Patent application number | Description | Published |
20110030390 | Vortex Tube - A vortex tube allowing for control of the velocities, flow, and pressure differentials otherwise present in a free vortex like that found in a tornado is disclosed. The presently disclosed vortex tube may be used for the control and implementation of the otherwise chaotic aspects of a true tornado and vortex (i.e., with less energy and a narrowed and more focused and intense vortex) when implementing the critical flow regime in a fluid flow system. | 02-10-2011 |
20110051549 | Nucleation Ring for a Central Insert - A central insert causes maximum fluid velocity to shift away from an external tube wall reducing friction losses at the tube wall. Centrifugal forces pull fluid away from a central insert wall minimizing friction at the insert wall. The insert may be used in the context of nozzles, flow tubes, vortex tubes, and other fluid pathways. In a nozzle, grooves may be added to the nozzle wall. By introducing these grooves at the exit or end of a nozzle, nucleation may be improved and cavitation may be triggered prior to a fluid entering an expansion tube. The nucleation ring may also be placed at the beginning of a nozzle such that cavitation starts within the nozzle. | 03-03-2011 |
20120000631 | Cooling of Heat Intensive Systems - Disclosed herein is a cooling system that utilizes a supersonic cooling cycle. The cooling system includes accelerating a compressible working fluid, and may not require the use of a conventional mechanical pump. The cooling system accelerates the fluid to a velocity equal to or greater than the speed of sound in the compressible fluid selected to be used in the system. A phase change of the fluid due at least in part to a pressure differential cools a working fluid that may be utilized to transfer heat from a heat intensive system. | 01-05-2012 |
20120118538 | Pump-Less Cooling - A method of cooling that accelerates a compressible working fluid without the use of a pump. The method accelerates the fluid to a velocity equal to or greater than the speed of sound in the compressible fluid selected to be used in the method. The fluid is accelerated to a supersonic velocity in a rotating evaporator tube. A phase change of the fluid due to a pressure differential may be utilized to transfer heat from an element to be cooled. | 05-17-2012 |
20120204593 | Supersonic Cooling with a Pulsed Inlet - A supersonic cooling system operates by pumping liquid without the need of a condenser. The compression system utilizes a compression wave in the generation of the cooling effect. An inlet of the system may be pulsed to reduce energy required of a pump. The evaporator of compression system operates in the critical flow regime where the pressure one or more evaporator tubes will remain almost constant and then ‘jump’ or ‘shock up’ to the ambient pressure. | 08-16-2012 |
20120260673 | COOLING SYSTEM UTILIZING A RECIPROCATING PISTON - Cooling in the supersonic region of a compressible fluid is disclosed. The fluid is accelerated by a reciprocating piston to a velocity equal to or greater than the speed of sound in the fluid in an evaporator. No conventional mechanical pump is required to accelerate the fluid. A phase change of the fluid due to a pressure differential may be utilized to transfer heat from an element to be cooled. | 10-18-2012 |
20120260676 | COOLING SYSTEM UTILIZING A CONICAL BODY - Cooling via acceleration of a compressible fluid is disclosed. The fluid is accelerated by a rotatable body to a velocity that may be equal to or greater than the speed of sound in the fluid. No conventional mechanical pump is required to accelerate the fluid. A phase change of the fluid may be utilized to transfer heat from an element to be cooled. | 10-18-2012 |
Patent application number | Description | Published |
20090297065 | METHOD FOR CREATING AND USING AFFECTIVE INFORMATION IN A DIGITAL IMAGING SYSTEM - An image file for storing a still digital image and metadata related to the still digital image, the image file including digital image data representing the still digital image, and metadata that categorizes the still digital image as an important digital image, wherein the categorization uses a range of levels and the range of levels includes at least three different integer values. | 12-03-2009 |
20090307222 | METHOD FOR CREATING AND USING AFFECTIVE INFORMATION IN A DIGITAL IMAGING SYSTEM - An image file for storing a still digital image and metadata related to the still digital image, the image file including digital image data representing the still digital image, and metadata that categorizes the still digital image as an important digital image, wherein the categorization uses a range of levels and the range of levels includes at least three different integer values. | 12-10-2009 |
20110320457 | METHOD FOR CREATING AND USING AFFECTIVE INFORMATION IN A DIGITAL IMAGING SYSTEM - An image file for storing a still digital image and metadata related to the still digital image, the image file including digital image data representing the still digital image, and metadata that categorizes the still digital image as an important digital image, wherein the categorization uses a range of levels and the range of levels includes at least three different integer values. | 12-29-2011 |
20120230542 | METHOD FOR CREATING AND USING AFFECTIVE INFORMATION IN A DIGITAL IMAGING SYSTEM - An image file for storing a still digital image and metadata related to the still digital image, the image file including digital image data representing the still digital image, and metadata that categorizes the still digital image as an important digital image, wherein the categorization uses a range of levels and the range of levels includes at least three different integer values. | 09-13-2012 |
20140086498 | METHOD FOR CREATING AND USING AFFECTIVE INFORMATION IN A DIGITAL IMAGING SYSTEM - An image file for storing a still digital image and metadata related to the still digital image, the image file including digital image data representing the still digital image, and metadata that categorizes the still digital image as an important digital image, wherein the categorization uses a range of levels and the range of levels includes at least three different integer values. | 03-27-2014 |
Patent application number | Description | Published |
20120179045 | Fetal Scalp Doppler Device and System - A fetal pulse monitor includes an ultrasound crystal. An ultrasound controller is electrically connected to the ultrasound crystal and operates the ultrasound crystal to produce ultrasound signals and receive reflected ultrasound signals. A wireless transmitter is electrically connected to the ultrasound controller. A biocompatible housing at least partially surrounds the ultrasound crystal, ultrasound controller, and the wireless transmitter. A system for monitoring fetal heart rate includes a fetal pulse monitor configured for insertion into a womb of a patient and for attachment to a fetus within the womb. The fetal pulse monitor includes an ultrasound crystal, an ultrasound controller electrically connected to the ultrasound crystal, and a wireless transmitter electrically connected to the ultrasound controller. A patient monitoring device is external to the womb and includes a wireless receiver and a processor that detects instantaneous fetal heart rate from the received ultrasound signal. A graphical display is communicatively connected to the patient monitoring device. The graphical display is operated by the patient monitoring device to present the determined fetal heart rate. | 07-12-2012 |
20120179046 | Abdominal Sonar System and Apparatus - An abdominal sonar includes an ultrasound transducer array with a plurality of ultrasound transducers. The abdominal sonar further includes at least one additional ultrasound transducer. A digital signal processor is communicatively connected to the plurality of ultrasound transducers and the at least one additional ultrasound transducer. The digital signal processor individually operates the plurality of ultrasound transducers and the at least one additional ultrasound transducer. The digital signal processor receives reflected ultrasound signals back from each of the plurality of ultrasound transducers and the at least one additional ultrasound transducer and converts the received reflected ultrasound signals into an audio signal. A system for monitoring a pregnancy includes an ultrasound transducer array and at least one additional ultrasound transducer. A digital signal processor is communicatively connected to the ultrasound transducer array and the at least one ultrasound transducer. The digital signal processor converts received raw fetal heart and uterine activity waveforms into an audio signal. A wireless transmitter broadcasts the received audio signal. A wireless receiver receives the broadcast audio signal. A patient monitor extracts the raw fetal heart and uterine activity waveforms from the audio signal and processes the waveforms to obtain an indication of fetal heart rate and an indication of uterine activity. | 07-12-2012 |
20130158406 | FETAL HEART MONITORING RANGE - An approximate distance between an ultrasonic transducer and a fetal heart is determined. A range of distances from the ultrasonic transducer is sensed using the ultrasonic transducer, wherein the range has a minimum distance based upon the approximate distance. A heart rate of the fetal heart is monitored using ultrasonic echo signals from the range. | 06-20-2013 |
20130158407 | MATERNAL CONTRIBUTION DETECTION DURING FETAL HEART MONITORING - A fetal heart signal contribution is determined from an ultra sound signal by suppressing any maternal contribution from the ultrasound signal. The fetal heart signal contribution is canceled or subtracted from the ultrasound signal. An alarm is outputted based upon a result of the cancellation. | 06-20-2013 |
20140249436 | Fetal Monitoring Device and Method - A fetal monitoring device includes a piezofilm sheet, a first electrode, and a second electrode. A controller is operably connected to the piezofilm sheet, first electrode, and second electrode and receives a biopotential and a piezofilm signal. The controller derives at least one of a maternal heart rate and a uterine activity for the biopotential and derives at least one of a fetal heart rate and fetal motion detection from the piezofilm signal. The controller derives an index of fetal health and operate an indicator to present the derived index of fetal health. | 09-04-2014 |
20140276070 | Method and Device for Fetal Heart Rate Monitoring with Maternal Contribution Detection - A method and device for monitoring a fetal heart rate includes a reference fetal heart rate detected across an ultrasound depth zone of sensitivity. The ultrasound depth zone of sensitivity is scanned in overlapping increments of a first depth. An average fetal heart rate detected for each overlapping increment is tested for a coincidence with the reference fetal heart rate. Overlapping increments with the coincidence and a maximized signal quality rate are identified. An ultrasound depth increment of a second depth is selected representing the selected adjacent increments. Fetal heart rate is determined from an ultrasound signal returned from a scan depth of the second depth. | 09-18-2014 |
Patent application number | Description | Published |
20090113988 | Mitigation of gas memory effects in gas analysis - The gas absorption/adsorption memory effect in gas analysis can be reduced by controlling gas flow conditions such that the partial pressure of the analyte of interest is held constant, if the measured analyte concentration is within a predetermined range. Keeping the analyte partial pressure constant is helpful for mitigating the memory effect because changes in analyte absorption/adsorption rates tend to be driven by changes in analyte partial pressure. The memory effect can also be mitigated by performing concentration measurements at two or more different gas flow conditions, and employing a mathematical model to estimate true concentration and “memory effect” contributions to measured concentrations at one or more of the flow conditions. The mathematical model can be based on an assumption that the true analyte concentration is independent of flow rate or pressure, while the “memory effect” contribution to measured concentration is inversely proportional to flow rate or pressure. | 05-07-2009 |
20110214479 | Method and apparatus for the photo-acoustic identification and quantification of analyte species in a gaseous or liquid medium - A method and apparatus for the photo-acoustic identification and quantification of one or more analyte species present in a gaseous or liquid medium in low concentration utilizing a laser and a resonant optical cavity containing the medium and having within the cavity at least two partially transparent mirrors, one of which is a cavity coupling mirror and one of which is moveably mounted on an assembly responsive to an input signal. | 09-08-2011 |
20110214480 | METHOD AND APPARATUS FOR THE PHOTO-ACOUSTIC IDENTIFICATION AND QUANTIFICATION OF ANALYTE SPECIES IN A GASEOUS OR LIQUID MEDIUM - A method and apparatus for the photo-acoustic identification and quantification of one or more analyte species present in a gaseous or liquid medium in low concentration utilizing a laser and a resonant optical cavity containing the medium and having within the cavity at least two partially transparent mirrors, one of which is a cavity coupling mirror and one of which is moveably mounted on an assembly responsive to an input signal. | 09-08-2011 |
20110214481 | METHOD AND APPARATUS FOR THE PHOTO-ACOUSTIC IDENTIFICATION AND QUANTIFICATION OF ANALYTE SPECIES IN A GASEOUS OR LIQUID MEDIUM - A method and apparatus for the photo-acoustic identification and quantification of one or more analyte species present in a gaseous or liquid medium in low concentration utilizing a laser and a resonant optical cavity containing the medium and having within the cavity at least two partially transparent mirrors, one of which is a cavity coupling mirror and one of which is moveably mounted on an assembly responsive to an input signal. | 09-08-2011 |
20110216311 | METHOD AND APPARATUS FOR LOCKING A LASER WITH A RESONANT CAVITY - A method and apparatus for the photo-acoustic identification and quantification of one or more analyte species present in a gaseous or liquid medium in low concentration utilizing a laser and a resonant optical cavity containing the medium and having within the cavity at least two partially transparent mirrors, one of which is a cavity coupling mirror and one of which is moveably mounted on an assembly responsive to an input signal. | 09-08-2011 |
20130044314 | CAVITY ENHANCED LASER BASED ISOTOPIC GAS ANALYZER - Systems and methods for measuring the isotope ratio of one or more trace gases and/or components of gas mixtures such as different gas species present in a gas mixture. The system includes a resonant optical cavity having two or more mirrors and containing a gas, the cavity having a free spectral range that equals the difference between frequencies of two measured absorption lines of different gas species in the gas, or of two different isotopes, divided onto an integer number. The system includes a continuous-wave tunable laser optically coupled with the resonant optical cavity and a detector system for measuring an absorption of laser light by the gas in the cavity. The detector system includes a photo-detector to measure an intensity of the intra-cavity light, or both a photo-acoustic sensor to measure photo-acoustic waves generated in the cavity and a photo-detector to measure an intensity of the intra-cavity light. | 02-21-2013 |
20130083328 | LASER BASED CAVITY ENHANCED OPTICAL ABSORPTION GAS ANALYZER WITH LASER FEEDBACK OPTIMIZATION - Optical feedback assisted cavity enhanced absorption spectroscopy systems and methods for measuring trace gases with improved long-term stability and reproducibility include a laser coupled with a resonant optical cavity containing a gaseous medium and having at least two cavity mirrors and a plurality of optical resonance cavity modes. The laser emits continuous wave laser light with a mean optical frequency of the laser being adjustable over a range of frequencies, and the laser is responsive to optical feedback light emerging from the cavity. The transmissivity of at least one of the cavity mirrors is selected such that the intensity of the optical feedback light impinging on the laser is below a threshold intensity value so as to ensure that a frequency hold interval range of the optical frequency of the laser is smaller than a free spectral range of the cavity. | 04-04-2013 |
20140123729 | CAVITY ENHANCED LASER BASED GAS ANALYZER SYSTEMS AND METHODS - Cavity enhanced absorption spectroscopy systems and methods for detecting trace gases using a resonance optical cavity, which contains a gas mixture to be analyzed, and a laser coupled to the cavity by optical feedback. The cavity has any of a variety of configurations with two or more mirrors, including for example a linear cavity, a v-shaped cavity and a ring optical cavity. The cavity will have multiple cavity resonant modes, or a comb of frequencies spaced apart, as determined by the parameters of the cavity, including the length of the cavity, as is well known. Systems and methods herein also allow for optimization of the cavity modes excited during a scan and/or the repetition rate. | 05-08-2014 |
20140125993 | CAVITY ENHANCED LASER BASED GAS ANALYZER SYSTEMS AND METHODS - Cavity enhanced absorption spectroscopy systems and methods for detecting trace gases using a resonance optical cavity, which contains a gas mixture to be analyzed, and a laser coupled to the cavity by optical feedback. The cavity has any of a variety of configurations with two or more mirrors, including for example a linear cavity, a v-shaped cavity and a ring optical cavity. The cavity will have multiple cavity resonant modes, or a comb of frequencies spaced apart, as determined by the parameters of the cavity, including the length of the cavity, as is well known. Systems and methods herein also allow for optimization of the cavity modes excited during a scan and/or the repetition rate. | 05-08-2014 |
20140192347 | CAVITY ENHANCED LASER BASED ISOTOPIC GAS ANALYZER - Systems and methods for measuring the isotope ratio of one or more trace gases and/or components of gas mixtures such as different gas species present in a gas mixture. The system includes a resonant optical cavity having two or more mirrors and containing a gas, the cavity having a free spectral range that equals the difference between frequencies of two measured absorption lines of different gas species in the gas, or of two different isotopes, divided onto an integer number. The system also includes a continuous-wave tunable laser optically coupled with the resonant optical cavity, and a detector system for measuring an absorption of laser light by the gas in the cavity. The detector system includes one of a photo-detector configured to measure an intensity of the intra-cavity light or both a photo-acoustic sensor configured to measure photo-acoustic waves generated in the cavity and a photo-detector configured to measure an intensity of the intra-cavity light. | 07-10-2014 |
Patent application number | Description | Published |
20100082724 | Method For Solving Reservoir Simulation Matrix Equation Using Parallel Multi-Level Incomplete Factorizations - A parallel-computing iterative solver is provided that employs a preconditioner that is processed using parallel-computing for solving linear systems of equations. Thus, a preconditioning algorithm is employed for parallel iterative solution of a large sparse system of linear system of equations (e.g., algebraic equations, matrix equations, etc.), such as the linear system of equations that commonly arise in computer-based 3D modeling of real-world systems (e.g., 3D modeling of oil or gas reservoirs, etc.). A novel technique is proposed for application of a multi-level preconditioning strategy to an original matrix that is partitioned and transformed to block bordered diagonal form. An approach for deriving a preconditioner for use in parallel iterative solution of a linear system of equations is provided. In particular, a parallel-computing iterative solver may derive and/or apply such a preconditioner for use in solving, through parallel processing, a linear system of equations. | 04-01-2010 |
20100211370 | Modeling Subsurface Processes On Unstructured Grid - Embodiments of the invention involve forming a prismatic grid and solving a convection-diffusion problem using the prismatic grid and mixed finite element analysis. The prismatic grid may be formed by providing a triangular mesh on a plane of a model. The mesh is then coarsened to make cells that are less desirable larger. The coarsened grid is then projected to form the prismatic grid. Each cell of the grid is then assigned a plurality of degrees of freedom. Mixed finite element analysis of the grid produces a matrix, which is then solved to yield a solution to the convention-diffusion problem. | 08-19-2010 |
20100223039 | Modeling In Sedimentary Basins - Embodiments of the invention operate to produce basin models that describe the basin in terms of compaction and fluid flow. The equations used to define compaction and fluid flow may be solved simultaneously. Embodiments of the invention use equations that define a set of unknowns that are consistent over the basis. The equations may define total pressure, hydrostatic pressure, thicknesses, and effective stress. | 09-02-2010 |
20120221302 | Method and System For Modeling Geologic Properties Using Homogenized Mixed Finite Elements - A method for hydrocarbon management of a reservoir is provided. The method includes generating a model of a reservoir comprising a plurality of homogenized mixed finite elements in an unstructured computational mesh. The unstructured computational mesh may be coarsened to form a plurality of coarser computational meshes in the model. A convection-diffusion subsurface process may be evaluated on a coarsest computation mesh. A result may be transferred from the coarsest computational mesh to a finest computational mesh, and a performance parameter for the hydrocarbon reservoir may be predicted from the model. The predicted performance parameter may be used for hydrocarbon management of the reservoir. | 08-30-2012 |
20120296619 | Method and System For Partitioning Parallel Simulation Models - A method is presented for partitioning a simulation model into a plurality of subdomains that may each be assigned to one of a plurality of processors. The method includes creating a representation of a topology graph of a simulation model in a tangible, computer readable medium. The topology graph includes a plurality of computational elements and a plurality of connections between those elements. Each of the plurality of connections is weighted to create a plurality of weights, and each of the plurality of weights is scaled. Optionally, the weights can be mapped to different interval of values. Based on the weights information the topology graph is partitioned into two or more subdomains, wherein a partition boundary follows a local topographical minimum in the topology graph. A subdomain is assigned to each of the plurality of processors. | 11-22-2012 |
20130090907 | Method and System For Parallel Simulation Models - A method for modeling a hydrocarbon reservoir. A representation of a simulation model is generated in a non-transitory, computer readable medium. The simulation model is used to generate computational tasks. The tasks are allocated among a plurality of computational nodes. Each processing node of the plurality of computational nodes includes core processors and a shared memory accessible by the core processors. The reservoir simulation is executed on the plurality of computational nodes. During the reservoir simulation, if a first processing node in the plurality of computational nodes finishes executing its allocated tasks, a migration request is sent from the first processing node to another processing node in the plurality of computational nodes. The migration request is configured to request migration of a movable task from the other processing node to the first processing node. The movable task is migrated from the other processing node to the first processing node. | 04-11-2013 |
20130116993 | Method and System For Parallel Multilevel Simulation - Exemplary embodiments of the present techniques provide methods and systems for coarsening a computational mesh, for example, for use in a reservoir simulation. An exemplary method of performing a reservoir simulation, includes generating a data representation in a storage system, wherein the data representation includes an interconnection weight that represents the magnitude of an interconnection between each of a number of computational cells in a computational mesh. A threshold value is compared to each interconnection weight and any interconnection weight that is equal to or less than the threshold value is set to zero. | 05-09-2013 |
20140236558 | Method For Partitioning Parallel Reservoir Simulations In the Presence of Wells - A method is disclosed for partitioning a grid representing a hydrocarbon reservoir. The grid is composed of a plurality of cells. A connectivity graph of nodes and edges is created. Each of the plurality of cells is represented by a node. Edges connect neighboring nodes. An edge that should not be cut by a partitioning algorithm is designated. Nodes connected by the designated edge are merged into a supernode. A first edge connecting a merged node and a non-merged node is replaced with a second edge connecting the non-merged node with the supernode. The connectivity graph is used with the supernode and the replaced edges to partition the grid. Nodes merged into supernodes are maintained in a single subdomain during partitioning. | 08-21-2014 |
Patent application number | Description | Published |
20110269764 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF SYNAPSE FUNCTION - The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate synapse function for treating said disease. | 11-03-2011 |
20120040940 | COMBINATION OF PILOCARPIN AND METHIMAZOL FOR TREATING CHARCOT-MARIETOOTH DISEASE AND RELATED DISORDERS - The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signaling and thyroid hormone pathway in a subject. | 02-16-2012 |
20120058992 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF ANGIOGENESIS - The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate angiogenesis for treating said disease. | 03-08-2012 |
20120071483 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF CELL STRESS RESPONSE - The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate cell stress response for treating said disease. | 03-22-2012 |
20120088744 | COMPOSITIONS FOR TREATING CMT AND RELATED DISORDERS - The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. | 04-12-2012 |
20120108528 | NEW THERAPEUTIC APPROACHES FOR TREATING NEUROINFLAMMATORY CONDITIONS - The present invention relates to novel compositions which can be used for the treatment of neuroinflammation, in particular in subjects having a neurodegenerative, autoimmune, infectious, toxic or traumatic disorder. More particularly, the invention relates to combined therapies for treating neuroinflammation. The invention also discloses new methods for treating neuroinflammation pathological conditions in a subject. | 05-03-2012 |
20120270836 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER'S DISEASE - The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease and related disorders. In particular, the invention concerns compounds which, alone or in combination(s), can effectively modulate synapse function and/or angiogenesis and/or cell stress response. The invention also relates to methods of producing a drug or a drug combination for treating Alzheimer's disease and to methods of treating Alzheimer's disease or a related disorder. | 10-25-2012 |
20120283114 | NEW DIAGNOSTIC TOOLS FOR ALZHEIMER DISEASE - The present invention relates to development, validation and application of new sets of biomarkers for diagnosis of Alzheimer's disease (AD) and related disorders including early diagnosis of MCI and early prodrome of AD, identification of disease sub types, prediction of their response to disease management procedures, drugs and their combinations and for monitoring response for these treatment, including validation of biomarkers for clinical trials. | 11-08-2012 |
20130085122 | BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS - The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination. | 04-04-2013 |
20130090307 | BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS - The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination. | 04-11-2013 |
20130217036 | NEW DIAGNOSTIC TOOLS FOR CHARCOT-MARIE-TOOTH DISEASE - The present invention relates in particular to methods of detecting predisposition to or diagnosis and/or prognosis of Charcot-Marie-Tooth (CMT) and related disorders. More specifically, the invention relates to development, validation and application of new biomarkers, which can be used for detecting the presence or risk of CMT disease and related disorders. In particular, the present invention relates to metabolite, lipid, carbohydrate and proteinaceous biomarkers that can be measured in biological body fluids and easily available extracts of biopsies, which can be used to aid in the detection, prediction of drug treatment and follow up of this treatment of neurodegenerative disorders, including CMT disease. The present invention also relates to methods for identification of CMT disease subtypes, assessing the responsiveness to the treatments and the efficacy of treatments in subjects having CMT or a related disorder. | 08-22-2013 |
20140038927 | COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS - The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury. | 02-06-2014 |
20140080873 | TREATMENT OF CEREBRAL ISCHEMIA - The present invention relates to new compositions and methods for protecting neuronal cells from ischemic or hypoxic events. More precisely, this invention provides new combinatorial therapies that efficiently protect neuronal cells from ischemia or hypoxia. | 03-20-2014 |
20140178463 | COMPOSITIONS FOR TREATING CMT AND RELATED DISORDERS - The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. | 06-26-2014 |
20140235599 | COMBINATION OF PILOCARPIN AND METHIMAZOL FOR TREATING CHARCOT-MARIETOOTH DISEASE AND RELATED DISORDERS - The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signalling and thyroid hormone pathway in a subject. | 08-21-2014 |
20140357648 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER'S DISEASE - The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease and related disorders. In particular, the invention concerns compounds which, alone or in combination(s), can effectively modulate synapse function and/or angiogenesis and/or cell stress response. The invention also relates to methods of producing a drug or a drug combination for treating Alzheimer's disease and to methods of treating Alzheimer's disease or a related disorder. | 12-04-2014 |
20140371229 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE - The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder. | 12-18-2014 |
20140371277 | COMPOSITIONS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS - The present invention relates to compositions and methods for the treatment of amyotrophic lateral sclerosis. More specifically, the present invention relates to novel combinatorial therapies for treating amyotrophic lateral sclerosis or a related disorder. | 12-18-2014 |
20140378440 | BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS - The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination. | 12-25-2014 |
20150157626 | THERAPEUTIC APPROACHES FOR TREATING CMT AND RELATED DISORDERS - Compositions and methods for the treatment of Charcot-Marie-Tooth disease and related disorders. Also provided are combination therapies for treating this disease by decreasing PMP22 expression in a subject. | 06-11-2015 |
20150224092 | NOOTROPIC COMPOSITIONS FOR IMPROVING MEMORY PERFORMANCE - The invention relates to compositions and methods for improving memory and related functions as alertness, attention, concentration, learning, and language processing. More particularly, the invention relates to compositions comprising at least two drugs selected from cinacalcet, baclofen, acamprosate, mexiletine, sulfisoxazole and torasemide useful to enhance memory and related functions in healthy subjects or subjects suffering from conditions or disorders having a negative impact on their memory. | 08-13-2015 |
Patent application number | Description | Published |
20100037586 | Method and system for feeding a gas-turbine engine with liquid fuel - A method is provided for supplying a liquid fuel to a gas-turbine engine, e.g. aviation engine. It includes selective fuel delivery through several fuel delivery lines for different engine operating modes based on a required engine power, providing, e.g. feeding the engine operating at minimal power with base or traditional for this type of engine fuel through a base fuel delivery line; in other operating modes the fuel is fed to the engine either through conditioned fuel delivery line with preliminary conditioning of base fuel or through both said fuel delivery lines simultaneously with mixing both fuel flows directly before entering an engine combustion chamber, e.g., in a line connecting intake manifold for the base fuel and each individual fuel injector. | 02-18-2010 |
20100255386 | Method and system for anode gas recirculation in fuel cells - One of the main objects in providing optimal mass exchange for fuel cells, especially mobile fuel cells, is anode gas supply to fuel cell stack based on stoichiometric characteristics depending on variable loads and anode gas recirculation. External loads may vary in wide range and arbitrary change, thus complicate the optimal mass exchange in fuel cell stack. A new original technology is disclosed for anode gas supply using a multi-stage ejector. This technology, an ejector design and control system allow increasing fuel cell efficiency with quick loads changing from minimal to maximal as well as at cold start. | 10-07-2010 |
20130008400 | Fuel Activation Method and Fuel Supply System - A process in which liquid fuel is saturated with a gas to provide a fuel/gas solution said fuel/gas solution fed to a combustion engine, a first portion of said fuel/gas solution that is fed to said combustion engine is combusted, a second portion of said fuel/gas solution that is fed to said combustion engine is not combusted, the temperature of said second portion of said fuel/gas solution is reduced in a heat exchanger to produce a reduced temperature second portion, evaporated gas in said reduced temperature second portion is then removed in a separator, and the fuel/gas solution thus produced is then fed back into the combustion engine. | 01-10-2013 |
20140000571 | METHOD AND SYSTEM FOR PROVIDING FUEL TO INTERNAL COMBUSTION ENGINES | 01-02-2014 |
20140048042 | Method of fuel activation and system to deliver it to a diesel engine - A method for activating fuel by saturating the fuel with a gas and delivering the saturated fuel to an internal combustion engine for combustion is provided. Fuel from a fuel tank is delivered to an absorber and gas is directed into the absorber, mixing with the dispersed fuel to form an activated fuel. Activated fuel is directed to a fuel rail by a low pressure pump through a pressure regulating valve and Y-connector. Excess fuel from the engine is directed to a separator through a heat exchanger and then through a pressure regulator and is mixed with fresh activated fuel from the absorber. Released gas is separated in a gas separator. The system runs independently and can be easily turned off and switched to the base fuel supply. If the system loses power, it automatically switches to the base fuel supply system without any interruption of engine operation. | 02-20-2014 |
20140345570 | METHOD OF FUEL ACTIVATION AND SYSTEM TO DELIVER IT TO A DIESEL ENGINE - A method for activating a diesel fuel by saturating it with air, CO | 11-27-2014 |
20140360474 | METHOD AND SYSTEM FOR PROVIDING FUEL TO INTERNAL COMBUSTION ENGINES - The present invention relates to a system and method for providing fuel to internal combustion engines including fuel activation prior to injection. The method carried out by the system comprises dissolving a mixture of gasses providing improved fuel dispersing after fuel injection into a combustion chamber. Dissolved gasses desorption is stimulated from a unsaturated fuel solution. Full control of fuel flows with dissolved gas/gasses to and from injectors and FET technology based on Henry's law (dissolving gasses in the liquids) and Kelvin principle (vapor pressure over droplet surface). The system consists of compact components, including exhaust gasses recirculation system which can be easily added to existing diesel and gasoline engine fuel supply systems. The method and system were tested with four different types of engines and provides fuel economy in 12-20% decrease of emissions and up to 25% at variable engine loads and significantly at engine cold start. | 12-11-2014 |
20150122216 | METHOD AND SYSTEM TO IMPROVE ATOMIZATION AND COMBUSTION OF HEAVY FUEL OILS - Presented a method and a system for improving atomization of heavy fuel oil or diesel fuel in heavy duty diesel engines, e.g. marine engines, wherein before injection into a combustion chamber the fuel is treated by gas/gases under elevated pressure of about 500 psi in an absorber; the heavy fuel oil/diesel fuel is fed to the absorber's dispensing means at a pressure of 1100 psi; a resulted fuel solution without a free gas phase is further mixed with a recirculating fuel stream forming a mixed fuel stream; the mixed fuel stream is directed for injection into a combustion chamber. | 05-07-2015 |
20150152346 | METHOD AND SYSTEM FOR WATER-FUEL EMULSIONS PRODUCTION - Water-fuel emulsions can be used in engines, predominantly in diesel engines, to achieve considerable fuel economy and reduce emissions of noxious exhaust components, NO | 06-04-2015 |
Patent application number | Description | Published |
20120083446 | NOVEL ALBUMIN-FREE FACTOR VIII FORMULATIONS - An albumin-free Factor VIII formulation comprising, 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent Alternatively, the formulation can comprise 2% to 6% hydroxyethyl starch; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent. In a further embodiment, the formulation can comprise: 300 mM to 500 mM NaCl; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; and a buffering agent. | 04-05-2012 |
20130184216 | NOVEL ALBUMIN-FREE FACTOR VIII FORMULATIONS - A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent for maintaining a pH of approximately between 6 and 8. Alternatively, the formulation can comprise 2% to 6% hydroxyethyl starch; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent for maintaining a pH of approximately between 6 and 8. In a further embodiment, the formulation can comprise: 300 mM to 500 mM NaCl; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; and a buffering agent. | 07-18-2013 |
20150025010 | NOVEL ALBUMIN-FREE FACTOR VIII FORMULATIONS - A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent for maintaining a pH of approximately between 6 and 8. Alternatively, the formulation can comprise 2% to 6% hydroxyethyl starch; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent for maintaining a pH of approximately between 6 and 8. In a further embodiment, the formulation can comprise: 300 mM to 500 mM NaCl; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; and a buffering agent. | 01-22-2015 |
Patent application number | Description | Published |
20100082399 | SYSTEMS AND METHODS FOR DISTRIBUTING ADVERTISEMENTS IN A NETWORK-BASED ENVIRONMENT - The present invention is directed to a system and method for distributing advertisements in a network-based advertisement campaign. The method and system includes determining a number of advertisement placements for a contract within a contract time interval where the advertisement placements may be presented to users having defined characteristics. The method and system includes reviewing forecasting information regarding user traffic, including forecasting information for predicting a volume of users having the defined characteristics. The method and system includes, in response to the forecasting information, procuring advertisement placements consistent with the contract during the contract time interval and distributing the advertisements in a network-based output. | 04-01-2010 |
20100082404 | SYSTEM AND METHOD FOR UTILIZING DATE CONSTRAINTS IN AN ADVERTISEMENT SERVING SYSTEM - Generally, embodiments of the present invention provide for methods, systems and computer program products for utilizing date constraints in an advertisement serving system. The method according to one embodiment of the present invention comprises receiving a request for one or more advertisements that satisfy one or more constraints. A set of advertisement contracts is generated, wherein the set of advertisement contracts comprise one or more advertisement contracts that satisfy the one or more constraints. The contractual time period for a given advertisement contract in the set of advertisement contracts is then determined. A subset of advertisement contracts is then generated, wherein the subset of advertisement contracts comprises the advertisement contracts in the set of advertisement contracts that are active on a given date. The subset of advertisement contracts is then inputted into an optimization algorithm and one or more advertisement contracts are selected by the optimization algorithm. | 04-01-2010 |
20100082412 | SYSTEM AND METHOD FOR OPTIMIZING AN ADVERTISEMENT PLAN FOR ALLOCATING ADVERTISEMENTS TO A CONTRACT IN A NETWORK-BASED ENVIRONMENT - The present invention is directed to a system and method for optimizing an advertisement plan for allocating advertisements to a contract in a network-based environment. The system and method includes determining a shadow price for an advertisement placement where the advertisement placement is associated with a user having defined characteristics. The system and method includes determining a contract price for the advertisement placement relative to a plurality of advertisement contracts for the user having the defined characteristics. The system and method includes determining an advertisement plan for allocating an advertisement to a given contract on the basis of the shadow price and the contract price. The system and method includes presenting a given advertisement associated with the given contract according to the advertisement plan on network-based output. | 04-01-2010 |
20100082607 | SYSTEM AND METHOD FOR AGGREGATING A LIST OF TOP RANKED OBJECTS FROM RANKED COMBINATION ATTRIBUTE LISTS USING AN EARLY TERMINATION ALGORITHM - An improved system and method for aggregating a list of top ranked objects from ranked combination lists using an early termination algorithm is provided. Ranked lists of individual object attributes may be aggregated into ranked lists of combination object attributes. The ranked lists of object attributes, including ranked lists of individual object attributes as well as ranked lists of combination object attributes, may be scanned in parallel. A fixed number of top scoring objects may be stored in a results list of top ranked objects. An upper bound of best possible aggregation scores of unseen object in the ranked lists of object attributes may be computed to incorporate the extra information given by the combination lists of attributes. If the upper bound computed is less than the score of top scoring objects in the results list, then the top scoring objects in the results list may be output. | 04-01-2010 |
20100094881 | SYSTEM AND METHOD FOR INDEXING SUB-SPACES - The present invention is directed to systems and methods for identifying compatible advertisement contracts to satisfy an advertisement opportunity. The systems and methods include receiving a number of attribute values associated with a user accessing a network-based location. The systems and methods include sorting an index of lists for a plurality of advertisement contracts on the basis of a number of contract term values. The systems and methods include traversing the index of lists to return a set advertisement contracts compatible with the number of attribute values associated with the user. The systems and methods include selecting a given advertisement contract from the set of advertisement contracts compatible with the number of attribute values associated with the user. The systems and methods include presenting an advertisement associated with the given advertisement contract on a display viewable by the user accessing the network-based location. | 04-15-2010 |
20100205213 | NON-EXACT CACHE MATCHING - The subject matter disclosed herein relates to returning cached object results based at least in part on a non-exact comparison with a query key. | 08-12-2010 |
20110166942 | CONTRACT AUCTIONS FOR SPONSORED SEARCH - Example methods, apparatuses, and articles of manufacture are disclosed that may be used to provide or otherwise support contract auctions for sponsored search advertising for use in auction management systems. | 07-07-2011 |