Patent application number | Description | Published |
20080241820 | MULTIPLEX CELLULAR ASSAYS USING DETECTABLE CELL BARCODES - We describe herein a cell-based multiplexing technique called detectable cell barcoding (DCB). In DCB, each individual sample is labeled with a different DCB signature that distinguishes each sample by one or both of detected intensity or type of detection characteristic. The samples are then combined and analyzed for a detectable characteristic of interest (e.g., presence of an analyte). By employing multiple distinct DCB labels at varying concentrations, one can perform multiplex analyses on up to hundreds or thousands (or more) of cell samples in a single reaction tube. DCB reduces reagent consumption by factors of 100-fold or more, significantly reduces data acquisition times and allows for stringent control sample analysis. | 10-02-2008 |
20100009364 | Methods for diagnosis, prognosis and methods of treatment - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 01-14-2010 |
20100099074 | COLLECTION DEVICE AND METHOD FOR STIMULATING AND STABILIZING A BIOLOGICAL SAMPLE - A collection device and methods for stimulating and stabilizing a biological sample are provided. Aspects of the device include an evacuated sample collection container having stimulating and stabilizing additives contained in separate internal chambers of the container. The internal chambers are arranged to facilitate stimulation upon collection of a sample, followed by stabilization of the sample after a desired period of time in the same sealed container. Also provided are methods for use of the subject device. The device and methods find use in a variety of different applications, including the collection and analysis of clinically relevant samples, such as whole blood and other body fluids, obtained directly from a patient. | 04-22-2010 |
20100151472 | Detection Composition - The invention provides methods, kits, devices and compositions for detecting one or more target analytes. In some embodiments, the invention provides binding elements and labeling elements capable of being joined through a plurality of joining elements. | 06-17-2010 |
20110263457 | Multiplex Cellular Assays Using Detectable Cell Barcodes - We describe herein a cell-based multiplexing technique called detectable cell barcoding (DCB). In DCB, each individual sample is labeled with a different DCB signature that distinguishes each sample by one or both of detected intensity or type of detection characteristic. The samples are then combined and analyzed for a detectable characteristic of interest (e.g., presence of an analyte). By employing multiple distinct DCB labels at varying concentrations, one can perform multiplex analyses on up to hundreds or thousands (or more) of cell samples in a single reaction tube. DCB reduces reagent consumption by factors of 100-fold or more, significantly reduces data acquisition times and allows for stringent control sample analysis. | 10-27-2011 |
20130024177 | HYPER-SPATIAL METHODS FOR MODELING BIOLOGICAL EVENTS - The present invention provides various methods of generating and using models of biological events. The models can be used to classify individuals according to the biological event. | 01-24-2013 |
20130130279 | METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 05-23-2013 |
20130287790 | USE OF JAM-A IN DIAGNOSING AND TREATING LEUKEMIA - Methods, compositions, and kits are provided for the use of JAM-A in diagnosing and treating leukemia. These methods, compositions, and kits find many uses, for example in diagnosing an individual with a leukemia, classifying a leukemia, providing a prognosis to an individual with a leukemia, treating an individual with a leukemia, screening candidate agents for the ability to treat a leukemia, and in basic research to better understand the molecular and cellular basis of leukemia. | 10-31-2013 |
20150017119 | METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 01-15-2015 |
Patent application number | Description | Published |
20110112686 | DEVICES AND METHODS AND SYSTEMS FOR DETERMINING AND/OR INDICATING A MEDICAMENT DOSAGE REGIME - In one aspect, the disclosure is directed to a device for determining and/or indicating a medicament dosage regime. The device may include a housing, a processor, a memory, an input device, and/or an indication device. The dosage determining and/or indicating device is configured for receiving user, e.g., patient, information, medicament information, and/or dosage information, and using that information to determine one or more of the following: the type of medicament recommended to be administered, how often and when the medicament should be administered, how much of the medicament should be administered, potential problematic cross reactivity information, and/or patient compliance information, such as when the when the medicament was last administered, when the medicament is next due to be administered, when a recommended administration was not administered, and the like. The device may further be coupled to an alarm to indicate when a dosage of the medicament is to be delivered. | 05-12-2011 |
20140031703 | ATHLETIC MONITORING - A system for determining a set of characteristics of a participant performing an activity is provided. The system includes two or more data collectors and a processor. The two or more data collectors include a physical data collector for collecting physical data associated with the activity and a physiological data collector for collecting physiological data associated with the activity. The processor has one or more data inputs in communication with the processor. Each of the one or more data inputs communicates with at least one of the data collectors to receive the physical data or the physiological data. The processor is adapted to receive the physical data and the physiological data from the one or more data inputs and process the physical data and the physiological data according to a characteristic generation program. The set of characteristics represents a performance level of the participant performing the physical activity. | 01-30-2014 |
Patent application number | Description | Published |
20090187535 | Method and Apparatus for Improved Information Transactions - Methods and systems for analyzing an image, such as a newspaper or magazine pager or the like including text by mapping the image to determine regions of text and analyzing portions of the image in accordance with characteristics of selected regions of the text to develop a desired ordering of at least the selected regions in accordance with a textual relationship between the selected regions. The desired order may be related to the order in which the selected regions, and or words therein, are to be presented in a different format appropriate for a specific use, such by a human reader, for transferring the text over a network, for use in a database or by a search function, word processor or printer. Normalizing, columnizing, regionalizing, frameset building and article tracing functions may be used to develop the desired order in related regions in an article within the image. | 07-23-2009 |
20100235353 | Method and Apparatus for Real Time Text Analysis and Text Navigation - An end user, by way of a submission interface, instructs an engine to select particular collections of documents to process. The engine processes all the text from within all the documents from within the selected collections. The result of the processing of such text is a distilled data set. Such distillate data set is accessed through APIs by a browser. Different views of the accessed distillate data set may be presented to the end user via the browser allowing them to more effectively assess the utility of the presented data and thereby responsively tune the presented data set with regard to their particular research task. One or more of such views may be used to create a new document from sentences, paragraphs, chapters or documents from the distillate data set that correspond to the one or more views for presentation to the end user. | 09-16-2010 |
20110302482 | METHOD AND APPARATUS FOR IMPROVED INFORMATION TRANSACTIONS - Methods and systems for analyzing an image, such as a newspaper or magazine pager or the like including text by mapping the image to determine regions of text and analyzing portions of the image in accordance with characteristics of selected regions of the text to develop a desired ordering of at least the selected regions in accordance with a textual relationship between the selected regions. The desired order may be related to the order in which the selected regions, and or words therein, are to be presented in a different format appropriate for a specific use, such by a human reader, for transferring the text over a network, for use in a database or by a search function, word processor or printer. Normalizing, columnizing, regionalizing, frameset building and article tracing functions may be used to develop the desired order in related regions in an article within the image. | 12-08-2011 |
Patent application number | Description | Published |
20130220907 | Portable Dialysis Machine with Improved Reservoir Heating System - The specification discloses a portable dialysis machine having a detachable controller unit and base unit with an improved reservoir heating system. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a reservoir with an internal pan and external pan, separated by a space that holds a heating element. The heating element is electrically coupled to electrical contacts attached to the external surface of the external pan. | 08-29-2013 |
20140174835 | Load Suspension and Weighing System for a Dialysis Machine Reservoir - A load suspension and weighing system for a removable reservoir unit of a portable dialysis machine includes a centrally located flexure assembly. The flexure assembly includes magnets and a number of flexure rings which allow for movement of the magnets about a fixed circuit board. Sensors in the circuit board sense changes in the magnetic field as the magnets move in relation to the circuit board. The magnetic field changes produce a voltage output which is used by a processor to generate weight calculations. The top of the flexure assembly is attached to the interior of the dialysis machine. The entirety of the reservoir unit is suspended by a first internal frame that is attached to the bottom of the flexure assembly. Having a single flexure assembly positioned above the reservoir unit provides more accurate weight measurements while also preventing damage to the assembly from water spillage. | 06-26-2014 |
20140175012 | Method and System of Monitoring Electrolyte Levels and Composition Using Capacitance or Induction - Methods and systems for monitoring fluid levels and electrolyte levels used in a dialysis machine. A receptacle, configured to receive a container, comprises a plurality of curved side panels and a base to form a cylindrical shaped cavity for receiving a container. Each panel includes a conductive material on its inner surface and, optionally, a shielding on its outer surface. An electronics component housed within, or near, the receptacle drives the capacitive process and interprets generated data to determine fluid levels and compositions. An alternate receptacle includes one or two coils wrapped about the container and uses induction to determine fluid level. | 06-26-2014 |
Patent application number | Description | Published |
20100072056 | SUBSTRATE HOLDERS FOR UNIFORM REACTIVE SPUTTERING - A substrate holder for a substrate including a frame body having an opening for the placement of the substrate. The frame body also includes a hollow portion therein. The substrate holder may be used in a sputtering apparatus for sputtering material onto the substrate. The substrate holder is particularly advantageous in the manufacturing of magnetic recording medium. | 03-25-2010 |
20100092802 | MULTI-STEP ETCH PROCESS FOR GRANULAR MEDIA - A method of forming a granular magnetic recording medium comprises etching a cap layer disposed on a granular magnetic recording layer. The etching process is carried out at a varying ion energy, including a first ion energy and a lower subsequent second energy. A device including the etched cap layer is also disclosed. | 04-15-2010 |
20100124671 | LOW COUPLING OXIDE MEDIA (LCOM) - A low-coupling perpendicular magnetic recording media comprising a magnetic storage layer and at least one low saturation magnetization layer. The magnetic storage layer has a saturation magnetization between about 400-900 emu/cm | 05-20-2010 |
20110076515 | Low-Coupling Oxide Media (LCOM) - A low-coupling perpendicular magnetic recording media comprising a magnetic storage layer and at least one low saturation magnetization layer. The magnetic storage layer has a saturation magnetization between about 400-900 emu/cm3 and the at least one low saturation magnetization layer has a saturation magnetization below that of the magnetic storage layer. | 03-31-2011 |
20130045394 | Low-Coupling Oxide Media (LCOM) - A low-coupling perpendicular magnetic recording media comprising a magnetic storage layer and at least one low saturation magnetization layer. The magnetic storage layer has a saturation magnetization between about 400-900 emu/cm3 and the at least one low saturation magnetization layer has a saturation magnetization below that of the magnetic storage layer. | 02-21-2013 |
20130163118 | RECORDING MEDIUM WITH THIN STABILIZATION LAYER HAVING HIGH MAGNETIC SATURATION AND ANISOTROPIC FIELD CHARACTERISTICS - A perpendicular recording medium with enhanced magnetic stability. In accordance with some embodiments, a multi-layer recording structure is formed on a base substrate and adapted to magnetically store a magnetic bit sequence in domains substantially perpendicular to said layers. A thin magnetic stabilization layer is formed on the multi-layer recording substrate to magnetically stabilize an upper portion of the recording structure. | 06-27-2013 |
Patent application number | Description | Published |
20110043939 | Magnetic Recording Media with Reliable Writability and Erasure - Methods and media structures are provided for increasing writability and reducing unintentional erasure of perpendicular magnetic recording media. Variable permeability is controlled within a thin soft underlayer (SUL) structure, independent of bulk SUL material properties such as magnetic moment (B | 02-24-2011 |
20120219827 | Stack Including a Magnetic Zero Layer - A stack including a crystallographic orientation interlayer, a magnetic zero layer disposed on the interlayer, and a magnetic recording layer disposed on the magnetic zero layer is disclosed. The magnetic zero layer is non-magnetic or has a saturation magnetic flux density (B | 08-30-2012 |
20130209835 | MULTIPLE LAYER FEPT STRUCTURE - A method involves depositing a seed layer comprising at least A1 phase FePt. A main layer of A1 phase FePt is deposited over the seed layer. The main layer includes FePt of a different stoichiometry than the seed layer. The seed and main layers are annealed to convert the A1 phase FePt to L10 phase FePt. The annealing involves heating the substrate prior to depositing at least part of the A1 phase FePt of the main or seed layers. | 08-15-2013 |
20130280556 | MAGNETIC RECORDING MEDIA WITH SOFT MAGNETIC UNDERLAYERS - Provided herein, is an apparatus that includes a nonmagnetic substrate having a surface; and a plurality of overlying thin film layers forming a layer stack on the substrate surface. The layer stack includes a magnetically hard perpendicular magnetic recording layer structure and an underlying soft magnetic underlayer (SUL), wherein the sum of a magnetic thickness of the layer stack is a magnetic thickness of up to about 2 memu/cm̂2. | 10-24-2013 |
20130288079 | Data Media With Tuned Thermal Conductivity and Magnetic Permeability - Various magnetic slack embodiments may be constructed with a soft magnetic underlayer (SUL) having a first thickness disposed between a substrate and a magnetic recording layer. A heatsink may have a second thickness and be disposed between the SUL and the magnetic recording layer. The first and second thicknesses may each be tuned to provide predetermined thermal conductivity and magnetic permeability throughout the data media. | 10-31-2013 |
20140044993 | PERPENDICULAR RECORDING MEDIUM WITH OXIDE GRADIENT LAYER - Apparatus for recording data and method for making the same. In accordance with some embodiments, a recording layer is supported by a substrate. The recording layer has a granular magnetic recording layer with a first oxide content, a continuous magnetic recording layer with nominally no oxide content, and an oxide gradient layer disposed between the respective granular magnetic recording layer and the continuous magnetic recording layer. The oxide gradient layer has a second oxide content less than the first oxide content of the granular layer. | 02-13-2014 |
20140127533 | PATTERNED TEMPLATE WITH 1xN NUCLEATION SITE TO GRAIN GROWTH FOR UNIFORM GRAIN SIZE RECORDING MEDIA - A perpendicular magnetic media includes a substrate, a patterned template, a seed layer and a magnetic layer. The patterned template is formed on the substrate and includes a plurality of growth sites that are evenly spaced apart from each other. The seed layer is formed over the patterned template and the exposed areas of the substrate. Magnetic material is sputter deposited onto the seed layer with one grain of the magnetic material nucleated over each of the growth sites. The grain size distribution of the magnetic material is reduced by controlling the locations of the growth sites which optimizes the performance of the perpendicular magnetic media. | 05-08-2014 |
20140272470 | Energy Assisted Segregation Material - Apparatus for recording data and method for making the same. In accordance with some embodiments, a magnetic layer is supported by a substrate and comprises a magnetic magnetic material, a non-magnetic material, and an energy assisted segregation material. The segregation material enhances segregation of the non-magnetic material into grain boundaries within the layer at an elevated, moderate energy level. | 09-18-2014 |
20140313615 | APPARATUS COMPRISING MAGNETICALLY SOFT UNDERLAYER - Provided herein is an apparatus, including a magnetically soft underlayer (SUL); an interlayer stack overlying the SUL, wherein the interlayer stack comprises a seed layer of an fcc material; and a perpendicular magnetic recording layer overlying the interlayer stack, wherein a thickness of the SUL in combination with a distance of the SUL from the perpendicular recording layer is sufficient to orient a total magnetic field corresponding to a magnetic transducer head at an angle of about 45°. | 10-23-2014 |
20150017481 | BIT PATTERNED GROWTH GUIDING MECHANISM - The embodiments disclose a structure, including a first layer selectively etched on a substrate with a seedlayer deposited thereon, a first layer bit patterned growth guiding mechanism on the seedlayer, and a plurality of bit patterned magnetic recording features grown on the seedlayer guided by the growth guiding mechanism. | 01-15-2015 |
20150017482 | METHOD FOR FABRICATING PLASMONIC CLADDING - The embodiments disclose a plasmonic cladding structure including at least one conformal plasmonic cladding structure wrapped around plural stack features of a recording device, wherein the conformal plasmonic cladding structure is configured to create a near-field transducer in close proximity to a recording head of the recording device, at least one conformal plasmonic cladding structure with substantially removed top surfaces of the stack features with exposed magnetic layer materials and a thermally insulating filler configured to be located between the stack features. | 01-15-2015 |
Patent application number | Description | Published |
20090214896 | PERPENDICULAR RECORDING MAGNETIC MEDIA HAVING A GRANULAR MAGNETIC RECORDING LAYER AND AN AMORPHOUS SOFT UNDERLAYER - A perpendicular magnetic recording medium having a substrate, an amorphous soft underlayer of thickness 30 nm or greater, and a granular magnetic recording layer for perpendicular recording is disclosed. The granular magnetic recording layer includes a non-magnetic region between magnetic grains, wherein the non-magnetic region includes metal nitride or metal carbide and provides exchange decoupling between the magnetic grains. The perpendicular recording medium of this invention reduces DC noise and increases media signal-to-noise ratio; it reduces surface roughness, which in turn reduces the head-to-media spacing and the head-to-amorphous soft underlayer spacing. | 08-27-2009 |
20100081012 | PERPENDICULAR MEDIA WITH Cr-DOPED Fe-ALLOY-CONTAINING SOFT UNDERLAYER (SUL) FOR IMPROVED CORROSION PERFORMANCE - A perpendicular magnetic recording medium having a substrate, a Cr-doped Fe-alloy-containing underlayer containing about 8 to 18 at % Cr and a perpendicular recording magnetic layer, and a process for improving corrosion resistance of the recording medium and for manufacturing the recording medium are disclosed. | 04-01-2010 |
20100177439 | PERPENDICULAR MEDIA WITH REDUCED SIDE TRACK ERASURE - A media for perpendicular recording and a method of creating the media is provided. The media includes a hard recording layer and a soft underlayer (SUL). The SUL is composed of at least two anti-ferromagnetically coupled (AFC) sub-underlayers. The sub-underlayers respond to a magnetic field established during dynamic reversal with respective magnetic fields. The sub-underlayers are formed and disposed to differ in one or more magnetic moment, anisotropy, and thickness, so that their respective magnetic fields constructively interfere in one or more points in the hard recording layer, thereby reducing a total SUL magnetic field response to the dynamic reversal field approximately to zero at one or more points in the hard recording layer, which reduces side track erasure. | 07-15-2010 |
20100209737 | MAGNETIC RECORDING MEDIA WITH ENHANCED WRITABILITY AND THERMAL STABILITY - Aspects are directed to recording media with enhanced magnetic properties for improved writability. Examples can be included or related to methods, systems and components that allow for improved writability while reducing defects so as to obtain uniform magnetic properties such as uniformly high anisotropy and narrow switching field distribution. Some examples include a recording medium with an exchange tuning layer inserted between the hard layer and the soft, semi-soft or thin semi-hard layer so as to maximize the writability improvement of the media. Preferably, the exchange tuning layer is granular and reduces or optimizes the vertical coupling between the hard layer and the soft, semi-soft or semi-hard layer of a magnetic recording or storing device. | 08-19-2010 |
20100282413 | MULTICHAMBER PROCESSING WITH SIMULTANEAOUS WORKPIECE TRANSPORT AND GAS DELIVERY - A method for treating/processing substrates/workpieces in a multi-chamber treatment/processing apparatus, comprising:
| 11-11-2010 |
20110129692 | MAGNETIC ALLOY MATERIALS WITH HCP STABILIZED MICROSTRUCTURE, MAGNETIC RECORDING MEDIA COMPRISING SAME, AND FABRICATION METHOD THEREFOR - A magnetic recording medium comprises:
| 06-02-2011 |
20110143167 | Tilted Recording Media with L10 Magnetic Layer - Magnetic recording media having a magnetic layer with an easy magnetization axis lying about 35° out of plane of the magnetic layer is disclosed. This media has a reduced total magnetic layer thickness and higher signal, while improving the media signal-to-noise ratio (SNR). | 06-16-2011 |
20110223445 | METHOD & APPARATUS FOR MULTI-STAGE SPUTTER DEPOSITION OF UNIFORM THICKNESS LAYERS - A method of forming a uniform thickness layer of a selected material on a surface of a substrate comprises steps of:
| 09-15-2011 |
20120026626 | APPARATUS INCLUDING A PERPENDICULAR MAGNETIC RECORDING LAYER HAVING A CONVEX MAGNETIC ANISOTROPY PROFILE - An apparatus may include a first magnetic layer, a first exchange break layer formed on the first magnetic layer, a second magnetic layer formed on the first exchange break layer, a second exchange break layer formed on the second magnetic layer, and a third magnetic layer formed on the second exchange break layer. The first magnetic layer has a first magnetic anisotropy energy, H | 02-02-2012 |
20120070694 | Perpendicular Media with Cr-Doped Fe-Alloy Containing Soft Underlayer (SUL) - A perpendicular magnetic recording medium having a substrate, a Cr-doped Fe-alloy-containing underlayer containing about 8 to 18 at % Cr and a perpendicular recording magnetic layer, and a process for improving corrosion resistance of the recording medium and for manufacturing the recording medium are disclosed. | 03-22-2012 |
20130004796 | RECORDING LAYER FOR HEAT ASSISTED MAGNETIC RECORDING - A magnetic stack includes multiple granular layers, at least one of the multiple granular layers is a magnetic layer that includes exchange coupled magnetic grains separated by a segregant having Ms greater than 100 emu/cc. Each of the multiple granular layers have anisotropic thermal conductivity. | 01-03-2013 |