Huang, PA
Audris Huang, New Hope, PA US
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20130184254 | AZAINDAZOLE COMPOUNDS - Disclosed are azaindazole compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein W is CR | 07-18-2013 |
20130310393 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS - Disclosed are heteroaryl compounds of Formula (I), (I), or pharmaceutically acceptable salts thereof, wherein Z is CH or N; W is CR | 11-21-2013 |
20140148453 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS - Disclosed are sulfonamide compounds of Formula (I): or stereoisomers, N-oxides, prodrugs, or pharmaceutically acceptable salts thereof, wherein ring A, R | 05-29-2014 |
20140235647 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS - Disclosed are azaindazole compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: X is O and Y is N; or X is S and Y is CH; Z is CR | 08-21-2014 |
Boan Huang, Quakertown, PA US
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20110276349 | Publishing Templates Having Practice Defined Triggers - A healthcare management system is presented where the management system can include a data routing engine configured to route patient data to various authorized providers as a function of one or more trigger rules. The routing engine can operate as a web portal, through which clients of system can define medical form templates, where a template can include one or more triggering rules that cause further action to take place. When a patient interfaces to the web portal, the portal can render a medical form for the patient based on the template. As the patient interacts with the form, including entering their patient data, the routing engine can determine if any triggering criteria have been satisfied. If so, further actions can place including routing the data to authorized entities or providing notifications. | 11-10-2011 |
Chichi Huang, Spring House, PA US
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20140255401 | Kv1.3 Antagonists and Methods of Use - The present invention relates to Kv1.3 antagonists, and polynucleotides encoding them, and methods of making and using the foregoing. | 09-11-2014 |
20140271648 | Interferon Alpha and Omega Antibody Antagonists - Broadly neutralizing interferon-α and interferon-ω antibody antagonists, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of diseases associated with increased production of IFNα and IFNω. | 09-18-2014 |
Chichi Huang, Radnor, PA US
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20090186020 | Melanocortin Receptor Binding Mimetibodies, Compositions, Methods and Uses - Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed. | 07-23-2009 |
20110118144 | ENGINEERED PHAGE VECTORS FOR THE DESIGN AND THE GENERATION OF A HUMAN NON-ANTIBODY PEPTIDE OR PROTEIN PHAGE LIBRARY VIA FUSION TO PIX OF M13 PHAGE - The invention relates to a compositions and methods for generating and using pIX phage display libraries for producing non-antibody peptide or protein proteins or peptides using engineered hybrid phage vectors derived from pIX of M 13 phage. | 05-19-2011 |
20120225085 | DISPLAY OF DISULFIDE LINKED DIMERIC PROTEINS IN FILAMENTOUS PHAGE - Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion polypeptide with filamentous phage pIX coat protein. Heterodimeric or more complex interchain bonded structure, such as disulfide-linked, multimeric proteins, may be displayed using the method of the invention. | 09-06-2012 |
20120225807 | BACTERIAL MEMBRANE PROTEIN SECRETION - Improved bacterial secretion signals derived from pelB and ompA are provided. The improved variants enhance bacterial membrane secretion are thus useful for production of proteins secreted from bacteria including proteins displayed on filamentous phage particles, and, in particular, proteins requiring oxidative formation of covalent bonds, such as disulfide bonds within or between polypeptide chains in order to form a correctly folded and functional protein structure. Described herein are methods for the multivalent display of complex dimeric proteins on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion polypeptide with filamentous phage pIX coat protein. Heterodimeric or more complex interchain bonded structures may also be displayed using the method of the invention. | 09-06-2012 |
20120308482 | Monkey Homolog of Human Interferon Omega - Cytokine IFNω nucleic acids from the Cynomolgus monkey are useful for expression of IFNω proteins that are functional homologs of human IFNω. The nucleic acids and proteins produced therefrom are useful in screening and safety testing of IFNω, the generation and testing of IFNω modulators and related activities. | 12-06-2012 |
Chichi Huang, Berwyn, PA US
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20080305130 | Marked Bovine Viral Diarrhea Virus Vaccines - The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals. | 12-11-2008 |
20090220506 | HUMAN EPO MIMETIC HINGE CORE MIMETIBODIES, COMPOSITIONS, METHODS AND USES - The present invention relates to at least one novel human EPO mimetic hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic hinge core mimetibody or specified portion or variant, EPO mimetic hinge core mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices. | 09-03-2009 |
20100249032 | Human EPO Mimetic Hinge Core Mimetibodies, Compositions, Methods and Uses - The present invention relates to at least one novel human EPO mimetic hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic hinge core mimetibody or specified portion or variant, EPO mimetic hinge core mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices. | 09-30-2010 |
20120021001 | MARKED BOVINE VIRAL DIARRHEA VIRUS VACCINES - The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals. | 01-26-2012 |
Chong Huang, Paoli, PA US
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20090137783 | CNGH0010 Specific Polynucleotides, Polypeptides, Antibodies, Compositions, Methods and Uses - Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases. | 05-28-2009 |
Chong Huang, Radnor, PA US
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20090270480 | Markers and Methods for Assessing and Treating Psoriasis and Related Disorders - A method for prognostic or diagnostic assessment of a skin-related disorder, such as psoriasis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies. | 10-29-2009 |
20100260675 | Oxytocin Receptor Antagonists and Their Use for the Treatment of Pulmonary Related Diseases - Methods of treating disorders related to Oxytocin Receptor activity utilize OXYTOCIN RECEPTOR antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, small molecule drugs, siRNA, shRNA, and DNAzymes. Disorders related to Oxytocin Receptor activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD. | 10-14-2010 |
Chris Huang, Radnor, PA US
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20100331209 | MARKERS AND METHODS FOR ASSESSING AND TREATING SEVERE OR PERSISTANT ASTHMA AND TNF RELATED DISORDERS - A method for assessment of the suitability of and/or effectiveness of a target therapy for a TNF-mediated-related disorder, such as severe or persistent asthma, in a subject evaluates the presence, absence, and/or magnitude of expression of one or more genes corresponding to contacting the sample with a panel of nucleic acid segments consisting of at least a portion of at least one member from the group consisting of the nucleotide sequences corresponding to at least one of TNFRSF1A SNP rs4149581 (SEQ ID NO:1), TNFRSF1 B SNP rs3766730 (SEQ ID NO:2) or TNFRSFI B SNP rs590977 (SEQ ID NO:3) SNPs which results in a determination that one or more of said SNPs in a sample are in linkage disequilibrium (LD). The method enables identification of the effectiveness of target therapies prior to or after starting a patient on such therapies. | 12-30-2010 |
Dong Huang, Pittsburgh, PA US
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20140204193 | DRIVER GAZE DETECTION SYSTEM - A method for detecting an eyes-off-the-road condition based on an estimated gaze direction of a driver of a vehicle includes monitoring facial feature points of the driver within image input data captured by an in-vehicle camera device. A location for each of a plurality of eye features for an eyeball of the driver is detected based on the monitored facial features. A head pose of the driver is estimated based on the monitored facial feature points. The gaze direction of the driver is estimated based on the detected location for each of the plurality of eye features and the estimated head pose. | 07-24-2014 |
Fei Huang, Philadelphia, PA US
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20130158982 | Computer-Implemented Systems and Methods for Content Scoring of Spoken Responses - Systems and methods are provided for scoring a non-scripted speech sample. A system includes one or more data processors and one or more computer-readable mediums. The computer-readable mediums are encoded with a non-scripted speech sample data structure, where the non-scripted speech sample data structure includes: a speech sample identifier that identifies a non-scripted speech sample, a content feature extracted from the non-scripted speech sample, and a content-based speech score for the non-scripted speech sample. The computer-readable mediums further include instructions for commanding the one or more data processors to extract the content feature from a set of words automatically recognized in the non-scripted speech sample and to score the non-scripted speech sample by providing the extracted content feature to a scoring model to generate the content-based speech score. | 06-20-2013 |
Gensheng Huang, Bethlehem, PA US
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20110204328 | NITRIDE BASED DEVICES INCLUDING A SYMMETRICAL QUANTUM WELL ACTIVE LAYER HAVING A CENTRAL LOW BANDGAP DELTA-LAYER - A symmetrical quantum well active layer provides enhanced internal quantum efficiency. The quantum well active layer includes an inner (central) layer and a pair of outer layers sandwiching the inner layer. The inner and outer layers have different thicknesses and bandgap characteristics. The outer layers are relatively thick and include a relatively low bandgap material, such as InGaN. The inner layer has a relatively lower bandgap material and is sufficiently thin to act as a quantum well delta layer, e.g., comprising approximately 6 Å or less of InN. Such a quantum well structure advantageously extends the emission wavelength into the yellow/red spectral regime, and enhances spontaneous emission. The multi-layer quantum well active layer is sandwiched by barrier layers of high bandgap materials, such as GaN. | 08-25-2011 |
20110240082 | THERMOELECTRIC MATERIALS BASED ON SINGLE CRYSTAL AlInN-GaN GROWN BY METALORGANIC VAPOR PHASE EPITAXY - The invention is a thermoelectric device fabricated by growing a single crystal AlInN semiconductor material on a substrate, and a method of fabricating same. In a preferred embodiment, the semiconductor material is AlInN grown on and lattice-matched to a GaN template on a sapphire substrate, and the growth is performed using metalorganic vapor phase epitaxy (MOVPE). | 10-06-2011 |
Jiyong Huang, Pittsburgh, PA US
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20140154785 | METHOD FOR MAKING POLYMER SINGLE NANOWIRES AND SENSORS UTILIZING THE SAME - A method of fabricating polymer single nanowires, comprising the steps of: spin coating a polymethylmethacrylate resist onto a silicon wafer patterned with at least one gold electrode pair; creating a nanochannel using e-beam lithography between each pair of the at least one gold electrode pairs; placing the silicon wafer into an aniline monomer polymerization solution; reacting the polymerization solution to give a coated wafer and a polyaniline film; and cleaning the coated wafer of polymethylmethacrylate resist and polyaniline film to give at least one gold electrode pair with a connecting polymer single nanowire. | 06-05-2014 |
Jui Han Huang, Wallingford, PA US
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20110041190 | NOVEL CHIMERIC PROTEINS - Novel chimeric proteins are disclosed. The proteins comprise at least two portions. The first portion binds to a first cell and decreases the cell's ability to send a trans signal to a second cell; the second portion sends its own trans signal to the second cell. Methods for making and using these proteins in the treatment of cancer, viral infections, autoimmune and alloimmune diseases are also disclosed, as are pharmaceutical formulations comprising the novel chimeric proteins and genes. Either the proteins themselves or a genetic sequence encoding the protein can be administered. Other methods are also disclosed in which two molecular components result in decrement of a first trans signal from a first cell and the conferring of a second trans signal to a second cell. | 02-17-2011 |
20130243697 | Novel Chimeric Proteins and Methods for Using The Same - Novel chimeric proteins are disclosed. The proteins comprise at least two portions. The first portion binds to a first cell and decreases the cell's ability to send a trans signal to a second cell; the second portion sends its own trans signal to the second cell. Methods for making and using these proteins in the treatment of cancer, viral infections, autoimmune and alloimmune diseases are also disclosed, as are pharmaceutical formulations comprising the novel chimeric proteins and genes. Either the proteins themselves or a genetic sequence encoding the protein can be administered. Other methods are also disclosed in which two molecular components result in decrement of a first trans signal from a first cell and the conferring of a second trans signal to a second cell. | 09-19-2013 |
Ke Huang, Philadelphia, PA US
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20080257414 | Method For Reduction Of Crude Oil Viscosity - The present invention relates to a method for reducing the viscosity and facilitating the flow of petroleum-based fluids. The method includes the step of applying an electric field of sufficient strength and for a sufficient time to the petroleum-based fluid to cause a reduction in viscosity of the fluid. | 10-23-2008 |
20100024783 | ELECTRIC-FIELD ASSISTED FUEL ATOMIZATION SYSTEM AND METHODS OF USE - An apparatus ( | 02-04-2010 |
20110048746 | AUTOMATIC REVERSIBLE TEMPERATURE RESPONSIVE VALVE AND FIRE SPRINKLER - A fire sprinkler including a generally tubular body having inlet and outlet ends is disclosed. The body defines a fluid flow passage extending between the inlet and the outlet such that the outlet is in fluid flow communication with the inlet. A magnetized member is disposed within the fluid flow passage and is movable between a first position wherein fluid flow communication between the outlet and the inlet is blocked and a second position wherein fluid flow communication between the outlet and the inlet is open. A temperature sensitive magnetic member is coupled to the body and has sufficient magnetic properties to attract the magnetized member below a predetermined temperature, thereby maintaining the magnetized member in the first position. The temperature sensitive magnetic member loses a sufficient percentage of its magnetic properties at and above the predetermined temperature, thereby allowing the magnetized member to move to the second position. | 03-03-2011 |
Kevin Huang, Export, PA US
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20100330450 | Tubular Solid Oxide Fuel Cells With Porous Metal Supports and Ceramic Interconnections - An intermediate temperature solid oxide fuel cell structure capable of operating at from 600° C. to 800° C. having a very thin porous hollow elongated metallic support tube having a thickness from 0.10 mm to 1.0 mm, preferably 0.10 mm to 0.35 mm, a porosity of from 25 vol. % to 50 vol. % and a tensile strength from 700 GPa to 900 GPa, which metallic tube supports a reduced thickness air electrode having a thickness from 0.010 mm to 0.2 mm, a solid oxide electrolyte, a cermet fuel electrode, a ceramic interconnection and an electrically conductive cell to cell contact layer. | 12-30-2010 |
20110033769 | Electrical Storage Device Including Oxide-ion Battery Cell Bank and Module Configurations - A rechargeable electrical storage device is disclosed, where one embodiment utilizes an anion (“A”) conducting electrolyte ( | 02-10-2011 |
20110038100 | Porous Carbon Oxide Nanocomposite Electrodes for High Energy Density Supercapacitors - A high energy density supercapacitor is provided by using nanocomposite electrodes having an electrically conductive carbon network having a surface area greater than 2,000 m | 02-17-2011 |
20110168572 | Composite Mixed Carbonate Ion and Electron Conducting Membranes and Reactant Gas Assisted Chemical Reactors for CO2 Separation and Capture - The present disclosure relates to a system for carbon dioxide seperation and capture. The system includes a porous metal membrane comprising Ni, Ag, or combinations thereof and having molten carbonate within the pores. A CO | 07-14-2011 |
20110256448 | MOLTEN SALT-CONTAINING METAL ELECTRODE FOR RECHARGEABLE OXIDE-ION BATTERY CELLS OPERATING BELOW 800?C - A rechargeable oxide-ion battery cell | 10-20-2011 |
20120014852 | Membranes and Reactors for CO2 Separation - The present disclosure relates to a system for carbon dioxide separation. The system includes a conducting membrane having two phases. The first phase is a solid oxide porous substrate. The second phase is molten carbonate. The second phase is positioned within the solid oxide porous substrate of the first phase. The system also includes a H | 01-19-2012 |
20120034520 | SELF-SEALED METAL ELECTRODE FOR RECHARGEABLE OXIDE-ION BATTERY CELLS - The outer surface of a metal electrode | 02-09-2012 |
20120058396 | OXIDATION-RESISTANT METAL SUPPORTED RECHARGEABLE OXIDE-ION BATTERY CELLS AND METHODS TO PRODUCE THE SAME - The invention describes the application of oxidation-resistant metal (preferably, stainless steel) | 03-08-2012 |
20120270088 | ALL SOLID STATE RECHARGEABLE OXIDE-ION BATTERY (ROB) SYSTEM - An all solid state rechargeable oxide-ion (ROB) battery ( | 10-25-2012 |
Liang Huang, Pittsburgh, PA US
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20150218438 | Dual-Mechanism Thickening Agents for Hydraulic Fracturing Fluids - The present invention relates to multi-arm star macromolecules which are used as thickening agents or rheology modifiers, including use in hydraulic fracturing fluid compositions. In one aspect of the invention, a star macromolecule is capable of thickening via a dual mechanism comprising (1) self-assembly of the hydrophobic polymerized segments of the star macromolecules via hydrophobic interactions or associations, and (2) association, reaction, or combination of the hydroxyl-containing polymerized segments of one or more of the star macromolecules. | 08-06-2015 |
Liquan Huang, Havertown, PA US
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20080307536 | Voltage-Gated, Ph-Sensitive Anion Channel And Its Novel Splice Variant Involved In Taste Sensation - The invention provides a novel splice-variant of the ClC-4 protein, termed ClC-4A. ClC-4A is expressed in taste bud cells and is involved in sour taste perception. The invention provides ClC-4A polynucleotides and ClC-4A polypeptides, vectors, host cells and ClC-4A specific antibodies as well as designing high potency taste stimuli, determining taste preferences in animals, developing breed-specific foods, and modifying the taste of foods and medications. | 12-11-2008 |
20150087610 | Method of Modifying Fertility - The present invention provides methods and compositions for modifying fertility in a male mammalian subject by contacting the subject's testis cells, germ cells or sperm with a sufficient amount of a composition comprising a ligand that binds, activates, or inhibits activation of, a TAS2R receptor expressed on the cells. Also described are methods for screening a test molecule for its effect on fertility by examining changes in male germ cells, testis cells or sperm resulting from contact with a molecule that binds, activates, or inhibits activation of, a TAS2R receptor expressed on the cells. Compositions for modifying fertility in a mammalian subject, e.g., contraceptive products, include a ligand that binds, inhibits or activates a TAS2R receptor in a pharmaceutically acceptable carrier. | 03-26-2015 |
Liying Huang, State College, PA US
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20120105471 | Systems and Methods for Data Aggregation and Prioritization - Computer-enabled systems and methods aggregate data related to a particular subject or field and present the data in a simplified display. The data is divided into predetermined categories, which are graphically displayed in a predetermined arrangement. Systems and methods differentiate and visually display critical data abnormalities separately from non-critical data. The systems and methods enable an observer to identify the critical deviations or anomalies of data with respect to a predetermined base line by an intuitive visual display of all of the data from any sized data universe on a single screen. The data is indexed at multiple display levels such as a stack of one patient's data, a stack of all patient data for the universe of patients of a single practitioner, or a group of practitioners of any size. A portion of the display preferably may be selected and expanded to show only that portion in greater detail. | 05-03-2012 |
Longchun Huang, Philadelphia, PA US
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20120329877 | Cycloalkyl-dione Derivatives And Methods Of Their Use - The present invention is directed to compounds of formula I: | 12-27-2012 |
Pearl S. Huang, Lansdale, PA US
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20100280987 | METHODS AND GENE EXPRESSION SIGNATURE FOR ASSESSING RAS PATHWAY ACTIVITY - Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of RAS pathway signaling in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating RAS pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated RAS signaling pathway; determining whether an agent modulates the RAS signaling pathway in sample; predicting response of a subject to an agent that modulates the RAS signaling pathway; assigning treatment to a subject; and evaluating the pharmacodynamic effects of cancer therapies designed to regulate RAS pathway signaling. | 11-04-2010 |
Philip Lin Huang, Maple Glen, PA US
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20090061031 | Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus - The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues. | 03-05-2009 |
20110142973 | Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus - The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues. | 06-16-2011 |
20140296141 | Compositions and Methods for Treating Obesity, Obesity Related Disorders and for Inhibiting the Infectivity of Human Immunodeficiency Virus - The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues. | 10-02-2014 |
Po-Hsun Huang, State College, PA US
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20150017023 | APPARATUSES AND METHODS FOR MODULATING FLUIDS USING ACOUSTICALLY OSCILLATING SOLID STRUCTURES - An acoustofluidic apparatus is provided that functions by the generation of microstreaming in fluid produced by the oscillation of oscillatory elements excited by an energy input such as acoustic energy. An acoustofluidic apparatus includes an oscillatory energy field generator in energetic contact with one or more oscillatory elements contained in a fluid passage. Oscillation of the oscillatory elements induces microstreaming in a fluid that can be used to mix laminar flows of differing fluids, as a micropump for the directional movement of fluid through a fluid passage, for the generation of waveforms in a fluid or plurality of fluids or for other purposes. | 01-15-2015 |
Qihong Huang, Philadelphia, PA US
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20100196357 | Microrna modulators and method for identifying and using the same - The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease. | 08-05-2010 |
20100317628 | MicroRNA Modulators and Method for Identifying and Using the Same - The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease. | 12-16-2010 |
20110064828 | TREATMENT OF METASTATIC TUMORS AND OTHER CONDITIONS - The present invention generally relates to pharmacology and, in particular, to the treatment of tumors and other conditions. In some aspects, the invention is directed to the treatment of subjects having tumors or cancers that are metastatic. Surprisingly, it has been found that certain compositions comprising oxidized glutathione-based compounds are able to effectively treat such cancers by inhibiting cell migration and/or invasion processes, and thus, inhibiting tumor cell metastases. Without being bound by any theory, it is believed that such compositions are effective since the compositions are able to suppress the activation of critical signaling pathways within cells that are used for cell migration, such as the ErbB2 and/or phosphoinositide-3 kinase (PI3K) pathways, including the downstream RhoA and AKT pathways. Such pathways are regulated by ERp5, which is a protein disulfide isomerase regulated using certain redox pathways, and those redox pathways are unusually sensitive to treatment using oxidized glutathione-based compounds. Thus, the composition of the instant invention, in some embodiments, are surprisingly effective at preventing tumor metastases. While other references have disclosed the treatment of cancers using oxidized glutathione-based compounds, no reference has suggested that signaling pathways used for cell migration, invasion and metastasis, such as the ErbB2, PI3K, RhoA, and AKT pathways, are highly susceptible to treatment by altering the redox state of the cell, e.g., by oxidized glutathione-based compounds. Accordingly, the use of such compositions to treat tumor metastases is surprising and could not be predicted given the teachings of the prior art. | 03-17-2011 |
20120010177 | MicroRNA Modulators and Method for Identifying And Using The Same - The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease. | 01-12-2012 |
20130023498 | MicroRNA Modulators and Method for Identifying and Using the Same - The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease. | 01-24-2013 |
20140255386 | MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME - The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease. | 09-11-2014 |
San-Jan Alan Huang, Pittsburgh, PA US
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20150238005 | CLEANING DEVICE HAVING ONBOARD REPLACEABLE CLEANING PAD AND ONBOARD REPLACEABLE CLEANING SOLUTION - A device for cleaning debris from a target surface. The device has a sole plate with permanent cleaning material, such as bristles, and a removable/replaceable pad. The device also has a replaceable, on-board supply of cleaning solution. The pad/cleaning solution may be replaced when depleted and replaced with a new pad/cleaning solution or may simply be replaced with a new pad/cleaning solution when that pad/cleaning solution is more suitable for a particular cleaning task. | 08-27-2015 |
Shaei Y. Huang, Jeffersonville, PA US
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20080280967 | Substituted acylhydroxamic acids and method of reducing TNFalpha levels - Imido and amido substituted acylhydroxamic acids which reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino)propanoate. | 11-13-2008 |
Shaei Y. Huang, Lansdale, PA US
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20080280902 | Inhibitors of Checkpoint Kinases - The instant invention provides for compounds which comprise substituted quinolinones that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer. | 11-13-2008 |
20090258852 | Inhibitors of Checkpoint Kinases - The instant invention provides for compounds which comprise benzoisoquinolinones and aza derivatives that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer. | 10-15-2009 |
20110124661 | OXAZOLOBENZIMIDAZOLE DERIVATIVES - The present invention is directed to oxazolobenzimidazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved. | 05-26-2011 |
Shu Huang, State College, PA US
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20140250032 | METHODS, SYSTEMS AND PROCESSOR-READABLE MEDIA FOR SIMULTANEOUS SENTIMENT ANALYSIS AND TOPIC CLASSIFICATION WITH MULTIPLE LABELS - Methods, systems and processor-readable media for simultaneous sentiment analysis and topic classification with multiple labels. A sentiment and topic associated with a post can be classified at similar time and a result can be incorporated to predict a feature so that a label of two (or more) tasks can promote and reinforce each other iteratively. A feature extraction and selection can be performed on the tasks and a multi-task multi-label classification model can be trained for each task with maximum entropy utilizing multiple labels to ascertain information derived from an extra label and to manage class ambiguities. Each task has a separate classification model with different predicting features and they can be trained collectively which allows flexibility in model construction. The multi-task multi-label classification model produces a probabilistic result and the classes can be ranked by the probabilistic result and the post can be classified with the multi-label. | 09-04-2014 |
Shuguang Huang, Pittsburgh, PA US
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20140072999 | METHODS OF SIMULATING CHEMOTHERAPY FOR A PATIENT - The present invention provides methods for predicting or modeling a chemotherapy outcome for a given patient, to assist physicians in the selection of chemotherapeutic agents for individualized cancer treatment. | 03-13-2014 |
Sun-Jun Alan Huang, Pittsburgh, PA US
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20130047358 | CLEANING DEVICE HAVING ONBOARD REPLACEABLE CLEANING PAD AND ONBOARD REPLACEABLE CLEANING SOLUTION - A device for cleaning debris from a target surface. The device has a sole plate with permanent cleaning material, such as bristles, and a removable/replaceable pad. The device also has a replaceable, on-board supply of cleaning solution. The pad/cleaning solution may be replaced when depleted and replaced with a new pad/cleaning solution or may simply be replaced with a new pad/cleaning solution when that pad/cleaning solution is more suitable for a particular cleaning task. | 02-28-2013 |
Tai-Yin Huang, Macungie, PA US
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20150021648 | COMPOSITE LED PACKAGE AND ITS APPLICATION TO LIGHT TUBES - A light emitting diode package includes a first lead frame, a second lead frame and an encapsulant. The first lead frame has a die deposition area on the top thereof for disposing LED die. The second lead frame has a contacting face on the top thereof for wire bonding. The die deposition area of the first lead frame has a first adhesion area such that the encapsulant is held by the first adhesion area when enclosing the top and bottom of the first and second lead frames. The light is emitted in all directions. | 01-22-2015 |
20150195895 | ENERGY STORAGE DEVICE - An energy storage device configured for a vehicle or a building is provided. The energy storage device includes a receiving element, a conduction element, a limiting current element, a voltage dividing element, and a storage element. The receiving element is configured for receiving a lightning's electrical power in an environment. The conduction element is coupled to the receiving element and is configured for conducting a first path or a second path in accordance with an electrical property of the lightning's electrical power. The voltage dividing element is coupled to the limiting current element and is configured for dividing a voltage of the lightning's electrical power. The storage element is coupled to the voltage dividing element and is configured for storing the lightning's electrical power. | 07-09-2015 |
Tony J. Huang, State College, PA US
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20110013287 | Tunable Liquid Gradient Refractive Index Lens Device - A lens device includes a substrate having a channel and a first fluid flow path and a second fluid flow path. The first and second fluid flow paths at least partially in communication with the channel. A light emitting device is positioned adjacent to the channel. At least one first fluid source is in communication with the first fluid path such that a first fluid is moveable along the first fluid path and at least one second fluid source in communication with the second fluid path such that a second fluid is moveable along the second fluid path. The first second fluid paths are configured so the first fluid and second fluid move through the channel to define an adjustable liquid gradient refractive index distribution in the channel. Adjustment of the liquid gradient refractive index distribution permits a change of liquid lens focal distance or an angular adjustment of light emitted by the light emitting device. | 01-20-2011 |
20130021673 | Tunable Liquid Gradient Refractive Index Lens Device - A lens device includes a substrate having a channel and a first fluid flow path and a second fluid flow path. The first and second fluid flow paths at least partially in communication with the channel. A light emitting device is positioned adjacent to the channel. At least one first fluid source is in communication with the first fluid path such that a first fluid is moveable along the first fluid path and at least one second fluid source in communication with the second fluid path such that a second fluid is moveable along the second fluid path. The fluid paths are configured so the first fluid and second fluid move through the channel to define an adjustable liquid gradient refractive index distribution in the channel. Adjustment of the liquid gradient refractive index distribution permits a change of liquid lens focal distance or an angular adjustment of light. | 01-24-2013 |
Tony Jun Huang, State College, PA US
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20090066936 | THREE-DIMENSIONAL (3D) HYDRODYNAMIC FOCUSING USING A MICROFLUIDIC DEVICE - A microfluidic device comprises inlets for a sample flow and an out-of-plane focusing sheath flow, and a curved channel section configured to receive the sample flow and out-of-plane focusing sheath and to provide hydrodynamic focusing of the sample flow in an out-of-plane direction, the out-of-plane direction being normal to a plane including the curved channel. | 03-12-2009 |
20100139377 | PARTICLE FOCUSING WITHIN A MICROFLUIDIC DEVICE USING SURFACE ACOUSTIC WAVES - Examples of the present invention include apparatus and methods for particle focusing, for particles within a fluid sample. An example apparatus, which may be a microfluidic device, comprises a substrate, a channel receiving the fluid sample, and at least one surface acoustic wave (SAW) generator. The SAW generator may comprise electrodes supported by the substrate. In some examples, the channel has a particle focusing region located near a region of the substrate surface in which a SAW is generated. Particles are concentrated within one or more particle focus regions of the sample flow (the particle focus regions being appreciably narrower than the channel dimensions) by the effects of the SAW. As an example, a pair of SAW generators can be used to generate a standing surface acoustic wave (SSAW) that is used for particle focusing. | 06-10-2010 |
20120196314 | THREE-DIMENSIONAL (3D) HYDRODYNAMIC FOCUSING USING A MICROFLUIDIC DEVICE - A microfluidic device comprises inlets for a sample flow and an out-of-plane focusing sheath flow, and a curved channel section configured to receive the sample flow and out-of-plane focusing sheath and to provide hydrodynamic focusing of the sample flow in an out-of-plane direction, the out-of-plane direction being normal to a plane including the curved channel. Examples of the invention also include improved flow cytometers. | 08-02-2012 |
20130192958 | MICROFLUIDIC MANIPULATION AND SORTING OF PARTICLES USING TUNABLE STANDING SURFACE ACOUSTIC WAVE - An apparatus for manipulating particles uses tunable standing surface acoustic waves includes a channel defined on a substrate and a pair of variable frequency interdigital transducers. The channel is disposed asymmetrically between the transducers such that the zero order node location is outside of a working region in the channel. | 08-01-2013 |
20140033808 | HIGH-EFFICIENCY SEPARATION AND MANIPULATION OF PARTICLES AND CELLS IN MICROFLUIDIC DEVICE USING SURFACE ACOUSTIC WAVES AT AN OBLIQUE ANGLE - An apparatus for manipulating particles within a fluid sample includes a substrate having a substrate surface. A surface acoustic wave (SAW) generator generates a SAW within a SAW region of the substrate surface. The SAW has an SAW direction aligned with a pressure node. A channel is configured to receive the fluid sample and the fluid sample has a flow direction which is at an oblique angle to the SAW direction. | 02-06-2014 |
20140146634 | SPATIOTEMPORAL CONTROL OF CHEMICAL MICROENVIRONMENT USING OSCILLATING MICROSTRUCTURES - Apparatuses and methods for generating a chemical gradient within a flow channel include providing at least one bubble support structure within the flow channel. A bubble support structure helps maintain a bubble at a predetermined location in flow channel when a fluid flow passes therethrough. Oscillations are induced in the bubble using acoustic waves, which may be provided by a piezoelectric transducer located proximate the flow channel. Two or more inlets provide fluids of different chemical compositions into the flow channel, and bubble oscillations are used to generate a dynamically controllable mixing process. | 05-29-2014 |
20150017023 | APPARATUSES AND METHODS FOR MODULATING FLUIDS USING ACOUSTICALLY OSCILLATING SOLID STRUCTURES - An acoustofluidic apparatus is provided that functions by the generation of microstreaming in fluid produced by the oscillation of oscillatory elements excited by an energy input such as acoustic energy. An acoustofluidic apparatus includes an oscillatory energy field generator in energetic contact with one or more oscillatory elements contained in a fluid passage. Oscillation of the oscillatory elements induces microstreaming in a fluid that can be used to mix laminar flows of differing fluids, as a micropump for the directional movement of fluid through a fluid passage, for the generation of waveforms in a fluid or plurality of fluids or for other purposes. | 01-15-2015 |
20150104845 | ACOUSTIC MANIPULATION PROCESS AND ACOUSTIC MANIPULATION DEVICE - An acoustic manipulation process and acoustic manipulation device are disclosed. The acoustic manipulation process includes providing a device having a pathway positioned to receive a flow of a particle-containing fluid, transporting the particle-containing fluid into the pathway, and applying standing surface acoustic waves to the particle-containing fluid while the particle-containing fluid is flowing through the pathway. The applying of the standing surface acoustic waves to the particle-containing fluid includes nodes and anti-nodes of the standing surface acoustic waves extending through the particle-containing fluid. The acoustic manipulation device includes a pathway positioned to receive a flow of a particle-containing fluid, and a mechanism for generating and applying standing surface acoustic waves to the particle-containing fluid while the particle-containing fluid is flowing through the pathway. | 04-16-2015 |
Wenlin Huang, Chadds Ford, PA US
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20130028868 | CLINICAL APPLICATIONS OF A RECOMBINANT HUMAN ENDOSTATIN ADENOVIRUS (E10A) INJECTION - The present invention relates to the genetic engineering field of angiogenesis-targeted therapy. Particularly, a recombinant human endostatin adenovirus injection is used along with certain antitumor agents for treating specific tumors. The methods of the invention offer significant improvement of effective response rate, disease control rate, survival and quality of life. The injection and treatment has no significant adverse reactions and side effects. | 01-31-2013 |
20130095558 | PROCESS FOR PRODUCING RECOMBINANT HUMAN ENDOSTATIN ADENOVIRUS - This invention discloses a production process for recombinant human endostatin adenovirus in order to optimize the procedure for small batch and mass industrialization. Exemplary process include steps of: (1) fermentation of eukaryotic cells (HEK293 cells) in the condition of 37° C. and 5% CO | 04-18-2013 |
20130216499 | COMPOSITIONS OF RECOMBINANT HUMAN ENDOSTATIN ADENOVIRUS INJECTIONS AND METHODS OF PRODUCTION - The invention generally relates to compositions of and methods for production of recombinant adenoviruses that carry therapeutic genes. More particularly, the invention relates to lyophilized recombinant adenoviruses injection and its related production procedures, including production procedures for the recombinant adenovirus vectors (or other viral vectors) that carry the genes of human endostatins. | 08-22-2013 |
Xiaoke Huang, Pittsburgh, PA US
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20150097836 | WEB BASED FAST QUERY VISUALIZATION OF TIME-VARYING MULTI-VARIATE VESSEL FLOW FIELD BY USING UNIFORM PARTITION STRATEGY - A method for visualizing flow data from computation fluid dynamics (CFD) applications in 2-dimensions (2D) includes receiving a 3-dimensional (3D) image volume from a CFD simulation of fluids flowing through vessels in a patient that is a snapshot of a fluid flow in the vessels at a certain time, subdividing the 3D image volume into 3D data blocks, minimizing a sum over a matrix of energy interactions defined for each pair of data blocks in the 3D image volume, where the minimization preserves a local shape of the vessels, where minimizing the sum over the matrix of energy interactions is performed on a graphics processing unit (GPU), and using the minimized energy interaction matrix to display on a monitor a 2D sketch of the 3D image volume, where the 2D sketch is displayed in real-time with respect to the time scale of the CFD simulation. | 04-09-2015 |
Xiaolei Huang, Bethlehem, PA US
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20090148013 | System and Methods for Generating Three-Dimensional Images From Two-Dimensional Bioluminescence Images and Visualizing Tumor Shapes and Locations - A system and methods for generating 3D images ( | 06-11-2009 |
20130070992 | System and Method for Generating Three-Dimensional Images From Two-Dimensional Bioluminescence Images and Visualizing Tumor Shapes and Locations - A system and methods for generating 3D images from 2D bioluminescent images and visualizing tumor locations are provided. A plurality of 2D bioluminescent images of a subject are acquired using any suitable bioluminescent imaging system. The 2D images are registered to align each image and to compensate for differences between adjacent images. After registration, corresponding features are identified between consecutive sets of 2D images. For each corresponding feature identified in each set of 2D images, an orthographic projection model is applied, such that rays are projected through each point in the feature. The intersection points of the rays are plotted in a 3D image space. All of the 2D images are processed in the same manner, such that a resulting 3D image of a tumor is generated. | 03-21-2013 |
Xiaoming Huang, State College, PA US
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20090042091 | Supported catalyst layers for direct oxidation fuel cells - A method of fabricating a supported catalyst layer for use in a fuel cell electrode, comprises sequential steps of: combining a fluid ink including a supported catalyst comprising at least one precious metal or alloy supported on particles of a support material, and a solution of at least one ionomeric polymer material, with at least one pore-forming material; forming a layer of the combined ink on a surface of a sheet of support material; hot pressing the layer; and treating the hot-pressed layer to remove pore-forming material to form a supported catalyst layer. | 02-12-2009 |
20110200914 | HIGH POWER DIRECT OXIDATION FUEL CELL - A high power density direct oxidation fuel cell (DOFC) with comprising an anode electrode with a microporous layer (MPL) configured to alleviate cathode dryout and thus reduce electrode resistance in the cathode that interfaces with a hydrocarbon membrane. The MPL is configured to alleviate cathode dryout by comprising a fluoropolymer and an electrically conductive material, wherein the MPL is loaded with fluoropolymer in the range from about 10 to about 25 wt. %. | 08-18-2011 |
Xinghui Huang, Pittsburgh, PA US
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20090154004 | Servo architecture for high areal density data storage - A track accessing mechanism includes a track accessing arm actuable by a primary actuation device for accessing concentric data tracks on a storage medium and at least one slider attached to the track accessing arm. The at least one slider includes a servo head configured to read positional information from a plurality of continuous, concentric rings radially spaced apart from each other on a storage medium and a data head configured to read and write user data to the least one concentric data track. At least a portion of each ring includes servo information. The at least one data track is positioned between each continuous, concentric ring on the storage medium. | 06-18-2009 |
Yifang Huang, City Lansdale, PA US
Yifang Huang, Lansdale, PA US
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20110105562 | ALKYNYL DERIVATIVES USEFUL AS DPP-1 INHIBITORS - The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1. | 05-05-2011 |
20110224209 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) - The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1. | 09-15-2011 |
Yixian Huang, Pittsburgh, PA US
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20150065443 | EMBELIN-BASED DELIVERY SYSTEM FOR WATER-INSOLUBLE ACTIVE AGENTS - A composition having a structure of: | 03-05-2015 |
20150231271 | FORMULATIONS AND CARRIER SYSTEMS INCLUDING FARNESYLTHIOSALYCYLIC MOITIES - A method of forming or creating a formulation for a compound to be delivered includes creating a carrier agent by conjugating at least one hydrophobic domain or hydrophobic compound with at least one hydrophilic domain or hydrophilic compound and associating the compound to be delivered with the carrier agent to create the formulation. The at least one hydrophobic compound has the formula: | 08-20-2015 |
Zhiyi Huang, Philadelphia, PA US
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20140379462 | REAL-TIME PREDICTION MARKET - A real-time prediction market is described. A plurality of predictor agents set forth respective predictions as to a likelihood that an advertisement will be selected when displayed together with certain publisher content. The advertisement is selected from amongst a plurality of advertisements based upon the plurality of predictions set forth by the plurality of predictor agents. Third parties corresponding to the predictor agents are compensated or penalized as a function of predictive accuracy of the predictor agents. | 12-25-2014 |
20140380321 | ENERGY EFFICIENT JOB SCHEDULING - The subject disclosure is directed towards scheduling jobs with a speed for running a processor(s) having variable speeds to save energy yet complete in time, in which the volume of the job is not known in advance, that is, in a non-clairvoyant setting. A non-clairvoyant algorithm uses an existing clairvoyant algorithm to determine the speed based upon information known from running one or more jobs, in full or in part. Also described is rounding jobs based upon their densities into rounding queues so that a hybrid of highest density first rules and FIFO rules may be used to obtain information used by the clairvoyant algorithm. | 12-25-2014 |