Day, PA
Andrew Phelps Day, Newtown, PA US
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20140108033 | HEALTHCARE ENTERPRISE SIMULATION MODEL INITIALIZED WITH SNAPSHOT DATA - Snapshot data may be received indicative of a current state of resources that deliver healthcare to a plurality of patients associated with a healthcare enterprise. The received snapshot data may be automatically used to initialize a healthcare enterprise simulation model. The healthcare enterprise simulation model may then be executed to automatically generate a predicted future state of the resources at a predetermined point in time. Some embodiments may automatically suggest mitigation strategies based on simulated scenarios reflecting potential bottlenecks and appropriate actions that may be taken by the enterprise. The system may continuously and automatically monitor forecast accuracy to detect potential anomalies. | 04-17-2014 |
20140108034 | CONTINUOUS AUTOMATED HEALTHCARE ENTERPRISE RESOURCE ASSIGNMENT SYSTEM AND METHOD - Current resource data may be continuously and automatically received indicative of a current state of resources that are used to deliver healthcare to a plurality of patients associated with a healthcare enterprise. The current resource data may be automatically used to update a healthcare enterprise simulation model. The healthcare enterprise simulation model may be executed to automatically generate a predicted future state of the resources. A resource request may then be received, and a resource assignment engine may automatically assign a particular resource to the resource request based at least in part on the predicted future state of the resources. | 04-17-2014 |
20140108035 | SYSTEM AND METHOD TO AUTOMATICALLY ASSIGN RESOURCES IN A NETWORK OF HEALTHCARE ENTERPRISES - According to some embodiments, first current resource data indicative of a current state of first resources that are used to deliver healthcare to a plurality of patients associated with a first healthcare enterprise is continuously and automatically received. The first current resource data may be automatically used to update a healthcare enterprise simulation model. The healthcare enterprise simulation model may automatically generate a predicted future state of the first resources, wherein the predicted future state of the first resources is based at least in part on second resource data indicative of a state of second resources that are used to deliver healthcare to a plurality of patients associated with a second healthcare enterprise remote from and networked with the first healthcare enterprise. | 04-17-2014 |
Billy W. Day, Pittsburgh, PA US
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20090036691 | ANALOGS OF DICODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF - A compound of the following structure: | 02-05-2009 |
20110190241 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX - Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3-diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-I viral replication in vitro. | 08-04-2011 |
20120122992 | SMALL MOLECULE INHIBITORS OF Dusp6 AND USES THEREFOR - Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses. | 05-17-2012 |
20140081054 | CLASS OF HDAC INHIBITORS EXPANDS THE RENAL PROGENITOR CELLS POPULATION AND IMPROVES THE RATE OF RECOVERY FROM ACUTE KIDNEY INJURY - The invention concerns separation methods and systems including those comprising a continuous chromatographic simulated moving bed integrated with vapor compression distillation to create a high efficiency separations platform applicable to a broad range of separation functions. | 03-20-2014 |
20140128388 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX - Drug candidates for inhibition of HIV-1 replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3-diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-1 viral replication in vitro. | 05-08-2014 |
20140161877 | PEDERIN AND PSYMBERIN AGENTS - Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The psymberin scaffold includes a substituent at the C8 and/or C11 positions that may include a linker that may be conjugated to a targeting moiety. The pederin/psymberin chimera scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The pederin, psymberin or pederin/psymberin chimera scaffold may be modified to include substituents at positions other than the C10 or C13 of pederin, or the C8 and C11 of psymberin. | 06-12-2014 |
20150246939 | Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury - Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided. | 09-03-2015 |
Billy W. Day, Upper St. Clair, PA US
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20150291534 | COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS - Disclosed herein are embodiments of a compound capable of treating HIV. In particular disclosed embodiments, the compound is capable of inhibiting Nef, such as by acting as antagonists of HIV Nef function. Also disclosed are embodiments of a method of making the compound, embodiments of a method of using the compound, and embodiments of a method of identifying HIV Nef antagonists. The disclosed compound may be used alone or in combination with other pharmacologically active agents in order to promote reducing drug resistance and/or cumulative toxicity. | 10-15-2015 |
Brad Day, Canonsburg, PA US
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20140091939 | ALARM ENHANCING PROECTIVE COVER FOR SAFETY INSTRUMENTS WITH OPTIONAL CALIBRATION CHAMBER - Methods and systems to redirect the audible and visible signals from alarms on a portable safety device. A cover ( | 04-03-2014 |
Deborah Day, Williamsport, PA US
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20150306063 | COMPOSITION AND METHOD FOR VAGINAL THERAPY - Provided are a composition and method for vaginal therapy. The composition includes a delivery compound and a pharmaceutically active agent dispersed in the delivery compound. The pharmaceutically active agent includes a centrally acting muscle relaxant. The method for vaginal therapy includes preparing a composition including a pharmaceutically active agent dispersed in a delivery compound, and administering the composition intravaginally. The pharmaceutically active agent includes a muscle relaxant. Another method includes administering the composition extravaginally and then administering the composition intravaginally. | 10-29-2015 |
James Clarence Day, North Wales, PA US
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20090084667 | Process for manufacturing high purity methacrylic acid - A process is provided herein for the high yield production of high purity glacial methacrylic acid (“HPMAA”) that is substantially pure, specifically 99% pure or greater with a water content of 0.05% or less. This improved process comprises providing a crude MAA stream and purifying the crude methacrylic acid stream in a series of successive distillation steps | 04-02-2009 |
James W. Day, Feasterville, PA US
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20100170197 | METHOD AND APPARATUS FOR ATTACHING A CUTTING BLADE TO A SUBSTRATE - A method and apparatus are provided for attaching a safety cutting blade onto a substrate, such as a cardboard blank. A piece of cutting blade material is cut to length and fed to a forming station that bends the piece to form a safety cutting blade having a plurality of cutting teeth. The cutting blade is fed to a crimping station where the cutting blade is mated with a substrate and affixed with the substrate. A transport then conveys the combined cutting blade and substrate away from the crimping station. | 07-08-2010 |
Jeffrey S. Day, Newtown, PA US
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20090068117 | STAY-ON SELENIUM FOAM - Provided, among other things, is a delivery module for a non-greasy, non-irritating selenium sulfide composition comprising: (A) an aerosol delivery device; (B) within the aerosol delivery device, the selenium sulfide composition comprising an effective amount of selenium sulfide that is 1% or more by weight of the composition, and a frothing agent, wherein the selenium sulfide composition has a viscosity low enough to support aerosol delivery and the selenium sulfide composition is effective to form a foam upon propellant-driven aerosol delivery; and (C) within the aerosol delivery device, a propellant. | 03-12-2009 |
20100092400 | Salicylic Acid Composition - Provided, among other things, is a delivery module for water-based salicylic acid composition comprising: an aerosol delivery system; within the aerosol delivery system, the salicylic acid composition comprising 0.5% or more salicylic acid by weight, lipophilic component(s), and a frothing agent, the salicylic acid composition having a viscosity low enough to support aerosol delivery, and the salicylic acid composition effective to form a foam upon propellant-driven aerosol delivery; and within the aerosol delivery system, a propellant, wherein the salicylic acid composition is non-irritating and has a non-watery feel. | 04-15-2010 |
20150209279 | STAY-ON SELENIUM FOAM - Provided, among other things, is a delivery module for a non-greasy, non-irritating selenium sulfide composition comprising: (A) an aerosol delivery device; (B) within the aerosol delivery device, the selenium sulfide composition comprising an effective amount of selenium sulfide that is 1% or more by weight of the composition, and a frothing agent, wherein the selenium sulfide composition has a viscosity low enough to support aerosol delivery and the selenium sulfide composition is effective to form a foam upon propellant-driven aerosol delivery; and (C) within the aerosol delivery device, a propellant. | 07-30-2015 |
Kenneth Day, Harleysville, PA US
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20100062061 | Method For Making Cetirizine Tablets - In one aspect, the present invention features a method of producing a tablet including cetirizine including the steps of: (i) mixing cetirizine, a polyol, and a solvent for the cetirizine to form a cetirizine:polyol complex, wherein the solvent comprises water and an alkalizing agent and has a pH from about 2 to about 7; (ii) isolating particles of the cetirizine:polyol complex from the mixture; and (iii) forming the particles into a tablet. | 03-11-2010 |
20130295174 | TABLET COMPRISING A FIRST AND SECOND REGION - In one aspect, the present invention features a tablet including a first region and a second region, wherein: (i) the first region and the second region each include at least 10%, by volume, of the tablet; (ii) the first region includes a pharmaceutically active agent and the composition of the first region is different from the composition of the second region; (iii) the first region has a density less than about 0.8 g/cc; and (iv) the first region disintegrates in the mouth when placed on the tongue in less than about 30 seconds; wherein the shape of the tablet includes two opposing major faces separated by a side wall, and the interface between the first region and the second region is along at least one major face of the tablet. | 11-07-2013 |
20130295175 | ORALLY DISINTEGRATING TABLET - The present invention features a tablet containing at least one first material, at least one second material, and at least one pharmaceutically active agent, wherein: | 11-07-2013 |
Mark Day, Phoenixville, PA US
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20110053956 | Treatment for Neurological and Mental Disorders - Methods for treating neurological or mental disorders in humans and the symptoms associated therewith are provided by administering eltoprazine and/or related compounds. In some embodiments, specific symptoms are treated by administering eltoprazine and/or a related compound in an effective amount to ameliorate the symptoms. Of particular significance are symptoms that are associated with cognitive dysfunction where eltoprazine will improve the symptoms and the disorder associated with that symptom. Of particular interest are non-ADHD-associated inattention, hyperactivity and impulsiveness. The methods provided herein are especially useful for improving functional recovery after CNS injury such as stroke where improved cognitive function will facilitate the acquisition of learning and memory of rehabilitative tasks. | 03-03-2011 |
20120071495 | Treatment for Neurological and Mental Disorders - Methods for treating neurological or mental disorders in humans and the symptoms associated therewith are provided by administering eltoprazine and/or related compounds. In some embodiments, specific symptoms are treated by administering eltoprazine and/or a related compound in an effective amount to ameliorate the symptoms. Of particular significance are symptoms that are associated with cognitive dysfunction where eltoprazine will improve the symptoms and the disorder associated with that symptom. Of particular interest are non-ADHD-associated inattention, hyperactivity and impulsiveness. The methods provided herein are especially useful for improving functional recovery after CNS injury such as stroke where improved cognitive function will facilitate the acquisition of learning and memory of rehabilitative tasks. | 03-22-2012 |
Nicole Day, West Norriton, PA US
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20110027294 | Anti-Respiratory Syncytial Virus Antibodies, Antigens and Uses Thereof - Anti-Respiratory Syncytial Virus (RSV) monoclonal antibodies, RSV F protein antigens and their uses are disclosed. | 02-03-2011 |
Robert Day, Newtown, PA US
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20140301980 | METHODS FOR THE TREATMENT OF PSORIATIC ARTHRITIS USING APREMILAST - Methods of treating, managing or preventing psoriatic arthritis are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with a second active agent. | 10-09-2014 |
20150174100 | METHODS FOR THE TREATMENT OF PSORIATIC ARTHRITIS USING APREMILAST - Methods of treating, managing or preventing psoriatic arthritis are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with a second active agent. | 06-25-2015 |
Steve A. Day, Pittsburgh, PA US
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20140362714 | NETWORK-SELECTING HYBRID FIBER COAXIAL MONITOR, SYSTEM INCLUDING SAME AND METHOD OF EMPLOYING - A device for monitoring a hybrid fiber coaxial network. The device includes a processing device and a switching mechanism in communication with, and controlled by, the processing device. The processing device is structured to receive data related to the hybrid fiber coaxial network and communicate the data via at least one of a plurality of communication pathways. The switching mechanism is structured to select from among the communication pathways the at least one pathway along which the data from the processing device is communicated in accordance with logic carried out by the processing device. The plurality of communication pathways comprises a communication pathway other than the hybrid fiber coaxial network. | 12-11-2014 |
Steven P. Day, Zelienople, PA US
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20090240449 | Power Distribution Monitoring System And Method - A power distribution monitoring system includes a number of power line mounted monitors. Each monitor can acquire data regarding the delivery of electrical power in the power line, wirelessly transmit and receive messages, and electromagnetically acquire and store operating electrical power from electrical current flowing in the power line. The system also includes an aggregator that can wirelessly transmit and receive messages and wirelessly output beacon messages. In response to beacon signals wirelessly output by the aggregator, each monitor co-acts with the aggregator to dynamically build a wireless communication network for the wireless communication of the data acquired by the monitor regarding the delivery of electrical power in the power line to the aggregator. | 09-24-2009 |
Thomas Day, West Chester, PA US
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20120210382 | Content Archive Model - An archive model can be used for managing networked storage of recorded content, such as network DVR (digital video recorder) content. Content may be initially recorded to an active storage device, with individual duplicate copies recorded for each requesting user, and subsequently archived to an archive storage device. For playback, the content can be reconstituted into the active storage device prior to delivery to the requesting user. Content can be predictively reconstituted in anticipation of user needs, and the reconstitution capacity of the system can be dynamically reallocated for load balancing. | 08-16-2012 |
20150242500 | Content Archive Model - An archive model can be used for managing networked storage of recorded content, such as network DVR (digital video recorder) content. Content may be initially recorded to an active storage device, with individual duplicate copies recorded for each requesting user, and subsequently archived to an archive storage device. For playback, the content can be reconstituted into the active storage device prior to delivery to the requesting user. Content can be predictively reconstituted in anticipation of user needs, and the reconstitution capacity of the system can be dynamically reallocated for load balancing. | 08-27-2015 |