Patent application number | Description | Published |
20120122832 | METHOD OF MAKING CEFQUINOME PARTICLES - Disclosed is a process for the production of particles of a cefquinome acid addition salt, preferably cefquinome sulfate particles, by precipitation of cefquinome acid addition salt, preferably the sulfate, from a cefquinome betaine solution, wherein acid, preferably sulfuric acid, is added to the betaine solution. According to the invention the acid, preferably sulfuric acid, is added quickly in a single shot, in a molar excess of 40% to less than 100%. As a result, particles are formed that comprise agglomerates of microscale primary crystalline particles. This enables providing particles of cefquinome acid addition salt, preferably cefquinome sulfate, in particle sizes commensurate with micronized material, but with improved stability. | 05-17-2012 |
20130281425 | USE OF LIQUID MEDIUM EXCHANGE BY CROSS FLOW FILTRATION IN THE PREPARATION OF DRUG SUSPENSIONS - Disclosed is a method of making particles of a drug wherein use is made of diafiltration. The diafiltration can be with anti-solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation. | 10-24-2013 |
Patent application number | Description | Published |
20090042815 | Macrolide Synthesis Process and Solid-State Forms - This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms. | 02-12-2009 |
20110053875 | Macrolide synthesis process and solid-state forms - This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms. | 03-03-2011 |
20130274270 | POLYMORPHS OF 3-CHLORO-4[(2R)-2-(4-CHLOROPHENYL)-4-[(1R)-1-(4-CYANOPHENYL)ETHYL]-1-PIPE- RAZINYL]-BENZONITRILE, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE COMPRISING SAID POLYMORPHS, AND A PROCESS FOR PREPARING THEM - Polymorphs of 3-chloro-4[(2R)-2-(4-chlorophenyl)-4-[(1R)-1-(4-cyanophenyl)ethyl]-1-piperazinyl]-benzonitrile are disclosed, as well as pharmaceutical compositions comprising said polymorphs, methods of using the polymorphs, and a process for preparing them. | 10-17-2013 |
Patent application number | Description | Published |
20080257720 | Electrode System for an Electrochemical Sensor - An electrode system for an electrochemical cell is provided, including a substrate, a measuring electrode connected to the substrate and formed from a number of electrically conducting and mutually connected microdisks, and a generating electrode formed from an electrically conducting sheet and having a diameter that is greater than that of the microdisks. In one implementation, the microdisks are provided in cavities in the substrate. | 10-23-2008 |
20090028194 | TUNABLE LASER - A mode hop-free tunable laser including a gain medium, a microfabricated blazed grating, defining an external cavity of a given length, the blazed grating lying in a general plane and including a plurality of elongate beams carrying mutually parallel respective reflection surfaces spaced apart from one another with a predefined pitch, and actuating elements designed so as to allow displacements of the assembly with respect to a grating support within a plane substantially parallel to the grating general plane, and including actuation elements designed so as to apply a stretching and a displacement of the assembly in a direction transverse to said reflection surfaces, the blazed grating being arranged relative to an incident light beam provided by the gain medium so that the incident light beam impinges on the reflection surfaces with a substantially normal incident angle. | 01-29-2009 |
20100220395 | FABRICATION PROCESS OF A MICROFABRICATED BLAZED GRATING - A blazed grating is disclosed as well as mode hop-free tunable lasers and a process for fabricating gratings of this type. The grating lies in a general plane and includes a plurality of elongate beams carrying mutually parallel respective reflection surfaces spaced apart from one another with a predefined pitch, each of these reflection surfaces having a normal direction inclined at a grating angle α to the normal direction of the general plane. The grating includes a plurality of resilient suspension arms connected to the beams and intended to be fastened to a grating support. A first pair of comb electrodes is provided for applying a mechanical force to this assembly, being placed on a first side of the grating, along an axis transverse to the beams, and designed so as to allow the pitch of the grating to be modified in response to the application of the mechanical force. | 09-02-2010 |
20120036921 | AMPEROMETRIC ELECTROCHEMICAL SENSOR AND METHOD FOR MANUFACTURING SAME - An amperometric electrochemical sensor with a fixed potential used in a probe for measuring the content of an oxidation reduction substance dissolved in a liquid, in particular the chlorine content. The sensor ( | 02-16-2012 |
20130135974 | BALANCE SPRING AND METHOD FOR MANUFACTURING SAME - The present invention relates to a balance spring intended to equip a balance of a mechanical timepiece, formed by a spiral bar resulting from machining a fused quartz plate, which has a positive thermal coefficient of rigidity, the bar constituting a core at least locally covered by at least one outer layer having a different structure to modify the thermal coefficient of rigidity. | 05-30-2013 |