Patent application number | Description | Published |
20130058930 | SUBCUTANEOUS NEEDLE ASSISTED JET INJECTION ADMINISTRATION OF METHOTREXATE - The present application is directed, at least in part, to a method of treating an autoimmune disorder in a subject in need of treatment. In one exemplary embodiment, the method comprises introducing into the subcutaneous tissue of the subject, from a needle assisted jet injection device, a composition comprising methotrexate in a dose ranging from about 5 mg to about 50 mg, wherein the pharmacokinetic profile of said methotrexate, obtained following administration of the methotrexate by the needle assisted jet injection device, is substantially the same as the pharmacokinetic profile of the same dose of methotrexate when administered by an intramuscular injection or a subcutaneous injection. The present invention provides benefits and improvements, including an improved clinical utility, improved therapeutic efficacy, over conventional methods of administering methotrexate. | 03-07-2013 |
20130303985 | NEEDLE ASSISTED JET INJECTION ADMINISTRATION OF TESTOSTERONE COMPOSITIONS - The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device. | 11-14-2013 |
20150119799 | Hazardous Agent Injection System - Injection systems comprising a powered injector and one or more hazardous agents are disclosed. | 04-30-2015 |
Patent application number | Description | Published |
20100286743 | Methods and Systems for Mitigating the Occurrence of Arrhythmia During Atrial Pacing - Noncaptured atrial paces can result in long-short cardiac cycles which are proarrhythmic for ventricular tachyarrhythmia. Approaches are described which are directed to avoiding proarrhythmic long-short cycles. For cardiac cycles in which the atrial pace captures the atrium, a first post ventricular refractory period (PVARP) and a first A-A interval are used. For cardiac cycles in which the atrial pace does not capture the atrium, both an extended PVARP and an extended A-A interval are used. The A-A interval following a noncaptured atrial pace is extended from an atrial depolarization sensed during the extended PVARP. | 11-11-2010 |
20110245890 | METHOD AND APPARATUS FOR PACING SAFETY MARGIN - An apparatus comprises a cardiac signal sensing circuit, a pacing therapy circuit, and a controller circuit. The controller circuit includes a safety margin calculation circuit. The controller circuit initiates delivery of pacing stimulation energy to the heart using a first energy level, changes the energy level by at least one of: a) increasing the energy from the first energy level until detecting that the pacing stimulation energy induces stable capture, or b) reducing the energy from the first energy level until detecting that the stimulation energy fails to induce capture, and continues changing the stimulation energy level until confirming stable capture or the failure of capture. The safety margin calculation circuit calculates a safety margin of pacing stimulation energy using at least one of a determined stability of a parameter associated with evoked response and a determined range of energy levels corresponding to stable capture or intermittent failure of capture. | 10-06-2011 |
20120035685 | USER INTERFACE SYSTEM FOR USE WITH MULTIPOLAR PACING LEADS - An interactive representation of electrostimulation electrodes or vectors can be provided, such as for configuring combinations of electrostimulation electrodes. In an example, electrodes or test parameters can be presented graphically or in a table. A user interface can be configured to receive user-input designating electrode combinations or vectors for test or for use in programming an implantable or ambulatory medical device. The interface can be used to indicate suggested electrode combinations or vectors in response to a first selection of an electrode. Tests can be performed on electrode combinations and vectors, and the results of the tests can be presented to a user using the interactive representation. In an example, test results can be analyzed by a processor and optionally used to program an implantable or ambulatory medical device. | 02-09-2012 |
20120303082 | Adjusting Cardiac Pacing Response Sensing Intervals - Discrimination between different types of possible cardiac pacing responses may depend on the timing of expected features that are sensed within a temporal framework. The temporal framework may include classification intervals, blanking periods and appropriately timed back up paces. The classification intervals and blanking periods of the temporal framework are intervals of time that have time parameters that include start time, end time, and length. The relationships and timing parameters of the elements of the temporal framework, e.g., blanking periods, classification intervals, delay periods, and backup pacing, should support detection of features used to discriminate between different types of pacing responses. As the system learns the morphology of the particular patient by analyzing the waveform of the pacing response signal, the temporal framework for pacing response determination may be adjusted to accommodate the individual patient. | 11-29-2012 |
20130310891 | AUTOMATIC PACING CONFIGURATION SWITCHER - A system or apparatus can provide electrostimulations via an electrode configuration that can be selected from multiple electrode configurations, the electrostimulations of the type for inducing a desired heart contraction, or a neurostimulation response. The system or apparatus can allow communicating with an external device to receive an input indicating a degree of patient discomfort with an electrostimulation delivered using a first electrode configuration, and can associate information about the degree of discomfort with information about the corresponding first electrode configuration for use by a controller circuit in determining a second electrode configuration for delivering a subsequent electrostimulation. | 11-21-2013 |
20140005742 | SYSTEM AND METHOD FOR SELECTION OF PACING VECTORS | 01-02-2014 |
20140018875 | METHOD AND APPARATUS FOR PACING SAFETY MARGIN - An apparatus comprises a cardiac signal sensing circuit, a pacing therapy circuit, and a controller circuit. The controller circuit includes a safety margin calculation circuit. The controller circuit initiates delivery of pacing stimulation energy to the heart using a first energy level, changes the energy level by at least one of: a) increasing the energy from the first energy level until detecting that the pacing stimulation energy induces stable capture, or b) reducing the energy from the first energy level until detecting that the stimulation energy fails to induce capture, and continues changing the stimulation energy level until confirming stable capture or the failure of capture. The safety margin calculation circuit calculates a safety margin of pacing stimulation energy using at least one of a determined stability of a parameter associated with evoked response and a determined range of energy levels corresponding to stable capture or intermittent failure of capture. | 01-16-2014 |
Patent application number | Description | Published |
20080256155 | System and Method to Compute Narrow Bounds on a Modal Interval Polynomial Function - A computer executable method of processing a representation of a modal interval polynomial is provided. A representation of a modal interval polynomial is generally provided as input, more particularly, a representation comprising a modal interval function variable and an array of modal interval coefficients. Each modal interval linear interpolation of each of the modal interval coefficients of the array are recursively processed until a single modal interval coefficient remains in the array. For each iteration of the recursive processing, a modal interval linear interpolation operation is executed. | 10-16-2008 |
20080256156 | Reliable and Efficient Computation of Modal Interval Arithmetic Operations - A computer executable method of performing a modal interval operation, and system for performing same is provided. The method includes providing representations of first and second modal interval operands. Each modal interval operand of the operands is delimited by first and second marks of a digital scale, each mark of the marks comprises a bit-pattern. Each bit-pattern of the bit-patterns of the marks of each of the modal interval operands are examined, and conditions of a set of status flags corresponding to each bit-pattern of the bit-patterns of the marks are set. A bit-mask is computed wherein the mask is based upon the set condition of the status flag sets and a presence/absence of an exceptional arithmetic condition, and a presence/absence of an indefinite operand are each represented by a bit of said bits of said bit mask. | 10-16-2008 |
20080263335 | Representation of Modal Intervals within a Computer - A modal interval representation having improved computational utility is provided. The modal interval representation generally includes a binary quantifier, and a set theoretical interval for select permutations of marks of a pair of marks of an IEEE standard 754 digital scale. The set theoretical interval includes combinations of real numbers, infinities, signed zeros, and pseudo-numbers, with select permutations of the marks comprising bounded, unbounded, pointwise and indefinite modal intervals. | 10-23-2008 |
20080307027 | System and Method to Compute Narrow Bounds on a Modal Interval Spherical Projection - A computer executable method of processing a representation of a modal interval spherical projection is provided. A representation of a vector comprised of modal intervals X, Y, and Z is provided wherein each modal interval of the modal intervals are delimited by first and second marks of a digital scale. An analytical expression of an azimuthal spherical projection is partitioned into terms of a pair of independent functions wherein a function of the pair exhibits a monotonicity over piecewise domains of the function. A modal interval analysis is performed upon the function wherein arguments of said piecewise domains are modal intervals. | 12-11-2008 |
20100188416 | SINGLE-PASS AND ORDER-INDEPENDENT TRANSPARENCY IN COMPUTER GRAPHICS USING CONTANT MEMORY - A single-pass, order-independent method in support of rendering transparency effects into a computer generated image is provided. A geometric primitive of a scene is rasterized so as to convert the geometric primitive into a set of pixels. For at least each pixel or subpixel, a stipple pattern is selected from a set of unique stipple patterns. The set of unique stipple patterns is characterized by a select opacity value with the stipple pattern delimiting a unique set of pixels in the computer generated image which contributes to a visible surface determination. | 07-29-2010 |
20110043532 | PSEUDO-RANDOM INTERVAL ARITHMETIC SAMPLING TECHNIQUES IN COMPUTER GRAPHICS - An improved branch-and-bound process of interval arithmetic subdivision in furtherance of computation of rigorous error bounds on integrated digital scene information for two dimensional display is provided. More particularly, a first aspect of the subject process includes pseudo-randomly subdividing an interval domain comprising a set of interval variables in furtherance of ascertaining a characteristic contribution of the interval variables of said set of interval variables to an image space comprising at least a sub-pixel area. A further aspect, either alone or in combination with the first aspect contemplates pseudo-randomly discarding a select partitioning of interval variables of a set of interval variables of a geometric function from a computed solution of an interval arithmetic branch-and-bound process. | 02-24-2011 |
20110225221 | MODAL INTERVAL PROCESSOR - A logic circuit computes various modal interval arithmetic values using a plurality of arithmetic function units. A multiplexer gates the desired arithmetic values to a storage register. | 09-15-2011 |
20120254275 | RELIABLE AND EFFICIENT COMPUTATION OF MODAL INTERVAL ARITHMETIC OPERATIONS - A computer executable method of performing a modal interval operation, and system for performing same is provided. The method includes providing representations of first and second modal interval operands. Each modal interval operand of the operands is delimited by first and second marks of a digital scale, each mark of the marks comprises a bit-pattern. Each bit-pattern of the bit-patterns of the marks of each of the modal interval operands are examined, and conditions of a set of status flags corresponding to each bit-pattern of the bit-patterns of the marks are set. A bit-mask is computed wherein the mask is based upon the set condition of the status flag sets and a presence/absence of an exceptional arithmetic condition, and a presence/absence of an indefinite operand are each represented by a bit of said bits of said bit mask. | 10-04-2012 |
20130339414 | SYSTEM AND METHOD TO COMPUTE NARROW BOUNDS ON A MODAL INTERVAL POLYNOMIAL FUNCTION - A computer executable method of processing a representation of a modal interval polynomial is provided. A representation of a modal interval polynomial is generally provided as input, more particularly, a representation comprising a modal interval function variable and an array of modal interval coefficients. Each modal interval linear interpolation of each of the modal interval coefficients of the array are recursively processed until a single modal interval coefficient remains in the array. For each iteration of the recursive processing, a modal interval linear interpolation operation is executed. | 12-19-2013 |
20150019609 | MODAL INTERVAL PROCESSOR - A logic circuit computes various modal interval arithmetic values using a plurality of arithmetic function units. A multiplexer gates the desired arithmetic values to a storage register. | 01-15-2015 |
20150116324 | IMAGE-GENERATED SYSTEM USING BETA DISTRIBUTION TO PROVIDE ACCURATE SHADOW MAPPING - A computer-based system forms a more accurate intensity value for virtual light reflected from computer-generated images. The reflected light intensity from the images is computed pixel by pixel using the mean and variance of the depth values of a filter region associated with the pixel, as well as the maximum and minimum values of the depth values in the filter region. The computations use the normalized, incomplete beta function algorithm. | 04-30-2015 |