Sutton, MA
Amanda Sutton, Hingham, MA US
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20080287474 | Antiproliferative Pyrimidyl, Fused Pyrimidyl and Pyrimidyl Hydrazones - The present invention is related to a novel series of pyrimidyl or fused pyrimidyl hydrazones. Compounds of Formula (I) wherein A is selected from the group consisting of Formulas (A1), (A2), (A3), (A4), (A5) are useful for the treatment and/or prevention of a proliferative disease. | 11-20-2008 |
20120238575 | ANTIPROLIFERATIVE PYRIMIDYL, FUSED PYRIMIDYL AND PYRIMIDYL HYDRAZONES - The present invention is related to a novel series of pyrimidyl or fused pyrimidyl hydrazones. Compounds of Formula (I) wherein A is selected from the group consisting of Formulas (A1), (A2), (A3), (A4), (A5) are useful for the treatment and/or prevention of a proliferative disease. | 09-20-2012 |
Amanda E. Sutton, Hingham, MA US
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20110053906 | PROTEIN KINASE INHIBITORS AND USE THEREOF - Disclosed are benzonaphthyridinyl derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to kinase signal transduction inhibition, regulation or modulation. | 03-03-2011 |
20110269758 | NAPHTHYRIDINONES AS PROTEIN KINASE INHIBITORS - Naphthyridinone derivative compounds that inhibit Aurora kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and/or disturbed Aurora kinases such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases. | 11-03-2011 |
20110282056 | PROTEIN KINASE INHIBITORS AND USE THEREOF - Disclosed are compounds according to Formula I: | 11-17-2011 |
20110312951 | C-Ring Modified Tricyclic Benzonaphthiridinone Protein Kinase Inhibitors and Use Thereof - Disclosed are C-ring modified tricyclic benzonaphthiridinone compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation. | 12-22-2011 |
20120022060 | Tricyclic Azaindoles - Disclosed are dipyridyl-pyrrole derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation. | 01-26-2012 |
20120046269 | Novel Amino Azaheterocyclic Carboxamides - The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer. | 02-23-2012 |
20120190654 | NOVEL BICYCLIC UREA COMPOUNDS - The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer. | 07-26-2012 |
20120277228 | Novel Azaheterocyclic Compounds - The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer. | 11-01-2012 |
20130137677 | Bicyclic Azaheterocyclic Carboxamides - The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer. | 05-30-2013 |
20130225569 | FUROPYRIDINE DERIVATIVES - Compounds of the formula I | 08-29-2013 |
20140107156 | Novel Amino Azaheterocyclic Carboxamides - The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer. | 04-17-2014 |
Amy Sutton, Cambridge, MA US
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20120094382 | MOLECULAR DELIVERY WITH NANOWIRES - A molecular delivery system including a plurality of nanowires (e.g., Si NWs), each of the nanowires having a surface layer formed of a silicon-containing material and a covalently bound linker (e.g., silane linker) attached to the surface layer and optionally including a substrate to which the nanowires are adhered or a molecule to be delivered attached to the linker. Also disclosed is a method of delivering into a cell an exogenous molecule. | 04-19-2012 |
20130260467 | MOLECULAR DELIVERY WITH NANOWIRES - A molecular delivery device including a plurality of nanowires (e.g., Si NWs) coated with an electrically conductive layer. Also disclosed are methods for delivering a molecule by nanowire-mediated electroporation. | 10-03-2013 |
Amy Alexandra Sutton, Cambridge, MA US
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20150093823 | Environmentally Responsive Microstructured Hybrid Actuator Assemblies For Use in Mechanical Stimulation of Cells - A method for mechanical stimulation of cells includes providing a substrate comprising a plurality of microactuators embedded in an environmentally responsive hydrogel polymer layer disposed on a region of the surface; adhering at least one cell to the substrate; and exposing the environmentally responsive hydrogel polymer layer to a stimulus, the stimulus changing a volume of the environmentally responsive hydrogel polymer layer from a first volume to a second volume and thereby moving the microactuators from a first position to a second position, wherein the movement of the microactuators provides localized mechanical force directly to cells on the substrate. | 04-02-2015 |
Eric Sutton, Roslindale, MA US
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20090322790 | SYSTEM AND METHOD FOR STREAMLINING USER INTERACTION WITH ELECTRONIC CONTENT - Various aspects and embodiments are directed to a graphical user interface that organizes interface elements into views of computer content for presentation to a user. Different views of are used to provide an interface that is responsive to configurations of the device and responsive to activity being performed by the user. Aspects include permitting the user to transition the device from one configuration to another during its use, for example from easel to laptop modes. Further the elements that comprise the graphical user interface are configured to present a summarized view of available actions and content, in order to simplify user interaction. The different views present different organizations of the interface elements and in some example display only certain ones of the modes of content in order to reduce the number of options a user must navigate to accomplish an objective. According to another aspect, methods and systems for streamlining user interaction with computer content are provided. In some embodiments, streamlining includes pre-configuring a user device based on received information. Other embodiments include presenting consistent visual representations used to navigated to views that present computer content. | 12-31-2009 |
Jeffrey Sutton, Raynham, MA US
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20100268151 | Intracranial Implant Emitting Light Between 450 nm and 600 nm - An intracranial implant emitting light having a wavelength between blue and yellow light | 10-21-2010 |
Jeffrey Sutton, Medway, MA US
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20080221652 | Red Light Implants for Treating Degenerative Disc Disease - Red light-emitting implants for treating degenerative disc disease. | 09-11-2008 |
20100152777 | Anti-Infective Spinal Rod with Surface Features - Mechanical modifications to a spinal rod that will enable the rod to accept various coating technologies in such a way that the spinal construct's biomechanical performance is not compromised. These modifications preserve construct biomechanics in the presence of a coating and increase the bactericidal payload of an anti-infective spinal rod coating. | 06-17-2010 |
20100222777 | WINDOWED THERMAL ABLATION PROBE - A method and apparatus for treating an intraosseous nerve. The method includes positioning a hollow shaft through the cortical shell of a vertebral body and into a cancellous bone region of the vertebral body. The hollow shaft includes an annular wall having a longitudinal bore therein, a proximal portion and a distal portion, and a first window extending transversely through the annular wall. An electrosurgical probe is advanced within the longitudinal bore from the proximal portion toward the distal portion. The electrosurgical probe includes a first treatment element at a distal end of the probe, wherein the first treatment element being in electrical connection with a power supply. The first treatment element is slidably disposed within the longitudinal bore so that the first treatment element is advanced radially outward from the window and shaft to affect treatment of the intraosseous nerve within the cancellous bone region. | 09-02-2010 |
20130103022 | THERMAL DENERVATION DEVICES AND METHODS - A method and apparatus for treating an intraosseous nerve. The method includes positioning a hollow shaft through the cortical shell of a vertebral body and into a cancellous bone region of the vertebral body. The hollow shaft includes an annular wall having a longitudinal bore therein, a proximal portion and a distal portion, and a first window extending transversely through the annular wall. An electrosurgical probe is advanced within the longitudinal bore from the proximal portion toward the distal portion. The electrosurgical probe includes a first treatment element at a distal end of the probe, wherein the first treatment element being in electrical connection with a power supply. The first treatment element is slidably disposed within the longitudinal bore so that the first treatment element is advanced radially outward from the window and shaft to affect treatment of the intraosseous nerve within the cancellous bone region. | 04-25-2013 |
Jeffrey K. Sutton, Raynham, MA US
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20100317948 | Photocatalytic Implant Having a Sensor - An implant comprises a photocatalytic layer on at least one surface and is adapted to act as a sensor. In some embodiments, the photocatalytic layer is a semiconductor oxide that is doped. According to some embodiments, the implant comprises a wave guide. According to some embodiments the implant comprises a light port. According to some embodiments, the implant comprises a reflective material on a surface of the waveguide. According to some embodiments the implant comprises a composite material comprising a first material that has a transmissivity when exposed to a predetermined wavelength of light and a second material that has photocatalytic activity when exposed to the predetermined wavelength of light. According to some embodiments the implant comprises a light source adapted to irradiate the photocatalytic surface. | 12-16-2010 |
Jeffrey K. Sutton, Medway, MA US
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20110244759 | Orthopaedic Component Manufacturing Method and Equipment - A system for use in preparing an articulating surface of a component of an orthopaedic implant is provided. The system includes a magnetorheological polishing fluid including a carrier fluid and a plurality of particles suspendable in said carrier fluid. The system also includes a vessel for containing the Magnetorheological polishing fluid. The system also includes a mechanism for delivering the fluid to form a polishing zone and a holder for securing the component and for moveably positioning the articulating surface of the component relative to the polishing zone. The system further includes a controller for determining the rate of material removal from the object, for determining the direction and velocity of movement of the polishing zone relative to the object and for determining the number of cycles of polishing required. | 10-06-2011 |
20140243937 | Red Light Implant for Treating the Spine - Red light-emitting implants for treating a spine. | 08-28-2014 |
20150057658 | THERMAL DENERVATION DEVICES AND METHODS - A method and apparatus for treating an intraosseous nerve. The method includes positioning a hollow shaft through the cortical shell of a vertebral body and into a cancellous bone region of the vertebral body. The hollow shaft includes an annular wall having a longitudinal bore therein, a proximal portion and a distal portion, and a first window extending transversely through the annular wall. An electrosurgical probe is advanced within the longitudinal bore from the proximal portion toward the distal portion. The electrosurgical probe includes a first treatment element at a distal end of the probe, wherein the first treatment element being in electrical connection with a power supply. The first treatment element is slidably disposed within the longitudinal bore so that the first treatment element is advanced radially outward from the window and shaft to affect treatment of the intraosseous nerve within the cancellous bone region. | 02-26-2015 |
Joan E. Sutton, Medway, MA US
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20120243200 | Personal video lighting system - A personal video lighting system to provide enhanced facial illumination for use with a personal computer and video communication. | 09-27-2012 |
Jonathon Sutton, Concord, MA US
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20140089980 | SYSTEM AND METHOD FOR MODIFYING ADVERTISEMENT RESPONSIVE TO EPG INFORMATION - A system and method for utilizing data stored in an EPG database for modifying advertisement information. In this way, a service provider and/or an advertiser can transmit a single advertisement to all the television stations regardless of their geographic location and other user specific information, and need not re-transmit the advertisement even if there is a change in the show's program description. When the advertisement is displayed, the correct updated information is retrieved from the EPG database and inserted into the advertisement. | 03-27-2014 |
20140208362 | SYSTEM AND METHOD FOR MODIFYING ADVERTISEMENT RESPONSIVE TO EPG INFORMATION - A system and method for utilizing data stored in an EPG database for modifying advertisement information. In this way, a service provider and/or an advertiser can transmit a single advertisement to all the television stations regardless of their geographic location and other user specific information, and need not re-transmit the advertisement even if there is a change in the show's program description. When the advertisement is displayed, the correct updated information is retrieved from the EPG database and inserted into the advertisement. | 07-24-2014 |
Richard Sutton, Cambridge, MA US
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20150019719 | MAPPING/TRANSLATION TECHNIQUES FOR GENERATING ASSOCIATIONS BETWEEN NETWORK ADDRESSES AND ATTRIBUTES THAT WERE NOT DIRECTLY OBSERVED - In one embodiment, a mapping/translation technique is provided for generating an association between an observed network address and one or more attributes that are not directly observed. A network address is observed that is associated with a source device. A first attribute is determined, the first attribute being a directly observed attribute. The first attribute is mapped to a second attribute based on at least a predefined spatial, temporal, or identity-related correspondence between the first attribute and the second attribute, wherein the second attribute was not directly observed in connection with the network address. An association is generated between the second attribute and the network address. A record that maintains the association between the second attribute and the network address is stored. | 01-15-2015 |
20150019720 | DETERMINING FIXED/MOBILE AND PROXY/NON-PROXY NETWORK ADDRESSES - In one embodiment, a processing technique is provided for determining a refined attribute of a network address based on one or more other attributes. A network address associated with a source device in communication with a network is observed. One or more first attributes of the network address are determined, where the one or more first attributes indicate at least a spatial or temporal property of the network address. The one or more first attributes are processed to determine a second attribute to be associated with the network address, where the second attribute indicates whether the network address is a fixed or mobile network address, or is a proxy or non-proxy network address. A record is stored that maintains the association between the second attribute and the network address. | 01-15-2015 |
20150019738 | PROPAGATING ATTRIBUTES BETWEEN NETWORK ADDRESSES - In one embodiment, a technique is provided for propagating network address to attribute associations between network addresses. One or more profiles are obtained that maintain an association between a first network address and one or more attributes, the association produced from network address observations of the first network address by one or more source devices in communication with a network. A second network address is determined that is associated with the first network address based on a similarity criteria. The second network address initially lacks an association with the one or more attributes. The one or more attributes are propagated from the first network address to the second address, to form an association between the second network address and the one or more attributes. The association between the second network address and the one or more attributes is then stored in an updated profile. | 01-15-2015 |
20150019758 | PROCESSING MULTIPLE NETWORK ADDRESS OBSERVATIONS - In one embodiment, a processing technique is provided that utilizes multiple network address observations. One or more records are obtained that maintain network address observations, each network address observation associating one or more attributes with a network address observed by one or more source devices. Multiple network addresses from the network address observations are clustered into one or more discrete groups of network addresses based on a clustering criteria. For a selected group of network addresses, an association is formed associating one or more refined attributes derived from the selected group with an individual network address that is a member of the selected group. | 01-15-2015 |
20150020195 | ENSURING DATA QUALITY BY FILTERING NETWORK ADDRESS OBSERVATIONS - In one embodiment, a filtering technique is provided for ensuring data quality of network address observations. A network address observation is obtained of a network address associated with a source device, the network address observation associating the network address with one or more directly observed attributes. The network address observation is filtered based on a comparison of a selected one of the one or more directly observed attributes to a predetermined criteria, and using a result of the comparison as indicative of whether the network address observation should be used for association of the network address with one or more directly observed attributes. The filtering either associates one or more indicators with the network address observation, or removes the network address observation. A network address to attribute association system executed on one or more electronic devices stores a record that maintains any network address observation that has not been removed and any indicator. | 01-15-2015 |
Richard J. Sutton, Cambridge, MA US
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20130260797 | METHOD AND SYSTEM FOR CAPTURING AND PROVIDING TYPOLOGICAL AND CONTEXTUAL INFORMATION ABOUT A LOCATION BASED ON WIRELESS BEACONS - Systems and methods for providing contextual information about a place within a range of a wireless signal beacon are provided. A reference database of wireless beacons stores attributes associated with wireless beacons. Wireless-enabled devices and/or server systems receive information identifying wireless beacons in range of the wireless-enabled devices and determine a received signal strength indication of the wireless beacons. The wireless-enabled devices and/or server systems then retrieve from the reference database extended attributes that are associated with the wireless beacons and determine at least one associated contextual attribute about the place within range of the wireless beacons. | 10-03-2013 |
20140009339 | METHODS OF AND SYSTEMS FOR EXTRACTING PATTERNS OF HUMAN EXTENT AND DENSITY FROM GEOGRAPHICALLY ANCHORED RADIO SIGNAL SOURCES - A method of and system for estimating at least one of a human development level and a human activity level. A method of estimating at least one of a human development level and a human activity level includes estimating positions of radio broadcast beacons. The positions of the radio broadcast beacons are stored in an electronically readable catalog. Each of the positions is grouped into sets of positions. Each set of positions includes positions of one or more geographically-related radio broadcast beacons. For each of the sets, at least one of a human development level and a human activity level is estimated for an area encompassing the positions of the set. | 01-09-2014 |
20140287778 | Method and System for Capturing and Providing Typological and Contextual Information About a location based on wireless beacons - Systems and methods for providing contextual information about a place within a range of a wireless signal beacon are provided. A reference database of wireless beacons stores attributes associated with wireless beacons. Wireless-enabled devices and/or server systems receive information identifying wireless beacons in range of the wireless-enabled devices and determine a received signal strength indication of the wireless beacons. The wireless-enabled devices and/or server systems then retrieve from the reference database extended attributes that are associated with the wireless beacons and determine at least one associated contextual attribute about the place within range of the wireless beacons. | 09-25-2014 |