Patent application number | Description | Published |
20120130940 | REAL-TIME ANALYTICS OF STREAMING DATA - Storage media, systems and methods are disclosed herein for analyzing data streams in real time. More particularly, storage media, systems and methods are presented for processing data streams to calculate results for prospective queries. The results may be advantageously computed prior to the formulation of the specific query, for example, based on a pre-established framework of potential query parameters. More particularly, a universe of potential queries may be extrapolated from the pre-established framework of potential query parameters. Results for each of the potential queries may them be tracked in real time. For example, results for each of the potential queries may be continuously updated based on real-time processing of events in a data stream. | 05-24-2012 |
20120131047 | SOCIAL GENOME - Systems and methods are provided for processing a data stream in real time to identify connections between one or more social elements social elements and aggregating and storing the identified connections over a rolling time window. Social elements may be stored as nodes and connection between social elements may be stored as labeled connections between nodes. | 05-24-2012 |
20120131139 | PROCESSING DATA FEEDS - Exemplary embodiments allow performance of stream computations on real-time data streams using one or more map operations and/or one or more update operations. A map operation is a stream computation in which stream events in one or more real-time data streams are processed in a real-time manner to generate zero, one or more new stream events. An update operation is a stream computation in which stream events in one or more real-time data streams are processed in a real-time manner to create or update one or more static “slate” data structures that are stored in a durable manner. | 05-24-2012 |
20120209857 | DUAL WEB GRAPH - Scoring a document is disclosed. One or more metrics is determined in a forward direction. One or more backwards metrics is determined. The document is scored based at least in part on a combination of the metrics. | 08-16-2012 |
20120297278 | INCLUDING HYPERLINKS IN A DOCUMENT - Techniques for including a hyperlink in a document is disclosed. A document is received via a communications interface. An entity pair is determined by a processor. The entity pair includes a concept included in a concept taxonomy and a textual representation included in the document. As output, a hyperlink is provided. | 11-22-2012 |
20130103389 | Selecting Terms in a Document - Determining a mapping between a textual representation in a document and a concept is disclosed. A document is received. A set of candidate textual representations in the document is identified. For at least one candidate textual representation included in the set, an associated concept included in a taxonomy of concepts is determined. The candidate textual representation and the associated concept are provided as output. | 04-25-2013 |
20130290303 | Categorizing Documents - Categorizing documents is disclosed. A hierarchy of topics is received. A seed for each topic is determined. One or more documents is received. The seed is used to evaluate the relevance of each document to one or more of the received topics. One or more topics is associated with each document. | 10-31-2013 |
20130346625 | SYSTEMS AND METHODS FOR EVENT STREAM PROCESSING - Disclosed are systems and methods for processing events in an event stream using a map-update application. The events may be embodied as a key-attribute pair. An event is processed by one or more instances implementing either a map or an update function. A map function receives an input event from the event stream and publishes one or more events to the event stream. An update function receives an event and updates a corresponding slate and publishes zero or more events. Systems and methods are also disclosed herein for implementing a map-update application in a multithreaded architecture and for handling overloading of a particular thread or node. Systems and methods for providing access to slates updated according to update operations are also disclosed. | 12-26-2013 |
20130346970 | SYSTEMS AND METHODS FOR EVENT STREAM PROCESSING - Disclosed are systems and methods for processing events in an event stream using a map-update application. The events may be embodied as a key-attribute pair. An event is processed by one or more instances implementing either a map or an update function. A map function receives an input event from the event stream and publishes one or more events to the event stream. An update function receives an event and updates a corresponding slate and publishes zero or more events. Systems and methods are also disclosed herein for implementing a map-update application in a multithreaded architecture and for handling overloading of a particular thread or node. Systems and methods for providing access to slates updated according to update operations are also disclosed. | 12-26-2013 |
20130346989 | SYSTEMS AND METHODS FOR EVENT STREAM PROCESSING - Disclosed are systems and methods for processing events in an event stream using a map-update application. The events may be embodied as a key-attribute pair. An event is processed by one or more instances implementing either a map or an update function. A map function receives an input event from the event stream and publishes one or more events to the event stream. An update function receives an event and updates a corresponding slate and publishes zero or more events. Systems and methods are also disclosed herein for implementing a map-update application in a multithreaded architecture and for handling overloading of a particular thread or node. Systems and methods for providing access to slates updated according to update operations are also disclosed. | 12-26-2013 |
20130346990 | SYSTEMS AND METHODS FOR EVENT STREAM PROCESSING - Disclosed are systems and methods for processing events in an event stream using a map-update application. The events may be embodied as a key-attribute pair. An event is processed by one or more instances implementing either a map or an update function. A map function receives an input event from the event stream and publishes one or more events to the event stream. An update function receives an event and updates a corresponding slate and publishes zero or more events. Systems and methods are also disclosed herein for implementing a map-update application in a multithreaded architecture and for handling overloading of a particular thread or node. Systems and methods for providing access to slates updated according to update operations are also disclosed. | 12-26-2013 |
20130347005 | SYSTEMS AND METHODS FOR EVENT STREAM PROCESSING - Disclosed are systems and methods for processing events in an event stream using a map-update application. The events may be embodied as a key-attribute pair. An event is processed by one or more instances implementing either a map or an update function. A map function receives an input event from the event stream and publishes one or more events to the event stream. An update function receives an event and updates a corresponding slate and publishes zero or more events. Systems and methods are also disclosed herein for implementing a map-update application in a multithreaded architecture and for handling overloading of a particular thread or node. Systems and methods for providing access to slates updated according to update operations are also disclosed. | 12-26-2013 |
20140059185 | Processing Data Feeds - Exemplary embodiments allow performance of stream computations on real-time data streams using one or more map operations and/or one or more update operations. A map operation is a stream computation in which stream events in one or more real-time data streams are processed in a real-time manner to generate zero, one or more new stream events. An update operation is a stream computation in which stream events in one or more real-time data streams are processed in a real-time manner to create or update one or more static “slate” data structures that are stored in a durable manner. | 02-27-2014 |
20140089130 | SYSTEM AND METHOD FOR MAKING GIFT RECOMMENDATIONS USING SOCIAL MEDIA DATA - Disclose are methods for evaluating a user's interests and making gift recommendations using social media data. Interests and attributes of a user may be detected from social media content and products corresponding to the interests and attributes may be selected and presented as gift recommendations for the user. Methods are disclosed for resolving ambiguity as to interests reflected by textual data in social media content. Also disclosed are methods for inferring a user's interests from the interests of friends of the user. | 03-27-2014 |
20140089132 | SYSTEM AND METHOD FOR MAKING GIFT RECOMMENDATIONS USING SOCIAL MEDIA DATA - Disclose are methods for evaluating a user's interests and making gift recommendations using social media data. Interests and attributes of a user may be detected from social media content and products corresponding to the interests and attributes may be selected and presented as gift recommendations for the user. Methods are disclosed for resolving ambiguity as to interests reflected by textual data in social media content. Also disclosed are methods for inferring a user's interests from the interests of friends of the user. | 03-27-2014 |
20140089327 | SYSTEM AND METHOD FOR MAKING GIFT RECOMMENDATIONS USING SOCIAL MEDIA DATA - Disclose are methods for evaluating a user's interests and making gift recommendations using social media data. Interests and attributes of a user may be detected from social media content and products corresponding to the interests and attributes may be selected and presented as gift recommendations for the user. Methods are disclosed for resolving ambiguity as to interests reflected by textual data in social media content. Also disclosed are methods for inferring a user's interests from the interests of friends of the user. | 03-27-2014 |
Patent application number | Description | Published |
20110052049 | APPARATUS, METHOD AND ARTICLE FOR EVALUATING A STACK OF OBJECTS IN AN IMAGE - An object evaluation system may determine a value for a stack of objects that appear in a pixelated color image. To determine the value of the stack of objects, the evaluation system preprocess at least a portion of the pixelated color image to produce a set of two color contour data, processes the two color contour data to identify a location of a top and a bottom of the stack (if any), and locates, for each of the objects in the stack, a respective set of color pixels from the pixelated color image corresponding to each object based on the identified locations of the top and bottom of the stack. Each of the objects in the stack are then classified into a color classification based on the object's respective set of color pixels, and the value of the object is determined based on a known correspondence between the color classification and a value. The cumulative value of the stack is determined by summing the determined values for each of the objects in the stack. | 03-03-2011 |
20120309524 | REMOTE GAME PLAY IN A WIRELESS GAMING ENVIRONMENT - A system employs a server computing system with an integrated database and wireless communications devices. The wireless communications devices permits players to take a position on a potential outcome of a game and includes remote game play and remote backline playing (taking a position on a potential outcome of a position on game outcome taken by a primary player occupying a player position at a gaming table) and other types of positions not involving money. In response to the electronic indication that the primary player is no longer occupying the player position at the gaming table the system automatically initiates a period locking out players taking positions on the potential outcome of the game such as a position on game outcome lock out period for such proposed backline positions on game outcome and modifies the user interface on a wireless device of the dealer accordingly. | 12-06-2012 |
20130071014 | APPARATUS, METHOD AND ARTICLE FOR EVALUATING A STACK OF OBJECTS IN AN IMAGE - An evaluation system to determine a value of a stack of objects preprocess a pixelated color image to produce a set of two color contour data, processes the two color contour data to identify a location of a top and a bottom of the stack, and locates, for each of the objects in the stack, a respective set of color pixels from the pixelated color image corresponding to each object based on the identified locations of the top and bottom of the stack. Each of the objects in the stack are then classified into a color classification based on the object's respective set of color pixels, and the value of the object is determined based on a known correspondence between the color classification and a value. The cumulative value of the stack is determined by summing the determined values for each of the objects in the stack. | 03-21-2013 |
20140357361 | APPARATUS, METHOD AND ARTICLE TO MONITOR GAMEPLAY USING AUGMENTED REALITY - A portable computing system acquires images representative of a gaming environment (e.g., a gaming table and game participants) and provides augmented reality images including player personal and financial information and/or game or employee related information. The portable computing system can include a tablet form factor computing system having a touchscreen display. Using the acquired images, the game table, game participants, and other objects are identified. Player personal and financial information and/or game information logically associated with the identified game participants and/or objects are retrieved. The player personal and financial information and the game information may be incorporated in real-time or near real-time into the acquired image data to provide an augmented reality monitor useful for monitoring table games. | 12-04-2014 |
20150039388 | SYSTEM AND METHOD FOR DETERMINING CONSUMER PROFILES FOR TARGETED MARKETPLACE ACTIVITIES - A system and method implemented by a computing system is provided for determining consumer economic profiles to form selected virtual marketplace communities. The created communities provide benefits to consumers, such as leveraging purchasing power for increased return on goods and services desired by the consumers. The system and method comprise three primary components or aspects, namely (1) a data gathering component in which consumer spending data is obtained, validated, analyzed, and categorized; (2) profiles created for each consumer regarding their spending history taking into account calculated spend scores and spend categories corresponding to each of the consumers; and (3) virtual marketplace communities created from the profiles for matched consumers and vendors enabling consumers to conduct commerce with the vendors in an e-commerce environment. An exchange pod can be created to provide an object in which consumers offer to purchase pre-designated amounts and categories of goods/services over pre-defined time periods. Vendors bid to obtain the right to offer the goods/services for sale. The bids are made with discount offers and consumers are able to select the most favorable bid. | 02-05-2015 |
20150356818 | REMOTE GAME PLAY IN A WIRELESS GAMING ENVIRONMENT - A system employs a server computing system with an integrated database and wireless communications devices. The wireless communications devices permits players to take a position on a potential outcome of a game and includes remote game play and remote backline playing (taking a position on a potential outcome of a position on game outcome taken by a primary player occupying a player position at a gaming table) and other types of positions not involving money. In response to the electronic indication that the primary player is no longer occupying the player position at the gaming table the system automatically initiates a period locking out players taking positions on the potential outcome of the game such as a position on game outcome lock out period for such proposed backline positions on game outcome and modifies the user interface on a wireless device of the dealer accordingly. | 12-10-2015 |
Patent application number | Description | Published |
20090012997 | CMDB-BASED POLICY PROPAGATION - A configuration management database (CMDB) that associates a policy with a configuration item (CI) in the CMDB. The policy contains an “applies to” field and a “type descriptor”. When a relationship is created between the CI and a second CI in the CMDB, the policy is associated with the second CI. | 01-08-2009 |
20110145790 | DEPLOYMENT AND DEPLOYMENT PLANNING AS A SERVICE - A system and method of deploying software provides for comparing a current software topology of a deployment site to a software deployment topology of an application, wherein the software deployment topology is required to deploy the application. One or more mismatches between the current software topology and the software deployment topology may be identified. | 06-16-2011 |
20120204187 | Hybrid Cloud Workload Management - A method, apparatus, and computer program product for managing a workload in a hybrid cloud. It is determined whether first data processing resources processing a portion of a workload are overloaded. Responsive to a determination that the first data processing resources are overloaded, second data processing resources are automatically provisioned and the portion of the workload is automatically moved to the second data processing resources for processing. The second data processing resources are data processing resources that are provided as a service on the hybrid cloud. Processing of a first portion of a workload being processed on first data processing resources of a hybrid cloud are monitored simultaneously with monitoring processing of a second portion of the workload being processed on second data processing resources of the hybrid cloud. The workload may be allocated automatically between the first portion and the second portion responsive to the simultaneous monitoring. | 08-09-2012 |
20140006749 | MANAGING COMPUTING RESOURCES THROUGH AGGREGATED CORE MANAGEMENT | 01-02-2014 |
Patent application number | Description | Published |
20080250139 | FACILITATING MONITORING AND SIMULTANEOUSLY ANALYZING OF NETWORK EVENTS OF MULTIPLE HOSTS VIA A SINGLE NETWORK INTERFACE - The substantially simultaneous tracing/monitoring of a plurality of sets of events via a single network interface. The plurality of events can be traced and/or monitored for one host or for a plurality of hosts coupled via the same network interface. The sets of events to be traced/monitored for a host are defined by the host and maintained in one or more configuration files. The configuration files may be dynamically updated. | 10-09-2008 |
20080301676 | Method for Delivering, Testing, and Applying Software Patches or Other Changes to a Conventionally Installed Application in Virtual Application Containers - A method for updating an application on a host system includes steps or acts of: installing an application on the host system; installing a virtual machine monitor on the host system, installing a first virtual container on the host system, wherein the first virtual container comprises at least one update to the installed application; and instantiating the first virtual container under the virtual machine monitor in a mode wherein the host system can be accessed but not modified and wherein instantiating the first virtual container includes updating the installed application in the first virtual computer and running the updated application in the first virtual container. The method may also include a step of confirming that the updated application runs properly. Optionally, the virtual container may be devirtualized. A system for updating an application on a host system includes: at least one virtual machine monitor, at least one virtual container; at least one application; at least one update to the application contained within the at least one virtual container; and a processor configured for carrying out the above method steps. The system may also include an input multiplexer configured for mediating access to the at least one virtual container; and an output analyzer configured for confirming that the updated application performed as expected in at least one virtual container. | 12-04-2008 |
20090089072 | CONFIGURATION MANAGEMENT DATABASE (CMDB) WHICH ESTABLISHES POLICY ARTIFACTS AND AUTOMATIC TAGGING OF THE SAME - The present invention discloses a solution for managing policy artifacts using a configuration management database (CMDB). Policies can be associated with a number of information technology resources, such as servers, businesses applications and the like. The solution permits automatic tagging of the policies (auto-discovery) as they enter the CMDB. For example, when a policy is added, it can be compared against a set of tagging rules. Multiple rules can match a new policy, which results in multiple tags being added for the policy. The policy specific tags can be optionally indexed for faster searching. Once indexed, the CMDB can support policy and policy tag based queries. In one embodiment, policy artifacts can be manipulated within a CMDB tool in a manner consistent with how the CMDB tool handles configuration items (CIs). | 04-02-2009 |
20140007134 | MANAGING COMPUTING RESOURCES THROUGH AGGREGATED CORE MANAGEMENT | 01-02-2014 |
Patent application number | Description | Published |
20090035573 | COLOR BIOFIBER FOR PLASTIC ARTICLES - Coated colored biofiber for thermoplastic articles is disclosed. The coating on the biofiber comprises film-forming polymeric binder, surfactant, and colorant. The colorant can be one or more pigments, one or more dyes, or combinations thereof. The coated colored biofiber can be used in thermoplastic compounds to simulate the appearance of natural wood while adding durability. | 02-05-2009 |
20090156732 | LIQUID COLOR CONCENTRATE - A liquid color concentrate is disclosed, having a liquid acrylic-based polymer carrier; colorant; and optionally other functional additives. The colorant can be one or more pigments, one or more dyes, or combinations thereof. The liquid polymer is compatible with a variety of plastic resins, especially optically clear plastic resins, such as polycarbonate, polymethyl methacrylate, and styrene-acrylonitrile. | 06-18-2009 |
20100280150 | PRE-PROCESSED THERMOPLASTIC COMPOUND - A pre-processed polymer composite is disclosed comprising a heat-sensitive polymer resin particle; particles of colorant or functional additive in association with the heat-sensitive polymer resin particle; and a thermoplastic encapsulant to form a film around the associated polymer and colorant or functional additive particles. The method of making the polymer composite avoids a melting of the heat-sensitive polymer resin particles, which avoids contributing to heat history of the polymer prior to extrusion or molding into the form of the final plastic article. | 11-04-2010 |
20130303644 | LOW GLOSS CAPSTOCK - A low gloss capstock compound is disclosed. The combination of gloss inhibiting agents and polyolefin elastomer added to conventional polyethylene polymer resin achieves a gloss angle at 85° of below 10 GU. Optionally, the compound can also include weathering agents to improve outdoor durability. The compound can be fully formulated or a masterbatch for let-down into polymer to form the fully formulated compound. | 11-14-2013 |
20130317139 | LOW GLOSS IONOMER-BASED CAPSTOCK - A low gloss capstock compound is disclosed. The combination of gloss inhibiting agents, metal-based ionomer thermoplastic resins, and acid scavenger added to conventional polyethylene polymer resin achieves a gloss angle at 85° of below 10 GU. Optionally, the compound can also include weathering agents to improve outdoor durability. The compound can be fully formulated or a masterbatch for let-down into polymer to form the fully formulated compound. | 11-28-2013 |
Patent application number | Description | Published |
20080276269 | User Interfaces For Web-Based Video Player - A system, method and various user interfaces enable association of advertising content with requested shared video content for access via a web-based video player. Advertising content is provided selectively in conjunction with playback of video content. Selection of how and where advertising is displayed is based on a flexibly managed balance between providing sufficiently noticeable opportunities to access advertising information and preserving a satisfying viewer experience in watching requested video content. | 11-06-2008 |
20080276272 | Animated Video Overlays - A video server provides video content to a client via a network. At the instruction of the video server, a player at the client contacts an ad server and downloads one or more creatives and a controller file to the client. The controller file indicates how the creative manifests itself in play. The player displays the video content in a display area at the client. The controller file causes the creative to appear as an animated overlay over the video content. User interface elements indicate the point in the video when the creative appears, and allow the user to minimize and replay the creative. The player can also display other creatives, such as a static creative that is associated with the animated creative. A user can select the creative to view additional information about a product advertised by the creative. | 11-06-2008 |
20100010893 | VIDEO OVERLAY ADVERTISEMENT CREATOR - Methods and systems for creating video overlay advertisements suitable for use with digital videos. In one embodiment, values specifying attributes of a desired video overlay advertisement are entered via a browser-based user interface functioning on a client device and communicated to a server. The server receives the values and in response provides to the client device a video overlay advertisement having the desired attributes, which the client displays within the browser-based user interface. | 01-14-2010 |
20120290933 | Contextual Video Browsing - A method and system for contextual browsing of videos that are relevant to a current video. Browsing controls that include labels and previews are presented in a user interface. The labels represent sets of videos that are organized according to their relevancy to a current video. The previews represent videos from a set of videos that is currently in focus. If the user switches focus from one set of videos to another set of videos, the previews are updated to correspond to the videos in the second set of videos. The user can also browse through the previews in order to select another video for playback. | 11-15-2012 |
20120320091 | Animated Video Overlays - A video server provides video content to a client via a network. At the instruction of the video server, a player at the client contacts an ad server and downloads one or more creatives and a controller file to the client. The controller file indicates how the creative manifests itself in play. The player displays the video content in a display area at the client. The controller file causes the creative to appear as an animated overlay over the video content. User interface elements indicate the point in the video when the creative appears, and allow the user to minimize and replay the creative. The player can also display other creatives, such as a static creative that is associated with the animated creative. A user can select the creative to view additional information about a product advertised by the creative. | 12-20-2012 |
20130247096 | User Interfaces For Web-Based Video Player - A system, method and various user interfaces enable association of advertising content with requested shared video content for access via a web-based video player. Advertising content is provided selectively in conjunction with playback of video content. Selection of how and where advertising is displayed is based on a flexibly managed balance between providing sufficiently noticeable opportunities to access advertising information and preserving a satisfying viewer experience in watching requested video content. | 09-19-2013 |
20150350739 | USER INTERFACES FOR WEB-BASED VIDEO PLAYER - A system, method and various user interfaces enable association of advertising content with requested shared video content for access via a web-based video player. Advertising content is provided selectively in conjunction with playback of video content. Selection of how and where advertising is displayed is based on a flexibly managed balance between providing sufficiently noticeable opportunities to access advertising information and preserving a satisfying viewer experience in watching requested video content. | 12-03-2015 |
20150350741 | Contextual Video Browsing - A method and system for contextual browsing of videos that are relevant to a current video. Browsing controls that include labels and previews are presented in a user interface. The labels represent sets of videos that are organized according to their relevancy to a current video. The previews represent videos from a set of videos that is currently in focus. If the user switches focus from one set of videos to another set of videos, the previews are updated to correspond to the videos in the second set of videos. The user can also browse through the previews in order to select another video for playback. | 12-03-2015 |
Patent application number | Description | Published |
20120016741 | TARGETING CONTENT WITHOUT KEYWORDS - Methods, systems, and apparatus, including computer programs encoded on computer storage media, that are operable to index a plurality of commercial landing web pages in a database using queries previously resolved to the commercial landing pages where each entry in the database includes at least one query and a pointer to a commercial landing web page. A query can be received. The query can be processed by one or more processors including identifying a relevant commercial landing web page using the query. An advertisement creative can be generated from the relevant commercial landing web page. | 01-19-2012 |
20120030014 | Automatic Ad Creative Generation - Methods, systems, and apparatus, including computer programs encoded on computer storage media, that are operable to identify a web page that is to be a basis for an advertisement creative; extract content to create an advertisement for serving in response to a request, extracting including extracting a title for the web page; create a title for the advertisement creative including computing a snippet of the title based on the request and the extracted title; combine a body with the advertising creative title; and combine with the body a uniform resource locator (URL) for a landing page that is to be associated with the advertisement creative. | 02-02-2012 |
20120030015 | AUTOMATIC ABSTRACTED CREATIVE GENERATION FROM A WEB SITE - Methods, systems, and apparatus, including computer programs encoded on computer storage media, that are operable to identify a web page that is to be a basis for an advertisement creative; extract content associated with the web page to create an advertisement for serving in response to a request, extracting including abstracting content extracted so that the advertisement is not specifically descriptive of the web page; create a title for the advertisement; combine a body with the title; and combine with the body a uniform resource locator (URL) for a landing page that is to be associated with the advertisement creative. | 02-02-2012 |
Patent application number | Description | Published |
20100178521 | SILANE COATING COMPOSITIONS CONTAINING SILICON-BASED POLYETHER COPOLYMERS, METHODS FOR COATING METAL SURFACES AND ARTICLESMADE THEREFROM - A silane coating composition containing a silicon-based copolymer, a method for treating the surfaces of a metal such as steel, zinc-coated steels, or aluminum, to provide for the formation of a uniform conversion and/or passivation coating which increases the corrosion resistance of bare or painted metal and/or the adhesion properties of the metal, along with a metal having a conversion and/or passivation coating applied thereto are disclosed. Methods of the invention include contacting the requisite metal surface with an aqueous solution of a silane compound and a silicon-based polyether copolymer. | 07-15-2010 |
20110308761 | REGENERATOR, REGENERATION PROCESS, AND LIQUID POLYMER MIXTURE FOR A REGENERATOR - Disclosed is a regenerator, a regeneration process, and a liquid polymer mixture for periodic cooling, storing, and heating of atmospheric gas. The regenerator, the regeneration process, and the liquid polymer mixture involve a liquid polymer that remains in contact with a thermally conductive solid material during a first operational period and a second operational period of a regeneration process. | 12-22-2011 |
20120142955 | SILICONE COMPOSITIONS AND METHODS FOR PREPARING THEM - A silicone composition comprising a formula: (M | 06-07-2012 |
20130296595 | SILICONE COMPOSITIONS AND METHODS FOR PREPARING THEM - A silicone composition comprising a formula: (M | 11-07-2013 |
Patent application number | Description | Published |
20100120626 | APPARATUS AND METHODS FOR HIGH THROUGHPUT NETWORK ELECTROPHYSIOLOGY AND CELLULAR ANALYSIS - Provided herein are apparatus and methods relating to the development of instrumentation for high throughput network electrophysiology and cellular analysis. More specifically, provided herein are multiwell microelectrode arrays (MEAs) and methods for the development of such an apparatus in an inexpensive fashion with a flexible, ANSI/SBS-compliant (American National Standards Institute/Society for Biomolecular Screening) format. Microelectrode arrays are a grid of tightly spaced microelectrodes useful for stimulating and sensing electrically active cells, networks and tissue. The techniques described herein relate to the use of microfabrication in combination with certain large-area processes that have been employed to achieve multiwell MEAs in ANSI/SBS-compliant culture well formats, which are also transparent for inverted/backside microscopy compatibility. These multiwell MEAs can be used to investigate two and three-dimensional networks of electrically active cells and tissue such as cardiac, neural, and muscular in a high throughput fashion. Also being ANSI/SBS-compliant, they are compatible with machinery and robotics developed for the pharmaceutical industry for drug screening applications. | 05-13-2010 |
20130306356 | METHOD FOR MAKING ELECTRICALLY CONDUCTIVE THREE-DIMENSIONAL STRUCTURES - Methods are provided for fabricating three-dimensional electrically conductive structures. Three-dimensional electrically conductive microstructures are also provided. The method may include providing a mold having at least one microdepression which defines a three-dimensional structure; filling the microdepression of the mold with at least one substrate material; molding the at least one substrate material to form a substrate; and depositing and patterning of at least one electrically conductive layer either during the molding process or subsequent to the molding process to form an electrically conductive structure. In one embodiment, the three-dimensional electrically conductive microstructure comprises an electrically functional microneedle array comprising two or more microneedles, each including a high aspect ratio, polymeric three dimensional substrate structure which is at least substantially coated by an electrically conductive layer. | 11-21-2013 |
20130338746 | 3D MICROELECTRODE DEVICE FOR LIVE TISSUE APPLICATIONS - A 3D microelectrode device includes a flexible substrate containing poly-dimethyl siloxane (PDMS). The device may be fabricated in a miniature form factor suitable for attachment to a small organ such as a lateral gastrocnemius muscle of a live rat. In addition to providing a miniaturized, conformable attachment, the device provides an anchoring action via one or more microelectrodes, each having an insertable tip particularly shaped to provide the anchoring action. Furthermore, a base portion of each of the microelectrodes is embedded inside conductive poly-dimethyl siloxane (cPDMS). The cPDMS is contained in a pad that is coupled to a conductive track embedded in the flexible substrate. Embedding of the base portion inside the cPDMS material not only allows the microelectrode to bend in various directions, but also provides good electrical conductivity while eliminating the need for attachment processes using solder or epoxy adhesives. | 12-19-2013 |
20140303471 | Non-Invasive Segmentable Three-Dimensional Microelectrode Array Patch For Neurophysiological Diagnostics And Therapeutic Stimulation - Implementations disclosed herein provide for a microneedle electrode system comprising a microneedle electrode patch connected to external electronics. The microneedle electrode patch comprises a first flexible substrate having a plurality of conductive pads disposed thereon, a plurality of three-dimensional, individually addressable microneedle electrode arrays where each array has a plurality of microneedles extending from an upper surface thereof and a lower surface adapted to contact a corresponding one of the plurality of conductive pads disposed on the first substrate, and a second flexible substrate having a plurality of openings defined therein dimensioned to accommodate at least a portion of the upper surface of the microneedle electrode array from which the microneedles extend. Each of the conductive pads is disposed in electrical communication with a corresponding one of the plurality of microneedle electrode arrays and the first and second substrate are bonded together such that each one of the plurality of microneedle electrode arrays extends through a corresponding one of the plurality of openings defined in the second substrate. | 10-09-2014 |
20150027885 | DEVICES, SYSTEMS AND METHODS FOR HIGH-THROUGHPUT ELECTROPHYSIOLOGY - Electrophysiology culture plates are provided and are formed from a transparent microelectrode array (MEA) plate. The MEA plate comprises a substrate, a first layer and a first insulating layer. The substrate has a plurality of vias extending from an upper to a lower surface, each via being in electrical contact with each of a plurality of contact pads disposed on the lower surface. The first layer is disposed on the upper surface of the substrate and has a plurality of MEA arrays in in electrical communication with at least a first routing layer. Each MEA array comprises a plurality of reference electrodes and a plurality of microelectrodes and the first routing layer is in electrical communication with a select number of the plurality of vias. A first insulating layer is disposed on the first layer. The MEA plate is joined to a biologic culture plate having a plurality of culture wells such that each culture well defines an interior cavity having a bottom surface that is at least partially transparent and in positioned in registration with a select optical port. The MEA plate is coupled to the biologic culture well plate such that each MEA array is operatively coupled to one culture well wherein each microelectrode and each reference electrode are in electrical communication with the interior cavity through the bottom surface of the culture well. | 01-29-2015 |
20150125942 | DEVICES, SYSTEMS, AND METHODS FOR TARGETED PLATING OF MATERIALS IN HIGH-THROUGHPUT CULTURE PLATES - Devices, systems, and methods for facilitating placement of cells and materials in culture plates configured for high-throughput applications are provided. A culture system is provided with a culture plate having a lid for guiding placement of cells and materials in each individual culture well of a culture plate. The lid may provide for coupling to an electrophysiology culture plate comprising a biosensor plate and a biologic culture plate, where the biosensor plate underlies and is coupled to the culture well plate such that each biosensor is operatively coupled to one culture well of the plurality of culture wells. A containment device that physically influences the positioning of fluid received in the culture plate is also provided herein. | 05-07-2015 |