Patent application number | Description | Published |
20090062841 | DEVICE FOR OCCLUDING VASCULAR DEFECTS - A multi-layer occluder for treating a target site within the body is provided. The occluder may include first and second layers. For example, the first layer may include braided strands of metallic material, and the second layer may include braided strands of polymeric material. At least one of the first or second layers may be configured to facilitate thrombosis. | 03-05-2009 |
20100049307 | STENT GRAFT HAVING EXTENDED LANDING AREA AND METHOD FOR USING THE SAME - A medical device for treating a target site within a lumen having an arcuate portion is provided. The medical device includes a first tubular portion comprising a proximal and distal end, and a second tubular portion comprising a proximal and distal end. A linking portion couples the first and second tubular portions, and an opening defined between the distal end of the first tubular portion and the proximal end of the second tubular portion. At least part of the linking portion is configured to conform to at least a portion of the arcuate portion of the lumen. Associated methods for using a medical device are also provided. | 02-25-2010 |
20100063536 | DOUBLE ENDED INTRAVASCULAR MEDICAL DEVICE - An intravascular medical device including an elongated member configured to be advanced along a vascular path of a patient, the elongated member having opposite first and second ends, the first end and second ends both being adapted for intravascular insertion, and the first end having a different structure than the second end. The elongated member has sufficient flexibility to be advanced through a human vasculature. Preferably, the first and second ends are adapted to have different operating characteristics. Depending on the operating characteristics needed for a particular procedure, a physician can insert either the first end portion or the second end portion of the elongated member into the patient's vasculature. | 03-11-2010 |
20100063537 | EMBOLIC PROTECTION SYSTEMS - An embolic protection device comprising an expandable structure and a catheter. The catheter has a distal region and a working channel dimensioned to slideably receive an interventional device. The expandable structure is attached to the distal region of the catheter. The expandable structure has an expandable working channel extension and a working channel opening, the expandable working channel extension has a proximal end and a distal end, the proximal end of the working channel extension is attached to a distal end of the working channel, and the distal end of the working channel extension forms the working channel opening. The working channel opening is disposed proximate an exterior surface of the expandable structure when the expandable structure is expanded. The working channel, working channel extension, and the working channel opening form a continuous lumen. | 03-11-2010 |
20100063578 | BIFURCATED MEDICAL DEVICE FOR TREATING A TARGET SITE AND ASSOCIATED METHOD - Embodiments of the present invention provide medical devices and methods for treating a target site within the body. For example, one embodiment provides a stent graft for treating a target site proximate to a bifurcated lumen, wherein the stent graft includes a first tubular structure having proximal and distal ends and a side wall extending therebetween. The first tubular structure includes an opening defined within the side wall and is configured to define a first portion having first and second ends and a second portion having first and second ends. The opening corresponds to the first ends of the first and second portions and the second ends of the first and second portions respectively correspond to the proximal and distal ends of the first tubular structure, and at least a portion of the first and second portions are configured to be positioned within respective branches of a bifurcated lumen. | 03-11-2010 |
20100211046 | MEDICAL DEVICE WITH STIFFENER WIRE FOR OCCLUDING VASCULAR DEFECTS - Embodiments of the present invention provide devices and methods for treating various target sites. For example, one exemplary device includes a tubular structure having proximal and distal ends and at least one layer of braided material configured to facilitate thrombosis. The tubular structure includes an end section at the proximal or distal end having a cross-sectional dimension that is larger than that of an opening of the target site. The device also includes a stiffener wire coupled to the tubular structure, wherein the wire is configured to extend at least partially through the opening and facilitate securing the end section over the opening. The tubular structure and stiffener wire include respective preset, expanded configurations and are configured to be constrained to respective reduced configurations for delivery to the target site and to at least partially return to their respective preset, expanded configurations at the target site when unconstrained. | 08-19-2010 |
20120323267 | OCCLUSION DEVICE AND ASSOCIATED DEPLOYMENT METHOD - An occlusion device for occluding a cavity defined by a body is provided, and includes first and second laterally-expandable portions each formed of a woven tubular fabric and having opposed proximal and distal ends. The first portion is insertable into the cavity so as to be substantially disposed therein upon lateral expansion thereof. A connective element tethers the distal end of the first portion and the second portion, and is cooperable therewith to form a collapsible assembly extending along an insertion axis. Retention members, operably engaged with each of the first and second portions and spaced apart about a laterally outward surface thereof, are adapted to engage the body, after insertion of the collapsed assembly, second portion-first, into the cavity, and subsequent lateral expansion of the first and second portions, so as to retain the assembly substantially within the cavity. An associated deployment method is also provided. | 12-20-2012 |
20140039541 | DOUBLE ENDED INTRAVASCULAR MEDICAL DEVICE - An intravascular medical device including an elongated member configured to be advanced along a vascular path of a patient, the elongated member having opposite first and second ends, the first end and second ends both being adapted for intravascular insertion, and the first end having a different structure than the second end. The elongated member has sufficient flexibility to be advanced through a human vasculature. Preferably, the first and second ends are adapted to have different operating characteristics. Depending on the operating characteristics needed for a particular procedure, a physician can insert either the first end portion or the second end portion of the elongated member into the patient's vasculature. | 02-06-2014 |
20140249567 | EMBOLIC PROTECTION DEVICE - Embolic protection devices and systems capture and/or deflect emboli from entering one or more arterial branches of the aorta. An embolic protection device may include an anchor section that is positionable within an arterial branch of the aorta and a shield section that is operatively coupled to the anchor section. The shield section is positionable relative to one or more ostia of the aortic branches and is held in that position by the anchor section. | 09-04-2014 |
20140249568 | EMBOLIC PROTECTION PASS THROUGH TUBE - An embolic protection device includes an outer surface that is configured to form a substantially sealed relationship with a body lumen such that emboli are deflected and/or captured by the outer surface before such emboli can travel to other parts of the body. An inner surface of the embolic protection device includes a longitudinally extending lumen through which instrumentation may be inserted, facilitating passage of such instrumentation through the body lumen while minimizing risk to the patient from emboli. | 09-04-2014 |
20140257357 | OCCLUSION DEVICE AND ASSOCIATED DEPLOYMENT METHOD - An occlusion device for occluding a cavity defined by a body is provided, and includes first and second laterally-expandable portions each formed of a woven tubular fabric and having opposed proximal and distal ends. The first portion is insertable into the cavity so as to be substantially disposed therein upon lateral expansion thereof. A connective element tethers the distal end of the first portion and the second portion, and is cooperable therewith to form a collapsible assembly extending along an insertion axis. Retention members, operably engaged with each of the first and second portions and spaced apart about a laterally outward surface thereof, are adapted to engage the body, after insertion of the collapsed assembly, second portion-first, into the cavity, and subsequent lateral expansion of the first and second portions, so as to retain the assembly substantially within the cavity. An associated deployment method is also provided. | 09-11-2014 |
20150025567 | EMBOLIC PROTECTION SYSTEMS - An embolic protection device comprising an expandable structure and a catheter. The catheter has a distal region and a working channel dimensioned to slideably receive an interventional device. The expandable structure is attached to the distal region of the catheter. The expandable structure has an expandable working channel extension and a working channel opening, the expandable working channel extension has a proximal end and a distal end, the proximal end of the working channel extension is attached to a distal end of the working channel, and the distal end of the working channel extension forms the working channel opening. The working channel opening is disposed proximate an exterior surface of the expandable structure when the expandable structure is expanded. The working channel, working channel extension, and the working channel opening form a continuous lumen. | 01-22-2015 |
Patent application number | Description | Published |
20100063066 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF - Compounds of Formulas (I), (IIA) and (IIIA) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formulas (I), (IIA) and (IIIA) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. | 03-11-2010 |
20110092479 | PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS - Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. | 04-21-2011 |
20110110889 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF - Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. | 05-12-2011 |
20120157439 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF - Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. | 06-21-2012 |
20120157451 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF - Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. | 06-21-2012 |
20120157452 | 1H-PYRAZOLO[3,4-B] PYRIDINE COMPOUNDS FOR INHIBITING RAF KINASE - Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. [FORMULA I] | 06-21-2012 |
20130018033 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF - Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. | 01-17-2013 |
20130252934 | SERINE/THREONINE KINASE INHIBITORS - Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. | 09-26-2013 |
20130338140 | SERINE/THREONINE KINASE INHIBITORS - Compounds having the formula I wherein Z, Z | 12-19-2013 |
20140249127 | SERINE/THREONINE KINASE INHIBITORS - Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. | 09-04-2014 |
Patent application number | Description | Published |
20100201798 | DEPTH-AWARE BLUR KERNEL ESTIMATION METHOD FOR IRIS DEBLURRING - A method of estimating a blur kernel distribution for visual iris recognition includes determining a first mathematical relationship between an in-focus position of a camera lens and a distance between the lens and an iris whose image is to be captured by the lens. The first relationship is used to estimate a second mathematical relationship between the in-focus position of the lens and a standard deviation defining a Gaussian blur kernel distribution. A position of an eye of a living being at a future point in time is predicted. A focus position of the camera lens is adjusted based upon the predicted position of the eye. The camera lens with the adjusted focus position is used to produce an image of the living being's eye at the point in time. An actual position of the living being's eye at the point in time is sensed. The first relationship is used to ascertain a desired focus position of the lens based upon the actual position of the living being's eye at the point in time. The second relationship is used to calculate a standard deviation defining a Gaussian blur kernel distribution. The calculating is based upon a difference between the adjusted focus position and the desired focus position of the lens. | 08-12-2010 |
20100202666 | TIME-OF-FLIGHT SENSOR-ASSISTED IRIS CAPTURE SYSTEM AND METHOD - A method of identifying a living being includes using a time-of-flight sensor to determine a location of a face of the living being. An image of an iris of the living being is produced dependent upon the location of the face as determined by the time-of-flight sensor. The produced image is processed to determine an identity of the living being. | 08-12-2010 |
20100202667 | IRIS DEBLURRING METHOD BASED ON GLOBAL AND LOCAL IRIS IMAGE STATISTICS - A method of identifying a living being includes using a camera to capture a blurred visual image of an iris of the living being. The blurred visual image is digitally unblurred based on a distribution of eye image gradients in an empirically-collected sample of eye images and characteristics of pupil region. The unblurred image is processed to determine an identity of the living being. | 08-12-2010 |
20100241431 | System and Method for Multi-Modal Input Synchronization and Disambiguation - Embodiments of a dialog system that utilizes a multi-modal input interface for recognizing user input in human-machine interaction (HMI) systems are described. Embodiments include a component that receives user input from a plurality of different user input mechanisms (multi-modal input) and performs certain synchronization and disambiguation processes. The multi-modal input components synchronizes and integrates the information obtained from different modalities, disambiguates the input, and recovers from any errors that might be produced with respect to any of the user inputs. Such a system effectively addresses any ambiguity associated with the user input and corrects for errors in the human-machine interaction. | 09-23-2010 |
20110050589 | GESTURE-BASED INFORMATION AND COMMAND ENTRY FOR MOTOR VEHICLE - A method of receiving input from a user includes providing a surface within reach of a hand of the user. A plurality of locations on the surface that are touched by the user are sensed. An alphanumeric character having a shape most similar to the plurality of touched locations on the surface is determined. The user is audibly or visually informed of the alphanumeric character and/or a word in which the alphanumeric character is included. Feedback is received from the user regarding whether the alphanumeric character and/or word is an alphanumeric character and/or word that the user intended to be determined in the determining step. | 03-03-2011 |
20110128365 | TIME-OF-FLIGHT SENSOR-ASSISTED IRIS CAPTURE SYSTEM AND METHOD - A method of identifying a living being includes using a time-of-flight sensor to determine a location of a face of the living being. An image of an iris of the living being is produced dependent upon the location of the face as determined by the time-of-flight sensor. The produced image is processed to determine an identity of the living being. | 06-02-2011 |
20120027266 | TIME-OF-FLIGHT SENSOR-ASSISTED IRIS CAPTURE SYSTEM AND METHOD - A method of identifying a living being includes using a time-of-flight sensor to determine a location of a face of the living being. An image of an iris of the living being is produced dependent upon the location of the face as determined by the time-of-flight sensor. The produced image is processed to determine an identity of the living being. | 02-02-2012 |
20130147937 | DEPTH-AWARE BLUR KERNEL ESTIMATION METHOD FOR IRIS DEBLURRING - Estimating a blur kernel distribution for visual iris recognition includes determining a first mathematical relationship between an in-focus position of a camera lens and a distance between the lens and an iris whose image is to be captured by the lens. A second mathematical relationship between the in-focus position of the lens and a standard deviation defining a Gaussian blur kernel distribution is estimated. The first mathematical relationship is used to ascertain a desired focus position of the lens based upon the actual position of the living being's eye at the point in time. The second mathematical relationship is used to calculate a standard deviation defining a Gaussian blur kernel distribution. The produced image is digitally unblurred by using the blur kernel distribution defined by the calculated standard deviation. | 06-13-2013 |
20130147977 | IRIS DEBLURRING METHOD BASED ON GLOBAL AND LOCAL IRIS IMAGE STATISTICS - A method of identifying a living being includes using a camera to capture a blurred visual image of an iris of the living being. The blurred visual image is digitally unblurred based on a distribution of eye image gradients in an empirically-collected sample of eye images and characteristics of pupil region. The unblurred image is processed to determine an identity of the living being. | 06-13-2013 |
Patent application number | Description | Published |
20130220413 | Plasmonic Structures, Methods for Making Plasmonic Structures, and Devices Including Them - The present invention relates generally to plasmonic structures, methods for making them, and devices including them. In one aspect, a plasmonic structure includes a plurality of metal particles disposed on a substrate; and one or more metal structures electrically coupled to and disposed on a surface of each of the plurality of metal particles. The metal structures have a structure that is different than the structure of the metal particles. The metal structures can be grown, for example, by electrodeposition on the metal particles. Growth of such metal structures can tune the response of the plasmonic structure. | 08-29-2013 |
20130228821 | Dendritic Metal Structures, Methods for Making Dendritic Metal Structures, and Devices Including Them - The present invention relates generally to dendritic metal structures and devices including them. The present invention also relates particularly to methods for making dendritic metal structures without the use of solid electrolyte materials. In one aspect, a method for constructing a dendritic metal structure includes providing a substrate having a surface and a cathode disposed on the surface; providing an anode comprising a metal; and disposing a liquid on the surface of the substrate, such that the liquid is in electrical contact with the anode and the cathode; and then applying a bias voltage across the cathode and the anode sufficient to grow the dendritic metal structure extending from the cathode. The methods described herein can be used to grow dedritic metal electrodes, which can be useful in devices such as LEDs, touchscreens, solar cells and photodetectors. | 09-05-2013 |
Patent application number | Description | Published |
20090097067 | OPTIMIZING RASTER OPERATION FUNCTIONS DURING PRINT JOB PROCESSING - Methods for processing print jobs in rendering devices include modifying a raster operation function to have fewer variables than originally specified by the print job. Processing may also include executing the modified function and determining how many variables the function originally includes and whether such is one or more. Preferably, the modifying of the function includes determining whether a variable of the function has a black or white identity, such as a black or white ink or a black or white image, stencil or character. It may also include determining whether a destination variable remains unaltered in a to-be-painted area. Printers having stored computer executable instructions for performing the steps are also disclosed as are host devices that may direct or control the printer to perform the same. | 04-16-2009 |
20090109459 | Processing Print Jobs - Methods for processing print jobs include flagging, or not, to-be-printed objects having PDL-specified math or logic functions requiring hard processing operations, such as two or more inputs. The math or logic functions preferably reside in ink attributes of display list objects corresponding to the to-be-printed objects. To-be-printed pages of the print job become divided into bands. Bands with to-be-printed objects therein have band display lists constructed in the event the to-be-printed objects become flagged. On a band-by-band basis, if bands have band display lists flagged with hard processing operations, contone bands become constructed. The contone bands result from color information blending between overlapping pixels of to-be-printed objects or an object and a contone page. A contone page includes color information of the to-be-printed page in a first color space. To-be-printed objects are rendered in a second color space in device specific page(s) of memory. | 04-30-2009 |
20110080602 | Optimizing To-Be Printed Objects During Print Job Processing - Methods for processing print jobs in rendering devices include representing multiple to-be-printed objects with fewer such objects before processing of the objects occurs. In this manner, processing and memory requirements are optimized. Examples include utilizing a single raster operation function of one object for an entirety of objects; using fewer raster operation functions than originally required for the entirety of objects; creating a no processing (NOP) situation; and effectively creating a mask. Other aspects include modifying raster operation functions of one or more objects to have fewer variables than originally specified by the print job. Printers having stored or accessible computer executable instructions for performing the steps are also disclosed as are host devices that may direct or control the printer to perform the same. | 04-07-2011 |
20110116130 | Processing Print Jobs - Methods for processing print jobs include flagging, or not, to-be-printed objects having PDL-specified math or logic functions requiring hard processing operations, such as two or more inputs. The math or logic functions preferably reside in ink attributes of display list objects corresponding to the to-be-printed objects. To-be-printed pages of the print job become divided into bands. Bands with to-be-printed objects therein have band display lists constructed in the event the to-be-printed objects become flagged. On a band-by-band basis, if bands have band display lists flagged with hard processing operations, contone bands become constructed. The contone bands result from color information blending between overlapping pixels of to-be-printed objects or an object and a contone page. A contone page includes color information of the to-be-printed page in a first color space. To-be-printed objects are rendered in a second color space in device specific page(s) of memory. | 05-19-2011 |
Patent application number | Description | Published |
20090276921 | Nucleic Acid Molecules Encoding Fatty Acid Desaturase Genes from Plants and Methods of Use - This invention relates generally to nucleic acid sequences encoding proteins that are related to the presence of seed storage compounds in plants. More specifically, the present invention relates to FAD2-like nucleic acid sequences encoding lipid metabolism regulator proteins and the use of these sequences in transgenic plants. In particular, the invention is directed to methods for manipulating lipid metabolism related compounds and for increasing oil level and altering the fatty acid composition in plants and seeds. The invention further relates to methods of using these novel plant polypeptides to stimulate plant growth and/or to increase yield and/or composition of seed storage compounds. | 11-05-2009 |
20090293148 | Improved Methods Controlling Gene Expression - The present invention is in the field of genetics, especially plant genetics, and provides agents capable of controlling gene expression. The present invention specifically provides sequences of naturally occurring, tissue-specifically expressed microRNAs. The invention further provides for transgenic expression constructs comprising sequences encoding said microRNAs. By incorporation of the microRNA encoding sequence the expression from said expression construct is specifically silenced in the tissue where the naturally occurring microRNA is naturally expressed. Thereby the expression profile resulting from the promoter is modulated and leakiness is reduced. The invention further provides for a method for modulating transgenic expression by incorporating sequences encoding said microRNAs into transgenic expression constructs. The compositions and methods of the invention can be used to enhance performance of agricultural relevant crops and for therapy, prophylaxis, research and diagnostics in diseases and disorders, which afflict mammalian species. | 11-26-2009 |
20100180352 | Compositions and Methods of Using RNA Interference for Control of Nematodes - The present invention relates to the use of RNA interference to inhibit expression of plant parasitic nematode target let-70 genes, and relates to the generation of plants that have increased resistance to parasitic nematodes. | 07-15-2010 |
20100192237 | Methods for Controlling Gene Expression Using Ta-Sira - The present invention is in the field of genetics, especially plant genetics, and provides agents capable of controlling gene expression. More specifically the inventions relates to methods for engineering ta-siRNA primary transcripts in order to target gene-of-interest (GOI) and control their expression. The invention further provides for a method for modulating transgenic expression by said engineered ta-siRNAs. | 07-29-2010 |
20120036594 | RNA-Mediated Induction of Gene Expression in Plants - The present invention is in the field of plant genetics and provides methods for increasing gene expression of a target gene in a plant or part thereof. In addition the invention relates to methods for modifying the specificity of plant specific promoters and for engineering small non-coding activating RNA (sncaRNA) in order to increase expression of a target gene in a plant or part thereof. The present invention also provides methods for the identification of sncaRNA, and its primary transcripts in a plant capable of increasing gene expression in a plant or part thereof. | 02-09-2012 |
20120047602 | RNA-Mediated Induction of Gene Expression in Plants - The present invention is in the field of plant genetics and provides methods for increasing gene expression of a target gene in a plant or part thereof. In addition the invention relates to methods for modifying the specificity of plant specific promoters and for engineering small non-coding activating RNA (sncaRNA) in order to increase expression of a target gene in a plant or part thereof. The present invention also provides methods for the identification of sncaRNA, and its primary transcripts in a plant capable of increasing gene expression in a plant or part thereof. | 02-23-2012 |
20120272406 | METHODS OF MODIFYING LIGNIN BIOSYNTHESIS AND IMPROVING DIGESTIBILITY - The present invention relates to methods for increasing digestibility and/or crude protein of a plant by modifying lignin biosynthesis of the plant. The methods involve the manipulation of the expression level of genes in the lignin biosynthesis pathway by directly reducing the expression of genes using miRNA or using regulation of transcription factors. Expression cassettes for achieving such gene expression manipulation and transgenic plant cells and plants comprising the constructs and cassettes are also provided. Transcription regulating nucleotide sequences for use in the expression cassettes have also been developed as well as methods of using these sequences and cassettes. | 10-25-2012 |
20130031665 | ENHANCED METHODS FOR GENE REGULATION IN PLANTS - The present invention is in the field of plant molecular biology and provides methods for regulating target gene expression in plants by suppression of the activity of endogenous small regulating RNAs targeting said target gene. | 01-31-2013 |
20130117885 | Novel Microrna Precursor and Methods of Use for Regulation of Target Gene Expression - Methods for modulating target gene expression in plants by expression of recombinant microRNA precursors are provided. Uses of the said recombinant microRNA precursors for the control of nematodes, in particular the control of soybean cyst nematodes are also provided. Methods for introduction of genetic material into plants that are susceptible to nematodes in order to increase resistance to nematodes are further provided. | 05-09-2013 |
Patent application number | Description | Published |
20120090047 | MAIZE CYTOPLASMIC MALE STERILITY (CMS) C-TYPE RESTORER RF4 GENE, MOLECULAR MARKERS AND THEIR USE - This disclosure concerns high-resolution mapping and candidate gene cloning of Rf4, a maize restorer of fertility gene that restores fertility to C-type cytoplasmic male sterility. The disclosure also relates to molecular markers that are tightly-linked to, or reside within, the Rf4 gene. In some embodiments, methods are provided whereby hybrid seeds may be produced from crosses of a male plant comprising nucleic acid molecular markers that are linked to or that reside within the Rf4 gene and a female plant carrying C-type CMS. | 04-12-2012 |
20140024037 | Endpoint Zygosity Assay To Detect RF4 Gene In Maize - A method is provided for determining the zygosity of an Rf4 gene in a corn plant. A method may include performing a first PCR assay, a second PCR assay, quantifying probes used in the first and second PCR assays, and comparing the quantified probes to determine zygosity. | 01-23-2014 |
20140283212 | MARKERS LINKED TO RENIFORM NEMATODE RESISTANCE - This disclosure concerns methods and compositions for identifying cotton plants that have a reniform nematode resistance trait. Some embodiments concern molecular markers to identify, select, and/or construct reniform nematode resistant plants and germplasm, or to identify and counter-select relatively susceptible plants. This disclosure also concerns cotton plants comprising a reniform nematode resistance trait that are generated by methods utilizing at least one marker described herein. | 09-18-2014 |
20140283213 | MARKERS LINKED TO RENIFORM NEMATODE RESISTANCE - This disclosure concerns methods and compositions for identifying cotton plants that have a reniform nematode resistance trait. Some embodiments concern molecular markers to identify, select, and/or construct reniform nematode resistant plants and germplasm, or to identify and counter-select relatively susceptible plants. This disclosure also concerns cotton plants comprising a reniform nematode resistance trait that are generated by methods utilizing at least one marker described herein. | 09-18-2014 |
Patent application number | Description | Published |
20100273761 | NUCLEAR SULFATED OXYSTEROL, POTENT REGULATOR OF LIPID HOMEOSTASIS, FOR THERAPY OF HYPERCHOLESTEROLEMIA, HYPERTRIGLYCERIDES, FATTY LIVER DISEASES, AND ATHEROSCLEROSIS - The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided. | 10-28-2010 |
20120264816 | Sulfated Oxysterol and Oxysterol Sulfation by Hydroxysterol Sulfotransferase Promote Lipid Homeostasis and Liver Proliferation - Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S. | 10-18-2012 |
20130143854 | NUCLEAR SULFATED OXYSTEROL, POTENT REGULATOR OF LIPID HOMEOSTASIS, FOR THERAPY OF HYPERCHOLESTEROLEMIA, HYPERTRIGLYCERIDES, FATTY LIVER DISEASES, AND ATHEROSCLEROSIS - The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided. | 06-06-2013 |
Patent application number | Description | Published |
20090326006 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors - The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved. | 12-31-2009 |
20110065713 | Benzazole Derivatives, Compositions, and Methods of Use as B-Secretase Inhibitors - The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved. | 03-17-2011 |
20110237570 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS - The present invention provides substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutically acceptable salts thereof, and tautomers of any of the foregoing, where such compounds inhibit β-site amyloid precursor protein-cleaving enzyme (BACE), which may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention also provides pharmaceutical compositions comprising any of these compounds and the use of any of these compounds and compositions in the treatment of diseases, disorders, or conditions in which BACE is involved. | 09-29-2011 |
20120101093 | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS - The present invention is directed to substituted imidazo[1,2-a]pyridine derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved. | 04-26-2012 |
20120101125 | SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS - The present invention is directed to substituted isoquinoline derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved. | 04-26-2012 |
20140066477 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors - The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved. | 03-06-2014 |
Patent application number | Description | Published |
20100140714 | LOW LOSS SUBSTRATE FOR INTEGRATED PASSIVE DEVICES - Electronic elements ( | 06-10-2010 |
20100140814 | RF DEVICE AND METHOD WITH TRENCH UNDER BOND PAD FEATURE - Electronic elements ( | 06-10-2010 |
20110266687 | ELECTRONIC ELEMENTS AND DEVICES WITH TRENCH UNDER BOND PAD FEATURE - Electronic elements having an active device region and bonding pad (BP) region on a common substrate desirably include a dielectric region underlying the BP to reduce the parasitic impedance of the BP and its interconnection as the electronic elements are scaled to higher power and/or operating frequency. Mechanical stress created by plain (e.g., oxide only) dielectric regions can adversely affect performance, manufacturing yield, pad-to-device proximity and occupied area. This can be avoided by providing a composite dielectric region having electrically isolated inclusions of a thermal expansion coefficient (TEC) less than that of the dielectric material in which they are embedded and/or closer to the substrate TEC. For silicon substrates, poly or amorphous silicon is suitable for the inclusions and silicon oxide for the dielectric material. The inclusions preferably have a blade-like shape separated by and enclosed within the dielectric material. | 11-03-2011 |
20120037969 | MONOLITHIC MICROWAVE INTEGRATED CIRCUIT - Low Q associated with passive components of monolithic integrated circuits (ICs) when operated at microwave frequencies can be avoided or mitigated using high resistivity (e.g., ≧100 Ohm-cm) semiconductor substrates ( | 02-16-2012 |
20120038023 | LOW LOSS SUBSTRATE FOR INTEGRATED PASSIVE DEVICES - Electronic elements having an active device region and integrated passive device (IPD) region on a common substrate preferably include a composite dielectric region in the IPD region underlying the IPD to reduce electro-magnetic (E-M) coupling to the substrate. Mechanical stress created by plain dielectric regions and its deleterious affect on performance, manufacturing yield and occupied area may be avoided by providing electrically isolated inclusions in the composite dielectric region of a material having a thermal expansion coefficient (TEC) less than that of the dielectric material in the composite dielectric region. For silicon substrates, non-single crystal silicon is suitable for the inclusions and silicon oxide for the dielectric material. The inclusions preferably have a blade-like shape separated by and enclosed within the dielectric material. | 02-16-2012 |
20130105892 | LATERALLY DIFFUSED METAL OXIDE SEMICONDUCTOR TRANSISTOR FOR RADIO FREQUENCY POWER AMPLIFIER AND METHOD THEREFOR | 05-02-2013 |
20140117446 | LDMOS Device with Minority Carrier Shunt Region - A device includes a semiconductor substrate, source and drain regions in the semiconductor substrate and having a first conductivity type, a gate structure supported by the semiconductor substrate between the source and drain regions, a well region in the semiconductor substrate, having a second conductivity type, and in which a channel region is formed under the gate structure during operation, and a shunt region adjacent the well region in the semiconductor substrate and having the second conductivity type. The shunt region has a higher dopant concentration than the well region to establish a shunt path for charge carriers of the second conductivity type that electrically couples the well region to a potential of the source region. | 05-01-2014 |
20140159198 | INTEGRATED CIRCUITS INCLUDING INTEGRATED PASSIVE DEVICES AND METHODS OF MANUFACTURE THEREOF - Embodiments of integrated passive devices (e.g., metal insulator metal, or MIM, capacitors) and methods of their formation include depositing a composite electrode over a semiconductor substrate (e.g., on a dielectric layer above the substrate surface), and depositing an insulator layer over the composite electrode. The composite electrode includes an underlying electrode and an overlying electrode deposited on a top surface of the underlying electrode. The underlying electrode is formed from a first conductive material (e.g., AlCuW), and the overlying electrode is formed from a second, different conductive material (e.g., AlCu). The top surface of the underlying electrode may have a relatively rough surface morphology, and the top surface of the overlying electrode may have a relatively smooth surface morphology. For high frequency, high power applications, both the composite electrode and the insulator layer may be thicker than in some conventional integrated passive devices. | 06-12-2014 |
20140252467 | LATERALLY DIFFUSED METAL OXIDE SEMICONDUCTOR TRANSISTORS FOR RADIO FREQUENCY POWER AMPLIFIERS - Embodiments of laterally diffused metal oxide semiconductor (LDMOS) transistors are provided. An LDMOS transistor includes a substrate having a source region, channel region, and a drain region. A first implant is formed to a first depth in the substrate. A gate electrode is formed over the channel region in the substrate between the source region and the drain region. A second implant is formed in the source region of the substrate; the second implant is laterally diffused under the gate electrode a predetermined distance. A third implant is formed to a second depth in the drain region of the substrate; the second depth is less than the first depth. | 09-11-2014 |
20140284716 | LDMOS DEVICE WITH MINORITY CARRIER SHUNT REGION - A device includes a semiconductor substrate, source and drain regions in the semiconductor substrate and having a first conductivity type, a gate structure supported by the semiconductor substrate between the source and drain regions, a first well region in the semiconductor substrate, having a second conductivity type, and in which a channel region is formed under the gate structure during operation, and a second well region adjacent the first well region, having the second conductivity type, and having a higher dopant concentration than the first well region, to establish a path to carry charge carriers of the second conductivity type away from a parasitic bipolar transistor involving a junction between the channel region and the source region. | 09-25-2014 |
Patent application number | Description | Published |
20120233551 | System Of Spatial Enterprise Solution - Disclosed is a system defined, designed and implemented to provide the platform for the spatial solutions of the enterprise business workflows. In this system, the spatial solutions can be configured into the different models, which include the data source model, the virtual data model, the rendering model, the user access model, the customization model and the resource model. The system provides the spatial solutions by integrating these models. Architecturally, the system consists of three major components—the server, the admin console and the clients. The server integrates the different models, processes the data, and passes the processing results to the clients. The admin console configures these models. The clients, which run on the different platforms, render the models in the graphic manner and execute the frontend business logics. | 09-13-2012 |
20140201705 | EXTENDED FRAMEWORK FOR NO-CODING DYNAMIC CONTROL WORKFLOW DEVELOPMENT ON SPATIAL ENTERPRISE SYSTEM - Disclosed is the extended framework which enables the business analysts to develop the enterprise solutions at the runtime without coding. The workflow framework has been developed on Spatial Enterprise System (SES). To develop this framework, the role model and the workflow model have been developed first to address the basic concepts involved in the development of the enterprise solutions. With the concepts clearly defined, the components and the data structures have been developed. Furthermore, the processing engine (DC engine) has been developed to process these components and data structures at the runtime. | 07-17-2014 |
Patent application number | Description | Published |
20100016766 | ROBOTIC REHABILITATION APPARATUS AND METHOD - This patent describes an 8+2 degrees of freedom (DOF) intelligent rehabilitation robot capable of controlling the shoulder, elbow, wrist and fingers individually and allowing functional arm movements with accompanying trunk and scapular motions. The rehabilitation robot uses the following integrated rehabilitation approach: 1) it has unique diagnostic capabilities to determine patient-specific multiple joint and/or multiple DOF biomechanical and neuromuscular changes; 2) it stretches the stiff joints/DOFs under intelligent control to loosen up the specific stiff joints and to reduce excessive cross-coupling torques/movements between the specific joints/DOFs, which can be done based on the above diagnosis for subject-specific treatment; 3) the patients practice voluntary reaching and some functional tasks to regain/improve their motor control capability, which can be done after the stretching loosened up the stiff joints; and 4) the outcome will be evaluated quantitatively at the levels of individual joints, multiple joints/DOFs, and the whole arm. | 01-21-2010 |
20100106059 | SYSTEM AND METHOD FOR EVALUATING NEUROMUSCULAR AND JOINT PROPERTIES - A pocket neuromuscular evaluator delivers controlled tendon taps, makes quantitative measures of the taps and the reflex responses invoked, evaluates not only the neurological reflexes but also the muscle-joint properties, analyzes the data, displays the results, and records them to provide quantitative characterizations of the neuromuscular and joint properties. | 04-29-2010 |
20100145233 | SYSTEM AND METHOD FOR TRAINING HUMAN SUBJECTS TO IMPROVE OFF-AXIS NEUROMUSCULAR CONTROL OF THE LOWER LIMBS - Anterior cruciate ligament (ACL) is the most commonly injured knee ligament in sports-related activities, especially in pivoting sports. Considering that the knee is free to flex/extend but has much more limited motions about the off-axis (tibia rotation and valgus/varus), ACL injuries are often associated with excessive off-axis loadings. A pivoting/sliding mechanism combined with sagittal plane movement/exercise is described as a diagnostic tool to evaluate off-axis neuromechanical and anatomical risk factors of noncontact ACL injuries. The pivoting/sliding mechanism is also described as an intervention tool for off-axis training, possibly based on the diagnosis, to reduce the incidence of ACL injuries. Training outcome can also be evaluated using the pivoting/sliding mechanism. In general, the pivoting/sliding mechanism can be used with many sagittal plane exercise machines and used to improve off-axis control of the lower limbs and reduce lower limb injuries. | 06-10-2010 |
20120165158 | Wearable and convertible passive and active movement training robot: apparatus and method - In respects of limitations and problems of motor function training devices, the present invention provides a wearable and convertible device and a method for controlling combined motor function training. This device integrates the functions of both passive stretching function in the existing CPM devices and additional active assistive training function. Without a force/torque sensor element in the device, the present passive stretching control can still be adapted to hypertonia (high muscle tone or stiffness of joints) of the limb, and the present active assistive control can still be implemented for enhancing voluntary active movement from patients. With such present method, much more applications of active assistive training are supported at substantially no additional cost. On the other hand, the safety of such stretching devices without using force/torque sensor is improved, which assists in increasing the efficiency of the device of the present invention. | 06-28-2012 |
20120172176 | Lower-Limb off-axis training apparatus and system - This invention provides a lower-limb off-axis movement training apparatus, which is mounted on the movement part of a sagittal plane exercise machine and allows the user to perform off-axis movement training during sagittal plane functional movements. The said apparatus for the lower limb off-axis training consists of a base, an off-axis movement generating part mounted on the base, and a foot container supported by the off-axis movement generating part. The said off-axis movement generating part comprising at least one of the following two: (1) off-axis pivoting generating part, which generates the pivoting movement of the foot container; (2) off-axis sliding generating part, which generates the sliding movement of the foot container. | 07-05-2012 |
20130030327 | Robotic Rehabilitation Apparatus and Method - This patent describes an 8+2 degrees of freedom (DOF) intelligent rehabilitation robot capable of controlling the shoulder, elbow, wrist and fingers individually and allowing functional arm movements with accompanying trunk and scapular motions. The rehabilitation robot uses the following integrated rehabilitation approach: 1) it has unique diagnostic capabilities to determine patient-specific multiple joint and/or multiple DOF biomechanical and neuromuscular changes; 2) it stretches the stiff joints/DOFs under intelligent control to loosen up the specific stiff joints and to reduce excessive cross-coupling torques/movements between the specific joints/DOFs, which can be done based on the above diagnosis for subject-specific treatment; 3) the patients practice voluntary reaching and some functional tasks to regain/improve their motor control capability, which can be done after the stretching loosened up the stiff joints; and 4) the outcome will be evaluated quantitatively at the levels of individual joints, multiple joints/DOFs, and the whole arm. | 01-31-2013 |
Patent application number | Description | Published |
20110180828 | SOLID STATE LIGHTING DEVICES AND ASSOCIATED METHODS OF MANUFACTURING - Solid state lighting devices and associated methods of manufacturing are disclosed herein. In one embodiment, a solid state light device includes a light emitting diode with an N-type gallium nitride (GaN) material, a P-type GaN material spaced apart from the N-type GaN material, and an indium gallium nitride (InGaN) material directly between the N-type GaN material and the P-type GaN material. At least one of the N-type GaN, InGaN, and P-type GaN materials has a non-planar surface. | 07-28-2011 |
20110193115 | LIGHT EMITTING DIODES AND ASSOCIATED METHODS OF MANUFACTURING - Light emitting diodes and associated methods of manufacturing are disclosed herein. In one embodiment, a light emitting diode (LED) includes a substrate, a semiconductor material carried by the substrate, and an active region proximate to the semiconductor material. The semiconductor material has a first surface proximate to the substrate and a second surface opposite the first surface. The second surface of the semiconductor material is generally non-planar, and the active region generally conforms to the non-planar second surface of the semiconductor material. | 08-11-2011 |
20110210353 | LIGHT EMITTING DIODES WITH N-POLARITY AND ASSOCIATED METHODS OF MANUFACTURING - Light emitting diodes (“LEDs”) with N-polarity and associated methods of manufacturing are disclosed herein. In one embodiment, a method for forming a light emitting diode on a substrate having a substrate material includes forming a nitrogen-rich environment at least proximate a surface of the substrate without forming a nitrodizing product of the substrate material on the surface of the substrate. The method also includes forming an LED structure with a nitrogen polarity on the surface of the substrate with a nitrogen-rich environment. | 09-01-2011 |
20110220866 | SOLID STATE LIGHTING DEVICES GROWN ON SEMI-POLAR FACETS AND ASSOCIATED METHODS OF MANUFACTURING - Solid state lighting devices grown on semi-polar facets and associated methods of manufacturing are disclosed herein. In one embodiment, a solid state light device includes a light emitting diode with an N-type gallium nitride (“GaN”) material, a P-type GaN material spaced apart from the N-type GaN material, and an indium gallium nitride (“InGaN”)/GaN multi quantum well (“MQW”) active region directly between the N-type GaN material and the P-type GaN material. At least one of the N-type GaN, InGaN/GaN MQW, and P-type GaN materials is grown a semi-polar sidewall. | 09-15-2011 |
20110233581 | SOLID STATE LIGHTING DEVICES WITH CELLULAR ARRAYS AND ASSOCIATED METHODS OF MANUFACTURING - Solid state lighting (“SSL”) devices with cellular arrays and associated methods of manufacturing are disclosed herein. In one embodiment, a light emitting diode includes a semiconductor material having a first surface and a second surface opposite the first surface. The semiconductor material has an aperture extending into the semiconductor material from the first surface. The light emitting diode also includes an active region in direct contact with the semiconductor material, and at least a portion of the active region is in the aperture of the semiconductor material. | 09-29-2011 |
20120013273 | SOLID STATE LIGHTING DEVICES WITHOUT CONVERTER MATERIALS AND ASSOCIATED METHODS OF MANUFACTURING - Solid state lighting devices that can produce white light without a phosphor are disclosed herein. In one embodiment, a solid state lighting device includes a first semiconductor material, a second semiconductor material spaced apart from the first semiconductor material, and an active region between the first and second semiconductor materials. The active region includes a first sub-region having a first center wavelength and a second sub-region having a second center wavelength different from the first center wavelength. | 01-19-2012 |
20120161151 | SOLID STATE LIGHTING DEVICES AND ASSOCIATED METHODS OF MANUFACTURING - Solid state lighting devices and associated methods of manufacturing are disclosed herein. In one embodiment, a solid state light device includes a light emitting diode with an N-type gallium nitride (GaN) material, a P-type GaN material spaced apart from the N-type GaN material, and an indium gallium nitride (InGaN) material directly between the N-type GaN material and the P-type GaN material. At least one of the N-type GaN, InGaN, and P-type GaN materials has a non-planar surface. | 06-28-2012 |
20130005065 | SOLID STATE LIGHTING DEVICES WITH CELLULAR ARRAYS AND ASSOCIATED METHODS OF MANUFACTURING - Solid state lighting (“SSL”) devices with cellular arrays and associated methods of manufacturing are disclosed herein. In one embodiment, a light emitting diode includes a semiconductor material having a first surface and a second surface opposite the first surface. The semiconductor material has an aperture extending into the semiconductor material from the first surface. The light emitting diode also includes an active region in direct contact with the semiconductor material, and at least a portion of the active region is in the aperture of the semiconductor material. | 01-03-2013 |
20130252365 | SOLID STATE LIGHTING DEVICES GROWN ON SEMI-POLAR FACETS AND ASSOCIATED METHODS OF MANUFACTURING - Solid state lighting devices grown on semi-polar facets and associated methods of manufacturing are disclosed herein. In one embodiment, a solid state light device includes a light emitting diode with an N-type gallium nitride (“GaN”) material, a P-type GaN material spaced apart from the N-type GaN material, and an indium gallium nitride (“InGaN”)/GaN multi quantum well (“MQW”) active region directly between the N-type GaN material and the P-type GaN material. At least one of the N-type GaN, InGaN/GaN MQW, and P-type GaN materials is grown a semi-polar sidewall. | 09-26-2013 |
20130288416 | SOLID STATE LIGHTING DEVICES AND ASSOCIATED METHODS OF MANUFACTURING - Solid state lighting devices and associated methods of manufacturing are disclosed herein. In one embodiment, a solid state light device includes a light emitting diode with an N-type gallium nitride (GaN) material, a P-type GaN material spaced apart from the N-type GaN material, and an indium gallium nitride (InGaN) material directly between the N-type GaN material and the P-type GaN material. At least one of the N-type GaN, InGaN, and P-type GaN materials has a non-planar surface. | 10-31-2013 |
20130342133 | SOLID STATE LIGHTING DEVICES WITHOUT CONVERTER MATERIALS AND ASSOCIATED METHODS OF MANUFACTURING - Solid state lighting devices that can produce white light without a phosphor are disclosed herein. In one embodiment, a solid state lighting device includes a first semiconductor material, a second semiconductor material spaced apart from the first semiconductor material, and an active region between the first and second semiconductor materials. The active region includes a first sub-region having a first center wavelength and a second sub-region having a second center wavelength different from the first center wavelength. | 12-26-2013 |
20140319536 | SOLID STATE LIGHTING DEVICES WITH CELLULAR ARRAYS AND ASSOCIATED METHODS OF MANUFACTURING - Solid state lighting (“SSL”) devices with cellular arrays and associated methods of manufacturing are disclosed herein. In one embodiment, a light emitting diode includes a semiconductor material having a first surface and a second surface opposite the first surface. The semiconductor material has an aperture extending into the semiconductor material from the first surface. The light emitting diode also includes an active region in direct contact with the semiconductor material, and at least a portion of the active region is in the aperture of the semiconductor material. | 10-30-2014 |
20150028347 | LIGHT EMITTING DIODES AND ASSOCIATED METHODS OF MANUFACTURING - Light emitting diodes and associated methods of manufacturing are disclosed herein. In one embodiment, a light emitting diode (LED) includes a substrate, a semiconductor material carried by the substrate, and an active region proximate to the semiconductor material. The semiconductor material has a first surface proximate to the substrate and a second surface opposite the first surface. The second surface of the semiconductor material is generally non-planar, and the active region generally conforms to the non-planar second surface of the semiconductor material. | 01-29-2015 |
Patent application number | Description | Published |
20140256534 | METAL OXIDE NANOROD ARRAYS ON MONOLITHIC SUBSTRATES - A metal oxide nanorod array structure according to embodiments disclosed herein includes a monolithic substrate having a surface and multiple channels, an interface layer bonded to the surface of the substrate, and a metal oxide nanorod array coupled to the substrate surface via the interface layer. The metal oxide can include ceria, zinc oxide, tin oxide, alumina, zirconia, cobalt oxide, and gallium oxide. The substrate can include a glass substrate, a plastic substrate, a silicon substrate, a ceramic monolith, and a stainless steel monolith. The ceramic can include cordierite, alumina, tin oxide, and titania. The nanorod array structure can include a perovskite shell, such as a lanthanum-based transition metal oxide, or a metal oxide shell, such as ceria, zinc oxide, tin oxide, alumina, zirconia, cobalt oxide, and gallium oxide, or a coating of metal particles, such as platinum, gold, palladium, rhodium, and ruthenium, over each metal oxide nanorod. Structures can be bonded to the surface of a substrate and resist erosion if exposed to high velocity flow rates. | 09-11-2014 |
Patent application number | Description | Published |
20090074704 | Multi-Arm Polymer Prodrugs - Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug. | 03-19-2009 |
20100152414 | MULTI-ARM POLYMER PRODRUGS - Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug. | 06-17-2010 |
20100184989 | De Novo Synthesis of Conjugates - The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path. | 07-22-2010 |
20100190933 | MULTI-ARM POLYMER PRODRUGS - Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug. | 07-29-2010 |
20100286084 | Oligomer-Nucleoside Phosphate Conjugates - The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble, non-peptidic oligomer. The conjugates of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds. | 11-11-2010 |
20100317707 | Oligomer-Nitroimidazole Anti-Infective Conjugates - The invention provides (among other things) small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. | 12-16-2010 |
20110098273 | Oligomer-Calcium Channel Blocker Conjugates - The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer. | 04-28-2011 |
20110237747 | Multi-Arm Polypeptide-Poly(ethylene glycol) Block Copolymers as Drug Delivery Vehicles - The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region. | 09-29-2011 |
20120004242 | Oligomer-Diarylpiperazine Conjugates - The invention relates to (among other things) oligomer-diarylpiperazine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated diarylpiperazine compounds. | 01-05-2012 |
20130158062 | MULTI-ARM POLYMER PRODRUGS - Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug. | 06-20-2013 |