Kou, US
Binbin Kou, Bloomington, IN US
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20110245164 | YL-BASED INSULIN-LIKE GROWTH FACTORS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR - Insulin-like growth factor analogs are disclosed wherein substitution of the IGF native amino acids, at positions corresponding to positions B16 and B17 of native insulin, with tyrosine and leucine, respectively, increases potency of the resulting analog at the insulin receptor by tenfold. Also disclosed are prodrug and depot formulations of the IGF analogs, wherein the IGF analog has been modified by the linkage of a dipeptide to the analog through an amide bond linkage. The prodrug and depot formulations disclosed herein have extended half lives of at least 2 hours, 10 hours, and more typically greater than 2 are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability. | 10-06-2011 |
20110257076 | AMIDE BASED INSULIN PRODRUGS - Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability. | 10-20-2011 |
20110288003 | AMIDE BASED GLUCAGON AND SUPERFAMILY PEPTIDE PRODRUGS - Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability. | 11-24-2011 |
20130123171 | AMIDE-BASED INSULIN PRODRUGS - Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability. | 05-16-2013 |
20130123462 | AMIDE BASED GLUCAGON SUPERFAMILY PEPTIDE PRODRUGS - Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability. | 05-16-2013 |
20160058881 | PRODRUGS WITH PROLONGED ACTION - A prodrug derivative of a bioactive peptide (or polypeptide) is provided that exhibits prolonged half-life in serum and prolonged action in vivo, compared to the parent peptide or polypeptide. In some embodiments, the peptide is selected from the group consisting of glucagon, exendin-4, GLP-1, GLP-2, GIP, vasoactive intestinal peptide (VIP), Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27), peptide histidine methionine (PHM), oxyntomodulin, secretin, osteocalcin, growth hormone releasing hormone, as well as analogs, derivatives and conjugates. | 03-03-2016 |
Hui Kou, Minneapolis, MN US
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20150183265 | Multilayered Laminate and Process For Preparing The Same - This disclosure is directed to a multilayered laminate, comprising (a) a support substrate having at least one releasable major surface; (b) a transparent overcoat formed of a first coating composition on the releasable major surface of the support substrate, wherein the first coating composition comprises an aqueous polymer dispersion having a particle size in the range of 30 to 400 nm; (c) a stone-like topcoat system on the transparent overcoat, wherein the stone-like topcoat system comprises a multicolored spot layer and a background color layer; (d) an adhesive primer coat formed of a second coating composition on the stone-like topcoat system, wherein the second coating composition comprises an aqueous polymer dispersion selected from aqueous acrylic dispersions, aqueous organic silicone dispersions and aqueous vinyl acetate dispersions, wherein the transparent overcoat in the multilayered laminate, when released from the support substrate, a gloss of at least 60% at 60°. | 07-02-2015 |
Jim H. Kou, Basking Ridge, NJ US
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20110207740 | PHARMACEUTICAL COMPOSITIONS - Disclosed are useful pharmaceutical compositions. | 08-25-2011 |
Leigang Kou, Austin, TX US
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20120254540 | METHOD AND SYSTEM FOR OPTIMIZING PREFETCHING OF CACHE MEMORY LINES - A method and system to optimize prefetching of cache memory lines in a processing unit. The processing unit has logic to determine whether a vector memory operand is cached in two or more adjacent cache memory lines. In one embodiment of the invention, the determination of whether the vector memory operand is cached in two or more adjacent cache memory lines is based on the size and the starting address of the vector memory operand. In one embodiment of the invention, the pre-fetching of the two or more adjacent cache memory lines that cache the vector memory operand is performed using a single instruction that uses one issue slot and one data cache memory execution slot. By doing so, it avoids additional software prefetching instructions or operations to read a single vector memory operand when the vector memory operand is cached in more than one cache memory line. | 10-04-2012 |
Min-Lan Kou, Austin, TX US
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20110068132 | TIRE INFLATION DEVICE - A tire inflation device includes a bottle having a valve on a top end of the bottle and a top part is mounted to the top end of the bottle. The top part has a frame having a U-shaped groove and the valve extends through top part and located in the frame. A block is movably engaged with the U-shaped groove and has a curved path defined therethrough. A first end and a second end of the curved path are respectively connected with a tube and the valve. An operation member is pivotably connected to the frame so that when pivoting the operation member, the press end of the operation member pushes the block to move along the U-shaped groove and the valve is pushed by the block so that the pressurized air is released via the path and the tube. | 03-24-2011 |
Rong Kou, Richland, WA US
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20110033746 | Self assembled multi-layer nanocomposite of graphene and metal oxide materials - Nanocomposite materials having at least two layers, each layer consisting of one metal oxide bonded to at least one graphene layer were developed. The nanocomposite materials will typically have many alternating layers of metal oxides and graphene layers, bonded in a sandwich type construction and will be incorporated into an electrochemical or energy storage device. | 02-10-2011 |
20110051316 | Mesoporous Metal Oxide Graphene Nanocomposite Materials - A nanocomposite material formed of graphene and a mesoporous metal oxide having a demonstrated specific capacity of more than 200 F/g with particular utility when employed in supercapacitor applications. A method for making these nanocomposite materials by first forming a mixture of graphene, a surfactant, and a metal oxide precursor, precipitating the metal oxide precursor with the surfactant from the mixture to form a mesoporous metal oxide. The mesoporous metal oxide is then deposited onto a surface of the graphene. | 03-03-2011 |
20120295027 | MESOPOROUS METAL OXIDE GRAPHENE NANOCOMPOSITE MATERIALS - A nanocomposite material formed of graphene and a mesoporous metal oxide having a demonstrated specific capacity of more than 200 F/g with particular utility when employed in supercapacitor applications. A method for making these nanocomposite materials by first forming a mixture of graphene, a surfactant, and a metal oxide precursor, precipitating the metal oxide precursor with the surfactant from the mixture to form a mesoporous metal oxide. The mesoporous metal oxide is then deposited onto a surface of the graphene. | 11-22-2012 |
20120305165 | SELF ASSEMBLED MULTI-LAYER NANOCOMPOSITE OF GRAPHENE AND METAL OXIDE MATERIALS - Nanocomposite materials having at least two layers, each layer consisting of one metal oxide bonded to at least one graphene layer were developed. The nanocomposite materials will typically have many alternating layers of metal oxides and graphene layers, bonded in a sandwich type construction and will be incorporated into an electrochemical or energy storage device. | 12-06-2012 |
Rong Kou, State College, PA US
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20110045347 | Self Assembled Multi-Layer Nanocomposite of Graphene and Metal Oxide Materials - Nanocomposite materials having at least two layers, each layer consisting of one metal oxide bonded to at least one graphene layer were developed. The nanocomposite materials will typically have many alternating layers of metal oxides and graphene layers, bonded in a sandwich type construction and will be incorporated into an electrochemical or energy storage device. | 02-24-2011 |
Ruqin Kou, Princeton, NJ US
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20160090590 | HIGH THROUGHPUT SEQUENCING OF END REGIONS OF LONG LINEAR DNAs - This invention relates to linking, amplifying and sequencing of two ends of long linear DNAs. In particular, this invention provides methods for pairing and sequencing VH and VL genes that encode two parts of one immunoglobulin. The method of the present invention can be applied to rapid antibody discovery and engineering. | 03-31-2016 |
Sindo Kou, Madison, WI US
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20110104515 | Method of friction stir welding dissimilar metals and workpiece assemblies formed thereby - In a process for friction stir welding together pieces of dissimilar material, a first piece of a second metal is overlaid onto a first piece of a first metal that is dissimilar from the second metal such that at least a portion of the first piece of second metal overlaps a portion of the first piece of first metal. A second piece of the first metal is placed in side-to-side relationship with the first piece of second metal and overlies another portion of the first piece of first metal. The relative arrangement between the second piece of first metal and the first piece of second metal define a joint line overlying the first piece of first metal. The first piece of first metal, the first piece of second metal, and the second piece of first metal are friction stir welded together along the joint line. | 05-05-2011 |
20140134449 | Process For Friction Stir Welding Dissimilar Metals And Workpiece Assemblies Formed Thereby - In a process for friction stir welding together pieces of dissimilar material, a first piece of a second metal is overlaid onto a first piece of a first metal that is dissimilar from the second metal such that at least a portion of the first piece of second metal overlaps a portion of the first piece of first metal. The first piece of second metal has a plurality of holes therein and the holes are disposed in overlapping relationship with the portion of the first piece of first metal. Each of the holes is filled with a plug formed from the first metal. The first piece of first metal is friction stir welded to the first piece of second metal at each of the plug locations. | 05-15-2014 |
Xiaoming Kou, Newark, DE US
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20110080241 | FERROMAGNETIC RESONANCE AND MEMORY EFFECT IN MAGNETIC COMPOSITE MATERIALS - Magnetic devices incorporating magnetic composite materials are disclosed. A tunable magnetic device includes magnetic composite material and a magnetic field source. The magnetic composite material includes an insulator and magnetic material embedded in the insulator. The magnetic material has a remanent magnetization. The magnetic field source is operable to apply a magnetic field to the magnetic composite material in order to change the remanent magnetization of the magnetic material. A magnetic device for detecting a magnetic pulse includes magnetic composite material and a sensor. The magnetic composite material includes an insulator and magnetic material embedded in the insulator. The magnetic material has a remanent magnetization. The remanent magnetization changes when the magnetic composite material receives the magnetic pulse. The sensor is positioned to determine the remanent magnetization of the magnetic material. The device detects the magnetic pulse based on a change in the remanent magnetization of the magnetic composite material. | 04-07-2011 |
Yang Kou, Minneapolis, MN US
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20140106031 | LOW-FAT BATTER-LIKE COMPOSITIONS AND METHODS OF PREPARING AND USING SAME - The invention relates to low-fat batter-like compositions comprising flour or a flour replacement, sweetener, about 3% weight or less of a fat component, a fat replacing fiber having a high water-holding capacity, a leavening system, a setting agent, and a total moisture content of about 40 to about 50 weight percent. | 04-17-2014 |
20140106050 | BATTER-LIKE COMPOSITIONS CONTAINING SETTING AGENT AND METHODS OF PREPARING AND USING SAME - The invention provides batter-like compositions including flour or flour replacement ingredient, sweetener, a fat source, a chemical leavening system, and a setting agent. The resulting batter-like compositions are capable of being formed into discrete product pieces (such as pucks), and maintaining the discrete product form throughout storage and handling of the batter-like composition prior to baking. The invention further provides methods of preparing batter-like compositions having a discrete form, and methods of using such batter-like compositions to provide baked goods. | 04-17-2014 |
Yang Kou, White Plains, NY US
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20140272009 | Chewy Granola Bar With Carbonated Candy - A chewy granola product and a method of cold form sheeting such chewy granola product from a combination of dry granola, binder, and a carbonated candy. | 09-18-2014 |
Yuen-Foo Michael Kou, Andover, MA US
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20090242457 | ELECTRONIC COMPONENT ORIENTATION FOR ASSEMBLY TO CIRCUIT BOARDS - Loading a component carrier strip carrying a series of discrete components to be assembled onto circuit boards is accomplished by first inserting a free end of the component carrier strip into a slot defined by a housing (e.g., a blind slot). Then, with the component carrier strip positioned in the slot, a physical orientation of a component marking that indicates polarity is indicated to a component placement machine, e.g., by manipulating a switch, or scanning a barcode. Thereafter, the component carrier strip is removed from the slot and loaded into the component placement machine, e.g., by splicing a leading edge of the component carrier strip onto a trailing edge of a previously loaded component carrier strip. | 10-01-2009 |
20100290885 | DETECTING COMPONENT CARRIER TAPE SPLICING - In one aspect, detecting a splice connection along a component carrier tape extending from a component carrier tape feeder in a feeder slot on a pick-and-place machine having a pickup head is accomplished by scanning a section of a component carrier tape with a sensor, the sensor attached to the pick-and-place machine and positioned above or below a path of the component carrier tape, and detecting a splice connection with the sensor, the sensor generating a signal in response to detecting the splice connection such that the detection of the splice connection indicates the component carrier tape splice and such that the sensor is mounted such that relative position of the sensor with respect to the component carrier tape path is not affected by removal of the component carrier tape feeder slot or movement of the pickup head. | 11-18-2010 |