Okun, CA
Alex Okun, San Diego, CA US
Patent application number | Description | Published |
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20090071268 | HIGH SPEED SAMPLE SUPPLY DEVICE - Disclosed herein is a sample supply device that alternates between the supply of samples from one sample line while cleaning a second sample line and then supplying a second sample from the second sample line while cleaning the first sample line. This is repeated in rapid succession to allow greater speed in analyzing a plurality of samples in a shorter amount of time. | 03-19-2009 |
20090186374 | APPARATUS FOR MEASURING EFFECT OF TEST COMPOUNDS ON BIOLOGICAL OBJECTS - An apparatus and method for real-time measurement of an effect of different concentrations of a test compound or series of test compounds on living cells, in which a flow of cell suspension is combined with a flow of the test compound and a cellular response of the living cells is repeatedly measured by a detector along a length of a detection zone where the cell suspension-test compound mixture is situated. The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test compounds and generation of three-dimensional dose/response/time profiles within a short timespan. | 07-23-2009 |
20110065172 | DIRECT MIXING AND INJECTION FOR HIGH THROUGHPUT FLUIDIC SYSTEMS - A system and method of mixing and injecting discrete sample mixtures into a flow cytometer or other sample analysis apparatus may generally comprise a sample injection guide coupling a liquid handling apparatus with a sample analysis apparatus and facilitating injection of discrete sample mixtures into a fluidic system of the apparatus. | 03-17-2011 |
20130109101 | METHODS FOR MULTIPLEXED SAMPLE ANALYSIS | 05-02-2013 |
Ilya Okun, San Diego, CA US
Patent application number | Description | Published |
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20090186374 | APPARATUS FOR MEASURING EFFECT OF TEST COMPOUNDS ON BIOLOGICAL OBJECTS - An apparatus and method for real-time measurement of an effect of different concentrations of a test compound or series of test compounds on living cells, in which a flow of cell suspension is combined with a flow of the test compound and a cellular response of the living cells is repeatedly measured by a detector along a length of a detection zone where the cell suspension-test compound mixture is situated. The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test compounds and generation of three-dimensional dose/response/time profiles within a short timespan. | 07-23-2009 |
20110098291 | ANTAGONIST OF SMOOTHENED - Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary diseases and disorders. | 04-28-2011 |
Ilya Matusovich Okun, San Diego, CA US
Patent application number | Description | Published |
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20110039825 | LIGANDS OF ALPHA-ADRENOCEPTORS, DOPAMINE, HISTAMINE, IMIDAZOLINE AND SEROTONIN RECEPTORS AND THEIR USE - The invention relates to novel ligands the broad spectrum of biological activity of which includes simultaneously α-adrenoceptors, dopamine receptors, histamine receptors, imidazoline receptors and serotonin receptors, among them serotonin 5-HT | 02-17-2011 |
20110046368 | LIGANDS OF 5-HT6 RECEPTORS, A PHARMACEUTICAL COMPOSITION, METHOD FOR THE PRODUCTION AND USE THEREOF - The invention relates to novel ligands of 5-HT | 02-24-2011 |
20110053915 | HETEROCYCLIC INHIBITORS OF AN Hh-SIGNAL CASCADE, MEDICINAL COMPOSITIONS BASED THEREON AND METHODS FOR TREATING DISEASES CAUSED BY THE ABERRANT ACTIVITY OF AN Hh-SIGNAL SYSTEM - The invention relates to novel heterocyclic compounds and to the use thereof, to pharmaceutical compositions containing said chemical compounds as an active ingredient and to the use thereof for producing medicinal preparations for the human being and warm-blood animals for treating diseases caused by the aberrant activity of an Hedgehog (Hh)-signal system, in particular oncological diseases. The invention also relates to the use of the above-mentioned compounds in the form of ‘molecular pharmacological tools’ for examining (in vitro and in vivo) the biochemical features of the Hh-signal system, in particular, the interaction of Hh protein and transmembrane proteins, namely, suppressor Patched (Ptc) and protooncogenic proteins. The eight groups of the claimed compounds comprise the derivatives of 2,6-dihydro-7H-pyrazolo[3,4-d]pyridazine-7-one and 1,4-dihydropyrazolo[3,4-b][1,4]thiazine-5-one; N-acidylated 4-imidazo[1,2-a]pyrimidine-2-il-anilines; ([4H-thino[3,2-b]pyrrol-5-il) carbonyl]piperidine-4-carbonic acid amides; 2-(4carbomoilpyperidine-1-il)-isonicotinic acid amides; N-sylphonyl-1,2,3,4-tetrahydroquinoline-6-carbonic acid amides; and pyridine 2-amino-4,5,6,7-tetrahydrothieno[2,3-c] N-acidylated 3-azole derivatives. | 03-03-2011 |
20110160197 | Substituted Indoles and a Method for the Production and Use Thereof - The invention relates to novel substituted indoles, to the use thereof in the form of pharmacological composition substances and to use of said composition for producing medicinal preparations used for preventing and treating viral diseases, in particular caused by viruses of infectious hepatitis (HCV, HBV), human immune deficiency (HIV), atypical pneumonia (SARS) and bird flu. The invention proposes novel substituted indoles of general formula (1) or the racemates or the optical isomers or the pharmaceutically acceptable salts and/or hydrates thereof, wherein R | 06-30-2011 |
Justin A. Okun, Lake Forest, CA US
Patent application number | Description | Published |
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20110238781 | AUTOMATED TRANSFER OF BULK DATA INCLUDING WORKLOAD MANAGEMENT OPERATING STATISTICS - Methods and systems for transferring bulk data, such as workload operation statistics, are disclosed. One method includes communicatively connecting a first computing system to a second computing system that stores bulk data, and determining a subset of the bulk data to be requested. The method further includes forming one or more extraction ranges representing the subset of the bulk data. For each of the one or more extraction ranges, the method includes transmitting a request for data including an identification of the extraction range, and receiving a data block defined by the extraction range and extracted from the bulk data. | 09-29-2011 |
20120323924 | METHOD AND SYSTEM FOR A MULTIPLE DATABASE REPOSITORY - Method, system, and programs for creating partitioned or fragmented log files during data logging to better manage file size, more easily facilitate data retrieval and file optimization. In an embodiment, typically large monolithic log files are fragmented or divided into smaller files that can be searched, stored, vacuumed and retrieved more easily. | 12-20-2012 |
20130024480 | METHOD AND SYSTEM FOR ANALYSIS OF DATABASE RECORDS - Method, system, and programs for analyzing data records, to easily identify problems with saved data, facilitate data retrieval and file report optimization. In an embodiment, the user is presented with a visual representation of the data records to alert the user of any problems, omissions, or errors in the data. | 01-24-2013 |
20130117436 | AUTOMATIC CONFIGURATION CONSISTENCY CHECK - Reliability and performance of complex applications executed across workload groups of one or more host computer systems may be improved by automating the verification of consistent policies across the workload groups. An automatic verification process may be executed on a host computer system to identify workload groups that are not collecting statistics, to identify polices that are not enforced on certain workload groups, to identify policies that are not in force for certain periods of the day, and to identify policies that are disabled. Where an application has a complex configuration, the automatic verification process allows an administrator to identify inconsistent policies. | 05-09-2013 |
Llya Matusovich Okun, San Diego, CA US
Patent application number | Description | Published |
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20100120792 | Substituted 2,3,4,5-Tetrahyrdo-1H-Pyrido[4,3-B]Indoles, Methods for the Production and Use Thereof - The invention relates to antagonists of serotonin 5-HT | 05-13-2010 |