Almond, US
Brian D. Almond, Fitchburg, WI US
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20090191622 | SYNTHETIC NUCLEIC ACIDS FROM AQUATIC SPECIES - A synthetic nucleic acid molecule is provided that includes nucleotides of a coding region for a fluorescent polypeptide having a codon composition differing at more than 25% of the codons from a parent nucleic acid sequence encoding a fluorescent polypeptide. The synthetic nucleic acid molecule has at least 3-fold fewer transcription regulatory sequences relative to the average number of such sequences in the parent nucleic acid sequence. The polypeptide encoded by the synthetic nucleic acid molecule preferably has at least 85% sequence identity to the polypeptide encoded by the parent nucleic acid sequence. | 07-30-2009 |
Bruce Almond, Phoenix, AZ US
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20100187119 | COLD SPRAY AND ANODIZATION REPAIR PROCESS FOR RESTORING WORN ALUMINUM PARTS - A method for repairing an aluminum part having a worn portion is provided. In one embodiment, the method includes the steps of: (i) producing a first substantially non-porous coating over the worn portion utilizing a cold spray process wherein a powder mixture is propelled against the worn portion of the aluminum part, and (ii) anodizing the aluminum part to grow an aluminum oxide layer overlaying the first substantially non-porous coating. The powder mixture includes aluminum and an alloy media. | 07-29-2010 |
20130209826 | METHODS FOR STRUCTURAL REPAIR OF COMPONENTS HAVING DAMAGED INTERNALLY THREADED OPENINGS AND COMPONENTS REPAIRED USING SUCH METHODS - Methods are provided for structurally repairing a component having a damaged internally threaded opening. The damaged internally threaded opening is machined to a predetermined diameter, thereby forming a machined opening. At least one notch is formed in the machined opening, thereby forming a notched opening. A selected amount of repair material is cold sprayed into the notched opening, including into the at least one notch. A plurality of internal threads is formed from the repair material to form a repaired internally threaded opening in the component. The repaired components are also provided. | 08-15-2013 |
Chris Almond, North Miami, FL US
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20150326517 | SYSTEM AND METHOD FOR DELIVERING INFORMATION VIA SECURE ELECTRONIC MESSAGING - A computer-implemented system for delivering information comprising: a sender device with an email client for composing and sending an original email message to a Simple Mail Transfer Protocol (SMTP) listener server with encryption enabled; a message processor that extracts the message body payload from the email message, stores it in a database, and creates a new email message with a message body containing a reference to the message body of the original email message; a file repository for storage of attachments to the email message; and an SMTP sender that sends the new email message to a recipient mail server. The listener server assigns the message to the message processor, and the new email message contains links to the attachments residing in the file repository. A method utilizing the system described above. | 11-12-2015 |
Harold R. Almond, Maple Glen, PA US
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20130281407 | NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES - The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders. | 10-24-2013 |
20150265672 | MODULATION OF HEPATITIS B VIRUS CCCDNA TRANSCRIPTION - The present invention provides small molecule inhibitors of hepatitis B virus (HBV) covalently closed circular (ccc) DNA, which are useful as therapeutics in the management of chronic HBV. The compounds of the invention achieve epigenetic modification of the cccDNA, histone modification and histone deacetylase activity inhibition, thus modulating HBV cccDNA. The present invention further provides methods for modulating HBV cccDNA, for treating or preventing HBV in a subject, and for modulating cccDNA transcription of hepatitis B in a subject. | 09-24-2015 |
Jennifer Lee Almond, Raleigh, NC US
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20090126043 | GENERATION OF PLANTS WITH IMPROVED PATHOGEN RESISTANCE AND DROUGHT TOLERANCE - The present invention is directed to plants that display a pathogen resistance and increased drought tolerance phenotype due to altered expression of a PRDT1 nucleic acid. The invention is further directed to methods of generating plants with a pathogen resistance and increased drought tolerance phenotype. | 05-14-2009 |
Jeremy Almond, Santa Cruz, CA US
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20150278887 | DYNAMICALLY DETERMINING PAYMENT PRICES ASSOCIATED WITH PAYMENT METHODS - In a computer-implement method for dynamically determining payment prices associated with payment methods, an online checkout system comprising a balance due is accessed, wherein payment of the balance due is provided by one of the payment methods. Payment prices for the balance due associated with each of the payment methods are dynamically determined. | 10-01-2015 |
Jonathan D. Almond, El Cajon, CA US
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20160052634 | HELICOPTER ROTOR ICING DETECTION SYSTEM AND METHOD - A system includes a signal monitor to monitor a time rate of change of a revolutions per minute (RPM) trim signal that is received from an RPM command path to control a velocity of a helicopter rotor. An icing detector detects for the presence of ice accumulation on the helicopter rotor by comparing the time rate of change of the RPM trim signal to a predetermined threshold for the time rate of change. | 02-25-2016 |
Merrick Almond, Apex, NC US
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20100297079 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTION - The present invention describes compounds of formulae I and II and methods for treating viral infection, such as Flaviviridae virus infection, including Hepatitis C infection (HCV). | 11-25-2010 |
20130035313 | Nucleoside Phosphonate Salts - The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: (I), wherein M | 02-07-2013 |
20150203519 | NUCLEOSIDE PHOSPHONATE SALTS - The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: | 07-23-2015 |
Merrick R. Almond, Apex, NC US
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20100249056 | Metabolically Stable Alkoxyalkyl Esters of Antiviral or Antiproliferative Phosphonates, Nucleoside Phosphonates and Nucleoside Phosphates - The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like. | 09-30-2010 |
20110015149 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER MEDICAL DISORDERS - The present application provides methods and compositions for improving the bioavailability of a lipid-containing antiviral compound, and in particular, an antiviral lipid-containing compound. In one embodiment, pharmaceutically acceptable compositions are provided that include an antiviral lipid-containing compound, or salt, ester, or prodrug thereof and one or more bioavailability enhancing compounds, such as inhibitors of cytochrome P450 enzymes. | 01-20-2011 |
20110021464 | METHODS OF TREATING VIRAL INFECTIONS - The present invention provides methods of treating human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, including administering a compound described in the invention in an amount effective treat the HIV and/or HBV infection and at least substantially inhibit the development of resistance to said antiviral compounds in the subject. Pharmaceutical compositions are also provided. | 01-27-2011 |
20110130559 | Methods to Manufacture 1,3-Dioxolane Nucleosides - This application provides a process for preparing enantiomerically pure β-D-dioxolane nucleosides. In particular, a new synthesis of (−)-DAPD, suitable for large scale development, is described. In one embodiment the invention provides a process for preparing a substantially pure β-D- or β-L-1,3-dioxolane nucleosides comprising a) preparing or obtaining an esterified 2,2-dialkoxy ethanol; b) cyclizing the esterified 2,2-dialkoxy ethanol with glycolic acid to obtain a 1,3-dioxolane lactone; c) resolving the 1,3-dioxolane lactone to obtain a substantially pure D- or L-lactone; d) selectively reducing and activating the D- or L-chiral lactone to obtain a substantially pure D- or L-1,3-dioxolane; e) coupling the D- or L-1,3-dioxolane to an activated and/or protected purine or pyrimidine base; and f) optionally purifying the nucleoside to obtain a substantially pure protected β-D- or β-L-1,3-dioxolane nucleoside. | 06-02-2011 |
20120058976 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof - The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives. | 03-08-2012 |
20120165295 | Compounds, Compositions and Methods for Treating Ocular Conditions - The present invention provides methods of treating viral infection of the eye or posterior ocular condition including administering a pharmaceutical composition comprising a compound described in the present application. In some embodiments, the pharmaceutical composition is topically administered. In another embodiment, the pharmaceutical composition is orally administered or intraocularly administered. | 06-28-2012 |
20140046085 | Phosphonate Ester Derivatives and Methods of Synthesis Thereof - The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives. | 02-13-2014 |
20140121186 | Compounds, Compositions and Methods for Treating Ocular Conditions - The present invention provides methods of treating viral infection of the eye or posterior ocular condition including administering a pharmaceutical composition comprising a compound described in the present application. In some embodiments, the pharmaceutical composition is topically administered. In another embodiment, the pharmaceutical composition is orally administered or intraocularly administered. | 05-01-2014 |
20140303092 | HEXADECYLOXYPROPYL CIDOFOVIR FOR THE TREATMENT OF DOUBLE-STRANDED DNA VIRUS INFECTION - The present application provides methods and compositions for treatment or prevention of dsDNA virus infection in post-hematopoietic cell transplant (HCT or HSCT) patients. | 10-09-2014 |
20150329575 | PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF - The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives. | 11-19-2015 |
Michael Almond, Boulder Creek, CA US
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20110314532 | IDENTITY PROVIDER SERVER CONFIGURED TO VALIDATE AUTHENTICATION REQUESTS FROM IDENTITY BROKER - Techniques are disclosed for an identity broker to authenticate users to a network device, system, or hosted application that uses certain legacy protocols for user authentication. For example, the identity broker may be configured to respond to a user authentication request from a network device formatted as a RADIUS or LDAP message. The identity broker may operate in conjunction with an identity provider to authenticate a user requesting access to a computing resource (e.g., to the network device, system, or hosted application). | 12-22-2011 |
20110314533 | IDENTITY BROKER CONFIGURED TO AUTHENTICATE USERS TO HOST SERVICES - Techniques are disclosed for an identity broker to authenticate users to a network device, system, or hosted application that uses certain legacy protocols for user authentication. For example, the identity broker may be configured to respond to a user authentication request from a network device formatted as a RADIUS or LDAP message. The identity broker may operate in conjunction with an identity provider to authenticate a user requesting access to a computing resource (e.g., to the network device, system, or hosted application). | 12-22-2011 |
Michael I. Almond, San Francisco, CA US
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20140340644 | DISPLAY ACCESSIBILITY FOR COLOR VISION IMPAIRMENT - Examples that increase accessibility of color vision impaired users to information on a display are provided herein. A plurality of graphical elements using a first color palette are presented. A user input indicating that the user has a color vision impairment is received. The color vision impairment can be, for example, deuteranopia, protanopia, or tritanopia. At least some of the plurality of graphical elements can be presented using a second color palette designed for users with the color vision impairment. The user input indicating that the user has a color vision impairment can be received in response to presenting a color vision impairment test to the user. | 11-20-2014 |
Nanda Christine Almond, Walton, KY US
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20150060317 | PACKAGE OF VISUALLY PERCEPTIBLE TAMPONS HOUSED WITHIN APPLICATORS - The present disclosure is directed to a package of one or more hygiene devices. The package can include one or more walls surrounding the first hygiene device and the second hygiene device. The first hygiene device can include a first tampon housed in a first applicator. The first applicator can include an insertion portion and a plunger operatively engaged with the insertion portion. The plunger can include a first transparent region that allows the first tampon to be visually perceptible through the applicator creating a first visual impression. The second hygiene device can include a second applicator housing a second tampon. The second applicator can include a plunger operatively engaged with an insertion portion. The plunger can include a second transparent region that allows the second tampon to be visually perceptible through the applicator creating a second visual impression. The first visual impression can be different from the second visual impression. | 03-05-2015 |
20150065942 | VISUALLY PERCEPTIBLE TAMPON HOUSED WITHIN AN APPLICATOR - The present disclosure is directed to a hygiene device including an applicator housing a tampon. The tampon can include a primary absorbent member having a leading end, a trailing end opposite the leading end, and an intermediate region. The primary absorbent member can include a first tampon color. The tampon can also include a secondary absorbent member adjacent the primary absorbent member. The secondary absorbent member can include a second tampon color. The tampon can further include a withdrawal member disposed on at least one of the secondary absorbent member and the primary absorbent member. The withdrawal member can include a third tampon color. The applicator can include an insertion portion and a plunger operatively engaged with the insertion portion. The plunger can have a transparent region such that at least one of the secondary absorbent member and the withdrawal member is visually perceptible through the applicator. | 03-05-2015 |
Philip M. Almond, Martinez, GA US
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20150056709 | METHOD FOR CHARACTERIZATION OF THE RATE OF MOVEMENT OF AN OXIDATION FRONT IN CEMENTITIOUS MATERIALS - Disclosed are methods for determining the redox condition of cementitious materials. The methods are leaching methods that utilize a redox active transition metal indicator that is present in the cementitious material and exhibits variable solubility depending upon the oxidation state of the indicator. When the leaching process is carried out under anaerobic conditions, the presence or absence of the indicator in the leachate can be utilized to determine the redox condition of and location of the oxidation front in the material that has been subjected to the leaching process. | 02-26-2015 |
20150056714 | METHOD FOR CHARACTERIZATION OF THE REDOX CONDITION OF CEMENTITIOUS MATERIALS - Disclosed are methods for determining the redox condition of cementitious materials. The methods are leaching methods that utilize an in situ redox indicator that is present in the cementitious materials as formed. The in situ redox indicator leaches from cementitious material and, when the leaching process is carried out under anaerobic conditions can be utilized to determine the redox condition of the material. The in situ redox indicator can exhibit distinct characteristics in the leachate depending upon the redox condition of the indicator. | 02-26-2015 |
Russ Almond, Woodinville, WA US
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20150379770 | DIGITAL ACTION IN RESPONSE TO OBJECT INTERACTION - A system and method are disclosed for identifying objects, and performing a digital action with respect to the object in a mixed reality environment. Objects may be recognized by a processing unit receiving feedback from a head mounted display worn by a user in a number of ways. Once an object is identified, the digital action performed may be displaying additional information on the object, either on a virtual display slate or as a three-dimensional virtual representation. | 12-31-2015 |
Russell G. Almond, Tallahassee, FL US
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20140193792 | Portal Assessment Design System for Educational Testing - A Portal Assessment Design System includes a system for designing assessment models and assessments (e.g., standardized tests). In assessment design, specifications are organized around three basic elements: 1) what knowledge, skill or abilities are important to measure; 2) what is necessary evidence of that knowledge, skill or ability; 3) what performance situations are needed to elicit the required evidence from students and other assessment users. The system includes three modules (i.e., Domain Analysis, Domain Modeling, Conceptual Assessment Framework), each of which targets a specific phase of the design process, for designing an assessment in accordance with the three basic elements. The sequence of modules represents the structure of a design process that helps assessment developers work through successive stages or phases of assessment design, from the gathering of raw information to the creation of a complete set of specifications for an assessment product. Each module has its own set of objects for organizing information, such as knowledge skills and abilities of interest of the students being tested, evidence of these, and situations structured to elicit this evidence. The modules and objects of the system are implemented as a software application executing in a client-server environment. | 07-10-2014 |
Stephen W. Almond, Spring, TX US
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20110062085 | Method of Removing Metal Contaminants from High-Density Brines - A method for the removal of soluble metal ion contamination from fluids is disclosed. The method includes passing the contaminated fluid through a filter medium comprising a reducing metal and a filter aid, such as diatomaceous earth, and collecting a filtrate with lower concentration of soluble metal ion contamination. The reducing metal can have a reduction potential of from −0.50 volt to −3.10 volt and can be capable of reducing the soluble metal ions to insoluble metal, which can then be entrapped in the filter medium or otherwise separated. | 03-17-2011 |
20120151847 | PROTECTIVE SYSTEM FOR LEACHING POLYCRYSTALLINE DIAMOND ELEMENTS - The disclosure provides to a PDC element protective system including a mask configured to protect a non-leached portion of a leached polycrystalline diamond compact (PDC) element during a leaching process. The mask may be formed from or coated with polytetrafluoroethylene (PTFE). The disclosure also provides a leaching system containing such a mask and a leaching vessel as well as methods of using the protective and leaching systems. The disclosure further provides a Lewis acid-based leaching agent and methods of its use. Finally, the disclosure provides a method of recycling a PDC or carbide element using a Lewis acid-based leaching agent. | 06-21-2012 |
20120152064 | CHEMICAL AGENTS FOR LEACHING POLYCRYSTALLINE DIAMOND ELEMENTS - The disclosure provides to a PDC element protective system including a mask configured to protect a non-leached portion of a leached polycrystalline diamond compact (PDC) element during a leaching process. The mask may be formed from or coated with polytetrafluoroethylene (PTFE). The disclosure also provides a leaching system containing such a mask and a leaching vessel as well as methods of using the protective and leaching systems. The disclosure further provides a Lewis acid-based leaching agent and methods of its use. Finally, the disclosure provides a method of recycling a PDC or carbide element using a Lewis acid-based leaching agent. | 06-21-2012 |
20120152065 | CHEMICAL AGENTS FOR RECOVERY OF LEACHED MATERIALS - The disclosure provides to a PDC element protective system including a mask configured to protect a non-leached portion of a leached polycrystalline diamond compact (PDC) element during a leaching process. The mask may be formed from or coated with polytetrafluoroethylene (PTFE). The disclosure also provides a leaching system containing such a mask and a leaching vessel as well as methods of using the protective and leaching systems. The disclosure further provides a Lewis acid-based leaching agent and methods of its use. Finally, the disclosure provides a method of recycling a PDC or carbide element using a Lewis acid-based leaching agent. | 06-21-2012 |
20120156408 | Polytetrafluoroethylene (PTFE) Masking Devices And Methods Of Use Thereof - The disclosure provides to a PDC element protective system including a mask configured to protect a non-leached portion of a leached polycrystalline diamond compact (PDC) element during a leaching process. The mask may be formed from or coated with polytetrafluoroethylene (PTFE). The disclosure also provides a leaching system containing such a mask and a leaching vessel as well as methods of using the protective and leaching systems. The disclosure further provides a Lewis acid-based leaching agent and methods of its use. Finally, the disclosure provides a method of recycling a PDC or carbide element using a Lewis acid-based leaching agent. | 06-21-2012 |
20120279711 | Environmentally Friendly Low Temperature Breaker Systems and Related Methods - An embodiment of the present invention includes a method comprising: (a) providing a filter cake on a surface in a subterranean formation, the filter cake comprising a polymer and a bridging agent; (b) providing a filter cake clean-up fluid that comprises an aqueous fluid and L-glutamic acid N,N-diacetic acid; and (c) contacting the filter cake with the filter cake clean-up fluid so that a portion of the subterranean formation neighboring the filter cake has a regain permeability of at least about 86%. | 11-08-2012 |
Stephen W. Almond, North Charleston, SC US
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20130217603 | USE OF NEUTRAL-DENSITY PARTICLES TO ENHANCE BARITE SAG RESISTANCE AND FLUID SUSPENSION TRANSPORT - The present invention relates to particles that are useful for enhancing hindered settling in suspensions. One embodiment of the present invention provides a method of providing a subterranean treatment fluid including a base fluid and a weighting agent having a first average settling velocity; and a neutral-density particle; and mixing the subterranean treatment fluid with the neutral-density particle thereby reducing the weighting agent to a second average settling velocity. | 08-22-2013 |
20140166361 | Systems and Methods for Real Time Drilling Fluid Management - Disclosed are systems and methods for monitoring drilling fluid components in real time. One system includes solids control equipment fluidly coupled to a borehole and configured to receive drilling fluid from the borehole, the solids control equipment having a first optical computing device arranged adjacent the inlet and configured to optically interact with the drilling fluid as it enters the solids control equipment and thereby generate a first output signal corresponding to a characteristic of the drilling fluid, a second optical computing device arranged adjacent the outlet and configured to optically interact with the drilling fluid as it exits the solids control equipment and thereby generate a second output signal corresponding to the characteristic of the drilling fluid, and a signal processor communicably coupled to the first and second optical computing devices and configured to receive the first and second output signals and provide a resulting output signal. | 06-19-2014 |
20140166871 | Systems and Methods for Measuring Fluid Additive Concentrations for Real Time Drilling Fluid Management - Disclosed are systems and methods for monitoring drilling fluid components in real time. One system includes a flow path fluidly coupled to a borehole and containing a drilling fluid having at least one component present therein, an optical computing device arranged in the flow path and having at least one integrated computational element configured to optically interact with the drilling fluid and thereby generate optically interacted light, and at least one detector arranged to receive the optically interacted light and generate an output signal corresponding to a characteristic of the at least one component. | 06-19-2014 |
20140172177 | Systems and Methods for Real Time Monitoring of Gas Hydrate Formation - Disclosed are systems and methods for monitoring a drilling fluid for the formation of gas hydrates. One system includes a borehole containing a drilling fluid being circulated therethrough, a first optical computing device arranged in the borehole and having at least one integrated computational element configured to optically interact with the drilling fluid and detect one or more gas hydrates present therein, and at least one detector arranged to receive optically interacted light generated from optical interaction between the at least one integrated computational element and the drilling fluid, the at least one detector being configured to generate a first output signal corresponding to a characteristic of the one or more gas hydrates. | 06-19-2014 |