Patent application number | Description | Published |
20100242300 | FREEZE DRYER BARRIER SYSTEM - This invention is directed to freeze dryers used in the pharmaceutical industry, and in particular, to a barrier system for freeze dryers located in an isolator or clean room facilitate sterilization of the isolator. | 09-30-2010 |
20110232123 | Freeze Dryer Slot Door Actuator and Method - Movement of a slot door of a freeze dryer is driven by a rack and pinion actuator. The actuator is easily sanitized and includes internal elements that are accessible to sanitizing sprays. The pinions are driven by pinion shafts that pass through a seal separating an aseptic area from a non-aseptic area where the drive train is positioned. Only rotary motion is transferred across the aseptic barrier, reducing the need for a bellows or sliding covers, which are difficult to sanitize. | 09-29-2011 |
20130118026 | BULK FREEZE DRYING USING SPRAY FREEZING AND STIRRED DRYING - A freeze dryer processes bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen. The resultant powder is freeze dried in a vessel, and the vessel contents is agitated to maintain product contact with heated vessel wall and to prevent agglomeration. | 05-16-2013 |
20150226478 | BULK FREEZE DRYING USING SPRAY FREEZING AND AGITATED DRYING - A freeze dryer processes bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen. The resultant powder is freeze dried in a vessel, and the vessel contents is agitated to maintain product contact with heated vessel wall and to prevent agglomeration. | 08-13-2015 |
Patent application number | Description | Published |
20110251301 | POLYMERIZABLE LIQUID COMPOSITION AND PROCESS FOR THE PRODUCTION OF ORGANIC GLASS STARTING FROM POLYMERIZABLE LIQUID COMPOSITIONS OF THE POLYURETHANE TYPE - Polymerizable liquid compositions of the polyurethane type, consisting of two components (A) and (B), wherein component (A) contains at least one cyclo-aliphatic diisocyanate monomer or a mixture of one cyclo-aliphatic diisocyanate monomer and a pre-polymer obtained by reaction, in the presence of an acid phosphate ester catalyst, between said cyclo-aliphatic diisocyanate monomer and one or more polyols having two or more hydroxy 1 groups per molecule and a molecular weight ranging from 50 to 2,000 g/mole; the second component (B) contains one or more polyols having a molecular weight ranging from 50 to 2,000 g/mole and a functionality between 2 and 5; in the absence of polyalkoxylated tertiary diamines and organometallic catalysts, said components (A) and (B) being present in a weight ratio which varies from 1:1 to 2:1 and the process for the production of organic glass starting from polymerizable liquid compositions of the polyurethane type. | 10-13-2011 |
20130066034 | POLYMERIZATION CATALYST FOR POLYTHIOURETHANES, POLYMERIZABLE LIQUID COMPOSITION AND PROCESS FOR THE PRODUCTION OF ORGANIC POLYTHIOURETHANE GLASS WITH A HIGH REFRACTIVE INDEX - Polymerization catalysts for organic polythiourethane glass which do not contain organometallic compounds contain a mixture of a tertiary aliphatic amine and a disubstituted phosphoric acid in a molar ratio ranging from 1/1.3 to 1/20. Polymerizable liquid compositions containing three components (A), (B) and (C) are also provided, wherein component (A) contains at least one cycloaliphatic diisocyanate monomer wherein the weight percentage of free isocyanate groups in component (A) ranges from about 20% to about 50% by weight with respect to the total weight of component (A); component (B) contains at least one polythiol having a molecular weight ranging from 50 to 1,200 g/moles and a functionality ranging from 2 to 5, said components (A) and (B) being present in a weight ratio varying from 0.5:1 to 2:1; and component (C) being said polymerization catalyst. A process for the production of organic glass using the polymerizable liquid composition is further provided. | 03-14-2013 |
20140323678 | POLYMERIZATION CATALYST FOR POLYTHIOURETHANES, POLYMERIZABLE LIQUID COMPOSITION AND PROCESS FOR THE PRODUCTION OF ORGANIC POLYTHIOURETHANE GLASS WITH A HIGH REFRACTIVE INDEX - Polymerizable liquid compositions containing three components (A), (B) and (C) are provided, wherein component (A) contains at least one cycloaliphatic diisocyanate monomer wherein the weight percentage of free isocyanate groups in component (A) ranges from about 20% to about 50% by weight with respect to the total weight of component (A); component (B) contains at least one polythiol having a molecular weight ranging from 50 to 1,200 g/moles and a functionality ranging from 2 to 5, the components (A) and (B) being present in a weight ratio varying from 0.5:1 to 2:1; and component (C) being a defined polymerization catalyst. A process for the production of organic glass using the polymerizable liquid composition is further provided. | 10-30-2014 |
20140327869 | POLYMERIZABLE COMPOSITION, OPTICAL ARTICLE OBTAINED THEREFROM AND METHOD FOR THE PRODUCTION OF SAID OPTICAL ARTICLE - The present invention relates to a polymerizable composition comprising polyisocyanate(s) (A), polythiol(s) (B), thiol(s) (C) and catalyst(s) (D). The polyisocyanate(s) (A) is at least one bifunctional or higher functional alicyclic polyisocyanate; the polythiol(s) (B) is at least one compound selected from polythiols represented by the following general formula (B1); the thiol(s) (C) is at least one compound selected from thiols having general formula (3); and the catalyst(s) (D) is at least one polymerization catalyst selected from metal compounds, quaternary ammonium salts, organic sulfonic acids, tertiary amines and relative inorganic or organic salts. | 11-06-2014 |
Patent application number | Description | Published |
20090029938 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR TREATING DISEASE INCLUDING INFLAMMATORY CONDITIONS - The invention relates to therapeutic antisense oligonucleotides directed against genes coding for phosphodiesterase (PDEs) and the use of these in combination. These antisense oligonucleotides may be used as analytical tools and/or as therapeutic agents in the treatment of disease associated with reduced cellular cAMP in a patient, such as inflammatory diseases of the respiratory tract including, for example, asthma, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, bronchitis, chronic bronchitis, silicosis, pulmonary fibrosis, lung allograft rejection, allergic rhinitis and chronic sinusitis as well as other conditions in which an increase in cyclic AMP or a decrease in PDE levels is beneficial. | 01-29-2009 |
20090087425 | Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease - There is provided a pharmaceutical composition for treating respiratory disease comprising an NO-donating steroid and at least one bronchodilator. Also provided is a method for treating respiratory diseases associated with inflammation comprising administering an NO-donating steroid with at least one bronchodilator. Method of use of the combination of an NO-donating compound, and a steroid with at least one bronchodilator for treating respiratory disease is also provided. | 04-02-2009 |
20090088411 | No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties - There are herein provided methods of treatment and nitric oxide donating compositions of matter for the treatment of respiratory diseases and associated conditions. | 04-02-2009 |
20090215861 | Antisense oligonucleotides for treating allergy and neoplastic cell proliferation - Antisense oligonucleotides for treating and/or preventing at least one of asthma, allergy, hypereosinophilia, general inflammation and cancer are provided. The oligonucleotides are directed against nucleic acid sequences coding for a receptor selected from the group consisting of a CCR3 receptor and a common sub-unit of IL-3, IL-5 and GM-CSF receptors. | 08-27-2009 |
20100048673 | OLIGONUCLEOTIDES AFFECTING EXPRESSION OF PHOSPHODIESTERASES - The invention relates to therapeutic antisense oligonucleotides directed against genes encoding phosphodiesterases (PDE) and the use of these antisense oligonucleotides in combination. These antisense oligonucleotides may be used as analytical tools and/or as therapeutic agents in the treatment of disease associated with reduced cellular cAMP in a patient, such as inflammatory diseases of the respiratory tract including, for example, asthma, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, bronchitis, chronic bronchitis, silicosis, pulmonary fibrosis, lung allograft rejection, allergic rhinitis and chronic sinusitis as well as other conditions in which an increase in cyclic AMP or a decrease in PDE levels is beneficial. | 02-25-2010 |
20100286235 | METHODS FOR INCREASING IN VIVO EFFICACY OF OLIGONUCLEOTIDES AND INHIBITING INFLAMMATION IN MAMMALS - The invention relates to the use of nucleotide substitutes for increasing the in vivo efficacy of nucleic acid molecules and also for inhibiting inflammation in mammals. More particularly, the present invention relates to the use of 2′6′ diaminopurine (DAP) and analogs thereof per se in anti-inflammatory compositions, and also for preparing nucleic acid molecules having an increased in vivo physiological efficiency and a reduced toxicity as compared to conventional oligos. The invention is particularly useful for the preparation of antisense oligonucleotides for treating pulmonary/respiratory diseases such as cystic fibrosis, asthma, chronic bronchitis, chronic obstructive lung disease, eosinophilic bronchitis, allergies, allergic rhinitis, pulmonary fibrosis, adult respiratory distress syndrome, sinusitis, respiratory syncytial virus or other viral respiratory tract infection and cancer. | 11-11-2010 |
20100286239 | ANTISENSE OLIGONUCLEOTIDES FOR TREATING ATOPIC DISEASES AND NEOPLASTIC CELL PROLIFERATION - The present invention relates to the use of antisense oligonucleotides directed against specific nucleic acid sequences coding for receptors, alone or in combination, in order to inhibit the inflammatory reaction that is present in asthma, atopy or hypereosinophilia and to inhibit neoplastic cell proliferation. The antisense oligonucleotides of the present invention are used for treating and/or preventing asthma, allergy, hypereosinophilia, general inflammation or cancer. The oligonucleotides of the present invention are more specifically directed against nucleic acid sequences coding for a CCR3 receptor, a common sub-unit of IL-4 and IL-13 receptors, or a common sub-unit of IL-3, IL-5 and GM-CSF receptors. | 11-11-2010 |
20110086901 | OLIGONUCLEOTIDES AFFECTING EXPRESSION OF PHOSPHODIESTERASES - The invention relates to therapeutic antisense oligonucleotides directed against genes encoding phosphodiesterases (PDE) and the use of these antisense oligonucleotides in combination. These antisense oligonucleotides may be used as analytical tools and/or as therapeutic agents in the treatment of disease associated with reduced cellular cAMP in a patient, such as inflammatory diseases of the respiratory tract including, for example, asthma, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, bronchitis, chronic bronchitis, silicosis, pulmonary fibrosis, lung allograft rejection, allergic rhinitis and chronic sinusitis as well as other conditions in which an increase in cyclic AMP or a decrease in PDE levels is beneficial. | 04-14-2011 |
20120065249 | ANTISENSE OLIGONUCLEOTIDES FOR TREATING ALLERGY AND NEOPLASTIC CELL PROLIFERATION - Antisense oligonucleotides for treating and/or preventing at least one of asthma, allergy, hypereosinophilia, general inflammation and cancer are provided. The oligonucleotides are directed against nucleic acid sequences coding for a receptor selected from the group consisting of a CCR3 receptor and a common sub-unit of IL-3, IL-5 and GM-CSF receptors. | 03-15-2012 |
Patent application number | Description | Published |
20130201273 | STREAMING VIDEO NETWORK SYSTEM - A distributed, digital, network-based, streaming video allows users to view live streaming digital video from multiple video sources in operating rooms at any location connected to a network. One or more video sources in an operating room are connected to a streaming video encoder capable of converting the video to a network packet stream. Once the digital video stream is available on the network, it may be accessed and routed through the use of a streaming video control server. The streaming video control server is responsible for user authentication and access for remote viewing and video source selection. The control server also provides audit logging services, operating room selection and overall system resource allocation. The video control server also provides a network-based remote control interface, which enables other systems to communicate on the streaming video network, and allows for remote control of visualization from an integrated operating room control system. | 08-08-2013 |
20140331248 | STREAMING VIDEO NETWORK SYSTEM - A distributed, digital, network-based, streaming video allows users to view live streaming digital video from multiple video sources in operating rooms at any location connected to a network. One or more video sources in an operating room are connected to a streaming video encoder capable of converting the video to a network packet stream. Once the digital video stream is available on the network, it may be accessed and routed through the use of a streaming video control server. The streaming video control server is responsible for user authentication and access for remote viewing and video source selection. The control server also provides audit logging services, operating room selection and overall system resource allocation. The video control server also provides a network-based remote control interface, which enables other systems to communicate on the streaming video network, and allows for remote control of visualization from an integrated operating room control system. | 11-06-2014 |
Patent application number | Description | Published |
20090215023 | HIGH TEMPERATURE FLOW-THROUGH DEVICE FOR RAPID SOLUBILIZATION AND ANALYSIS - Devices and methods for thermally lysing of biological material, for example vegetative bacterial cells and bacterial spores, are provided. Hot solution methods for solubilizing bacterial spores are described. Systems for direct analysis are disclosed including thermal lysers coupled to sample preparation stations. Integrated systems capable of performing sample lysis, labeling and protein fingerprint analysis of biological material, for example, vegetative bacterial cells, bacterial spores and viruses are provided. | 08-27-2009 |
20120004144 | MICROELECTROPORATION DEVICE FOR GENOMIC SCREENING - We have developed an microelectroporation device that combines microarrays of oligonucleotides, microfluidic channels, and electroporation for cell transfection and high-throughput screening applications (e.g. RNA interference screens). Microarrays allow the deposition of thousands of different oligonucleotides in microscopic spots. Microfluidic channels and microwells enable efficient loading of cells into the device and prevent cross-contamination between different oligonucleotides spots. Electroporation allows optimal transfection of nucleic acids into cells (especially hard-to-transfect cells such as primary cells) by minimizing cell death while maximizing transfection efficiency. This invention has the advantage of a higher throughput and lower cost, while preventing cross-contamination compared to conventional screening technologies. Moreover, this device does not require bulky robotic liquid handling equipment and is inherently safer given that it is a closed system. | 01-05-2012 |
20120085644 | FLUID DELIVERY MANIFOLDS AND MICROFLUIDIC SYSTEMS - Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction. | 04-12-2012 |
20130020492 | ION CHAMBER BASED NEUTRON DETECTORS - A neutron detector with monolithically integrated readout circuitry, including: a bonded semiconductor die; an ion chamber formed in the bonded semiconductor die; a first electrode and a second electrode formed in the ion chamber; a neutron absorbing material filling the ion chamber; and the readout circuitry which is electrically coupled to the first and second electrodes. The bonded semiconductor die includes an etched semiconductor substrate bonded to an active semiconductor substrate. The readout circuitry is formed in a portion of the active semiconductor substrate. The ion chamber has a substantially planar first surface on which the first electrode is formed and a substantially planar second surface, parallel to the first surface, on which the second electrode is formed. Desirably, the distance between the first electrode and the second electrode may be equal to or less than the 50% attenuation length for neutrons in the neutron absorbing material filling the ion chamber. | 01-24-2013 |