Patent application number | Description | Published |
20140249448 | Insertable Endoscopic Instrument For Tissue Removal - An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool. | 09-04-2014 |
20150018710 | ENDOSCOPE INCLUDING AN TORQUE GENERATION COMPONENT OR TORQUE DELIVERY COMPONENT DISPOSED WITHIN AN INSERTABLE PORTION OF THE ENDOSCOPE AND A SURGICAL CUTTING ASSEMBLY INSERTABLE WITHIN THE ENDOSCOPE - An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component. | 01-15-2015 |
20150018711 | ENDOSCOPE INCLUDING AN TORQUE GENERATION COMPONENT OR TORQUE DELIVERY COMPONENT DISPOSED WITHIN AN INSERTABLE PORTION OF THE ENDOSCOPE AND A SURGICAL CUTTING ASSEMBLY INSERTABLE WITHIN THE ENDOSCOPE - An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component. | 01-15-2015 |
20150025541 | INSERTABLE ENDOSCOPIC INSTRUMENT FOR TISSUE REMOVAL - An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool. | 01-22-2015 |
20150031951 | ENDOSCOPE INCLUDING AN TORQUE GENERATION COMPONENT OR TORQUE DELIVERY COMPONENT DISPOSED WITHIN AN INSERTABLE PORTION OF THE ENDOSCOPE AND A SURGICAL CUTTING ASSEMBLY INSERTABLE WITHIN THE ENDOSCOPE - An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component. | 01-29-2015 |
20150032024 | METHODS AND APPARATUS FOR REMOVING MATERIAL FROM WITHIN A MAMMALIAN CAVITY USING AN INSERTABLE ENDOSCOPIC INSTRUMENT - An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component. | 01-29-2015 |
20150065911 | INSERTABLE ENDOSCOPIC INSTRUMENT FOR TISSUE REMOVAL - An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool. | 03-05-2015 |
Patent application number | Description | Published |
20090035825 | Devices, Systems, and Methods for Preparing Emulsions - A vortex mixer and method for forming an emulsion wherein the mixer is adapted to form an emulsion with a desired droplet size and having a desired volume. The vortex mixer provides improved uniformity in emulsion preparation and may be used to create multiple emulsions simultaneously. | 02-05-2009 |
20090062129 | REAGENTS, METHODS, AND LIBRARIES FOR GEL-FREE BEAD-BASED SEQUENCING - The present disclosure provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles typically comprise steps of extension, ligation, and cleavage. In certain embodiments, the methods make use of extension probes containing phosphorothiolate linkages and agents capable of cleaving such linkages. Methods of determining information about a sequence using at least two distinguishably labeled probe families are provided, as are methods of performing multiple sequencing reactions on a single template. Automated sequencing systems, flow cells, image processing methods, and computer-readable media that store computer-executable instructions and/or sequence information that can be used in accordance with such methods are also provided. In certain embodiments, blocking oligonucleotides are provided to facilitate sequencing using disclosed methods. | 03-05-2009 |
20090181385 | Reagents, methods, and libraries for bead-based sequencing - The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate to cleave such linkages. The invention provides methods of determining information about a sequence using at least two distinguishably labeled probe families. In certain embodiments the methods acquire less than 2 bits of information from each of a plurality of nucleotides in the template in each cycle. In certain embodiments the sequencing reactions are performed on templates attached to immobilized beads. The invention further provides sets of labeled probes containing phosphorothiolate linkages. In addition, the invention includes performing multiple sequencing reactions on a single template by removing initializing oligonucleotides and extended strands and performing subsequent reactions using different initializing oligonucleotides. | 07-16-2009 |
20100297626 | Reagents, Methods, and Libraries for Bead-Based Sequencing - The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate to cleave such linkages. In certain embodiments the methods make use of extension probes containing an abasic residue or a damaged base and employ agents appropriate to cleave linkages between a nucleoside and an abasic residue and/or agents appropriate to remove a damaged base from a nucleic acid. The invention provides methods of determining information about a sequence using at least two distinguishably labeled probe families. In certain embodiments the methods acquire less than 2 bits of information from each of a plurality of nucleotides in the template in each cycle. In certain embodiments the sequencing reactions are performed on templates attached to beads, which are immobilized in or on a semi-solid support. The invention further provides sets of labeled extension probes containing phosphorothiolate linkages or trigger residues that are suitable for use in the method. In addition, the invention includes performing multiple sequencing reactions on a single template by removing initializing oligonucleotides and extended strands and performing subsequent reactions using different initializing oligonucleotides. The invention further provides efficient methods for preparing templates, particularly for performing sequencing multiple different templates in parallel. The invention also provides methods for performing ligation and cleavage. The invention also provides new libraries of nucleic acid fragments containing paired tags, and methods of preparing microparticles having multiple different templates (e.g., containing paired tags) attached thereto and of sequencing the templates individually. The invention also provides automated sequencing systems, flow cells, image processing methods, and computer-readable media that store computer-executable instructions (e.g., to perform the image-processing methods) and/or sequence information. In certain embodiments the sequence information is stored in a database. | 11-25-2010 |
20110077169 | Reagents, Methods, and Libraries for Bead-Based Sequencing - The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate to cleave such linkages. In certain embodiments the methods make use of extension probes containing an abasic residue or a damaged base and employ agents appropriate to cleave linkages between a nucleoside and an abasic residue and/or agents appropriate to remove a damaged base from a nucleic acid. The invention provides methods of determining information about a sequence using at least two distinguishably labeled probe families. In certain embodiments the methods acquire less than 2 bits of information from each of a plurality of nucleotides in the template in each cycle. In certain embodiments the sequencing reactions are performed on templates attached to beads, which are immobilized in or on a semi-solid support. The invention further provides sets of labeled extension probes containing phosphorothiolate linkages or trigger residues that are suitable for use in the method. In addition, the invention includes performing multiple sequencing reactions on a single template by removing initializing oligonucleotides and extended strands and performing subsequent reactions using different initializing oligonucleotides. The invention further provides efficient methods for preparing templates, particularly for performing sequencing multiple different templates in parallel. The invention also provides methods for performing ligation and cleavage. The invention also provides new libraries of nucleic acid fragments containing paired tags, and methods of preparing microparticles having multiple different templates (e.g., containing paired tags) attached thereto and of sequencing the templates individually. The invention also provides automated sequencing systems, flow cells, image processing methods, and computer-readable media that store computer-executable instructions (e.g., to perform the image-processing methods) and/or sequence information. In certain embodiments the sequence information is stored in a database. | 03-31-2011 |
Patent application number | Description | Published |
20100297429 | COMPOSITE MEMBRANE AND METHOD OF MAKING - The present invention provides a composite membrane comprising a porous base membrane and a polyamide coating disposed on said porous base membrane, said polyamide coating comprising a C | 11-25-2010 |
20110049055 | REVERSE OSMOSIS COMPOSITE MEMBRANES FOR BORON REMOVAL - Improved methods for reducing boron concentration in seawater or brackish water, while simultaneously maintaining or improving the salt rejection of membrane and flow performance of polyamide reverse osmosis (RO) membranes include contacting the water with a composite membrane comprising moieties derived from an aromatic sulfonyl halide, a heteroaromatic sulfonyl halide, a sulfinyl halide; a sulfenyl halide; a sulfuryl halide; a phosphoryl halide; a phosphonyl halide; a phosphinyl halide; a thiophosphoryl halide; a thiophosphonyl halide, an isocyanate, a urea, a cyanate, an aromatic carbonyl halide, an epoxide or a mixture thereof. | 03-03-2011 |
20120255909 | REVERSE OSMOSIS COMPOSITE MEMBRANES FOR BORON REMOVAL - Improved methods for reducing boron concentration in seawater or brackish water, while simultaneously maintaining or improving the salt rejection of membrane and flow performance of polyamide reverse osmosis (RO) membranes include contacting the water with a composite membrane comprising moieties derived from an aromatic sulfonyl halide, a heteroaromatic sulfonyl halide, a sulfinyl halide; a sulfenyl halide; a sulfuryl halide; a phosphoryl halide; a phosphonyl halide; a phosphinyl halide; a thiophosphoryl halide; a thiophosphonyl halide, an isocyanate, a urea, a cyanate, an aromatic carbonyl halide, an epoxide or a mixture thereof. | 10-11-2012 |
20120292249 | COMPOSITE MEMBRANE AND METHOD OF MAKING - The present invention provides a composite membrane comprising a porous base membrane and a polyamide coating disposed on said porous base membrane, said polyamide coating comprising a C | 11-22-2012 |
Patent application number | Description | Published |
20140221780 | COMPLEXITY BASED METHODS AND SYSTEMS FOR DETECTING DEPRESSION - Major depression can affect multiple physiologic systems. Analysis of signals that reflect integrated function may be useful in probing dynamical changes in this syndrome. Complex variability can be used as a marker of healthy, adaptive control mechanisms and dynamical complexity decreases with aging and disease. The heart rate (HR) dynamics in non-medicated, young to middle-aged males during an acute major depressive episode exhibit lower complexity compared with healthy counterparts. By analyzing HR time series, a neuroautonomically regulated signal, during sleep, using the multiscale entropy method, a measure of complexity of HR dynamics can be determined. The complexity of the HR dynamics is significantly lower for depressed than for non-depressed subjects for the entire night and combined sleep stages 1 and 2, providing an indication of depression. These complexity signals, individually, or in combination with the complexity of other physiologic signals, can be used to define novel dynamical biomarkers of depression. | 08-07-2014 |
20140330159 | QUANTITATIVE METHODS AND SYSTEMS FOR NEUROLOGICAL ASSESSMENT - Typical neurological examinations focus on qualitative and subjective assessments, including obtaining a patient history, assessing the patient's cognitive status, motor and sensory skills, and cranial nerve functionality. A quantitative assessment of neurological condition includes recording a subject performing a visuomotor task and processing the performance data to determine a level of complexity in the task activity and determine a complexity index. For a sample healthy population, a baseline level of complexity and baseline complexity index can be determined. A patient's complexity index can be compared to this baseline complexity index as an indication of disease or disability. A baseline complexity index can be determined for a patient at part of a health maintenance examination and used as the baseline complexity to detect disease or disability in the future based on lower complexity index values in future examinations. | 11-06-2014 |
Patent application number | Description | Published |
20080238611 | Authentication of source, plus, for goods and services system, method, and components - A unique identifier is created for each article (clothing, accessories, jewels, fragrances, manufactures, etc.) for which the provider of the article desires to authenticate its Brand source to the party acquiring the article to substantiate to that acquiring party that they are receiving a genuine article. The unique identifier is so provided from a secure third party that also stores the unique identifier, possibly with other historical information, in a secure data base accessable only by authorized parties. The unique identifier may be provided on tags to be carried by the respective article or it may be applied directly to the article as by direct part marking from the material of the article and when so provided it includes a brand source identifier of the party providing the unique identifier as an additional protective measure. The unique identifier furthermore may be provided as an encoded, imageable symbology such as a “Data Matrix”. | 10-02-2008 |
20110101087 | Authentication of source, plus, for goods and services system, method, and components - A unique identifier is created for each article (clothing, accessories, jewels, fragrances, manufactures, etc.) for which the provider of the article desires to authenticate its Brand source to the party acquiring the article to substantiate to that acquiring party that they are receiving a genuine article. The unique identifier is so provided from a secure third party that also stores the unique identifier, possibly with other historical information, in a secure data base accessible only by authorized parties. The unique identifier may be provided on tags to be carried by the respective article or it may be applied directly to the article as by direct part marking from the material of the article and when so provided it includes a brand source identifier of the party providing the unique identifier as an additional protective measure. | 05-05-2011 |
20110211727 | Authentication of "SOURCE" for brands - A unique identifier and Authentication System is created to Authenticate to interested parties the BRAND “SOURCE” of: articles (such as clothing, accessories, jewels, fragrances, manufactures, etc.); of authorized dealers for such articles (wholesalers, retailers, etc.); of authorized service entities for such articles: and for the like; of the BRAND “SOURCE” which the provider of the article desires to authenticate its Brand source to the party acquiring the article(s) to substantiate to that acquiring party that they are receiving a genuine article and/or dealing with a “SOURCE” authorized entity. The Authentication System accommodates not only camera enabled imagers and hard wiring but also camera enabled smart phones and internet communications. In addition to responding, in real time, to Authentication Inquiries the system establishes a communication link between the “SOURCE” and the inquirer for marketing and other APP like matters. | 09-01-2011 |
20140263604 | System, method, proceedure and components for preparing an article for authentication and tracking - Persons and/or business entities (inquirers), interested in acquiring a BRANDED article, or availing themselves of a BRANDED service, upon seeing IDENTIFIER | 09-18-2014 |