Tuckwell
Daniel Scott Tuckwell, Eccles GB
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20080206220 | 2031 Oxidoreductase - Method of identifying an anti-fungal agent which targets an essential protein or gene of a fungus comprising contacting a candidate substance with | 08-28-2008 |
Daniel Scott Tuckwell, Glossop GB
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20120196763 | ANTIFUNGAL TARGET - A method of identifying an antifungal agent which targets a PPTB protein of a fungus comprising determining whether a candidate compound binds to or inhibits a PPTB protein, wherein binding or inhibition indicates that the candidate sub-stance is an antifungal agent. | 08-02-2012 |
Daniel Scott Tuckwell, Manchester GB
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20110081348 | FUNGAL SIGNALLING AND METABOLIC ENZYMES - Method of identifying an anti-fungal agent which targets as an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a protein which comprises the sequence shown by SEQ ID NOS: 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 48, 50, 53, 56, 59, 61 or 63, or (ii) a protein which has 60% identity with (i), or (iii) a protein comprising a fragment of (i) or (ii) which fragment has a length of at least 50 amino acids, or (iv) a polynucleotide that comprises a sequence which encodes (i), (ii) or (iii), or (v) a polynucleotide comprising a sequence which has at least 70% identity with the coding sequence of (iv), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), or (v), wherein binding or modulation of (i), (ii), (iii), (iv), or (v) indicates that the candidate substance is an anti-fungal agent. | 04-07-2011 |
Jonathan D. Tuckwell, Cambridge, MA US
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20110230827 | MIXING DEVICE FOR A TWO-CHAMBER AMPOULE - A device for administering a product (e.g. a medicinal or therapeutic substance), the device including a receptacle for the product or constituents of the product and a casing, wherein the receptacle and casing are engaged, and an outer sleeve, wherein the casing can be moved relative to the receptacle into the outer sleeve. | 09-22-2011 |
Jonathan David Tuckwell, London GB
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20110186047 | Dry Powder Inhalers with Rotating Piercing Mechanisms and Related Devices and Methods - Dry powder inhalers with rotatable piercing mechanisms facilitate the use of dose container assemblies having dose containers arranged in concentric rows. A piercing mechanism is operably associated with the dose container assembly and is configured to pierce sealants that seal a dose container. The piercing mechanism is rotatable such that it can serially alternate between the two rows of dose containers. The piercing mechanism includes a rotatable drum, an elongate piercing member, and a biasing member operably associated with the piercing member. The rotatable drum has an open end, an opposite closed end, and a cylindrical wall that extends from the closed end and terminates at the open end. The closed end includes an aperture formed therein in a location adjacent to the wall. The elongate piercing member is extended and retracted through the aperture to pierce the sealants of a dose container. | 08-04-2011 |
Jonathan David Tuckwell, Cambridge GB
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20100168712 | RECONSTITUTION DEVICE - A reconstitution device for storing a first component of a pharmaceutical preparation includes a receptacle, a cap having a first end secured to the receptacle, a second end, and an inner bore having a central aperture. The device further includes a stopper located between the receptacle and the cap, the stopper including a portion capable of being perforated. The device also includes a plunger secured to the second end of the cap, a locking mechanism located in the cap, and an actuating mechanism. The actuating mechanism may prevent the device from inadvertent activation. | 07-01-2010 |
20130118490 | INHALERS WITH AIRWAY DISKS HAVING DISCRETE AIRWAY CHANNELS AND RELATED DISKS AND METHODS - Dry powder inhalers include radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers. | 05-16-2013 |
20130133653 | DRY POWDER INHALERS WITH DUAL PIERCING MEMBERS - A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions. | 05-30-2013 |
20140137864 | METHODS OF OPERATING AND FABRICATING INHALERS WITH AIRWAY DISKS HAVING DISCRETE AIRWAY CHANNELS - Methods of fabricating and operating dry powder inhalers that include dose disks and airway channel disks with sealant layers, the airway channel disks forming radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers. | 05-22-2014 |
20140166511 | Reconstitution Device - A reconstitution device having an opening surrounded by a neck, and a cap including a first end, a second end, and an inner bore having a central aperture. A stopper is positioned in the opening of the neck and includes a portion capable of being perforated. A plunger is located at the second end of the cap, is configured to slide along the inner bore of the cap, and includes a shaft extending downwardly in a direction towards the stopper and having a pointed end for piercing the stopper. A locking mechanism is located in the cap and includes an aperture. The locking mechanism is configured such that when the plunger is pushed downwardly the shaft is allowed to pass through the aperture, but when the plunger is pulled upwardly the second aperture changes shape such that the shaft cannot freely pass through the aperture. | 06-19-2014 |
Jon David Tuckwell, Cambridgeshire GB
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20090260623 | Aeorosolization apparatus with air inlet shield - An aerosolization apparatus comprises a housing defining a chamber having a plurality of air inlets. The chamber contains an aersolizable pharmaceutical formulation or is sized to receive a receptacle which contains an aerosolizable pharmaceutical formulation. A shield covers at least one of the air inlets or a portion of at least one of the air inlets. The shield prevents blockage of the air inlet by a user grasping the apparatus and inadvertently covering the air inlet. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the receptacle. | 10-22-2009 |
Mark Tuckwell, Knebworth Hertfordshire GB
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20130127548 | APPARATUS AND METHODS FOR VOLTAGE CONVERTERS - Apparatus and methods for voltage converters are provided. In one embodiment, a voltage conversion system includes a bypass circuit and a voltage converter including an inductor and a plurality of switches configured to control a current through the inductor. The bypass circuit includes a first p-type field effect transistor (PFET), a second PFET, a first n-type field effect transistor (NFET), and a second NFET. The first and second NFET transistors and the first and second PFET transistors are electrically connected between a first end and a second end of the inductor such that a source of the first PFET transistor and a drain of the first NFET transistor are electrically connected to the first end of the inductor and such that a drain of the second PFET transistor and a source of the second NFET transistor are electrically connected to the second end of the inductor. | 05-23-2013 |
Mark Tuckwell, Knebworth GB
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20140300334 | APPARATUS AND METHODS FOR VOLTAGE CONVERTER BYPASS CIRCUITS - Apparatus and methods for voltage converter bypass circuits are provided. In one embodiment, a voltage conversion system includes a bypass circuit and a voltage converter including an inductor and a plurality of switches configured to control a current through the inductor. The bypass circuit includes a first p-type field effect transistor, a second p-type field effect transistor, a first n-type field effect transistor, and a second n-type field effect transistor. The first and second n-type field effect transistors are electrically in series between a first end and a second end of the inductor. Additionally, the first and second p-type field effect transistor transistors are electrically connected in series between the first end and the second end of the inductor. | 10-09-2014 |
Mark David Tuckwell, Hertfordshire GB
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20140262983 | MEDICAL FLUID SENSORS AND RELATED SYSTEMS AND METHODS - This disclosure relates to medical fluid sensors and related systems and methods. In some aspects, a circuit includes a radio frequency coil tuned to at least one frequency and at least one switching circuit directly connected to the radio frequency coil. The radio frequency coil is characterized by a high impedance. | 09-18-2014 |
20140263017 | MEDICAL FLUID SENSORS AND RELATED SYSTEMS AND METHODS - This disclosure relates to medical fluid sensors and related systems and methods. In certain aspects, a nuclear magnetic resonance device includes a support frame, a first magnet connected to the support frame, a second magnet connected to the support frame in a manner such that the second magnet is disposed within the magnetic field of the first magnet and a magnetic attraction exists between the first magnet and the second magnet, and a spacer disposed between the first magnet and the second magnet. The spacer is configured to maintain a space between the first magnet and the second magnet. | 09-18-2014 |
20140263064 | MEDICAL FLUID SENSORS AND RELATED SYSTEMS AND METHODS - This disclosure relates to medical fluid sensors and related systems and methods. In certain aspects, a method includes reading an indicia of a medical fluid cartridge to determine a volume of a fluid passageway of the medical fluid cartridge indicated by the indicia, receiving radio frequency energy generated by excited atoms in medical fluid in the fluid passageway of the medical fluid cartridge, and determining a concentration of a substance in the medical fluid based on the determined volume of the fluid passageway of the medical fluid cartridge indicated by the indicia and the received radio frequency energy generated by the excited atoms in the medical fluid in the fluid passageway of the medical fluid cartridge. | 09-18-2014 |