Win, US
Hla Y. Win, Tampa, FL US
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20090130195 | PROSTATE CARCINOGENESIS PREDICTOR - A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-ι and (c) comparing the expression level in (b) to a level of expression in a normal control, wherein overexpression of PKC-ι, with respect to the control, indicates the presence of prostate cancer in the subject. The present invention is based upon the discovery that PKC-ι levels are elevated during prostate tumorigenesis. Furthermore, the proliferation rate of the tumor correlates with the level of PKC-ι. The invention also provides methods of treating prostate cancer by administering to the subject a compound that inhibits the expression of PKC-ι. The compound can be a small interfering RNA (siRNA) molecule. | 05-21-2009 |
20120294932 | Prostate Carcinogenesis Predictor - A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-ι and (c) comparing the expression level in (b) to a level of expression in a normal control, wherein overexpression of PKC-ι, with respect to the control, indicates the presence of prostate cancer in the subject. The present invention is based upon the discovery that PKC-ι levels are elevated during prostate tumorigenesis. Furthermore, the proliferation rate of the tumor correlates with the level of PKC-ι. The invention also provides methods of treating prostate cancer by administering to the subject a compound that inhibits the expression of PKC-ι. The compound can be a small interfering RNA (siRNA) molecule. | 11-22-2012 |
20140065208 | PROSTATE CARCINOGENESIS PREDICTOR - A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-ι and (c) comparing the expression level in (b) to a level of expression in a normal control, wherein overexpression of PKC-ι, with respect to the control, indicates the presence of prostate cancer in the subject. The present invention is based upon the discovery that PKC-ι levels are elevated during prostate tumorigenesis. Furthermore, the proliferation rate of the tumor correlates with the level of PKC-ι. The invention also provides methods of treating prostate cancer by administering to the subject a compound that inhibits the expression of PKC-ι. The compound can be a small interfering RNA (siRNA) molecule. | 03-06-2014 |
Hla Yee Win, Tampa, FL US
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20090075932 | METHOD OF SELECTIVELY INHIBITING PKCiota - PKCiota inhibitor 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-,[1R-(1α,2β,3β,4α)], (ICA-1), targets a unique sequence (amino acid residues 469-475) in the catalytic domain of PKCiota and inhibits PKCiota activity. The data shows suprising and unexpected ability of ICA-1 to selectively inhibit the proliferation of cells that overexpress PKCiota. | 03-19-2009 |
Maung Nyan Win, San Gabriel, CA US
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20090098561 | Higher-order cellular information processing devices - The invention provides various signal processing devices for integrating two or more biological signals (e.g., the presence, absence or concentration of specific ligands, etc.) to generate a status output, or a response that modulates one or more biological activities based on the status of the biological signals. The various described signal processing/integration mechanisms may be combined with one another to provide the device with more flexibility in integrating high-order cellular information. The signal processing devices of the invention have many uses in various biological systems, including gene expression control or ligand-concentration sensing. | 04-16-2009 |
20090143327 | General composition framework for ligand-controlled regulatory systems - The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom. The invention contemplates improving the design of the switches (ligand-controlled regulatory systems) through the design of an information transmission domain (ITD). The improved ITD eliminates free-floating ends of the switching and the competing strands, and localizes competitive hybridization events to a contiguous strand of competing and switching strands in a strand-displacement mechanism-based switch, thereby improving the kinetics of strand-displacement. The improved regulatory systems have many uses in various biological systems, including gene expression control or ligand-concentration sensing. | 06-04-2009 |
20110002892 | MODULAR APTAMAR-REGULATED RIBOZYMES - An extensible RNA-based framework for engineering ligand-controlled gene regulatory systems, called ribozyme switches, that exhibit tunable regulation, design modularity, and target specificity is provided. These switch platforms typically contain a sensor domain, comprised of an aptamer sequence, and an actuator domain, comprised of a hammerhead ribozyme sequence. A variety of modes of standardized information transmission between these domains can be employed, and this application demonstrates a mechanism that allows for the reliable and modular assembly of functioning synthetic hammerhead ribozyme switches and regulation of ribozyme activity in response to various effectors. In some embodiments aptamer-regulated cis-acting hammerhead ribozymes are provided. | 01-06-2011 |
20120165387 | General composition framework for ligand-controlled RNA regulatory systems - The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom. The invention contemplates improving the design of the switches (ligand-controlled regulatory systems) through the design of an information transmission domain (ITD). The improved ITD eliminates free-floating ends of the switching and the competing strands, and localizes competitive hybridization events to a contiguous strand of competing and switching strands in a strand-displacement mechanism-based switch, thereby improving the kinetics of strand-displacement. The improved regulatory systems have many uses in various biological systems, including gene expression control or ligand-concentration sensing. | 06-28-2012 |
20120263691 | MODULAR APTAMER-REGULATED RIBOZYMES - An extensible RNA-based framework for engineering ligand-controlled gene regulatory systems, called ribozyme switches, that exhibit tunable regulation, design modularity, and target specificity is provided. These switch platforms typically contain a sensor domain, comprised of an aptamer sequence, and an actuator domain, comprised of a hammerhead ribozyme sequence. A variety of modes of standardized information transmission between these domains can be employed, and this application demonstrates a mechanism that allows for the reliable and modular assembly of functioning synthetic hammerhead ribozyme switches and regulation of ribozyme activity in response to various effectors. In some embodiments aptamer-regulated cis-acting hammerhead ribozymes are provided. | 10-18-2012 |
20130102651 | GENERAL COMPOSITION FRAMEWORK FOR LIGAND-CONTROLLED RNA REGULATORY SYSTEMS - The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom. The invention contemplates improving the design of the switches (ligand-controlled regulatory systems) through the design of an information transmission domain (ITD). The improved ITD eliminates free-floating ends of the switching and the competing strands, and localizes competitive hybridization events to a contiguous strand of competing and switching strands in a strand-displacement mechanism-based switch, thereby improving the kinetics of strand-displacement. The improved regulatory systems have many uses in various biological systems, including gene expression control or ligand-concentration sensing. | 04-25-2013 |
Moe Z. Win, Framingham, MA US
Patent application number | Description | Published |
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20080268873 | Cooperative localization for wireless networks - A system and corresponding method using a cooperative localization technique for self identifying a location of a wireless device in a wireless network is presented. The system may estimate an arbitrary signal metric as a function of a signal received by the wireless device from the at least one other wireless device in the wireless network. The system may also convert at least one belief representing a distribution of at least one possible location of the at least one other wireless device to generate at least one converted belief. The system may further determine a self-belief as a function of the at least one converted belief and identify a self location, as a function of the self-belief, within the wireless network. | 10-30-2008 |
20110177786 | Method and system for identification and mitigation of errors in non-line-of-sight distance estimation - Ultra-wide bandwidth (UWB) transmission is a promising technology for indoor localization due to its fine delay resolution and obstacle-penetration capabilities. However, the presence of walls and other obstacles present a significant challenge in terms of localization, as they result in positively biased distance estimates. Measurement campaigns with FCC-compliant UWB radios can quantify effects of non-line-of-sight (NLOS) propagation. Features of waveforms measured during a campaign can be extracted for use in distinguishing between NLOS and line-of-sight situations in embodiments of the present invention. Embodiments further include classification and regression methods based on machine learning that improve the localization performance while relying solely on the received signal. Applications for systems employing an example embodiment of the invention include indoor or outdoor search and recovery with high accuracy and low cost. | 07-21-2011 |
20120310591 | TRACKING A BODY BY NONLINEAR AND NON-GAUSSIAN PARAMETRIC FILTERING - A general framework for parametric filters is based on belief condensation (BC), which can cope with highly nonlinear and non-Gaussian system models. The methodology exploits the specific structure of the problem and decomposes it in such a way that the linear and Gaussian part can be solved in closed form, while the remaining parts are addressed by an optimization process, referred to as BC. Simulation results show that the performance of the proposed BC filter is close to that of the particle filter, but with a much lower complexity. | 12-06-2012 |
Moe Z. Win, Cambridge, MA US
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20110038439 | Method of Selecting Receive Antennas for MIMO Systems - A method of performing receive antenna selection is presented. The method executes a determination operation for a set of receive antennas, determines a maximum result of the determination operation for two of the antennas, eliminates one of the two antennas from the set of antennas, and repeats the determination and elimination process until only a predetermined number of antennas remain in the set. The signals from these remaining antennas are then processed. The present invention reduces receiver complexity and cost. | 02-17-2011 |
20140307837 | METHOD OF SELECTING RECEIVE ANTENNAS FOR MIMO SYSTEMS - A method of performing receive antenna selection is presented. The method executes a determination operation for a set of receive antennas, determines a maximum result of the determination operation for two of the antennas, eliminates one of the two antennas from the set of antennas, and repeats the determination and elimination process until only a predetermined number of antennas remain in the set. The signals from these remaining antennas are then processed. The present invention reduces receiver complexity and cost. | 10-16-2014 |
Patrick Win, St. Louis, MO US
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20110118624 | Reuseable skin testing device - The present invention provides a device and method for skin testing. The device includes a handle assembly connected to a cylinder assembly having a first and second cylinder housing. Each cylinder housing is connected to at least one testing head assembly that includes a plurality of pins having a plurality of tips positionable against the skin and a socket assembly that is structured and operable to pivot the testing head to apply equal and even pressure to all the pins. Further, the method provides positioning the device tangent to the surface of the skin, and pivoting the testing head assembly horizontally to apply equal and even pressure to the pins. | 05-19-2011 |
Patrick H. Win, Richmond Heights, MO US
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20120101406 | BIAXIAL TEST HEAD - The present invention provides a device for skin testing. The device includes a handle assembly connected to a cylinder assembly having two mutually parallel and spaced apart cylinder housings. Each cylinder housing connects to at least one testing head assembly that includes a plurality of pins having a plurality of tips positionable against the skin. Each head assembly has a collar and cooperating tip structured to pivot the testing head on two axes only and still apply even pressure to the pins. Each testing head readily inserts into the collar for usage and ejects promptly from the handle using a trigger mechanism. The cylinder housing construction minimizes accumulation of detritus therein. | 04-26-2012 |
Phyo Win, Rockville, MD US
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20140114674 | Health Insurance Plan Comparison Tool - A tool comparing different health insurance plans. A User can review a plurality of health plans for likely cost, quality, and provider availability. The results are arranged in a table according to selectable criteria, such as actuarially estimated total costs (premiums plus actuarial estimate of out-of-pocket). Actuarial cost estimates are used with one or more of the following: personalized summary quality measures produced by the User's applying personal weights to different aspects of quality; availability of User-selected health care providers indicating if these providers participate in each listed plan; information on the costs and quality of available health care providers; ability for User to adjust actuarial estimates based on User-predicted health care conditions, procedures, and products; and ability for User to adjust premiums based on User preference as to whether to accept the full available subsidy. User can sort, filter, and select plans based on displayed features. | 04-24-2014 |
Thazin Win, Fremont, CA US
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20150025566 | MECHANICALLY DETACHABLE VASO-OCCLUSIVE DEVICE - A device for delivering an occlusive element includes an elongate pusher member having a lumen. A locking member is disposed within the lumen of the elongate pusher member. A moveable elongate releasing member is disposed within the lumen of the elongate pusher member. A filament is secured to the distal end of the elongate releasing member. The occlusive member is locked to the elongate releasing member when the filament passes through a securing member on the occlusive member and is pinched or wedged between the looking member and the elongate releasing member. The occlusive element is in an unlocked state when the elongate releasing member is retracted proximally relative to the elongate pusher member. The filament, along with the elongate releasing member, are retracted proximally until the filament is detached or uncoupled from the securing member of the occlusive member. | 01-22-2015 |
Thazin Win, Chicago, IL US
Patent application number | Description | Published |
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20080300616 | MECHANICALLY DETACHABLE VASO-OCCLUSIVE DEVICE - A device for delivering an occlusive element includes an elongate pusher member having a lumen extending between distal and proximal ends. An elongate releasing member is slideably disposed within the lumen of the elongate pusher member. A retaining member is disposed on the distal end of the elongate pusher member and includes a finger portion having an aperture sized to receive the distal end of the elongate releasing member. An occlusive element such as a coil is provided and includes a securing member positioned at a proximal end thereof. The securing member is releasably secured to the finger portion of the retaining member. The securing member is secured to the finger portion when the elongate releasing member is disposed in the aperture of the finger portion and unsecured when the elongate releasing member is retracted proximally from the aperture of the finger portion. | 12-04-2008 |
20080306503 | MECHANICALLY DETACHABLE VASO-OCCLUSIVE DEVICE - A device for delivering an occlusive element such as a vaso-occlusive coil includes an elongate sheath. An elongate releasing member having a distal tip or end is moveable within a lumen of the elongate sheath. A filament is provided having first and second ends with each end being fixed relative to the elongate sheath to form a loop segment. The loop segment of the filament is passed through a securing member located on the proximal end of the occlusive element. The distal tip of the elongate releasing member is inserted into the portion of the loop segment that passes through the securing member to lock the occlusive element relative to the elongate sheath. The occlusive element is released by pulling the elongate releasing member proximally to retract the distal tip from the loop segment of the filament. | 12-11-2008 |
20080306504 | MECHANICALLY DETACHABLE VASO-OCCLUSIVE DEVICE - A device for delivering an occlusive element includes an elongate pusher member having a lumen. A locking member is disposed within the lumen of the elongate pusher member. A moveable elongate releasing member is disposed within the lumen of the elongate pusher member. A filament is secured to the distal end of the elongate releasing member. The occlusive member is locked to the elongate releasing member when the filament passes through a securing member on the occlusive member and is pinched or wedged between the locking member and the elongate releasing member. The occlusive element is in an unlocked state when the elongate releasing member is retracted proximally relative to the elongate pusher member. The filament, along with the elongate releasing member, are retracted proximally until the filament is detached or uncoupled from the securing member of the occlusive member. | 12-11-2008 |
Win Nunu Win, Schaumburg, IL US
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20120250537 | ADAPTIVE POWER SAVING FOR A MOBILE SUBSCRIBER UNIT IN A WIRELESS COMMUNICATION NETWORK - A method and apparatus for adaptive power saving for a mobile subscriber unit in a wireless communication network includes receiving beacons from an access point, measuring timing periods between received beacons, determining a delay in timing periods, and associating the delay in timing periods to a change in a quality of a communication link. The link quality can be quantified and used for reconfiguring power-save parameters in response to a change in link quality. | 10-04-2012 |
Win Nu Nu Win, Palatine, IL US
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20140315542 | ESTABLISHING MOBILE CONNECTIVITY CONDITIONS FOR MOBILE SUBSCRIBER UNITS IN A WIRELESS COMMUNICATION NETWORK - An apparatus and method for establishing mobile connectivity conditions for mobile subscriber units in a wireless communication network includes scanning, by each mobile subscriber unit, for candidate access points and affiliated channels for roaming, whereupon the unit can roam from an originating access point to one of the candidate access points on an affiliated channel for roaming. A link record in the mobile subscriber unit is used for recording an entry including the originating access point, the candidate access point, the affiliated channel for roaming, and a handoff experience value. The link record can be used upon subsequent roaming of the unit to attempt a self-devised handoff without further scanning for access points and affiliated channels. Link records can be shared between mobile subscriber units to speed up map building of link records. | 10-23-2014 |
Zaw Win, San Jose, CA US
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20130110029 | IMPLANTABLE FLOW CONNECTOR | 05-02-2013 |
20140180191 | IMPLANTABLE FLOW CONNECTOR - An implantable flow connector for fluidically coupling a source tissue-enclosed body space with a destination element, comprising: a conduit having a lumen terminating at an orifice at a first end of the conduit implantable in the source body space through an opening formed in a tissue wall of the source body space, and a second end of the conduit implantable in the destination element through an opening in a surface of the destination element; and a circumferential flange, radially extending from the conduit proximate the conduit first end, configured to be implanted in the source body space adjacent an opening in the tissue wall of the source body space such that the conduit extends through the opening, the flange comprising one or more circumferentially adjacent sections at least one of which has a rigidity that decreases in a radially-increasing direction. | 06-26-2014 |
Zaw N. Win, Philadelphia, PA US
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20090036817 | IMPLANTABLE FLOW CONNECTOR - An implantable flow connector for fluidically coupling a source tissue-enclosed body space with a destination element, comprising: a conduit having a lumen terminating at an orifice at a first end of the conduit implantable in the source body space through an opening formed in a tissue wall of the source body space, and a second end of the conduit implantable in the destination element through an opening in a surface of the destination element; and a circumferential flange, radially extending from the conduit proximate the conduit first end, configured to be implanted in the source body space adjacent an opening in the tissue wall of the source body space such that the conduit extends through the opening, the flange comprising one or more circumferentially adjacent sections at least one of which has a rigidity that decreases in a radially-increasing direction. | 02-05-2009 |
20090036820 | IMPLANTABLE FLOW CONNECTOR - An implantable flow connector for fluidically coupling a source tissue-enclosed body space with a destination element, comprising: a conduit having a lumen terminating at an orifice at a first end of the conduit implantable in the source body space through an opening formed in a tissue wall of the source body space, and a second end of the conduit implantable in the destination element through an opening in a surface of the destination element; and a circumferential flange, radially extending from the conduit proximate the conduit first end, configured to be implanted in the source body space adjacent an opening in the tissue wall of the source body space such that the conduit extends through the opening, the flange comprising one or more circumferentially adjacent sections at least one of which has a rigidity that decreases in a radially-increasing direction. | 02-05-2009 |