Patent application number | Description | Published |
20090233285 | SPECIFIC METHOD OF PROSTATE CANCER DETECTION BASED ON PCA3 GENE, AND KITS THEREFOR - The present invention relates, in general, to prostate cancer. More specifically, the present invention relates to a method to diagnose prostate cancer in a patient by detecting a PCA3 sequence, and more particularly a PCA3 RNA, the PCA3 sequence detected in a sample from the patient being specifically associated with prostate cancer. In a particular embodiment the method and kit enables an amplification of a PCA3 RNA through an exon-exon junction of a spliced PCA3 mRNA. The invention also relates to methods and kits to detect such an amplified PCA3 RNA, using a probe which spans the amplified exon-exon junction. In particular the methods and kits are designed to detect a PCA3 RNA which lacks one intron or more, and in particular case is intron-less. The invention further relates to a method of detecting PCA3 RNA expressed in non-prostate tissue or cells of the urinary tract, that comprises PCA3 intron 3. | 09-17-2009 |
20120309006 | SPECIFIC METHOD OF PROSTATE CANCER DETECTION BASED ON PCA3 GENE, AND KITS THEREFOR - The invention relates to a method to diagnose prostate cancer by detecting a PCA3 sequence. In one embodiment the method and kit enables amplification of PCA3 RNA through an exon-exon junction of a spliced PCA3 mRNA, and methods and kits to detect an amplified PCA3 RNA, using a probe which spans the amplified exon-exon junction. The methods and kits can detect a PCA3 RNA lacking one intron or more. Also provided are methods of detecting PCA3 RNA expressed in non-prostate tissue or cells of the urinary tract, which comprises PCA3 intron 3. In addition, methods are provided to determine whether a sample from a subject contains or lacks prostate cells, by performing a hybridization and/or amplification reaction on RNA from the sample to detect the presence or level of PCA3 RNA that lacks at least one intron and distinguishing a prostate cell from a non-prostate cell. | 12-06-2012 |
20130261171 | PROSTATE CANCER PROGNOSTIC COMPOSITIONS AND KITS - Described herein are method, compositions and kits for prognosis of prostate cancer. The methods include determining the ratio of PCA3 and of a prostate-specific marker expression in a urine sample and correlating the value of the PCA3/prostate-specific marker ratio with the aggressiveness and mortality risk of prostate cancer in the subject. The method for prognosing prostate cancer in a sample of a patient includes assessing the amount of a prostate cancer specific PCA3 mRNA and the amount of prostate-specific marker in the sample; determining a ratio value of this amount of prostate cancer specific PCA3 mRNA over the amount of prostate-specific marker; comparing the ratio value to at least one predetermined cut-off value, wherein a ratio value above the predetermined cut-off value is indicative of a higher risk of mortality of prostate cancer as compared to a ratio value below the predetermined cut-off value. | 10-03-2013 |
20150307948 | PROSTATE CANCER PROGNOSTIC COMPOSITIONS AND KITS - Described herein are method, compositions and kits for prognosis of prostate cancer. The methods include determining the ratio of PCA3 and of a prostate-specific marker expression in a urine sample and correlating the value of the PCA3/prostate-specific marker ratio with the aggressiveness and mortality risk of prostate cancer in the subject. The method for prognosing prostate cancer in a sample of a patient includes assessing the amount of a prostate cancer specific PCA3 mRNA and the amount of prostate-specific marker in the sample; determining a ratio value of this amount of prostate cancer specific PCA3 mRNA over the amount of prostate-specific marker; comparing the ratio value to at least one predetermined cut-off value, wherein a ratio value above the predetermined cut-off value is indicative of a higher risk of mortality of prostate cancer as compared to a ratio value below the predetermined cut-off value. | 10-29-2015 |
Patent application number | Description | Published |
20130250371 | TWO-DIMENSIONAL CALIBRATION OF IMAGE SENSOR ALIGNMENT IN OPTICAL SCANNERS - Disclosed is a method of processing image signals from a first and a second image sensor, both of a document scanner unit, where the first image sensor provides a first image, and the second image sensor provides a second image. The first and the second image are two-dimensional images wherein said first and second image are recorded at respective areas of a scanned medium, where a portion of the respective areas is recorded also by the other of the respective image sensors. Thereby image data from overlapping and non-overlapping areas are present in the first and the second image. The method comprises: correlating the first image with the second image, creating a correlation image and processing the correlation image to determine a displacement between the first and the second image. Consequently, a versatile calibration method is provided that can determine a displacement between the first and the second image in two dimensions. | 09-26-2013 |
20130258418 | COMPENSATING FOR IMAGE SENSOR PROFILE VARIATIONS - Disclosed is a method of scanning a physical medium by an image scanner comprising a first image sensor having a plurality of image sensor elements that provide an image, and a first light source associated with the first image sensor, the method comprising: guiding light from the first light source towards a first group of image sensor element(s); recording a first light calibration value using the first group of image sensor element(s). The method further comprises repeating the above step by using a second group of image sensor element(s) thus resulting in a second light calibration value; generating a first compensation signal for image sensor elements positioned between the first and the second group of image sensor element(s) by processing the first and the second light calibration value together; compensating said image signals provided by the first image sensor using the first compensation signal. | 10-03-2013 |
20130286451 | SIGNAL INTENSITY MATCHING OF IMAGE SENSORS - Disclosed is a method of processing signals from a large-format scanner comprising a first and a second image sensor that provide respective image signals recorded at respective areas of a scanned medium, where a portion of the respective areas is recorded also by the other of the respective image sensors, whereby image data from overlapping and non-overlapping areas are present in the respective signals; the method comprising: determining a first and a second level of intensity from image signals from the first and the second image sensor at the overlapping area, respectively; determining a compensation value by processing the first level of intensity and the second level of intensity to determine a discrepancy between the level of intensities; applying compensation values to image data from overlapping and non-overlapping areas to provide compensated image data to compensate for a discrepancy between levels of intensity from the first and the second image sensor. | 10-31-2013 |
Patent application number | Description | Published |
20100187527 | TAMPER-RESISTANT SEMICONDUCTOR DEVICE AND METHODS OF MANUFACTURING THEREOF - The invention relates to a tamper-resistant semiconductor device comprising a substrate ( | 07-29-2010 |
20100234209 | PARTICLE COMPRISING CORE AND SHELL AND APPLICATIONS THEREOF - The present invention relates to particles comprising a core and a shell, a method of producing said particle, various uses of said particle as well as various products comprising said particle. The particle according to the invention may be used as photocatalyst, as antibacterial agent, as cleaning agent, as anti-fogging agent and as decomposing agent. Furthermore the particle is applicable as solar cells. | 09-16-2010 |
20110180931 | ROBUST HIGH ASPECT RATIO SEMICONDUCTOR DEVICE - The invention relates to an semi-conductor device comprising a first surface and neighboring first and second electric elements arranged on the first surface, in which each of the first and second elements extends from the first surface in a first direction, the first element having a cross section substantially perpendicular to the first direction and a sidewall surface extending at least partially in the first direction, wherein the sidewall surface comprises a first section and a second section adjoining the first section along a line extending substantially parallel to the first direction, wherein the first and second sections are placed at an angle with respect to each other for providing an inner corner wherein the sidewall surface at the inner corner is, at least partially, arranged at a constant distance R from a facing part of the second element for providing a mechanical reinforcement structure at the inner corner. | 07-28-2011 |
20110183186 | SOLID STATE BATTERY - The present invention relates to a method of manufacturing a solid-state battery with a high flexibility. The method comprises the steps of: forming an arrangement of battery cells ( | 07-28-2011 |
20110272786 | ENERGY STORAGE SYSTEM - An energy storage device ( | 11-10-2011 |