Patent application number | Description | Published |
20090209626 | Duplex Oligonucleotides with Enhanced Functionality in Gene Regulation - Disclosed are methods of enhancing functionality of duplex oligonucleotides and compositions made by the methods. The duplex oligonucleotides include siRNAs, miRNA mimics, and piRNA mimics which contain modified nucleotides and mismatches between the two strands of the molecule at specific nucleotide positions. | 08-20-2009 |
20090280567 | STABILIZED SIRNAS AS TRANSFECTION CONTROLS AND SILENCING REAGENTS - RNA molecules, including siRNA molecules and related control, trackability and exaequo agents with specific stability modifications are provided. These molecules are particularly advantageous as transfection control reagents. The molecules include first and second 5′ terminal sense nucleotides with 2′-O-alkyl groups and a label on the first 5′ terminal sense nucleotide, in conjunction with at least one additional 2′-O-alkyl pyrimidine modified sense nucleotide, and either: (i) at least one 2′ fluoro modified pyrimidine antisense nucleotide and a phosphorylated first 5′ terminal antisense nucleotide; or (ii) a first and second 5′ terminal antisense nucleotide with 2′-O-alkyl modifications and at least one additional 2′-O-alkyl pyrimidine modified antisense nucleotide. | 11-12-2009 |
20100184209 | COMPOSITIONS AND METHODS FOR INHIBITING GENE SILENCING BY RNA INTERFERENCE - The present invention provides compositions and methods for inhibiting gene silencing by the RNAi pathway. The RNAi inhibitors of the invention have a reverse complement (RC) region to the target molecule of interest (e.g., miRNA) in association with at least one flanking region coupled to either at the 3′ or 5′ end of the RC region. The flanking regions can be single-stranded or can have one or more regions of double stranded nucleic acid with or without a hairpin loop. The RNAi inhibitors described herein can inhibit endogenous targets, including but not limited to microRNAs, or piRNAs, or can be used to inhibit the effects of exogenously introduced molecules, such as synthetic siRNAs, siRNAs expressed from vector constructs (e.g., viral expression systems), or siRNAs generated by enzymatic methods. Inhibition is specific, potent, prolonged, and can be performed on a single target or multiple targets simultaneously. | 07-22-2010 |
20100273856 | SCREENING OF MICRO-RNA CLUSTER INHIBITOR POOLS - The disclosure provides methods for inhibiting the activity of a miRNA cluster in a cell, and also for screening a cell for a phenotype(s) of interest resulting from inhibition of a miRNA cluster. The methods use a cluster pool which comprises at least one miRNA inhibitor specific for each miRNA in the miRNA cluster. MiRNA inhibitors are described that induce apoptosis in breast cancer cells and hence are useful in the treatment of breast cancer. The disclosure also provides pharmaceutical compositions which are useful for the treatment of breast cancer; methods for inducing the nuclear translocation of NF-κB in a breast cancer cell; methods for inducing the nuclear translocation of c-Jun in a breast cancer cell; method for inhibiting the nuclear translocation of NF-κB in a breast cancer cell; and methods for providing prognostic medical information relating to breast cancer progression. | 10-28-2010 |
20120259001 | Duplex Oligonucleotides with Enhanced Functionality in Gene Regulation - Disclosed are methods of enhancing functionality of duplex oligonucleotides and compositions made by the methods. The duplex oligonucleotides include siRNAs, miRNA mimics, and piRNA mimics which contain modified nucleotides and mismatches between the two strands of the molecule at specific nucleotide positions. | 10-11-2012 |
Patent application number | Description | Published |
20130025281 | GASIFICATION SYSTEM AND METHOD - A system configured for the production of at least one product selected from the group consisting of syngas, Fischer-Tropsch synthesis products, power, and chemicals, the system comprising a dual fluidized bed gasification apparatus and at least one apparatus selected from power production apparatus configured to produce power from the gasification product gas, partial oxidation reactors configured for oxidation of at least a portion of the product gas, tar removal apparatus configured to reduce the amount of tar in the product gas, Fischer-Tropsch synthesis apparatus configured to produce Fischer-Tropsch synthesis products from at least a portion of the product gas, chemical production apparatus configured for the production of at least one non-Fischer-Tropsch product from at least a portion of the product gas, and dual fluidized bed gasification units configured to alter the composition of the product gas. Methods of operating the system are also provided. | 01-31-2013 |
20130028801 | GASIFICATION SYSTEM AND METHOD - A system configured for the production of at least one product selected from the group consisting of syngas, Fischer-Tropsch synthesis products, power, and chemicals, the system comprising a dual fluidized bed gasification apparatus and at least one apparatus selected from power production apparatus configured to produce power from the gasification product gas, partial oxidation reactors configured for oxidation of at least a portion of the product gas, tar removal apparatus configured to reduce the amount of tar in the product gas, Fischer-Tropsch synthesis apparatus configured to produce Fischer-Tropsch synthesis products from at least a portion of the product gas, chemical production apparatus configured for the production of at least one non-Fischer-Tropsch product from at least a portion of the product gas, and dual fluidized bed gasification units configured to alter the composition of the product gas. Methods of operating the system are also provided. | 01-31-2013 |
20130028802 | GASIFICATION SYSTEM AND METHOD - A system configured for the production of at least one product selected from the group consisting of syngas, Fischer-Tropsch synthesis products, power, and chemicals, the system comprising a dual fluidized bed gasification apparatus and at least one apparatus selected from power production apparatus configured to produce power from the gasification product gas, partial oxidation reactors configured for oxidation of at least a portion of the product gas, tar removal apparatus configured to reduce the amount of tar in the product gas, Fischer-Tropsch synthesis apparatus configured to produce Fischer-Tropsch synthesis products from at least a portion of the product gas, chemical production apparatus configured for the production of at least one non-Fischer-Tropsch product from at least a portion of the product gas, and dual fluidized bed gasification units configured to alter the composition of the product gas. Methods of operating the system are also provided. | 01-31-2013 |
20130030062 | GASIFICATION SYSTEM AND METHOD - A system configured for the production of at least one product selected from the group consisting of syngas, Fischer-Tropsch synthesis products, power, and chemicals, the system comprising a dual fluidized bed gasification apparatus and at least one apparatus selected from power production apparatus configured to produce power from the gasification product gas, partial oxidation reactors configured for oxidation of at least a portion of the product gas, tar removal apparatus configured to reduce the amount of tar in the product gas, Fischer-Tropsch synthesis apparatus configured to produce Fischer-Tropsch synthesis products from at least a portion of the product gas, chemical production apparatus configured for the production of at least one non-Fischer-Tropsch product from at least a portion of the product gas, and dual fluidized bed gasification units configured to alter the composition of the product gas. Methods of operating the system are also provided. | 01-31-2013 |
20130030064 | GASIFICATION SYSTEM AND METHOD - A system configured for the production of at least one product selected from the group consisting of syngas, Fischer-Tropsch synthesis products, power, and chemicals, the system comprising a dual fluidized bed gasification apparatus and at least one apparatus selected from power production apparatus configured to produce power from the gasification product gas, partial oxidation reactors configured for oxidation of at least a portion of the product gas, tar removal apparatus configured to reduce the amount of tar in the product gas, Fischer-Tropsch synthesis apparatus configured to produce Fischer-Tropsch synthesis products from at least a portion of the product gas, chemical production apparatus configured for the production of at least one non-Fischer-Tropsch product from at least a portion of the product gas, and dual fluidized bed gasification units configured to alter the composition of the product gas. Methods of operating the system are also provided. | 01-31-2013 |
Patent application number | Description | Published |
20130105008 | SEAL POT DESIGN | 05-02-2013 |
20130109765 | GASIFIER FLUIDIZATION | 05-02-2013 |
20130161563 | SUPPLEMENTAL FUEL TO COMBUSTOR OF DUAL FLUIDIZED BED GASIFIER - A method of gasification by introducing a feed material to be subjected to gasification into a dual fluidized bed gasifier comprising a pyrolyzer fluidly connected with a combustor such that a circulation stream comprising a heat transfer material can be continuously circulated between the pyrolyzer, in which the temperature of the circulation stream is reduced, and the combustor, in which the temperature of the circulation stream is increased, wherein the pyrolyzer is operable to convert at least a portion of the feed material into a gasifier product gas comprising hydrogen and carbon monoxide, and wherein the combustor is operable to increase the temperature of the circulation stream via combustion of char introduced thereto with the circulation stream and at least one supplemental fuel. A system for carrying out the method is also provided. | 06-27-2013 |
20130165534 | SYSTEM AND METHOD FOR PRODUCTION OF FISCHER-TROPSCH SYNTHESIS PRODUCTS AND POWER - A method for generation of power and Fischer-Tropsch synthesis products by producing synthesis gas comprising hydrogen and carbon monoxide, producing Fischer-Tropsch synthesis products and Fischer-Tropsch tailgas from a first portion of the synthesis gas, and generating power from a second portion of the synthesis gas, from at least a portion of the Fischer-Tropsch tailgas, or from both. The method may also comprise conditioning at least a portion of the synthesis gas and/or upgrading at least a portion of the Fischer-Tropsch synthesis products. A system for carrying out the method is also provided. | 06-27-2013 |
20140037509 | SUPPLEMENTAL FUEL TO COMBUSTOR OF DUAL FLUIDIZED BED GASIFIER - A method of gasification by introducing a feed material to be subjected to gasification into a dual fluidized bed gasifier comprising a pyrolyzer fluidly connected with a combustor such that a circulation stream comprising a heat transfer material can be continuously circulated between the pyrolyzer, in which the temperature of the circulation stream is reduced, and the combustor, in which the temperature of the circulation stream is increased, wherein the pyrolyzer is operable to convert at least a portion of the feed material into a gasifier product gas comprising hydrogen and carbon monoxide, and wherein the combustor is operable to increase the temperature of the circulation stream via combustion of char introduced thereto with the circulation stream and at least one supplemental fuel. A system for carrying out the method is also provided. | 02-06-2014 |
20140161676 | SEAL POT DESIGN - An apparatus including at least one seal pot having at least one penetration through a surface other than the top of the seal pot, each of the at least one penetrations being configured for introduction, into the at least one seal pot, of solids from a separator upstream of the at least one seal pot; a substantially non-circular cross section; or both at least one penetration through a surface other than the top of the seal pot and a substantially non-circular cross section. | 06-12-2014 |
20150232769 | GASIFICATION SYSTEM AND METHOD - A method including introducing a carbonaceous feedstock and a heated heat transfer material into a gasifier, whereby at least a portion of the carbonaceous material is pyrolyzed; removing a gasification product gas comprising, entrained therein, char, particulate heat transfer material, and optionally unreacted carbonaceous feedstock; separating a solids product comprising char, heat transfer material and optionally unreacted carbonaceous material from the gasification product gas; heating at least a portion of the solids product via a combustor, thus producing a heated portion of the solids product and a combustor flue gas, wherein a portion of the heat for heating is obtained via combustion of the char; separating the heated portion from the flue gas, and introducing the separated heated portion into the gasifier, providing heat for pyrolysis; and utilizing at least a portion of the gasification product gas for Fischer-Tropsch synthesis and/or power production. | 08-20-2015 |
Patent application number | Description | Published |
20110071899 | Creating, Managing and Optimizing Online Advertising - Systems and methods for creating, managing and optimizing online advertising campaigns include groups of independent human resources working through a marketplace to suggest and optimize appropriate choices for how, where and how much to pay for online advertising. Optimization is achieved through the use of market-based incentives that pay participants based on the quality, quantity and efficiency of the results of their suggestions. The systems and methods enable a marketplace that leverages the inherent knowledge of a large group of people to come up with all search terms, placements, targeting and advertisements that might be relevant to a product, and determine the optimal auction prices for these search terms, placements, targeting and ads on the search engine systems. | 03-24-2011 |
20110131098 | SYSTEM AND METHOD FOR FACILITATING AFFILIATE MARKETING RELATIONSHIPS - Embodiments of the present invention relate to a system and method for facilitating an affiliate marketing relationship. According certain to embodiments of the present invention, an affiliate marketing optimization system enters into an affiliate marketing relationship with a plurality of merchants. In addition, the affiliate marketing optimization system establishes relationships with publishers thereby acting as in intermediary between the publishers and the plurality of merchants. As a result, a publisher may better monetize web traffic by utilizing the affiliate marketing relationships in place between the affiliate marketing optimization system and the plurality of merchants. | 06-02-2011 |
20120036007 | Creating, Managing and Optimizing Online Advertising - Systems and methods for creating, managing and optimizing online advertising campaigns include groups of independent human resources working through a marketplace to suggest and optimize appropriate choices for how, where and how much to pay for online advertising. Optimization is achieved through the use of market-based incentives that pay participants based on the quality, quantity and efficiency of the results of their suggestions. The systems and methods enable a marketplace that leverages the inherent knowledge of a large group of people to come up with all search terms, placements, targeting and advertisements that might be relevant to a product, and determine the optimal auction prices for these search terms, placements, targeting and ads on the search engine systems. | 02-09-2012 |
20120036008 | Creating, Managing and Optimizing Online Advertising - Systems and methods for creating, managing and optimizing online advertising campaigns include groups of independent human resources working through a marketplace to suggest and optimize appropriate choices for how, where and how much to pay for online advertising. Optimization is achieved through the use of market-based incentives that pay participants based on the quality, quantity and efficiency of the results of their suggestions. The systems and methods enable a marketplace that leverages the inherent knowledge of a large group of people to come up with all search terms, placements, targeting and advertisements that might be relevant to a product, and determine the optimal auction prices for these search terms, placements, targeting and ads on the search engine systems. | 02-09-2012 |