Naemura
Joseph Naemura, Bellevue, WA US
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20150071914 | METHODS OF TREATMENT USING CTLA4 MUTANT MOLECULES - The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule. | 03-12-2015 |
Joseph R. Naemura, Bellevue, WA US
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20090041769 | Methods of treatment using CTLA4 mutant molecules - The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule. | 02-12-2009 |
20100183612 | METHODS OF TREATMENT USING CTLA4 MUTANT MOLECULES - The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule. | 07-22-2010 |
Kazuo Naemura, Kanagawa JP
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20090028694 | Structure of Exhaust Turbocharger Having Waste Gate Valve - An exhaust turbocharger is provided which is enhanced in durability and reliability by making the valve body of the waste gate valve to contact uniformly the seat face of the turbine housing at the opening of two exhaust gas bypass passages without affected by the end face of the partition wall partitioning the two bypass passages, thereby preventing generation of vibration and vibration sound (chattering) of the valve body and occurrence of gas leakage due to defective seating of the valve body against the seat face of the turbine housing. The turbocharger has a twin scroll type turbine housing having two exhaust gas entrance channels and two exhaust gas bypass passages for allowing exhaust gas entered the turbine housing to bypass the turbine rotor and being equipped with a waste gate valve for opening/closing the two exhaust gas bypass passages by allowing a plate-like valve body to seat against and depart from a seat face at an outlet end side of the two bypass passages, wherein a depression is formed to a seat-side face of the valve body or to the end face of the partition wall so that the seat-side face of the valve body does not contact the end face of the partition wall at least in the central region of the end face of the partition wall when the valve body seats against the seat face at the outlet end side of the bypass passages. | 01-29-2009 |
Kenji Naemura, Tatsuno JP
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20110045039 | Hair Care Compositions Comprising First and Second Sucrose Polyesters - A hair care composition comprising: a) at least one first sucrose polyester has a melting point of above 30° C. and an iodine value (IV) of from 0 to 70; b) at least one second sucrose polyester has a melting point of 30° C. or less and an iodine value (IV) of from above 70 to about 180; and c) an aqueous carrier, for delivering conditioning benefits especially friction reduction on dry hair. | 02-24-2011 |
Kenjiro Naemura, Mitaka JP
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20150193475 | TIME-SERIES DATA ACCUMULATION DEVICE - A storage unit of a time-series data accumulation device of an embodiment stores statistical value data. A determination unit determines an interval function on the basis of data capacity, and a total amount of time elapsed from the beginning of measurement of a time-series data. A first calculation unit calculates an interval indicating an amount of time required to measure all the time-series data items constituting desired statistical value data on the basis of the determined interval function. A second calculation unit acquires all the time-series data items on the basis of the calculated interval, and thereafter calculates the statistical value on the basis of all the acquired time-series data items. A write unit writes the calculated statistical value to the storage unit as the statistical value data. | 07-09-2015 |
20150199506 | POLICY UPDATE SYSTEM AND POLICY UPDATE APPARATUS - According to one embodiment, a policy update system includes a server apparatus configured to be able to provide a plurality of services to a user, the server apparatus including storage device for storing a first user ID; a policy storage device configured to store a plurality of policies, each policy being composed of condition describing user attribute information in which a plurality of items including a second user ID corresponding to the first user ID are associated, and each policy specifying a use privilege of each service; a policy update apparatus configured to be able to update each stored policy; and a user attribute information storage device configured to store post-change user attribute information, and a change content for each second user ID. | 07-16-2015 |
Makiko Naemura, Tokyo JP
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20090013221 | Multi-component system - To reset only the CPU in a component in an abnormal condition without affecting CPUs of components in a normal condition, a multi-component system, in which a plurality of components each including at least a CPU are connected via a common bus to each other, includes a first reset signal generating unit which generates a reset signal by a switch operation to send the reset signal to respective components and a judge unit which is disposed in each component to determine whether or not resetting of a CPU is allowed. The judge unit inhibits, if the CPU is in a normal condition, the resetting of the CPU in response to the reset signal and resets, if the CPU is in an abnormal condition, the CPU in response to the reset signal. | 01-08-2009 |
Shohei Naemura, Tottori JP
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20130002990 | LIQUID CRYSTAL DISPLAY PANEL, LIQUID CRYSTAL DISPLAY, AND ELECTRONIC UNIT - A liquid crystal display panel includes: a liquid crystal layer including a liquid crystal material with positive dielectric constant anisotropy; a vertical alignment film being in contact with the liquid crystal layer; a first substrate and a second substrate disposed to face each other with the liquid crystal layer in between; and an electrode disposed on a surface of one or both of the first substrate and the second substrate and generating, in the liquid crystal layer, an electric field in a direction orthogonal to or intersecting with a normal to the first substrate. | 01-03-2013 |
Takayoshi Naemura, Okazaki-Shi, Aichi-Ken JP
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20160056534 | VEHICLE ATTACHED COMPONENT, AND ON-BOARD ANTENNA - The purpose of the present invention is to enable a secure attachment of an antenna element and to facilitate adjustment of the antenna element characteristics. Rearward of a spoiler are formed a plurality of lateral grooves extending in a left-right direction of a vehicle, and a plurality of vertical grooves extending in a front-rear direction of the vehicle. The plurality of lateral grooves and the plurality of vertical grooves form latticed grooves as grooves in the shape of a lattice for installing an antenna element. The antenna element is formed by a conductive wire. One end of the antenna element is connected to an amplifier, and the other end is opened. The antenna element extends from the amplifier via a power feeding groove and the right-end one of the vertical grooves to the rear end of the groove, from which the antenna element is fitted in a route along the most rearward one of the lateral grooves to the vicinity of the left-end one of the vertical grooves, thus being securely attached to the spoiler. | 02-25-2016 |