Nicholas, CA
Adrian Macdonald Nicholas, Danville, CA US
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20100295749 | Radome for tracking antenna - A radome for a tracking antenna system may include a dome for covering the tracking antenna, wherein the dome includes a dome wall having inner and outer skins sandwiching a low dielectric material layer therebetween, and wherein the dome wall includes a gel coat layer covering the outer skin to protect the dome in a marine environment. The inner and outer skins may have a thicknesses of approximately 0.007 to 0.027 inches, more preferably approximately 0.014 to 0.020 inches, and most preferably 0.017 inches. The low dielectric material layer may have a thickness of approximately 0.153 to 0.173 inches, more preferably approximately 0.160 to 0.166 inches, and most preferably 0.163 inches. The gel coat may have a thickness of approximately 0.010 to 0.030 inches, more preferably approximately 0.017 to 0.023 inches, and most preferably 0.020 inches. The tracking antenna system may include a tracking antenna having a resonant frequency of approximately 3 Hz to 5 Hz., and a radome including a base for supporting the tracking antenna and a dome secured to the base for enclosing the tracking antenna, wherein the base may have a resonant frequency above approximately 10 Hz. | 11-25-2010 |
Alcov Nicholas, Arroyo Grande, CA US
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20130036664 | Eco-safe plant protector - An eco-safe plant protector, consisting of a top surface of highly reflective material, preferably silver, which repels aphids, white flies, and other plant pests. A copper material forms a barrier around the perimeter of the plant protector. This repels snails and kills certain micro organisms. An adhesive on the surface of the plant protector traps insects and other plant pests. An important aspect of the eco-safe plant protector is that it deters or kills plant pests by mechanical means rather than ecologically harmful chemicals, increases plant growth and yield and has a pleasant decorative appearance so that it can be used both indoors and outdoors. | 02-14-2013 |
Christopher G. Nicholas, Alameda, CA US
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20140247279 | REGISTRATION BETWEEN ACTUAL MOBILE DEVICE POSITION AND ENVIRONMENTAL MODEL - A user interface enables a user to calibrate the position of a three dimensional model with a real-world environment represented by that model. Using a device's sensor, the device's location and orientation is determined. A video image of the device's environment is displayed on the device's display. The device overlays a representation of an object from a virtual reality model on the video image. The position of the overlaid representation is determined based on the device's location and orientation. In response to user input, the device adjusts a position of the overlaid representation relative to the video image. | 09-04-2014 |
20140247280 | FEDERATED MOBILE DEVICE POSITIONING - A user interface enables a user to calibrate the position of a three dimensional model with a real-world environment represented by that model. Using a device's sensor suite, the device's location and orientation is determined. A video image of the device's environment is displayed on the device's display. The device overlays a representation of an object from a virtual reality model on the video image. The position of the overlaid representation is determined based on the device's location and orientation. In response to user input, the device adjusts a position of the overlaid representation relative to the video image. | 09-04-2014 |
Cory R. Nicholas, San Francisco, CA US
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20150361393 | In Vitro Production of Medial Ganglionic Eminence Precursor Cells - Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons. | 12-17-2015 |
Eckelberry Nicholas, Los Angeles, CA US
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20130164812 | Systems and Methods for Increasing Growth of Biomass Feedstocks - Methods and systems for developing and bio-refining or processing biomass feedstocks into a spectrum of bio-based products which can be used as a substitute for fossil oil derivatives in various types of product manufacturing processes and/or the production of bio-energy are disclosed. In addition, methods and systems for identifying, measuring and controlling key parameters in relation to specific biomass developing processes and bio-refining processes so as to maximize the efficiency and efficacy of such processes while standardizing the underlying parameters to facilitate and enhance large-scale production of bio-based products and/or bio-energy are disclosed. | 06-27-2013 |
Guy C. Nicholas, Santa Rosa, CA US
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20140280258 | Methods and apparatus for exporting digital content using a profile - A system examines an object descriptor containing metadata, the metadata associated with a first object. The system identifies at least one characteristic of the first object using the metadata, and applies the at least one characteristic of the first object to a second object. The system exports the second object. The second object is formatted with the at least one characteristic of the first object. Prior to examining the object description, the system receives the first object from a user. | 09-18-2014 |
James Nicholas, Stockton, CA US
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20150290055 | ANTI-TIPPING SAFETY DEVICE - An electromagnetic anti-tipping device uses electromagnets to steady users and prevent falls by persons with impaired mobility and balance. The device's steadying effect is accomplished by magnetically attracting the legs and/or wheels of balance and mobility assisting apparatus (“balance and mobility aid(s)”) to a stationary surface such as a floor which is made of or covered with a magnetically responsive material. In one embodiment, the device's electromagnet attraction to the floor or other stationary surface is actuated when the operator of the device triggers the device's mechanism or sensor by grip or touch. Once actuated, and until deactivation by the user, the device's electromagnet(s) secure the legs or wheels of the balance and mobility aid to the magnetically responsive floor or other stationary surface. The electromagnets are battery-powered. | 10-15-2015 |
Jeffrey William Coyte Nicholas, Los Angeles, CA US
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20110197266 | METHODS AND SYSTEMS FOR SECURE USER AUTHENTICATION - Methods and systems for secure user authentication using a OTP involve, for example, pre-storing a OTP application on a first computing device for generating a valid OTP value for the user responsive to receiving entry of a valid PIN value of the user, no part of the valid PIN value is stored on the first computing device and pre-storing on a back-end server the valid PIN value and a valid shared secret for the user. Upon receiving entry of a purported PIN value of the user, a purported shared secret is dynamically synthesized on the first computing device by the OTP application based on the purported PIN value of the user and a purported OTP value is generated on the first computing device. When entry of the purported OTP value is received by the back-end server in an attempt to log on the back-end server from a second computing device, the back-end server cryptographically calculates a window of OTP values, and log on to the back-end server from the second computing device is allowed if the calculated window of OTP values corresponds to the received OTP value. | 08-11-2011 |
John B. Nicholas, Redwood City, CA US
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20110081315 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formulae I, Ia, II, III, IV, V, VI-1, VI-2, VII, VIII, IX, X, XI, and XII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 04-07-2011 |
20110129444 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 06-02-2011 |
20110152246 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 06-23-2011 |
20110312996 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formulae VI, VII, VIII, IX, X, XI, XII, XIII, XIV, and XV as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 12-22-2011 |
20120094897 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formulae I, and II, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 04-19-2012 |
20120095211 | SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods. | 04-19-2012 |
20120101032 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IV, IVa, V, Va, VI and VIa, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 04-26-2012 |
20120251493 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 10-04-2012 |
20130072449 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS - Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided. | 03-21-2013 |
John Beamond Nicholas, Redwood City, CA US
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20140094456 | ANTI-FIBROTIC PYRIDINONES - Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders. | 04-03-2014 |
20140107110 | ANTI-FIBROTIC PYRIDINONES - Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders. | 04-17-2014 |
20140200215 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS - Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided. | 07-17-2014 |
20140213538 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS - Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided. | 07-31-2014 |
20150266899 | ANTI-FIBROTIC PYRIDINONES - Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders. | 09-24-2015 |
Littleton Glen Nicholas, Saratoga, CA US
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20140137900 | PROCESS AND APPARATUS FOR PERFORMING FORCED IMMERSION OSCILLATORY CLEANING - An open top tank assembly and process for performing forced immersion oscillatory cleaning of products, parts, assemblies or other materials with or without non-line of sight (NLOS) features, wherein the process is repeated during application of pressure gradients to the fluid in the tank to develop a consistent rhythmic oscillation that creates movement of product in a center cavity of the tank to repeatedly transfer the fluid through the product to clean the product. | 05-22-2014 |
Melissa Nicholas, Monterey, CA US
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20100121169 | CELLULOSIC-BASED INTERFERENCE DOMAIN FOR AN ANALYTE SENSOR - The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based interference domain. | 05-13-2010 |
Melissa A. Nicholas, Monterey, CA US
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20090076356 | DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain. | 03-19-2009 |
20100185071 | DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain. | 07-22-2010 |
20110046467 | DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain. | 02-24-2011 |
20130131478 | ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE - Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. | 05-23-2013 |
20140128703 | ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE - Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. | 05-08-2014 |
20140128704 | ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE - Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. | 05-08-2014 |
20140161969 | CELLULOSIC-BASED RESISTANCE DOMAIN FOR AN ANALYTE SENSOR - The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based resistance domain. | 06-12-2014 |
Melissa A. Nicholas, San Diego, CA US
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20100286496 | DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR - Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain. | 11-11-2010 |
Paul Nicholas, Burbank, CA US
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20090309328 | AMPHIBIOUS SPORT AIRCRAFT TRAILER - An amphibious aircraft trailer includes a frame supported on a wheel/suspension bearing axle for movements over a roadway surface. Incorporated into the trailer is a cradle configured to engage a hull of the amphibious aircraft when it is loaded and unloaded in water conditions. A lift mechanism interposed between and coupled to the frame and the cradle is operable to displace the cradle vertically with respect to the frame such that landing gear associated with the amphibious aircraft can be extended or retracted while on the trailer. The trailer may also include a plurality of wheel tracks aligned with the landing gear to facilitate the aircraft's loading and unloading in its ground based mode of operation. | 12-17-2009 |
20110180657 | TWO-MOTION WING-FOLD MECHANISM WITH INDEPENDENT LOAD PATH - An aircraft wing folding system folds an outboard wing section relative to an inboard wing section between a deployed position and a stored position in two discrete motions where each motion has an independent load path separate of the loading of the wing experienced by in-flight aerodynamic forces. The wing-fold mechanism of the present invention includes a fold assembly comprising a twist component and a fold component operable to fold the outboard wing section from the deployed position to the stored position that remains substantially unloaded with respect to in-flight aerodynamic forces when the wing is in the deployed or flight configuration. | 07-28-2011 |
Rodney G. Nicholas, San Leandro, CA US
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20110232508 | Pitter Apparatus with Rotary Operated Drive System - A pitting knife assembly including a pitting knife mount and a pulley drive assembly coupled and configured to move the knife mount around a circular or substantially circular path, and a fruit pitting apparatus including such an assembly. During operation of the pitting knife assembly with at least one pitting knife mounted to the knife mount and a fruit conveying assembly positioned to convey fruit to the pitting knife assembly, the pitting knife can produce pitted fruit by moving into engagement with fruit conveyed by the conveying assembly (to pit the fruit) as the knife mount moves through a first portion of the path, and the pitting knife can then move out of engagement with (and away from) the pitted fruit as the knife mount moves through a second portion of the path. Typically, the pitting knife assembly includes a drive shaft assembly rotatably mounted to a frame, at least one pair of pulleys coupled to and drivable by the drive shaft assembly, and a connector rotatably connected between the pulleys of each said pair so as to remain oriented at least substantially parallel to a line through the centers of the pulleys of the pair while the pulleys are driven by the drive shaft assembly, and the pitting knife mount is coupled to the connector such that said connector moves the pitting knife mount around the at least substantially circular path when each said pair of pulleys is driven by the drive shaft assembly. | 09-29-2011 |
Royce J. Nicholas, San Diego, CA US
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20150261260 | METHOD OF WATER-PROOFING ELECTRONIC COMPONENTS - A process for water-proofing devices from the inside out, the process is suited for application to completely fabricated electronic devices to enable them to be used with full functionalities in and under the water and in a variety of aquatic environments, shockproof and corrosion resistant. Multilayer technology fills empty spaces in the electronic device with a first layer of a hydrophobic medium like silicone and then a second layer of an anti-corrosive agent. Creating a vacuum removes air from the insulating mediums, slowly eliminating the vacuum to allow air to push the mediums into the device's internal voids, and then curing while preserving button functionality and patency of electronic pathways. | 09-17-2015 |
Susanne B. Nicholas, Los Angeles, CA US
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20120003201 | VAULT AGENTS FOR CHRONIC KIDNEY DISEASE - The invention relates to compositions of vault complexes containing cell adhesion inhibiting agents, such as a RGD-peptide, and methods of using the vault complexes in the treatment of diseases, such as chronic kidney disease. | 01-05-2012 |
20140194361 | Vault Agents for Treating Chronic Kidney Disease - The invention relates to compositions of vault complexes containing cell adhesion inhibiting agents, such as a RGD-peptide, and methods of using the vault complexes in the treatment of diseases, such as chronic kidney disease. | 07-10-2014 |