a body releasably mounted on the ring element. The adjustable device includes a first member for movement in a direction generally perpendicular to the ring element. A second member is pivotally connected to the first member for angular movement with respect to the ring. A third member is mounted on the second member for movement in a direction parallel to the second member and with respect to a circumference of the planar ring element. The method includes providing an external fixation system and inserting a k-wire through a first piece of bone and affixing the k-wire or half pin to the ring element. Then inserting a second k-wire or half pin through a second piece of bone and affixing the k-wire or half pin to an adjustable device. The pieces of bone are realigned, compressed or distracted by adjusting at least one of a first and second adjustable member forming the device. | 04-07-2011 |
20130204248 | EXTERNAL FIXATOR SYSTEM - An external fixation frame for correcting a bone deformity includes a first fixation ring and a second fixation ring. A posterior adjustable length strut couples a posterior portion of the first fixation ring to a posterior portion of the second fixation ring and has universal joint. Medial and lateral adjustable length struts couples medial and lateral portions of the first fixation ring to medial and lateral portions of the second fixation ring respectively, each of the medial and lateral adjustable length struts including a constrained hinge joint. The fixation frame also includes a half ring hingedly coupled to the second fixation ring, and an anterior adjustable length strut coupling an anterior portion of the first fixation ring to the half ring. | 08-08-2013 |
20140058389 | BONE TRANSPORT EXTERNAL FIXATION FRAME - Disclosed herein are systems and methods for manipulating the orientation of a plurality of bone fragments with respect to one another. A bone transport frame including first and second rings, a plurality of elongate struts, and a plurality of ring transport assemblies for orienting a first bone segment with respect to a second bone segment is disclosed. A third ring may be included in the bone transport frame for orienting a third bone segment with respect to the first and second bone segments. Manipulation of an adjustable member of the bone transport frame can transport a ring in either a proximal or distal direction with respect to other rings of the frame. Manipulation of another adjustable member of the bone transport frame can translate a central axis of one of the rings either toward or away from the central axes of the plurality of elongate struts. | 02-27-2014 |
Manoj Kumar Singh, Ahmedabad IN
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20090247765 | PROCESS FOR PREPARING PURE ANASTROZOLE - The present invention discloses two new related substances (6) and (7) of Anastrozole synthesis from Q. A. Salt (5) as in Scheme—1 and purification procedures to get Anastrozole (1) free from (6) and (7). | 10-01-2009 |
20100190997 | Process for the Preparation of Letrozole - The present invention relates to the process for the preparation of Letrozole free from its regioisomer (7) and other impurities by selective extraction of desired intermediate (3) using suitable solvent and mixture of solvents. | 07-29-2010 |
20110065927 | PROCESS FOR PREPARING PURE ANASTROZOLE - The present invention discloses two new related substances (6) and (7) of Anastrozole synthesis from Q.A. Salt (5) as in Scheme-1 and purification procedures to get Anastrozole (1) free from (6) and (7). | 03-17-2011 |
20140148593 | PROCESS FOR PREPARING FLUTICASONE PROPIONATE/FUROATE - The present invention relates to an improved process for the preparation of substituted Fluticasone derivatives. The invention also reveals the processes for the purification of Fluticasones and related intermediates to provide the highly pure product. | 05-29-2014 |
Manoj Kumar Singh, Gujarat IN
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20090221837 | Process for the Preparation of Pure Anastrozole - The present invention relates to the improved process for the preparation of Anastrozole free from the impurities arising due to impure 3,5-bis-(1-cyano-1-methylethyl)benzylbromide (2) and other related impurities resulting from incomplete/over-reaction of 2,2-(5-methyl-1,3-phenylene)-bis(2-methylpropionitrile (I). | 09-03-2009 |
Manoj Kumar Singh, Ghaziabad IN
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20090318661 | A BIOCOMPATIBLE, NON-BIODEGRADABLE, NON-TOXIC POLYMER USEFUL FOR NANOPARTICLE PHARMACEUTICAL COMPOSITIONS - The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidone (VP), N-Isopropylacrylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds. | 12-24-2009 |
Manoj Kumar Singh, Noida IN
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20080300408 | Process for Preparing a Pure Polymorphic Form of 3-Pyridyl-1-Hydroxyethylidine-1, 1-Bisphosphonic Acid Sodium Salt - This process in general relates to the novel process for preparing polymorphic forms of 3-pyridyl-1-hydroxyethylidine-1,1-bisphosphonic acid sodium salt (Risedronate Sodium) in particular risedronate Form A and B employing a solvent system in an appropriate ratio. An improved process for preparation of risedronic acid is also disclosed in the present invention. | 12-04-2008 |
20090312551 | Process for producing biphosphonic acids and forms thereof - Disclosed herein is a process for producing bisphosphonic acids and salts thereof. The process comprising reacting a carboxylic acid of Formula [I] with phosphorous acid and halophosphorus compound in the presence of a solvent selected from aliphatic hydrocarbon or water miscible cyclic ether. Further, the present invention also provides novel forms of bisphosphonic acids and process for preparation thereof. | 12-17-2009 |
Manoj Kumar Singh, Uttar Pradesh IN
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20080293682 | Novel Betulinic Acid Derivatives - The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH | 11-27-2008 |
Manoj Kumar Singh, Harayana IN
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20120041439 | EXTERNAL FIXATOR SYSTEM - An external fixator system comprising at least two fixation plates which are arranged at a distance to each another, at least one adjustable length having a first end region and a second end region which are in connection with the fixation plates and at least one actuation unit to adjust the length of the strut in order to adjust the distance and/or orientation between the fixation plates. The actuation unit is in a fixed connection with at least one of the fixation plates as well as with at least one of the end regions of the respective strut in order to connect the strut with the fixation plate. The actuation unit comprises a feedback unit which provides the user with a feedback concerning the degree of the actuation. | 02-16-2012 |
Manoj Kumar Singh, Ghaziabad (up) IN
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20130274211 | BIOCOMPATIBLE, NON-BIODEGRADABLE, NON-TOXIC POLYMER USEFUL FOR NANOPARTICLE PHARMACEUTICAL COMPOSITIONS - The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidne (VP), N-Isopropylactylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds. | 10-17-2013 |
Manoj Kumar Singh, Mahwah, NJ US
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20130253512 | DYNAMIC EXTERNAL FIXATOR AND METHODS FOR USE - An external fixation system has a planar ring with an adjustable device having a body releasably mounted on the ring. The adjustable device includes a first member for movement in a direction generally perpendicular to the ring. A second member is mounted on the first member for movement in a direction parallel to a side wall of the planar ring. A method for treating a broken bone includes providing an external fixation system and inserting a first k-wire or half pin through a first piece of the bone and affixing the first k-wire or half pin to the ring, then inserting a second k-wire or half pin through a second piece of bone and affixing the second k-wire or half pin to the adjustable device. The pieces of bone are realigned, compressed, or distracted by adjusting at least one of the first and second adjustable members. | 09-26-2013 |
20140350557 | EXTERNAL FIXATOR SYSTEM - An external fixator system comprising at least two fixation plates which are arranged at a distance to each another, at least one adjustable length strut having a first end region and a second end region which are in connection with the fixation plates and at least one actuation unit to adjust the length of the strut in order to adjust the distance and/or orientation between the fixation plates. The actuation unit is in a fixed connection with at least one of the fixation plates as well as with at least one of the end regions of the respective strut in order to connect the strut with the fixation plate. The actuation unit comprises a feedback unit which provides the user with a feedback concerning the degree of the actuation. | 11-27-2014 |
20140378972 | DYNAMIC EXTERNAL FIXATOR AND METHODS FOR USE - An external fixation system and method for realigning, compressing or distracting broken bones has a planar ring element with an adjustable device having a body releasably mounted on the ring element. The adjustable device includes a first member for movement in a direction generally perpendicular to the ring element. A second member is mounted on the first member for movement in a direction parallel to the first member and with respect to a circumference of the planar ring element. The method includes inserting a k-wire through a first piece of bone and affixing the k-wire to the ring element. Then inserting a second k-wire through a second piece of bone and affixing the k-wire to the adjustable device second member. The pieces of bone are realigned, compressed or distracted by adjusting at least one of a first and second adjustable members forming the device. | 12-25-2014 |
20150088135 | BONE POSITION TRACKING SYSTEM - A method of correcting a bone deformity includes fixing first and second support members to first and second fragments of a bone, respectively. The first support member may have a receiver connected thereto. First and second tracking devices are connected to the first and second bone fragments, respectively. A deformity correction plan is determined, and a position of the first support member is adjusted relative to the second support member based on the plan. Location data is transmitted from the first and second trackers to the receiver. Based on the tracker location data, a real position of the first and second bone fragments is determined. The real position of the first and second bone fragment is compared to the deformity correction plan, and the deformity correction plan is reprogrammed based on the comparison. The first and second support members may then be adjusted based on the reprogrammed deformity correction plan. | 03-26-2015 |