Chen, Waltham
Brendan Chen, Waltham, MA US
Patent application number | Description | Published |
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20150073011 | Beta-Lactamase Inhibitor Compounds - The present invention is directed to compounds which are beta-lacatamase inhibitors. The compounds and their pharmaceutically acceptable salts, are useful in combination with beta-lactam antibiotics, or alone, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to formula (Ia): | 03-12-2015 |
Christine Hiu-Tung Chen, Waltham, MA US
Patent application number | Description | Published |
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20090247547 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B - The present teachings relate to compounds of Formula I: | 10-01-2009 |
20110053925 | Hydroxamate-Based Inhibitors of Deacetylases - The present teachings relate to compounds of Formula I: | 03-03-2011 |
20110060009 | Hydroxamate-Based Inhibitors of Deacetylases - The present teachings relate to compounds of Formula I: | 03-10-2011 |
20130005663 | SMAC PEPTIDOMETICS USEFUL AS IAP INHIBITORS - The present invention is directed to a compound of the formula: | 01-03-2013 |
20130231373 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES - The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R | 09-05-2013 |
20140004101 | SMAC PEPTIDOMETICS USEFUL AS IAP INHIBITORS | 01-02-2014 |
Hongmin Chen, Waltham, MA US
Patent application number | Description | Published |
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20090238224 | Directly Modulated Laser with Isolated Modulated Gain Electrode for Improved Frequency Modulation - A DBR laser, such as a semiconductor DBR laser is disclosed having improved frequency modulation performance. The laser includes a split gain electrode and a tuning electrode. A modulating current encoding a data signal is injected into a first section of the gain electrode whereas a substantially DC bias voltage is imposed on a second section of the gain electrode positioned between the first gain electrode and the tuning electrode. The first and second gain electrodes are electrically isolated from each other and the tuning electrode by a large isolation resistance. In some embodiments, the isolation resistance is generated by forming the electrodes on a P+ layer and removing portions of the P+ layer between adjacent electrodes. Capacitors may couple to one or both of the second gain electrode and the tuning electrode. | 09-24-2009 |
20090269069 | PASSIVE WAVE DIVISION MULTIPLEXED TRANSMITTER HAVING A DIRECTLY MODULATED LASER ARRAY - An wave division multiplexed (WDM) optical transmitter is disclosed including a directly modulated laser array and a planar lightwave chip (PLC) having a plurality of OSRs that receive outputs of the laser array and increase the extinction ratio of the received light. An optical multiplexer receives the outputs of the OSRs and couples them to a single output port. The multiplexer has transmission peaks through its ports each having a 0.5 dB bandwidth including the frequency of a laser in the array. The optical multiplexer may be embodied as cascaded Mach-Zehnder interferometers or ring resonators. | 10-29-2009 |
Weirong Chen, Waltham, MA US
Patent application number | Description | Published |
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20090036419 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS - The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. | 02-05-2009 |
20100130515 | Polymorphs and solvates of a pharmaceutical and method of making - Polymorphic and solvated forms of solid 3-(4-amino-3-methylbenzyl)-7-(furan-2-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine, and methods of making them, are described. | 05-27-2010 |
20100173914 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME - Compounds that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning. | 07-08-2010 |
20130065858 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS - The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. | 03-14-2013 |
20150080568 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS - The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. | 03-19-2015 |
20150126745 | SYNTHESIS OF AMINE SUBSTITUTED 4,5,6,7-TETRAHYDROBENZOTHIAZOLE COMPOUNDS - The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process. | 05-07-2015 |
Xiaoxi (kevin) Chen, Waltham, MA US
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20090023897 | METHOD AND APPARATUS FOR PURIFYING AND DESALTING BIOLOGICAL SAMPLES - The subject invention provides a sample processing technique for purifying a biological or chemical sample. The invention is particularly well-suited to prepare a sample for mass spectrometry. The process is to be performed in an article having at least one well, in which the surface of the well is at least partially hydrophobic and/or modified with bio-specific ligands. Targeted solutes, such as salts or small molecule contaminants, can be removed from a solution to allow for a purified solution of a desired type of solute, such as peptides and/or proteins. | 01-22-2009 |
Yong-Min Chen, Waltham, MA US
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20160077927 | METHODS AND APPARATUS FOR MANAGING A LARGE-SCALE ENVIRONMENT OF COPY DATA MANAGEMENT APPLIANCES - Techniques disclosed herein provide for global management of a set of data management services being executed by at least one of one or more physical data management appliances and one or more virtual data management appliances. First instructions are transmitted to a first copy data management appliance that cause the first copy data management appliance to send first data associated with protecting a first application entity to the management server. Second instructions are transmitted to a second copy data management appliance that cause the second copy data management appliance to send second data associated with protecting a second application entity to the management server. A plurality of data management policies associated with the first copy data management appliance and the second copy data management appliance are scheduled using a third service level template, which includes a merged set of schedules for the first and second copy data management appliances. | 03-17-2016 |
20160078080 | GUARDRAILS FOR COPY DATA STORAGE - Techniques are disclosed for preventing a user from configuring a service level agreement from creating a data management schedule that creates a set of data backups that exceeds data resource limits available for storing the set of data backups. A first amount of pool resources associated with the backup of each of the at least one application is determined according to a received schedule. A first amount of data volumes associated with the backup of each of the at least one application is determined according to the received schedule. A resource shortage warning is transmitted when the aggregate amount of pool resources exceeds an available amount of pool resources or the aggregate amount of data volume resource exceeds an available amount of data volume resource, thereby preventing a user from configuring a service level agreement that exceeds data resource limits. | 03-17-2016 |