Moore, MA
Anna Moore, Dracut, MA US
Patent application number | Description | Published |
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20090155292 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS - The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases. | 06-18-2009 |
20110059121 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS - The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases. | 03-10-2011 |
20110208064 | Curcumin Derivatives for Amyloid-Beta Plaque Imaging - The present invention provides curcumin-derived near infrared (NIR) imaging probes. Upon interacting with amyloid β aggregates, these probes undergo a range of changes, qualifying them as “smart” probes. The inventors have demonstrated that probes of the invention have the capacity to monitor the progression of Alzheimer's disease in an in vivo animal model. In addition, the present invention encompasses probes useful as PET imaging agents, MRI imaging agents and multimodal imaging agents, as well as related methods of detecting and imaging amyloid β aggregates and plaques. | 08-25-2011 |
20120004531 | Innately Multimodal Nanoparticles - A gold-coated iron oxide nanoparticle, method of making thereof, and method of using thereof is disclosed. The nanoparticle is substantially toxin free (making it clinically applicable), easily functionalized, and can serve as a contrast agent for a number of imaging techniques, including imaging a subject in at least two distinct imaging modes. Further, the nanoparticle is well-suited for therapeutic uses. | 01-05-2012 |
20120183474 | Methods and System for Detecting Soluble Amyloid-Beta - The present invention provides methods of detecting soluble amyloid β using curcumin-derived near infrared (NIR) imaging probes. Upon interacting with soluble amyloid β, these probes undergo a range of changes, qualifying them as “smart” probes. In addition, the invention provides methods of detecting soluble amyloid β by positron emission tomography (PET), magnetic resonance imaging (MRI) and multimodal imaging based on the curcumin-derived NIR imaging probes and derivatives thereof. | 07-19-2012 |
20120270262 | METHODS FOR MOBILE ZINC MEASUREMENT - This invention relates to a method for using a zinc sensor compound to detect a disease associated with the disruption of zinc homeostasis, such as prostate cancer. The zinc sensor compound comprises an optical reporter having two or more recognition units where each of the recognition units is capable of associating with at least one zinc ion. | 10-25-2012 |
20130129579 | COLORIMETRIC METHOD AND DEVICE FOR DETECTING ANALYTE QUANTITIES IN FLUIDS AND MATERIALS - A method and device for detecting an analyte in a solution or compound mixture use colorimetric detection to detect the quantity of an analyte in the solution or compound. The analyte sensor demonstrates a clear change in peak light absorption wavelength as a function of the stoichiometric relationship between the analyte sensor and the analyte. The method involves combining the analyte sensor and the analyte in solution and observing a color change of the mixture. Additionally, predefined amounts of the analyte sensor can be added until color change is detected and the quantity of analyte can be determined as a function of the total amount of analyte sensor in the mixture. Alternatively, a device having multiple wells or compartments, each with a different concentration of the analyte sensor. The analyte sample can be introduced to each well and the well that demonstrates the color change can, from its know analyte sensor concentration, be used to quickly and accurately determine the concentration of the analyte. | 05-23-2013 |
20130302421 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS - The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases. | 11-14-2013 |
20140241996 | THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF - Provided herein are therapeutic nanoparticles having a diameter of between 10 nm to 30 nm, and containing a polymer coating, and a nucleic acid containing a sequence complementary to a sequence within a micro-RNA identified as having a role in cancer cell metastasis or anti-apoptotic activity in a cancer cell (e.g., miR-10b) or a sequence within an mRNA encoding a pro-apoptotic protein that is covalently linked to the nanoparticle. Also provided are pharmaceutical compositions containing these therapeutic nanoparticles. Also provided herein are methods of decreasing cancer cell invasion or metastasis in a subject having a cancer and methods of treating a metastatic cancer in a lymph node in a subject that require the administration of these therapeutic nanoparticles to a subject. | 08-28-2014 |
20150087937 | CURCUMIN DERIVATIVES FOR AMYLOID-BETA PLAQUE IMAGING - The present invention provides curcumin-derived near infrared (NIR) imaging probes. Upon interacting with amyloid β aggregates, these probes undergo a range of changes, qualifying them as “smart” probes. The inventors have demonstrated that probes of the invention have the capacity to monitor the progression of Alzheimer's disease in an in vivo animal model. In addition, the present invention encompasses probes useful as PET imaging agents, MRI imaging agents and multimodal imaging agents, as well as related methods of detecting and imaging amyloid β aggregates and plaques. | 03-26-2015 |
Anna Moore, Stoneham, MA US
Patent application number | Description | Published |
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20140370009 | THERAPEUTIC NANOPARTICLES AND METHODS OF USE THEREOF - Provided herein are therapeutic nanoparticles having a diameter of between 10 nm to 30 nm, and containing a polymer coating, and a nucleic acid containing a sequence complementary to a sequence within a micro-RNA identified as having a role in cancer cell metastasis or anti-apoptotic activity in a cancer cell (e.g., miR-10b) or a sequence within an mRNA encoding a pro-apoptotic protein that is covalently linked to the nanoparticle. Also provided are pharmaceutical compositions containing these therapeutic nanoparticles. Also provided herein are methods of decreasing cancer cell invasion or metastasis in a subject having a cancer and methods of treating a metastatic cancer in a lymph node in a subject that require the administration of these therapeutic nanoparticles to a subject. | 12-18-2014 |
20150158841 | Curcumin Analogs - Provided herein are curcumin analogues that are able to interact with amyloid β (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds in the treatment of Alzheimer's Disease or a related disorder. | 06-11-2015 |
Anna R. Moore, Newton, MA US
Patent application number | Description | Published |
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20150361156 | METHODS OF MODULATING GABAERGIC INHIBITORY SYNAPSE FORMATION AND FUNCTION - The present technology relates to methods of modulating the number of GABAergic synapses between at least two neurons. These methods include contacting at least one of the neurons with a PlexinB agonist or a nucleic acid molecule encoding a PlexinB agonist, such as a composition including a Sema4D polypeptide or an extracellular fragment thereof, or a nucleic acid molecule encoding the Sema4D polypeptide or extracellular fragment thereof. The present technology also relates to methods of modulating neuronal activity in the central nervous system or peripheral nervous system of a subject in need thereof by modulating the number of GABAergic synapses between at least two neurons. The present technology further relates to methods of treating a neuro logical disorder that would benefit from modulating neuronal activity in the central nervous system or peripheral nervous system of a subject in need thereof. | 12-17-2015 |
Anna V. Moore, Dracut, MA US
Patent application number | Description | Published |
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20160000940 | MIRNA PROFILING COMPOSITIONS AND METHODS OF USE - Disclosed herein is a nanosensor of miRNA activity in a target cell, and methods of use, for detection and diagnostic applications. The nanosensor comprises a delivery particle comprising an iron oxide crystal coated with a polymer; and a sensor oligonucleotide covalently attached to the polymer. The sensor oligonucleotide comprises a seed region, comprising a nucleic acid sequence that is completely complementary to the target miRNA and comprises a cleavage site which can be engaged and cleaved by the target miRNA. | 01-07-2016 |
Bonnie L. Moore, Attleboro, MA US
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20090107811 | Electrical switch system for use with vehicular transmissions - A linear vehicle transmission switch ( | 04-30-2009 |
Charles Moore, Boston, MA US
Patent application number | Description | Published |
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20090149395 | NOVEL MACROCYCLIC POLYENE LACTAMS - The invention relates generally to novel macrocyclic polyene lactams and their analogs, to processes for the preparation of these novel macrocyclic polyene lactams, to pharmaceutical compositions comprising the novel macrocyclic polyene lactams; and to methods of using the novel macrocyclic polyene lactams to treat or inhibit various disorders. | 06-11-2009 |
20090156514 | NOVEL MACROLACTAM COMPOUNDS - The invention relates generally to novel macrolactams and their analogs, to processes for the preparation of these novel macrolactams, to pharmaceutical compositions comprising the novel macrolactams; and to methods of using the novel macrolactams to treat or inhibit various disorders. | 06-18-2009 |
Charles J. Moore, Cambridge, MA US
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20130099174 | LITHIUM MANGANESE BORATE COMPOUNDS - The present invention generally relates to certain lithium materials, including lithium manganese borate materials. Such materials are of interest in various applications such as energy storage. Certain aspects of the invention are directed to lithium manganese borate materials, for example, having the formula Li | 04-25-2013 |
Charles P. Moore, Wayland, MA US
Patent application number | Description | Published |
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20140172672 | SYSTEM AND METHOD OF A PLATFORM FOR CROSSING BONDS - This disclosure provides a unique process for firms wishing to cross bonds internally, from one customer account to another. This process allows the selling firm to list the bonds for sale on the bond auction platform and simultaneously to bid on the listed bonds. In doing so, the seller must also have a willingness to sell the bonds away to any firm that outbids the crossing price. By bidding on the seller's own bonds, and then exposing that bid on the platform, the selling firm is able to expose the bid (the cross price) to the market and thereby receive market validation of the price. If another firm chooses to out-bid the seller's bid, the bonds will trade away to the other firm. | 06-19-2014 |
Christopher Herbert Moore, Belmont, MA US
Patent application number | Description | Published |
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20090019672 | Clipboard with improved ergonomics - An apparatus for writing or drawing on paper or pads of paper held by a clipboard, the clipboard allowing the paper or pad to be moved upward by the user to maintain support for his or her writing hand as the user writes down the page. The pad-holding clamp is placed along the longer left edge of the clipboard so that it cannot interfere with the pad as the user raises it to and beyond the top edge of the clipboard, Previous designs placed the clamp on the top narrow edge of the panel, where it constitutes an obstruction that prevents the user from moving the pad up. Spring clips that snap into place provide the clamping force required to keep the pad from slipping, and rubber grip strip on leading edge, underside of the clamp and extending the length of the clamp holds even a single sheet firmly. | 01-22-2009 |
Christopher Irwin Moore, Cambridge, MA US
Patent application number | Description | Published |
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20100324440 | REAL TIME STIMULUS TRIGGERED BY BRAIN STATE TO ENHANCE PERCEPTION AND COGNITION - An approach is provided for real time stimulus triggered by brain state and includes receiving data that indicates a brain state and a set of one or more stimuli associated with the brain state. Onset of an instance of the brain state is detected in a subject. In response to detecting onset of the instance, application to the subject of a stimulus of the set is initiated before the instance ends. In some embodiments, the brain state is determined based on a range of values for a function of brain signal data, wherein the range of values is associated with desired performance in response to an associated stimulus. The approach can enhance performance, enhance learning or enhance the probing of impact of that state on perception, action or cognition. | 12-23-2010 |
Darren L. Moore, Somerville, MA US
Patent application number | Description | Published |
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20090215282 | PROCESSES FOR CURING SILICON BASED LOW-K DIELECTRIC MATERIALS - Processes for curing silicon based low k dielectric materials generally includes exposing the exposing the silicon based low k dielectric material to ultraviolet radiation in an inert atmosphere having an oxidant in an amount of about 10 to about 500 parts per million for a period of time and intensity effective to cure the silicon based low k dielectric material so to change a selected one of chemical, physical, mechanical, and electrical properties and combinations thereof relative to the silicon based low k dielectric material prior to the ultraviolet radiation exposure. Also disclosed herein are silicon base low k dielectric materials substantially free of sub-oxidized SiO species. | 08-27-2009 |
Daryl L. Moore, Worcester, MA US
Patent application number | Description | Published |
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20130048773 | REPLACEABLE WEAR ELEMENT FOR ROLLING MILL LAYING HEAD - Selectively replaceable wear elements for rolling mill laying heads. One replaceable wear element forms the end ring guide surface and is installed within the end ring inner diameter without removing the guide ring from the laying head. A plurality of wear element bodies may be installed about one or more portions of the end ring guide surface inner diameter. Size, configuration and material properties of the end ring guide surface wear element bodies may vary for different sections within the ring guide inner diameter. Another replaceable wear element is a tripper paddle that forms a laying head tripper mechanism guide surface. The tripper paddle and guide surface wear element bodies are replaceable external the end ring without removing the end ring or tripper mechanism from the laying head. Either or both types of wear element may be used in a laying head. | 02-28-2013 |
20130062447 | Modular Coolant Jacket for Rolling Mills - A modular coolant water jacket has a coolant tube cartridge portion and a selectively separable outer flange portion. Separation of the larger diameter outer flange portion from the cartridge portion facilitates axially oriented insertion and removal of the cartridge tube portion in radially confined spaces. Modular construction also facilitates reuse of the outer flange portion and replacement of only a worn cartridge tube portion. | 03-14-2013 |
20150082584 | CLAMP FOR ROLLING MILL ROLL STAND - A clamp for releasably securing a rolling mill roll stand on a support structure, comprises a tubular housing adapted to be secured to the support structure. A piston subdivides the interior of the housing into front and rear chambers. A clamping jaw projects forwardly from the piston through an open front end of the housing. The piston is reciprocally movable between a locked position at which the clamping jaw engages the roll stand, and an unlocked position at which the clamping jaw is disengaged from the roll stand. Resilient elements act in the rear chamber to exert a locking force urging the piston into its locked position, and pressurized fluid acts in the front chamber to overcome the resilient locking force when unlocking the clamp. | 03-26-2015 |
David N. Moore, Hampden, MA US
Patent application number | Description | Published |
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20130180151 | BARREL NUT MOUNTED MOUNTING STRUCTURE FOR A RIFLE ACCESSORY ITEM AND SYSTEM COMPRISING SAME - A main body of a rifle accessory mounting apparatus comprises an accessory mounting structure having opposing end portions and a barrel nut engaging structure connected to a first one of the end portions of the accessory mounting structure. An end face of the accessory mounting structure defines a front end face of the main body and an end face of the barrel nut engaging structure defines a rear end face of the main body. A central passage of the main body extends through the accessory mounting structure and the barrel nut engaging structure. | 07-18-2013 |
Dawn Moore, Belchertown, MA US
Patent application number | Description | Published |
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20130303927 | ECG LEAD SET AND ECG ADAPTER SYSTEM - A method for coupling an ECG monitor with an incompatible ECG lead set includes the steps of providing an ECG adapter including an adapter body having at least one monitor connector adapted for coupling to an input of an ECG monitor and at least one lead set receptacle adapted for coupling to a connector of an ECG lead set incompatible with the input of the ECG monitor, coupling the at least one monitor connector of the adapter body with the input of the ECG monitor and coupling the at least one lead set receptacle of the adapter body with the connector of the ECG lead set to thereby electrically couple the ECG lead set with the ECG monitor. | 11-14-2013 |
Dawn Moore, Sturbridge, MA US
Patent application number | Description | Published |
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20120323104 | Electrode Array - A sensor array apparatus for monitoring medical signals includes a flexible substrate adapted for positioning relative to the torso of a patient. The flexible substrate includes a central segment defining a central axis and is adapted to generally conform to an area extending along the sternum of a patient. The flexible substrate further includes an upper segment extending traversal across the central segment and adapted to generally conform to the chest area of a patient and a lower segment extending traversal across the central segment and adapted to generally conform to the abdominal area of the patient. The apparatus further includes a medical electrode disposed on at least one of the segments and a connector in electrical communication with the medical electrode and adapted to connect to an electronic monitoring system. | 12-20-2012 |
20150265177 | ECG LEAD SET AND ECG ADAPTER SYSTEM - A method for coupling an ECG monitor with an incompatible ECG lead set includes the steps of providing an ECG adapter including an adapter body having at least one monitor connector adapted for coupling to an input of an ECG monitor and at least one lead set receptacle adapted for coupling to a connector of an ECG lead set incompatible with the input of the ECG monitor, coupling the at least one monitor connector of the adapter body with the input of the ECG monitor and coupling the at least one lead set receptacle of the adapter body with the connector of the ECG lead set to thereby electrically couple the ECG lead set with the ECG monitor. | 09-24-2015 |
Derek Moore, South Dartmouth, MA US
Patent application number | Description | Published |
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20130236876 | Generating Visually Enhanced Question Topic Repetition Learning Content - A method performed by one or more processing devices, comprises: displaying, through a graphical user interface, test information in a layered structure; wherein a first layer in the layered structure is configured to display the test information following selection of a control in the graphical user interface; wherein a second layer in the layered structure is configured to display the test information following a display of the test information in the first layer; receiving, through the graphical user interface, one or more answers to one or more questions received in the test information; and generating, in response to receiving, information indicative of a test score. | 09-12-2013 |
20140136224 | Educational Media Evidence Rating and Technology Analysis Solution - A computer-implemented method includes receiving a comment to a medical study; prior to enabling storage of the comment in a data repository, transmitting, to a device used by a user who submitted the comment, a graphical user interface that prompts the user to enter an identifier that uniquely references a data repository record to a medical resource; receiving information indicative of the identifier that uniquely references the data repository record to the medical resource; verifying that the identifier references a data repository record to a medical resource; in response to verification of the identifier, storing the comment in association with the medical study in the data repository; and storing the identifier in association with the comment that is stored in the data repository, wherein the identifier provides evidence to support the comment. | 05-15-2014 |
Doug Moore, North Grafton, MA US
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20150097495 | Display Lighting and Related Devices and Methods - A method for creating a display lighting presentation is provided. The method includes providing a light sequence definition graphical user interface configured to enable entry of lighting states associated with a lighting sequence to be included in the display lighting presentation, and receiving input via the light sequence publication user interface, the input specifying lighting states to be included in the display lighting presentation. | 04-09-2015 |
Douglas C. Moore, North Grafton, MA US
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20080215240 | Integrating User Interfaces - Generating a user interface includes integrating elements of a first graphical user interface into a second graphical user interface to produce a combined graphical user interface, where the first graphical user interface is for a portable navigation system and the second graphical user interface is for a vehicle media device, and controlling the vehicle media device and the portable navigation system through the combined graphical user interface. | 09-04-2008 |
Dustin Moore, Norton, MA US
Patent application number | Description | Published |
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20090031603 | Double Bridged Tag - A tag comprising: a hang tab body; a hang tab; a ratchet; a cutting channel; a guide channel; and, a tail, the tail comprising teeth and at least one knob. The tail may be fed through the guide channel and the cutting channel into the ratchet, thereby allowing the ratchet to engage the teeth, which in turn prevents the tail from being disengaged from the ratchet, thereby securing the tag to a product. The product may be easily released by severing the portion of the tag in the cutting channel. The cutting channel can also provide a guide which helps to prevent damaging the product as the tag is remove. | 02-05-2009 |
H. D. Moore, Boston, MA US
Patent application number | Description | Published |
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20120240235 | METHODS AND SYSTEMS FOR PROVIDING A FRAMEWORK TO TEST THE SECURITY OF COMPUTING SYSTEM OVER A NETWORK - A security tool can utilize a vulnerability in a computing system or credentials for the computing system to gain access to the computing system. Once access is gained, the security tool can deliver an agent to the computing system. The agent can execute, detected or undetected, on the computing system in order to establish a network link between the computing system and the security tool. Once established, the security tool creates a virtual network interface on the computing system on which it is running and instructs the agent to relay network traffic between the virtual network interface of the computing system executing the security tool and the existing network interfaces of computing system executing the agent. | 09-20-2012 |
James F. Moore, Cambridge, MA US
Patent application number | Description | Published |
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20090077040 | Using RSS Archives - In some aspects, at least two different probes are applied to datafeed archives to derive information based on data in the archives. The probes are part of a probe plan to determine a result based on the derived information. The result is determined based on the derived information. | 03-19-2009 |
20120150813 | USING RSS ARCHIVES - In some aspects, at least two different probes are applied to datafeed archives to derive information based on data in the archives. The probes are part of a probe plan to determine a result based on the derived information. The result is determined based on the derived information. | 06-14-2012 |
James F. Moore, Lincoln, MA US
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20080244091 | Dynamic Feed Generation - Syndicated feeds are generated from enterprise data using an interface that dynamically adapts user requests to an enterprise system and dynamically conforms the responsively provided enterprise data to a format suitable for presentation in a syndicated data feed. | 10-02-2008 |
20090172773 | Syndicating Surgical Data In A Healthcare Environment - Disclosed herein are systems and methods for syndication and management of structured and unstructured data to assist institutional healthcare delivery, healthcare providers' practices, healthcare providers' group practices, collaborative academic research and decision making in healthcare, including through the utilization of medical devices and healthcare pools. | 07-02-2009 |
20130104251 | SECURITY SYSTEMS AND METHODS FOR USE WITH STRUCTURED AND UNSTRUCTURED DATA - Disclosed herein are systems and methods including hardware, software and electronic service components and systems to provide large-scale, reliable, and secure foundations for distributed databases and content management systems combining unstructured and structured data, and allowing post-input reorganization to achieve a high degree of flexibility. | 04-25-2013 |
20130291060 | SECURITY FACILITY FOR MAINTAINING HEALTH CARE DATA POOLS - Disclosed herein are systems and methods for syndication and management of structured and unstructured data to assist institutional healthcare delivery, healthcare providers' practices, healthcare providers' group practices, collaborative academic research and decision making in healthcare, including through the utilization of medical devices and healthcare pools. | 10-31-2013 |
20160004820 | SECURITY FACILITY FOR MAINTAINING HEALTH CARE DATA POOLS - Disclosed herein are systems and methods for syndication and management of structured and unstructured data to assist institutional healthcare delivery, healthcare providers' practices, healthcare providers' group practices, collaborative academic research and decision making in healthcare, including through the utilization of medical devices and healthcare pools. | 01-07-2016 |
James K. Moore, Stow, MA US
Patent application number | Description | Published |
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20110046009 | METHODS FOR DETECTING DNA METHYLATION USING ENCODED PARTICLES - Methods for detecting the methylation status of a target genomic locus are provided. Methods described allow for simultaneous assay of multiple cytosines in a target genomic locus. Assays of multiple cytosines in a target genomic locus provide detection of an aggregate cytosine methylation state of the target genomic locus. Methods to detect methylation of a genomic locus associated with a disease or disorder characterized by aberrant methylation of the genomic locus, such as, but not limited to, Fragile X mental retardation syndrome, Prader-Willi syndrome, Angelman sydrome, Beckwith-Wiedemann syndrome, and Russell-Silverman syndrome, diabetes, cancer, multiple sclerosis or schizophrenia are described herein. | 02-24-2011 |
Jeffrey Moore, West Barnstable, MA US
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20160100242 | Exercise System With Headphone Detection Circuitry - Described is a circuit arrangement for detection of a tone whose presence indicates insertion of a headphone plug into a jack. The circuit includes a receptacle having contacts configured to receive a plug inserted into the receptacle, a current sense circuit, an amplifier coupled to the current sense circuit and a band pass filter coupled to an output of the amplifier, the band pass filter configured to pass a signal having a frequency in a range of about 2 Hz to 20 Hz. Circuitry converts the passed signal into a digital signal to provide an input signal to a controller to indicate that a headphone plug was inserted into the receptacle. | 04-07-2016 |
Jeffrey W. Moore, West Barnstable, MA US
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20160096069 | Cardio-Based Exercise Systems With Visual Feedback On Exercise Programs - In general, a computing device disposed in a cardio exercise machine receives data related to a fitness level of a user. The computing device selects a workout program based at least in part on the data. The operations of the cardio exercise machine are controlled based at least in part on the workout program. The computing device generates visual feedback based on at least one of the user's operation of the cardio exercise machine and the selected workout program measured against performance criteria. | 04-07-2016 |
Joel Moore, Lexington, MA US
Patent application number | Description | Published |
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20110150834 | CRTH2 MODULATORS - Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I: | 06-23-2011 |
20110248127 | Display - Devices are disclosed having a magnet disposed thereon, operatively configured for retaining a ferrous element thereagainst. | 10-13-2011 |
20110311483 | CRTH2 MODULATORS - Compounds of Formulae I-1 to I-9 are disclosed, which are modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders. | 12-22-2011 |
20110312945 | CRTH2 MODULATORS - Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I | 12-22-2011 |
20120184516 | sGC Stimulators - Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 07-19-2012 |
20130178475 | sGC STIMULATORS - Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 07-11-2013 |
20130259830 | CRTH2 MODULATORS - Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by Formula I: | 10-03-2013 |
20130292523 | Display - Devices having a magnet disposed thereon are disclosed. The devices are operatively configured for suspending and displaying articles, such as tags, signage, clothing, and baseball caps containing ferrous elements. | 11-07-2013 |
20140088071 | sGC STIMULATORS - Compounds of Formula (IA) and Formula (IB) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 03-27-2014 |
20140323448 | sGC STIMULATORS - Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 10-30-2014 |
20150018353 | 2-BENZYL, 3-(PYRIMIDIN-2-YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS - Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 01-15-2015 |
20150232461 | SGC STIMULATORS - The present patent application discloses at least the compounds according to Formula I or Formula Ib shown below, or pharmaceutically acceptable salts thereof, | 08-20-2015 |
20150250795 | sGC STIMULATORS - Compounds of Formula IA and Formula IB are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 09-10-2015 |
20150274712 | sGC STIMULATORS - Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 10-01-2015 |
20150342954 | 2-BENZYL, 3-(PYRIMIDIN-2-YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS - Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 12-03-2015 |
20160031903 | sGC STIMULATORS - Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed. | 02-04-2016 |
Joel D. Moore, Somerville, MA US
Patent application number | Description | Published |
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20080267917 | N-FUNCTIONALIZED AMIDES AS HEPATITIS C SERINE PROTEASE INHIBITORS - The present invention relates to functionalized amides of Formula I or Formula II, including pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. | 10-30-2008 |
20080269228 | HYDRAZIDE-CONTAINING HEPATITIS C SERINE PROTEASE INHIBITORS - The present invention relates to novel hydrazide-containing compounds of Formula I or Formula II, including pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. | 10-30-2008 |
Kyle S. Moore, Acushnet, MA US
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20080221569 | Orthopaedic instrumentation with integral load-bearing members - An orthopaedic instrument includes a metallic load-bearing member and a non-metallic support structure formed integrally with the load-bearing member such that the load-bearing member is permanently attached to the non-metallic support structure. | 09-11-2008 |
20090082774 | Surgical cutting guide - A surgical cutting guide is adapted to receive a cutting instrument during a surgical procedure. The surgical cutting guide comprises at least one body portion including a bone engaging surface. A plurality of separate plates are secured to the at least one body portion. At least one cutting slot is formed in the surgical cutting guide between the plurality of separate plates. The at least one cutting slot is configured to receive the cutting instrument and orient the cutting instrument for the surgical procedure. The at least one body portion is comprised of a first material, such as a plastic material, and the plurality of separate plates are comprised of a second material, such as a metal material. | 03-26-2009 |
20130256167 | CONTAINER FOR SURGICAL INSTRUMENTS AND SYSTEM INCLUDING SAME - A system for use in an orthopaedic surgical procedure including a container for orthopaedic surgical instruments. The container includes a first shell, and a second shell configured to be coupled to the first shell to define a chamber therein. The second shell is configured to be coupled to the first shell in a plurality of orientations including a first orientation in which fluid is permitted to advance into and out of the chamber, and a second orientation in fluid is prevented from advancing into and out of the chamber. | 10-03-2013 |
20130261505 | ORTHOPAEDIC SURGICAL SYSTEM FOR DETERMINING JOINT FORCES OF A PATIENT'S KNEE JOINT - An orthopaedic surgical system includes a sensor module for determining the joint force of a patient's knee joint and an adaptor for coupling various tibial trialing components to the sensor module. The sensor module includes a tibial paddle to which the adaptor is configured to couple. The adaptor and tibial paddle include structures that control the orientation at which the adaptor is attachable to the tibial paddle. Some tibial trialing components may be positioned over the adaptor in a mobile orientation that facilities rotation of the tibial trialing component relative to the tibial paddle or a fixed orientation that restricts the rotation of the tibial trialing component. | 10-03-2013 |
Larry Moore, Boston, MA US
Patent application number | Description | Published |
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20080252459 | METHODS AND SYSTEMS OF A MULTIPLE RADIO FREQUENCY NETWORK NODE RFID TAG - In embodiments of the present invention improved capabilities are described for a Radio Frequency ID (RFID) tag that contains multiple Radio Frequency (RF) network nodes that may include memory storage for the RFID tag, the memory storage may include one time programmable (OTP) memory and many time programmable (MTP) memory and the storage of the information may be within the OTP and MTP memory. | 10-16-2008 |
20090289776 | COMPOSITE MULTIPLE RFID TAG FACILITY - In embodiments of the present invention improved capabilities are described for a composite RFID tag, where the composite RFID tag may include a plurality of individual tags that are arranged to respond to a reader as one tag. | 11-26-2009 |
20120168502 | Visualizing and Auditing Elections and Election Results - Disclosed are methods, systems, and computer program products for visualizing results of elections. A set of ballots, each including one or more areas for expression of intent, are received and analyzed with a computerized image analysis tool. The image analysis tool provides a score associated with the areas for expression of intent for one or more of the set of ballots. The analyzed areas are displayed on an image-display device according to a predetermined criterion. | 07-05-2012 |
20120173307 | Visualizing and Auditing Elections and Election Results - Described are methods, systems, and computer program products for auditing an election. A computer-readable image of a ballot is received. The image of the ballot is analyzed with a computerized image analysis tool to generate a ballot definition file associated with the ballot. The ballot definition file is validated. Validation involves comparing a predicted election outcome and a simulated election outcome based on tabulation of machine-marked ballots using the ballot definition file. Auditing an election involves comparing a predicted election outcome generated by processing voter-marked ballots with the validated ballot definition file in one vote tabulator and an actual election outcome generated by an election department using its own ballot definition file and vote tabulator to process the voter-marked ballots. | 07-05-2012 |
20120206243 | METHODS AND SYSTEMS OF A MULTIPLE RADIO FREQUENCY NETWORK NODE RFID TAG - In embodiments of the present invention improved capabilities are described for a Radio Frequency ID (RFID) tag that contains multiple Radio Frequency (RF) network nodes that may include memory storage for the RFID tag, the memory storage may include one time programmable (OTP) memory and many time programmable (MTP) memory and the storage of the information may be within the OTP and MTP memory. | 08-16-2012 |
20120261479 | METHOD FOR MEMORY MAPPING IN A COMPOSITE RFID TAG FACILITY - In embodiments of the present invention improved capabilities are described for a method of memory mapping disparate memories on a composite radio frequency identification (RFID) tag, where the RFID tag includes a plurality of individual RFID devices each having a memory store with a physical memory address range and mounted to a common substrate, where at least one of the individual RFID devices comprises memory configuration information, and where a memory addressing facility maps the physical memory address ranges of each of the individual RFID devices to a single logical addressing space and presents the address space as a single memory, where the memory addressing facility is included on a computing facility separate from the composite RFID tag. | 10-18-2012 |
20130176115 | RFID DRIVE MANAGEMENT FACILITY - In embodiments of the present invention improved capabilities are described for managing RFID tags, where an RFID tag and associated RFID tag data are presented to a computing device through an RFID drive management facility as a seamless extension of a logical file system within the computing device such that the RFID tag and associated RFID tag data can be managed in a manner that is consistent with other items within the file system. | 07-11-2013 |
20140292490 | Methods and systems of a radio frequency network node RFID tag with hardened memory system - In embodiments of the present invention improved capabilities are described for a Radio Frequency identification (RFID) tag that includes an OTP-based hardened memory system for the RFID tag. | 10-02-2014 |
20150061840 | METHODS AND SYSTEMS OF A RADIO FREQUENCY NETWORK NODE RFID TAG WITH HARDENED MEMORY SYSTEM - In embodiments of the present invention improved capabilities are described for a Radio Frequency identification (RFID) tag that includes an OTP-based hardened memory system for the RFID tag. | 03-05-2015 |
20150129666 | RADIO FREQUENCY IDENTIFICATION TAG WITH HARDENED MEMORY SYSTEM - In embodiments of the present invention improved capabilities are described for RFID tags with hardened memory, where the memory comprises a plurality of one time programmable (OTP) non-volatile memory locations for storing data, wherein the plurality of OTP non-volatile memory locations are configured to emulate a hardened memory system that retains data stored in the OTP non-volatile memory locations, wherein the data stored is retained after exposure of the RFID tag to an ionizing radiation exposure with an exposure level equal to or greater than 25 kGy. | 05-14-2015 |
Laurence Moore, Newton, MA US
Patent application number | Description | Published |
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20090297519 | ANTINEOPLASTIC COMBINATIONS WITH mTOR INHIBITOR, TRASTUZUMAB, AND/OR HKI-272 - A combination of temsirolimus and trastuzumab in the treatment of cancer is provided. A combination of temsirolimus and HKI-272 is provided. A combination of a trastuzumab and a HKI-272 is also provided. Regimens and kits for treatment of metastatic breast cancer, containing trastuzumab, temsirolimus and/or HKI-272, optionally in combination with other anti-neoplastic agents, or immune modulators are described. | 12-03-2009 |
20120308560 | Antineoplastic Combinations with mTOR Inhibitor, Trastuzumab and/or HKI-272 - A combination of temsirolimus and trastuzumab in the treatment of cancer is provided. A combination of temsirolimus and HKI-272 is provided. A combination of a trastuzumab and a HKI-272 is also provided. Regimens and kits for treatment of metastatic breast cancer, containing trastuzumab, temsirolimus and/or HKI-272, optionally in combination with other anti-neoplastic agents, or immune modulators are described. | 12-06-2012 |
20140050721 | Antineoplastic Combinations with mTOR Inhibitor, Trastuzumab and/or HKI-272 - A combination of temsirolimus and trastuzumab in the treatment of cancer is provided. A combination of temsirolimus and HKI-272 is provided. A combination of a trastuzumab and a HKI-272 is also provided. Regimens and kits for treatment of metastatic breast cancer, containing trastuzumab, temsirolimus and/or HKI-272, optionally in combination with other anti-neoplastic agents, or immune modulators are described. | 02-20-2014 |
Margaret Moore, Wellesley, MA US
Patent application number | Description | Published |
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20100010829 | EMPLOYEE ASSISTANCE COACHING PROGRAM - The invention features a method for providing an EAP (employee assistance program) to multiple members of a first organization having at least fifty members. The method includes having a second organization provide to the first organization multiple EAP coaches who assist the multiple members of the first organization in achieving behavior change to address health, wellness, mental health, and productivity issues, wherein the coaches have undertaken coach training and use substantially the same coaching skills and methodology. Generally, the coaches of the second organization are as a group heterogeneous in that some of the coaches, for example, possess credentials in nutrition and weight management, and some of the coaches possess credentials in mental health. | 01-14-2010 |
20120149972 | Personalized, electronically-conveyed self-improvement messaging - The invention features a computer for fostering self-improvement in a person. The computer includes means for electronically conveying an audible message to the person. The message includes content that is generated by the person and that relates to the person's self-improvement, and includes phrases generated by the person. At least a portion of the message is an audible voice, the person's own voice or the voice of the person's coach family member, coach, or other trusted individual. Alternatively, the voice can be computer-generated. The computer can also include, or be operationally connected to, a monitor which displays messages to the person relating to the person's self-improvement. | 06-14-2012 |
20140018608 | Empathic Stimulation of the Parasympathetic Nervous System - A method for improving a health disorder related to, e.g., insufficient activation of the parasympathetic nervous system; the method can include pairing a subject and a partner, and having a session in which a relevant physiological parameter of the partner is transmitted to the subject, with the subject moving her own parameter in the direction of the partner's. | 01-16-2014 |
Martin J. Moore, Somerville, MA US
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20090106680 | DRAG AND DROP OBJECT ATTRIBUTE ASSIGNMENT FOR OBJECTS IN A GRAPHICAL USER INTERFACE (GUI) - Embodiments of the present invention address deficiencies of the art in respect to object attribution modification and provide a novel and non-obvious method, system and computer program product for drag and drop attributes for objects in a graphical user interface. In one embodiment of the invention, a method for drag and drop object attributes in a GUI can be provided. The method can include presenting draggable object attributes in the GUI, dragging one of the draggable object attributes into a separate target object in the GUI, and applying a value for the draggable object attribute to the separate target object. In one aspect of the embodiment, each of the draggable object attributes in the GUI can be separate and independent from any particular object in the GUI. In another aspect of the embodiment, each of the draggable object attributes in the GUI can be draggable from the particular object to a target object in the GUI. | 04-23-2009 |
Martin T. Moore, Somerville, MA US
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20090007113 | SYSTEM AND METHOD FOR INITIATING THE EXECUTION OF A PROCESS - A method and computer program product for defining a plurality of tags, each of which is associated with a discrete process executable on activity content. At least one of the plurality of tags is associated with a piece of content within an activity, thus defining one or more associated tags. | 01-01-2009 |
20090125837 | TAB CONTROL WITH TYPE AHEAD AND THUMBNAIL IMAGES - Embodiments of the present invention address deficiencies of the art in respect to tab control presentation and provide a method, system and computer program product for tab control management with type-ahead and thumbnail imagery. In an embodiment of the invention, a tab control navigation method can be provided. The method can include arranging thumbnail images for corresponding tabs in a tab control within a tab navigation view, and, in response to a selection of one of the thumbnail images, activating a corresponding one of the tabs in the tab control. The method further can include receiving text in a type-ahead filter, and filtering the tab navigation view to include only thumbnail images corresponding to tabs associated with the text. | 05-14-2009 |
20090171898 | SYSTEM AND METHOD FOR LEVERAGING TAG CONTEXT - A method and computer program product for leveraging the creation context of a tag includes creating one or more tags, each of the one or more tags associated with a respective piece of content. A creation context is associated with each of the one or more tags. The one or more tags are searched based upon, at least in part, the creation context. | 07-02-2009 |
20100113155 | GENERATING CONTENT RECOMMENDATIONS FROM AN ONLINE GAME - A content recommendation method can include retrieving contacts for a player of a content recommendation game and listing content associated with the retrieved contacts and prompting the player in response to a selection of a particular one of the listed content to identify a specific one of the retrieved contacts as a source associated with the particular one of the listed content. The particular one of the listed content can be recommended to the identified specific one of the retrieved contacts when the player has incorrectly identified the specific one of the retrieved contacts as a source associated with the particular one of the listed content. Otherwise, the player can be awarded points in the game to a game score for the player for having correctly identified the specific one of the retrieved contacts as a source associated with the particular one of the listed content. | 05-06-2010 |
Martin T. Moore, Westford, MA US
Patent application number | Description | Published |
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20110040742 | VARIABLE DENSITY QUERY ENGINE - Embodiments of the present invention address deficiencies of the art in respect to search engines and provide a novel and non-obvious method, system and computer program product for a variable density query engine. In an embodiment of the invention, a search engine data processing system can be provided. The system can include a content index, and a variable density search engine coupled to the content index. The variable density search engine can include program code enabled to vary a density of entries in a result set according to a varying size of the result set. In this regard, in one aspect of the embodiment, the density can range from a title for each entry in the result set to a full textual description for each entry in the result set to an audiovisual element for each entry in the result set. | 02-17-2011 |
20110041081 | ALERT LOG ACTIVITY THREAD INTEGRATION - Embodiments of the present invention address deficiencies of the art in respect to alert management in an activity-centric collaborative computing environment and provide a novel and non-obvious method, system and computer program product for activity thread integration of an alert log. In one embodiment of the invention, an alert log activity thread integration method can be provided. The method can include logging a reference to an alert for an activity in an activity thread, and, in response to the selection of the alert from within the activity thread, displaying the content of the alert. For instance, logging a reference to an alert for an activity in an activity thread can include creating a branch of the activity thread for inserting all alerts pertaining to the activity and inserting the reference to the alert in the created branch. | 02-17-2011 |
Matthew Moore, Jamaica Plain, MA US
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20130100155 | System and Method for Monochromatic Tinting Using Saturation Maps - There are provided systems and methods for tinting an image by monochromatic tinting using saturation maps for use by an application providing a user interface supporting customizable tinted images. By using saturation map and a monochromatic value map derived from the image and configuring the saturation map to specify areas for tinting, a tint color can be applied to the image by a series of quickly processed arithmetic calculations. This provides a lightweight and high quality method for tinting images within an application without wasting unnecessary network bandwidth or processor resources. Furthermore, the method can be adapted to apply multiple tint colors for multiple tints or use an alpha channel to restore color information lost due to the monochromatic value map. The resulting tinted image can also be used as a texture for a three-dimensional rendering engine. | 04-25-2013 |
Matthew Moore, Somerville, MA US
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20130024241 | METHODS AND SYSTEMS FOR COLLECTING AND PROVIDING INFORMATION REGARDING COMPANY CULTURE - Aspects of the present invention provide an efficient way for the job seeker to search for a company that fits the seeker's desired cultural traits by enabling the job seeker to identify key traits sought after in a prospective employer, and to use those traits to focus the job search. Thus, a job seeker is able to use a formal framework for assessing a company culture, can have access to a more-comprehensive listing of companies that meet certain criteria, can identify traits that are the most and least relevant to a company's culture, and can, as a result, see relative rankings of companies along various cultural dimensions. | 01-24-2013 |
Matthew Thomas Moore, Somerville, MA US
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20120197835 | METHODS AND SYSTEMS FOR PREDICTING JOB SEEKING BEHAVIOR - Embodiments of the present invention analyze information available from social-media websites to predict the likelihood that a prospective candidate will become an active recruitement candidate. | 08-02-2012 |
20140089216 | METHODS AND SYSTEMS FOR PREDICTING JOB SEEKING BEHAVIOR - Embodiments of the present invention analyze information available from social-media websites to predict the likelihood that a prospective candidate will become an active recruitment candidate. | 03-27-2014 |
Melissa J. Moore, Chestnut Hill, MA US
Patent application number | Description | Published |
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20110092375 | Deducing Exon Connectivity by RNA-Templated DNA Ligation/Sequencing - A technology is described that is capable of generating high-throughput sequencing (HTS) read length DNA products to accurately and reliably provide exon connectivity information for alternatively spliced isoforms. The method is not limited by the initial size of the isoform as the technology removes the template oligonucleotide sequence and a newly formed full length ligated product provides an HTS-compatible read length sequence that comprises information that corresponds to the consecutive order of the exons in the original template oligonucleotide. | 04-21-2011 |
20150099671 | Compositions and Methods for Constructing cDNA Libraries that Allow for Mapping the 5' and 3' Ends of RNAs - This disclosure provides methods and compositions for preparing and constructing cDNA libraries. | 04-09-2015 |
20150240232 | Deducing Exon Connectivity by RNA-Templated DNA Ligation/Sequencing - A technology is described that is capable of generating high-throughput sequencing (HTS) read length DNA products to accurately and reliably provide exon connectivity information for alternatively spliced isoforms. The method is not limited by the initial size of the isoform as the technology removes the template oligonucleotide sequence and a newly formed full length ligated product provides an HTS-compatible read length sequence that comprises information that corresponds to the consecutive order of the exons in the original template oligonucleotide. | 08-27-2015 |
Michael A. Moore, Dighton, MA US
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20130160503 | Apparatus and Methods for Restricting Access to a Gas Source - In some embodiments, a locking cap system useful for controlling access to a gaseous system includes an outer cap, an inner lock, a metallic key and a magnetic opener. The inner lock rotates freely relative to the outer cap and is releasably engaged with the gaseous system. The metallic key is configured to be at least partially axially movable within the inner lock and the outer cap. The magnetic opener is useful to bias the metallic key so that the metallic key engages the inner lock and the outer cap simultaneously to allow the inner lock to rotate concurrently with rotation of the outer cap and engage or disengage from the gaseous system. | 06-27-2013 |
20140157840 | Mechanical Apparatus and Methods for Restricting Access to a Gas Source - A cap lock system for limiting access to an access port of a gaseous system includes an outer cap including first and second key insertion passages, an inner lock having first and second key receivers and a rotatable key having first and second engagement fingers each engageable with an aligned set of key insertion passages and key receivers. | 06-12-2014 |
Michael A. Moore, Swansea, MA US
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20150107277 | Apparatus And Methods for Temporarily Holding the Evaporator/Fan Unit of a Ductless Mini-Split HVAC System Proximate to a Wall - A portable and reusable installation platform for easing the installation or maintenance of an air conditioner on a vertical wall includes at least one support base upon which at least part of the air conditioner is positioned during the installation or maintenance thereof. At least one connector extends from the first end of the support base and is configured to releasably engage the wall. At least one support leg extends downwardly from the support base and is configured to abut the wall to support the weight of the air conditioner placed upon the support base. | 04-23-2015 |
Michael Douglas Moore, Charlestown, MA US
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20140163068 | Pharmaceutical Compositions for the Treatment of CFTR Mediated Diseases - Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed. | 06-12-2014 |
Nigel S. Moore, Shrewsbury, MA US
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20140343066 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS - The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, | 11-20-2014 |
N. St. John Moore, Shrewsbury, MA US
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20090203690 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS - The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, | 08-13-2009 |
Richard H. Moore, Concord, MA US
Patent application number | Description | Published |
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20080285712 | Imaging System and Related Techniques - An imaging method and apparatus is described in which distances between a source and an object are changed and projection images are generated at each of the different distances. | 11-20-2008 |
20100020925 | Tomography System - A measurement system is presented. The measurement system includes a source and a detector located a selected distance from the source with the source and the detector movable about a point, an axis or about a plane located proximate the detector. | 01-28-2010 |
20150302594 | System and Method For Object Detection Using Structured Light - A system and method for determining a volume of a body, body part, object, or stimulated or emitted field and identifying surface anomalies of the object of interest. A first set of image data is acquired corresponding to the object of interest from an imaging device. Depth data and a second set of image data is acquired from a structured light emitter including at least one sensor. A processor receives the first and second set of image data and based thereon, generates a resultant image including the depth data. A display is configured to display the resultant image to identify surface anomalies. A geometric model is applied to the resultant image to calculate a volume of the object of interest. | 10-22-2015 |
Richard Hardwick Moore, Concord, MA US
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20150325010 | COMPUTED TOMOGRAPHY SYSTEM FOR CARGO AND TRANSPORTED CONTAINERS - An imaging system includes an x-ray or gamma ray source that emits an x-ray or gamma ray beam, a tunnel having a plurality of detectors, and a translatable platform. The detectors each receive a portion of the beam. The translatable platform supports cargo or a transported container and moves through the tunnel so that the cargo or transported container crosses the portions of the beam received by the detectors. The translatable platform may rotate and move through the tunnel at multiple angles. The imaging system may also include a computer and a graphical interface. The computer may receive information collected by the detectors and may reconstruct a three-dimensional image of the cargo or transported container. The graphical interface may display the three-dimensional image or information derived from the three-dimensional image. According to other embodiments, a system for creating a three-dimensional image may receive data from a wide vertical beam angle and generate and output a three-dimensional model. | 11-12-2015 |
Russel L. Moore, Hudson, MA US
Patent application number | Description | Published |
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20090167926 | Auto-focus and zoom module - An optical module includes a first optics group, a second optics group, and an image sensor, wherein the first optics group and second optics group are configured to provide an image having a focus and a magnification to the image sensor. In some embodiments of the present invention, a first optics assembly includes a first optics group coupled to a threaded portion of a first lead screw so that rotation of the first lead screw results in translation of the first optics group along an axis of the first lead screw, a first actuator for rotating the first lead screw; and a first sensing target configured to permit detection of rotation of the first lead screw. In some embodiments of the present invention a second optics assembly includes a second optics group coupled to a threaded portion of a second lead screw so that rotation of the second lead screw results in translation of the second optics group along an axis of the second lead screw, a second actuator for rotating the second lead screw, and second means for sensing configured to detect rotation of the second lead screw. | 07-02-2009 |
20110292526 | SYSTEM FOR STABILIZING AN OPTICS ASSEMBLY DURING TRANSLATION - An optical module includes a first optics group, a second optics group, and an image sensor, wherein the first optics group and second optics group are configured to provide an image having a focus and a magnification to the image sensor. In some embodiments of the present invention, a first optics assembly includes a first optics group coupled to a threaded portion of a first lead screw so that rotation of the first lead screw results in translation of the first optics group along an axis of the first lead screw, a first actuator for rotating the first lead screw; and a first sensing target configured to permit detection of rotation of the first lead screw. In some embodiments of the present invention a second optics assembly includes a second optics group coupled to a threaded portion of a second lead screw so that rotation of the second lead screw results in translation of the second optics group along an axis of the second lead screw, a second actuator for rotating the second lead screw, and second means for sensing configured to detect rotation of the second lead screw. | 12-01-2011 |
Scott Moore, Westford, MA US
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20110057573 | LED BALLAST POWER SUPPLY HAVING DIGITAL CONTROLLER - A power supply for an LED lamp has a set of coupled coils, primary-side power circuitry including a converter power switch for conducting input power, and secondary-side power circuitry including a dimming power switch. Power control circuitry includes converter control circuitry which generates a converter control signal for the converter power switch to maintain a desired undimmed level of lamp current at a normal operating value of a lamp voltage. Dimming control circuitry generates a dimming control signal for the dimming power switch to pulse-width modulate the lamp current at a duty cycle corresponding to a desired dimming. Operation of the converter control circuitry is modified during dimming to prevent an automatic increase of the lamp voltage in response to a decrease in lamp current, avoiding undesirable overshooting of the lamp current and providing more accurate and effective control over dimming operation. | 03-10-2011 |
20140292297 | POWER SUPPLY HAVING SELECTABLE OPERATION BASED ON COMMUNICATIONS WITH LOAD - A power supply includes signaling circuitry coupled to output terminals for engaging in bidirectional communications with a load. A controller is capable of conducting the bidirectional communications and selecting among different operating modes for the power supply based on the communications. The modes may include a constant-current mode suitable for applications such as battery charging and power LED lamps, and a constant-voltage mode suitable for a variety of conventional uses such as powering electronic circuitry. The signaling circuitry may include a power switching transistor in series with the load, which is pulsed in a binary fashion to transmit communications to the load. A signal-forming resistor in parallel with the power switching transistor develops a signaling voltage monitored by the controller to receive communications from the load. | 10-02-2014 |
Scott B. Moore, Medway, MA US
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20150181714 | SYSTEMS AND METHODS FOR CONTINUOUS FLASH LAMP SINTERING - A flash lamp system for providing at least one continuous flash lamp pulse including at least two stages for sintering. The pulse can include a first portion for a first time period to reach a first peak energy level, and a second portion for a second time period to reach a second peak energy level. The one or more pulses have sufficient energy to sinter the layer of particles such that the printed electronic circuit is conductive. | 06-25-2015 |
Stephen C. Moore, Farmingham, MA US
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20080302950 | System and Method for Performing Single Photon Emission Computed Tomography (Spect) with a Focal-Length Cone-Beam Collimation - A system and method are provided for obtaining data that may be used to generate images of a brain or other bodily organ. The system can include a pair of detecting arrangements and a collimating arrangement associated with each detecting arrangement. A first collimating arrangement can include a cone-beam collimating arrangement having a focal point located within the brain or other organ being imaged. A second collimating arrangement can include a fan-beam collimating arrangement having a focal length selected such that the organ being imaged lies within its field of view to ensure data sufficiency. Cone-beam collimating arrangements having improved hole geometries can also be utilized to provide further increases in imaging sensitivity. | 12-11-2008 |
Tim Moore, Newton, MA US
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20100222641 | SYSTEMS AND METHODS FOR DELIVERING A MEDICAL IMPLANT TO AN ANATOMICAL LOCATION IN A PATIENT - Medical implant delivery devices and systems are disclosed. In general, an exemplary delivery device comprises a shaft and a handle. An exemplary system includes any number of the following: a delivery device, a sling assembly, guide members, and connectors that interconnect the above. Embodiments of all the above components and their combinations are disclosed. Methods of using the above system in trans-obturator approaches are disclosed. | 09-02-2010 |
20120215059 | SYSTEMS AND METHODS FOR DELIVERING A MEDICAL IMPLANT TO AN ANATOMICAL LOCATION IN A PATIENT - Medical implant delivery devices and systems are disclosed. In general, an exemplary delivery device comprises a shaft and a handle. An exemplary system includes any number of the following: a delivery device, a sling assembly, guide members, and connectors that interconnect the above. Embodiments of all the above components and their combinations are disclosed. Methods of using the above system in trans-obturator approaches are disclosed. | 08-23-2012 |
20150216647 | SYSTEMS AND METHODS FOR DELIVERING A MEDICAL IMPLANT TO AN ANATOMICAL LOCATION IN A PATIENT - Medical implant delivery devices and systems are disclosed. In general, an exemplary delivery device comprises a shaft and a handle. An exemplary system includes any number of the following: a delivery device, a sling assembly, guide members, and connectors that interconnect the above. Embodiments of all the above components and their combinations are disclosed. Methods of using the above system in trans-obturator approaches are disclosed. | 08-06-2015 |