Patent application number | Description | Published |
20100094446 | FEATURE DRIVEN RULE-BASED FRAMEWORK FOR AUTOMATION OF MODELING WORKFLOWS IN DIGITAL MANUFACTURING - A method for designing a prosthetic device includes acquiring a three-dimensional image of an anatomical surface. A rules script for automatically performing a plurality of image processing rules using a script interpreter is executed. For each particular rule of the plurality of rules, one or more anatomical features that are relevant to the particular rule using a surface shaping engine are determined, the one or more determined anatomical features are automatically segmented from the acquired three-dimensional image using a feature detector, and the particular image processing rule is performed on the acquired three-dimensional image based on the automatically segmented anatomical features using a CAD tool. A prosthetic device design is produced based on the three-dimensional image upon which the rules of the plurality of image processing rules have been performed. | 04-15-2010 |
20100100362 | Point-Based Shape Matching And Distance Applied To Ear Canal Models - A method for determining a degree of similarity between ear canal models includes receiving a first mesh model representing an inner surface of a first ear. A set of points is sampled within the first mesh model. Each of the sampled set of points is matched to a corresponding point of a second mesh model representing an inner surface of a second ear. A shape distance between the first mesh model and the second mesh model is calculated based on the matched sets of points. A determination of the degree of similarity between the inner surface of the first ear and the inner surface of the second ear is provided based on the calculated shape distance. | 04-22-2010 |
20100103170 | SYSTEM AND METHOD FOR AUTOMATIC DETECTION OF ANATOMICAL FEATURES ON 3D EAR IMPRESSIONS - A method for detecting anatomical features in 3D ear impressions includes receiving a 3D digital image of a 3D ear impression, obtaining a surface of the ear impression from the 3D image, analyzing the surface with one or more feature detectors, the detectors adapted to detecting generic features, including peak features, concavity features, elbow features, ridge features, and bump features, and derived features that depend on generic features or other derived features, and forming a canonical ear signature from results of the detectors, where the canonical ear signature characterizes the 3D ear impression. | 04-29-2010 |
20100217417 | SYSTEM AND METHOD FOR PROTOTYPING BY LEARNING FROM EXAMPLES - A method for specifying design rules for a manufacturing process includes providing a training set of 3D point meshes that represent an anatomical structure, for each 3D point mesh, finding groupings of points that define clusters for each shape class of the anatomical structure, calculating a prototype for each shape class cluster, and associating one or more manufacturing design rules with each shape class prototype. The method includes providing a new 3D point mesh that represents an anatomical structure, calculating a correspondence function that maps the new 3D point mesh to a candidate shape class prototype by minimizing a cost function, calculating a transformation that aligns points in the new 3D point mesh with points in the candidate shape class prototype, and using the rules associated with the shape class prototype, if the candidate shape class prototype is successfully aligned with the new 3D point mesh. | 08-26-2010 |
20110103630 | METHODS FOR INLET AND OUTLET MODELLING OF VENT AS LARGE AS POSSIBLE FOR HEARING AID DEVICES - A method of modeling an opening of a hearing aid vent includes defining a trimming surface through a tip of the vent as one of a planar surface or a non-planar surface, and trimming the shell along the trimming surface to the expose the interior of the shell to create the vent opening. The tip includes an endpoint of the vent and the hearing aid shell fits inside an ear of a patient. | 05-05-2011 |
Patent application number | Description | Published |
20090095970 | WHITE PHOSPHORS, METHODS OF MAKING WHITE PHOSPHORS, WHITE LIGHT EMITTING LEDS, METHODS OF MAKING WHITE LIGHT EMITTING LEDS, AND LIGHT BULB STRUCTURES - Phosphor compositions, white phosphor compositions, methods of making white phosphor compositions, tinted white phosphor compositions, methods of making tinted white phosphor compositions, LEDs, methods of making LEDs, light bulb structures, paints including phosphor compositions, polymer compositions including phosphor compositions, ceramics including phosphor compositions, and the like are provided. | 04-16-2009 |
20110284798 | WHITE PHOSPHORS, METHODS OF MAKING WHITE PHOSPHORS, WHITE LIGHT EMITTING LEDS, METHODS OF MAKING WHITE LIGHT EMITTING LEDS, AND LIGHT BULB STRUCTURES - Phosphor compositions, white phosphor compositions, methods of making white phosphor compositions, tinted white phosphor compositions, methods of making tinted white phosphor compositions, LEDs, methods of making LEDs, light bulb structures, paints including phosphor compositions, polymer compositions including phosphor compositions, ceramics including phosphor compositions, and the like are provided. | 11-24-2011 |
Patent application number | Description | Published |
20110120333 | DIRECT INKJET IMAGING LITHOGRAPHIC PLATES AND METHODS FOR IMAGING THE PLATES - Wet lithographic printing members for imaging by an inkjet printer using pigment-based aqueous ink and method for calibrating the amount of the inkjet ink to be injected in solid areas of an image are disclosed. An exemplary printing member can be a lithographic printing plate that comprises a base substrate and a top hydrophilic coating layer having a thickness in the range of 2 to 10 microns above the base substrate. A volume of 10 nl/mm | 05-26-2011 |
20120031291 | PRINTING MEMBERS FOR DIRECT IMAGING AND METHODS OF PRODUCING SAME - Embodiments of the invention are directed to a printing member for imaging with an inkjet printer using pigment-based aqueous inkjet ink. The printing member may include a substrate and a hydrophilic coating layer. The coating layer may include acidic colloidal silica whose particles have an elongated shape, a hydrophilic polymer and a crosslinking agent. | 02-09-2012 |
20120055363 | THERMAL IMAGABLE WATERLESS LITHOGRAPHIC MEMBER - A layered printing plate that attains a high degree of clarity and improved clean out. The printing plate may include an oleophilic substrate, a laser absorbing imaging layer and an oleophobic silicon layer. One embodiment utilizes an amine resin rather than a traditional polymer as the basic organic matter of the imaging layer, adds of colloidal silica into the imaging layer to improve the cleanout properties, and utilizes a substrate that absorbs IR radiation rather than reflects it. | 03-08-2012 |
20130027462 | DIRECT INKJET IMAGING LITHOGRAPHIC PLATES, METHODS FOR IMAGING AND PRE-PRESS TREATMENT - Wet lithographic printing members for imaging by an inkjet printer using pigment-based aqueous ink and method for calibrating the amount of the inkjet ink to be injected in solid areas of an image are disclosed. An exemplary printing member can comprises a base substrate and a top hydrophilic coating layer having a thickness in the range of 2 to 10 microns above the base substrate. A volume of less than 10 nl/mm2 of inkjet ink is used in order to image areas in which the image is solid. Areas of the top hydrophilic coating layer, which are imagewise covered by aqueous pigmented inkjet ink, become hydrophobic. In some embodiments after imaging, the surface of the imaged printing member can be treated with acidic colloidal silica solution. Exemplary treatment can comprise wiping the surface of the imaged printing member with the acidic colloidal silica solution. | 01-31-2013 |
Patent application number | Description | Published |
20090285714 | Implantable medical Devices Composed of a Radiopaque Alloy and Method of Making the Alloy - Implantable medical devices made from a single beta phase Tantalum alloy utilizing Titanium as an alloying agent that are biocompatible, radiopaque and visible under x-ray and fluoroscopy, the alloy having mechanical properties that allow it to be machined by conventional, machining methods for forming the devices, and a method for making the alloy. The alloy is between approximately 10 percent and 25 percent Ti by weight and preferably has a density of 12 g/cm | 11-19-2009 |
20140105781 | TITANIUM BASED CERAMIC REINFORCED ALLOY FOR USE IN MEDICAL IMPLANTS - A titanium based, ceramic reinforced alloy ingot for use in producing medical implants. An ingot is formed from an alloy having comprising from about 5 to about 35 wt. % niobium, from about 0.5 to about 3.5 wt. % A silicon, and from about 61.5 to about 94.5 wt. % of titanium. The alloy has a hexagonal crystal lattice a phase of from about 20 vol % to about 70 vol %, and a cubic body centered 13 crystal lattice phase of from about 30 vol. % to about 80 vol. %. The ingot has an ultimate tensile strength of about 940 MPa or more, and a Young's modulus of about 150 GPa or less. A molten substantially uniform admixture of a niobium, silicon, and titanium alloy is formed, cast into a shape, and cooled into an ingot. The ingot may then be formed into a medical implant and optionally annealed. | 04-17-2014 |
Patent application number | Description | Published |
20090175801 | CNS-TUMOR TREATMENT METHOD AND COMPOSITION - A method, aerosol composition, and aerosolizing device for treating a brain tumor in a subject are disclosed. The method includes intranasally administering to the subject, an amount of a telomerase inhibitor, such as an oligonucleotide telomerase inhibitor, effective to inhibit growth of the tumor in the subject. | 07-09-2009 |
20090286853 | MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION - Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics. | 11-19-2009 |
20100016416 | Oligonucleotide Conjugates - Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity. | 01-21-2010 |
20110294213 | 2'-ARABINO-FLUOROOLIGONUCLEOTIDE N3'-P5' PHOSPHORAMIDATES: THEIR SYNTHESIS AND USE - Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(═O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-aribino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable. | 12-01-2011 |
20120129918 | MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION - Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics. | 05-24-2012 |
20120329858 | MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION - Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics. | 12-27-2012 |
20130065950 | MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION - Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics. | 03-14-2013 |
20130253034 | 2'-Arabino-Fluorooligonucleotide N3'-->P5' Phosphoramidates: Their Synthesis and Use - Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside | 09-26-2013 |
20130296405 | Compounds Having Anti-Adhesive Effects on Cancer Cells - Compounds of the form O-(x-L)n, where O is an oligonucleoside having at least a plurality of N3′->P5′ thiophosphoramidate (NPS) internucleoside linkages, a conjugated lipid moiety L, and at least one G-rich sequence motif as described, are effective to morphologically alter and reduce adhesion of cancer cells. | 11-07-2013 |
20140349292 | OLIGONUCLEOTIDE N3'-->P5' THIOPHOSPHORAMIDATES: THEIR SYNTHESIS AND USE - Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3′-NHP(O)(S | 11-27-2014 |
Patent application number | Description | Published |
20090220511 | Ifn-alpha/beta-independent mechanism of antiviral protection through a novel ligand-receptor pair: Ifn- ligands engage a novel receptor Ifn-Rn (CRF2-12) and IL-10R2 (CRF2-4) for signaling andinduction of biological activities - A novel IFN-α/β independent ligand receptor system which upon engagement leads, among other things, to the establishment of an anti-viral state is disclosed. Further disclosed are three closely positioned genes on human chromosome 19 that encode distinct but highly homologous proteins, designated IFN-λ1, IFN-λ2, IFN-λ3, based, inter alia, in their ability to induce antiviral protection. Expression of these proteins is induced upon viral infection. A receptor complex utilized by all three IFN-λ proteins for signaling is also disclosed. The receptor complex is generally composed of two subunits, a novel receptor designated IFN-λR1 or CRF2-12, and a second subunit, IL-10R2 or CRF2-4, which is also a shared receptor component for the IL-10 and IL-22 receptor complexes. The gene encoding IFN-λR1 is generally widely expressed, including many different cell types and tissues. Expression of these proteins is induced by immune events, including, for example, upon viral infection. Apoptotosis may also be induced under effective conditions. | 09-03-2009 |
20110171173 | IFN-ALPHA/BETA-INDEPENDENT MECHANISM OF ANTIVIRAL PROTECTION THROUGH A NOVEL LIGAND-RECEPTOR PAIR: IFN- LIGANDS ENGAGE A NOVEL RECEPTOR IFN-RN (CRF2-12) AND IL-10R2 (CRF2-4) FOR SIGNALING ANDINDUCTION OF BIOLOGICAL ACTIVITIES - A novel IFN-α/β independent ligand receptor system which upon engagement leads, among other things, to the establishment of an anti-viral state is disclosed. Further disclosed are three closely positioned genes on human chromosome 19 that encode distinct but highly homologous proteins, designated IFN-λ1, IFN-λ2, IFN-λ3, based, inter alia, in their ability to induce antiviral protection. Expression of these proteins is induced upon viral infection. A receptor complex utilized by all three IFN-λ proteins for signaling is also disclosed. The receptor complex is generally composed of two subunits, a novel receptor designated IFN-λR1 or CRF2-12, and a second subunit, IL-10R2 or CRF2-4, which is also a shared receptor component for the IL-10 and IL-22 receptor complexes. The gene encoding IFN-λR1 is generally widely expressed, including many different cell types and tissues. Expression of these proteins is induced by immune events, including, for example, upon viral infection. Apoptotosis may also be induced under effective conditions. | 07-14-2011 |
20120114603 | IFN-ALPHA/BETA-INDEPENDENT MECHANISM OF ANTIVIRAL PROTECTION THROUGH A NOVEL LIGAND-RECEPTOR PAIR: IFN- LIGANDS ENGAGE A NOVEL RECEPTOR IFN-RN (CRF2-12) AND IL-10R2 (CRF2-4) FOR SIGNALING ANDINDUCTION OF BIOLOGICAL ACTIVITIES - A novel IFN-α/β independent ligand receptor system which upon engagement leads, among other things, to the establishment of an anti-viral state is disclosed. Further disclosed are three closely positioned genes on human chromosome 19 that encode distinct but highly homologous proteins, designated IFN-λ1, IFN-λ2, IFN-λ3, based, inter alia, in their ability to induce antiviral protection. Expression of these proteins is induced upon viral infection. A receptor complex utilized by all three IFN-λ proteins for signaling is also disclosed. The receptor complex is generally composed of two subunits, a novel receptor designated IFN-λR1 or CRF2-12, and a second subunit, IL-10R2 or CRF2-4, which is also a shared receptor component for the IL-10 and IL-22 receptor complexes. The gene encoding IFN-λR1 is generally widely expressed, including many different cell types and tissues. Expression of these proteins is induced by immune events, including, for example, upon viral infection. Apoptotosis may also be induced under effective conditions. | 05-10-2012 |
Patent application number | Description | Published |
20100131186 | METHOD OF GENERATING IMPROVED MAP DATA FOR USE IN NAVIGATION DEVICES, MAP DATA AND NAVIGATION DEVICE THEREFOR - In one embodiment of the present invention, an end-user can input a correction to a map error, directly on the device. The device is then able to use the correction without external processing of the correction. Hence, it is no longer necessary for an end-user to simply report errors to the map vendor over a web link, then wait for that map vendor to verify the error, update its maps and finally supply the end-user with updates—a cycle that can take months and sometimes years to complete. Instead, the navigation device can use the correction immediately. End-users can also share corrections with other end-users and also with a shared remote server that aggregates, validates and distributes corrections. | 05-27-2010 |
20100332118 | NAVIGATION DEVICE AND METHOD USING MAP DATA CORRECTION FILES - A method of operating a PND or navigation system is described, together with a PND or navigation system for performing such a method. The PND or navigation system includes memory storing map data consisting of base map data files and supplemental corrective data files. In at least one embodiment, the method includes correlating the current location with the map data, and in the event that the current location and derived map data are seemingly at odds with one another, performing at least one secondary action. In at least one embodiment, the secondary action may be the issuing of an approve/reject prompt to the user, or the automatic creation, modification or deletion of a new or pre-existing correction. In a further aspect, at least one embodiment of the invention also provides for a PND or navigation system storing an indication of a home location, and prompting a user to visit nearby locations for which corrections exist, followed by prompted or automatic confirmation or rejection thereof. | 12-30-2010 |
20100332119 | NAVIGATION DEVICE AND METHOD - A method of operating a PND or navigation system is described, together with a PND or navigation system for performing such a method. The PND or navigation system includes memory storing map data consisting of base map data files, a display, GPS signal reception and processing device, such together forming a basis for navigation, route guidance, and map information display. In at least one embodiment, the method includes correlating the current location with the map data to derive map-specific parameters for that location and comparing the map-specific parameters with a motion-specific parameter, a vehicle-specific parameter, or the current location to determine whether the current location, motion or vehicle-related characteristic is permissible or appropriate therefore; and in the event that the current location, motion, or vehicle-related characteristic and derived map-specific parameter are seemingly at odds with one another, performing at least one secondary action. The secondary action may include but is not limited to the issuing of an approve/reject prompt to the user, or the automatic creation, modification or deletion of a new or pre-existing correction. | 12-30-2010 |
Patent application number | Description | Published |
20100004985 | Incentive structure for centralized trading market - An automated marketplace is separated into tiers, with behavioral requirements for each tier. Tier eligibility is a “structural incentive” for market participants to exhibit desirable behavior and eschew undesirable behavior. Tiered eligibility also reflects the natural imbalance of liquidity in the market and the need to preserve the identity of a class of liquidity providers, which further leads to a structure that can preserve the integrity of person-to-person trading relationships even in an automated environment. Within each tier, participant behavior leads to a ranking for that participant. When specific events occur, these events are allocated based on participant ranking. Participant ranking is an “activity incentive” that influences the behavior of market participants. Certain events are defined as desirable or undesirable, and when performed by a market participant, lead to positive incentives or negative incentives, of structural and/or monetary type. | 01-07-2010 |
20120150711 | LINKED SHORT ORDER AND SECURITIES LOAN OR LOCATE - A stock loan system receives a sell short order for a financial instrument such as a stock, and determines whether it can provide a locate for the sell short order. If so, then the stock loan system sends sell short order and the locate to a marketplace for execution. In some cases, the sell short order is required to have a stock loan, not merely a locate, to be eligible for execution, and the stock loan system provides the loan, then sends the sell short order with notice of the loan to a marketplace for execution. In some embodiments, an order execution marketplace receives a sell short order for a financial instrument, and, if it can provide a locate, the marketplace provides the locate and executes the sell short order. In some cases, the sell short order is required to have a stock loan, not merely a locate, to be eligible for execution, and the marketplace obtains a stock loan from a stock loan system then executes the sell short order. | 06-14-2012 |
20120191592 | INCENTIVE STRUCTURE FOR CENTRALIZED TRADING MARKET - An automated marketplace is separated into tiers, with behavioral requirements for each tier. Tier eligibility is a “structural incentive” for market participants to exhibit desirable behavior and eschew undesirable behavior. Tiered eligibility also reflects the natural imbalance of liquidity in the market and the need to preserve the identity of a class of liquidity providers, which further leads to a structure that can preserve the integrity of person-to-person trading relationships even in an automated environment. Within each tier, participant behavior leads to a ranking for that participant. When specific events occur, these events are allocated based on participant ranking. Participant ranking is an “activity incentive” that influences the behavior of market participants. Certain events are defined as desirable or undesirable, and when performed by a market participant, lead to positive incentives or negative incentives, of structural and/or monetary type. | 07-26-2012 |
Patent application number | Description | Published |
20110008177 | GAS TURBINE VANE WITH IMPROVED COOLING - The disclosure relates to a hollow gas turbine vane that is cooled by an arrangement configured to sequential cooling an endwall of the vane and its airfoil and, at the same time, the two endwalls of the vane. This arrangement can reduce cooling air demand, which can have a positive effect on the turbines efficiency. | 01-13-2011 |
20110014054 | GUIDE VANE OF A GAS TURBINE AND METHOD FOR REPLACING A COVER PLATE OF A GUIDE VANE OF A GAS TURBINE - The guide vane of a gas turbine comprises a blade having an outer platform connectable to a guide vane carrier or gas turbine casing, and at the opposite end an inner platform that carries a cover plate. The inner platform has a dovetail housing to which the cover plate is connected. The method for replacing the cover plate consists in separating the cover plate from the inner platform by cutting along the profile of the dovetail housing, then making the cover plate to slide out of the dovetail housing, thus inserting a new or refurbished cover plate into the dovetail housing. | 01-20-2011 |
20110070089 | GUIDE VANE FOR A GAS TURBINE - A stator blade for a gas turbine includes a blade airfoil extending in a longitudinal direction of the blade and is delimited by leading and trailing edges. The stator blade includes a shroud, whose inner side is exposed to hot gas which flows through the gas turbine. A hook-like fastening element for fastening the stator blade on a casing of the gas turbine projects outwards in the region of the trailing edge. The fastening element has a locating slot above the trailing edge for fixing a heat shield, which is connected to the shroud in the flow direction of the hot gas. A cavity is provided on the shroud between the locating slot for the heat shield and the trailing edge of the blade airfoil for reducing the thermal and mechanical stresses in the region of transition between the trailing edge and shroud, thereby extending the service life of the stator blade. | 03-24-2011 |
Patent application number | Description | Published |
20110064585 | COOLING DUCT ARRANGEMENT WITHIN A HOLLOW-CAST CASTING - Described is a cooling passage arrangement inside a hollow-cast cast part, with a flow region, delimited by at least two spaced apart cast-part walls, for a cooling medium (K), which flow region is divided in the flow direction into two cooling passages ( | 03-17-2011 |
20110223036 | BLADE FOR A GAS TURBINE - The blade for a gas turbine includes a blade airfoil having a leading edge and a trailing edge and extending in the blade longitudinal direction up to a blade tip, and at the blade tip the blade airfoil merges into a shroud segment, wherein on the shroud segment a first rib, projecting upwards, is arranged in the flow direction, extending transversely to the flow direction, and upstream of the first rib, in the region of the leading edge of the blade airfoil, a winglet is formed on the shroud segment for guiding of the hot gas flow in this region. With such a blade, a longer service life is achieved by provision being made for direct cooling of the winglet. | 09-15-2011 |
20110236223 | BLADE FOR A GAS TURBINE - A blade for a gas turbine includes an airfoil extending in a longitudinal direction and extending transversely to the longitudinal direction between a leading edge and a trailing edge. The airfoil has a pressure side, a suction side, and a slot-like cooling medium outlet extending along the trailing edge. The cooling medium outlet is configured to discharge cooling medium supplied from an inner space of the blade. A platform extends transversely to the longitudinal direction. An end of the airfoil merges into an underside of the platform and has a transition from the airfoil to the platform at the trailing edge of the airfoil that increases in thickness in a direction toward the underside of the platform. The cooling medium outlet extends into the platform so as to reduce an operating temperature in a region of the transition from the blade airfoil to the platform. | 09-29-2011 |
20110268582 | COOLED BLADE FOR A GAS TURBINE - A blade for a gas turbine, is provided and includes a blade airfoil which extends in a blade longitudinal direction and at the lower end merges into a shank which terminates in a blade root for fastening the blade on a blade carrier, particularly on a rotor disk. Devices for cooling the blade, which are supplied with a cooling medium, especially cooling air, via a feed hole arranged on the shank at the side, are arranged inside the blade airfoil. In the region of the feed hole provision is made for a planar stiffening element which reaches beyond the immediate region of the feed hole for reducing peaks of mechanical stress. | 11-03-2011 |
20120036864 | GAS TURBINE ENGINE AND METHOD FOR COOLING THE COMPRESSOR OF A GAS TURBINE ENGINE - A gas turbine engine includes a compressor with rotor blades having roots connected into seats of a compressor drum. The rotor blade roots and/or the compressor drum have longitudinal passages for a cooling fluid, connecting higher pressure areas to lower pressure areas of the gas turbine engine. | 02-16-2012 |
20120070309 | BLADE FOR A GAS TURBINE - A blade, for a gas turbine, includes a blade airfoil, having a shroud segment arranged on its upper end. The shroud segment together with shroud segments of other blades of a blade row forming an annular shroud which delimits hot gas passage of the gas turbine, and said shroud segment, on sides on which it adjoins adjacent shroud segments of the annular shroud, is provided with upwardly projecting side rails which extend along a side edge, to improve sealing to the hot gas passage. The side rails include rail-parallel or essentially rail-parallel, upwardly open slots through which cooling air, which is introduced via the shroud segment from an interior of the blade airfoil, discharges into the space above the shroud segment. | 03-22-2012 |
20150050160 | ROTOR SHAFT FOR A TURBOMACHINE - A rotor shaft adapted to rotate about a rotor axis thereof. The rotor shaft includes a rotor cavity configured concentrically to the rotor axis inside the rotor shaft. The rotor shaft further includes a plurality of cooling bores extending radially outward from the rotor cavity to feed cooling air into an internal cooling system in a blade. Each cooling bore includes a bore inlet portion and a distal bore outlet portion. The respective bore inlet portion ends in a plateau, projecting above the outer circumference contour of the rotor cavity. Thus, cooling bore inlets are shifted to a low stress area and the lifetime of the rotor is improved. | 02-19-2015 |
Patent application number | Description | Published |
20080221806 | SENSOR HAVING A THIN-FILM INHIBITION LAYER, NITRIC OXIDE CONVERTER AND MONITOR - Sensors and detection systems suitable for measuring analytes, such as biomolecule, organic and inorganic species, including environmentally and medically relevant volatiles and gases, such as NO, NO2, CO2, NH3, H2, CO and the like, are provided. Certain embodiments of nanostructured sensor systems are configured for measurement of medically important gases in breath. Applications include the measurement of endogenous nitric oxide (NO) in breath, such as for the monitoring or diagnosis of asthma and other pulmonary conditions. | 09-11-2008 |
20100085067 | ANESTHESIA MONITOR, CAPACITANCE NANOSENSORS AND DYNAMIC SENSOR SAMPLING METHOD - Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such as anesthesia gases, CO2 and the like in human breath. An integrated monitor system and disposable sensor unit is described which permits a number of different anesthetic agents to be identified and monitored, as well as concurrent monitoring of other breath species, such as CO2. The sensor unit may be configured to be compact, light weight, and inexpensive. Wireless embodiments provide such enhancements as remote monitoring. A simulator system for modeling the contents and conditions of human inhalation and exhalation with a selected mixture of a treatment agent is also described, particularly suited to the testing of sensors to be used in airway sampling. | 04-08-2010 |
20100323925 | Nanosensor array for electronic olfaction - A detector system is described including arrays having a plurality of nanoelectronic sensors comprising a channel including a nanostructured element disposed on a substrate, the nanostructured element functionalized by one or more materials disposed on or adjacent to the nanostructured element so as to operatively influence one or more sensor electrical properties. In certain embodiments, the nanostructured element comprise one or more nanotubes, and the functionalization material may include nanoparticles composed of one or more metals, metal oxides, salts, or other inorganic or organic materials or composites of these. | 12-23-2010 |
20120006102 | SENSOR HAVING A THIN-FILM INHIBITION LAYER - Sensors and detection systems suitable for measuring analytes, such as biomolecule, organic and inorganic species, including environmentally and medically relevant volatiles and gases, such as NO, NO2, CO2, NH3, H2, CO and the like, are provided. Certain embodiments of nanostructured sensor systems are configured for measurement of medically important gases in breath. Applications include the measurement of endogenous nitric oxide (NO) in breath, such as for the monitoring or diagnosis of asthma and other pulmonary conditions. | 01-12-2012 |
20130075690 | Ammonia Nanosensors, and Environmental Control System - Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such ammonia. An environmental control system employing nanoelectronic sensors is described. A personnel safety system configured as a disposable badge employing nanoelectronic sensors is described. A method of dynamic sampling and exposure of a sensor providing a number of operational advantages is described. | 03-28-2013 |
20130075794 | NANO-ELECTRONIC SENSORS FOR CHEMICAL AND BIOLOGICAL ANALYTES, INCLUDING CAPACITANCE AND BIO-MEMBRANE DEVICES - Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes inorganic gases, organic vapors, biomolecules, viruses and the like. A number of embodiments of capacitive sensors having alternative architectures are described. Particular examples include integrated cell membranes and membrane-like structures in nanoelectronic sensors. | 03-28-2013 |
20140273187 | POINT OF CARE SENSOR SYSTEMS - Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors. After providing a sample to a cartridge, the cartridge can be inserted into a reader, which can interact with the cartridge to perform on-cartridge sensing and receive signals indicating the presence and/or quantity of one or more targets in the sample. Examples of cartridges can include cardiac panels, sepsis panels and the like. In some embodiments, the same sensor hardware may be configured for multiple measurements of different targets conducted at different time frames. Also provided herein are novel on-cartridge solid and liquid reagent storage and delivery mechanisms. | 09-18-2014 |
Patent application number | Description | Published |
20080304826 | Semiconductor optical amplifier for an external cavity diode laser - In one embodiment, a gain medium for an external cavity diode laser (ECDL) includes a gain section to provide a gain operation on optical energy in the ECDL that is controlled by a first electrical signal, a semiconductor optical amplifier (SOA) section disposed adjacent to the gain section to amplify the gained optical energy responsive to a second electrical signal, and a trench disposed between the gain section and the SOA section to act as an integrated mirror. Other embodiments are described and claimed. | 12-11-2008 |
20090140718 | WAVELENGTH METER AND ASSOCIATED METHOD - A wavelength meter, an associated method, and system are generally described. In one example, an apparatus includes a photodiode to receive an optical signal and to generate a photocurrent upon receiving the optical signal, the photodiode having an absorption edge that is substantially aligned with a band of wavelengths, wherein the absorption edge shifts toward longer wavelengths when a reverse bias is applied to the photodiode, and control electronics coupled with the photodiode to apply at least a first reverse bias and a second reverse bias to the photodiode, wherein a ratio of a first measurement of the photocurrent at the first reverse bias and a second measurement of the photocurrent at the second reverse bias provides information about the wavelength of the optical signal. | 06-04-2009 |
20110033192 | Small Packaged Tunable Optical Transmitter - According to one embodiment, the present application includes a tunable optical transmitter configured in a small package. The tunable optical transmitter includes a housing with a volume formed by exterior walls. An electrical input interface is positioned at the first end of the housing and configured to receive an information-containing electrical signal. An optical output interface is positioned at the second end of the housing and configured to transmit an optical communication beam. A tunable semiconductor laser is positioned in the interior space and operable to emit a laser beam having a selectable wavelength. A semiconductor-based modulator is positioned in the interior space along an optical path of the laser beam and operatively coupled to the optical output interface. The semiconductor-based modulator is configured to impart modulation to the laser beam corresponding to an information-containing electrical signal received through the electrical input interface. | 02-10-2011 |
20120163137 | METHOD AND SYSTEM FOR OPTICALLY COUPLING A LASER WITH A TRANSDUCER IN AN ENERGY ASSISTED MAGNETIC RECORDING DISK DRIVE - A method and system for providing an energy assisted magnetic recording (EAMR) head are described. The EAMR head includes a laser, a slider, and an EAMR transducer. The laser has a main emitter and at least one alignment emitter. The slider includes at least one alignment waveguide, at least one output device, and an air-bearing surface (ABS). The alignment waveguide(s) are aligned with the alignment emitter(s). The EAMR transducer is coupled with the slider and includes a waveguide aligned with main emitter. The waveguide is for directing energy from the main emitter toward the ABS. | 06-28-2012 |
Patent application number | Description | Published |
20090100550 | Artificial Plant Minichromosomes - Artificial plant minichromosomes comprising a functional centromere which specifically bind centromeric protein C (CENPC) and methods for making such minichromosomes are described. | 04-16-2009 |
20090165176 | Artificial Plant Minichromosomes - Artificial plant minichromosomes comprising a functional centromere which specifically bind centromeric protein C (CENPC) and methods for making such minichromosomes are described. | 06-25-2009 |
20110119795 | ARTIFICIAL PLANT MINICHROMOSOMES - Artificial plant minichromosomes comprising a functional centromere which specifically bind centromeric protein C (CENPC) and methods for making such minichromosomes are described. | 05-19-2011 |
20130263324 | METHODS FOR PRODUCING A COMPLEX TRANSGENIC TRAIT LOCUS - Methods for producing in a plant a complex transgenic trait locus comprising at least two altered target sequences in a genomic region of interest are disclosed. The methods involve the use of two or more double-strand-break-inducing agents, each of which can cause a double-strand break in a target sequence in the genomic region of interest which results in an alteration in the target sequence. Also disclosed are complex transgenic trait loci in plants. A complex transgenic trait locus comprises at least two altered target sequences that are genetically linked to a polynucleotide of interest. Plants, plant cells, plant parts, and seeds comprising one or more complex transgenic trait loci are also disclosed. | 10-03-2013 |
20140223606 | COMPOSITIONS AND METHODS COMPRISING SEQUENCES HAVING MEGANUCLEASE ACTIVITY - Compositions and methods comprising polynucleotides and polypeptides having meganuclease activity are provided. Further provided are nucleic acid constructs, yeast, plants, plant cells, explants, seeds and grain having the meganuclease sequences. Various methods of employing the meganuclease sequences are provided. Such methods include, for example, methods for producing a meganuclease with increased activity at a wide range of temperatures, methods for producing a yeast, plant, plant cell, explant or seed comprising a meganuclease with increased activity. | 08-07-2014 |
20150082478 | PLANT GENOME MODIFICATION USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS AND METHODS OF USE - Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification of a nucleotide sequence in the genome of a cell or organism, for gene editing, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell. | 03-19-2015 |
Patent application number | Description | Published |
20120038120 | SYSTEM AND METHOD FOR CRYOGENIC COOLING - In accordance with an embodiment of the invention, there is provided a system for cooling a load. The system comprises a closed loop primary refrigeration system comprising: a primary compressor taking in a primary refrigerant at a low pressure and discharging the primary refrigerant at a high pressure; an insulated enclosure comprising an inlet receiving the primary refrigerant at the high pressure from the primary compressor and an outlet returning the primary refrigerant at the low pressure to the primary compressor; at least one heat exchanger within the insulated enclosure receiving the primary refrigerant at the high pressure and cooling the primary refrigerant using a secondary refrigerant from a secondary refrigeration system, the secondary refrigerant being in heat exchange relationship with the primary refrigerant in the at least one heat exchanger; an expansion unit within the insulated enclosure receiving the primary refrigerant at the high pressure from the at least one heat exchanger and discharging the primary refrigerant at the low pressure; and a supply line delivering the primary refrigerant at the low pressure to the load and a return line returning the primary refrigerant from the load to the primary refrigeration system. The system further comprises the secondary refrigeration system, wherein the secondary refrigeration system comprises at least one secondary cryogenic refrigerator. A system control unit controls operation of at least one of the primary refrigeration system and the secondary refrigeration system to provide a variable refrigeration capacity to the load based on at least one of: a pressure of the primary refrigerant delivered to the load, and at least one temperature of the load. | 02-16-2012 |
20130205805 | MULTI-REFRIGERATOR HIGH SPEED CRYOPUMP - A refrigerator system or cryopump includes a first refrigerator having at least first and second stages, and a second refrigerator. A thermal coupling between the first stage of the first refrigerator and a cold end of the second refrigerator is restricted to maintain a temperature difference between the cold end of the second refrigerator and the first stage of the first refrigerator. The refrigerator system or cryopump also includes a radiation shield in thermal contact with the cold end of the second refrigerator, and a condensing surface, spaced from and surrounded by the radiation shield, and in thermal contact with a second stage, e.g., coldest stage, of the first refrigerator. The restricted thermal coupling can be configured to balance the cooling load on the two refrigerators. | 08-15-2013 |
20130312431 | Cryopump - A cryopump has a simple-to-manufacture frontal baffle plate with improved gas distribution and has a large-area second-stage array plate to capture Type II gases. The cryopump has a first-stage frontal baffle plate having orifices and flaps bent from and attached to the orifices. The cryopump has a second-stage top plate that is larger in area than cooling baffles of the second stage array. | 11-28-2013 |
Patent application number | Description | Published |
20090044279 | Systems and methods for fraud detection via interactive link analysis - Fraud detection is facilitated by developing account cluster membership rules and converting them to database queries via an examination of clusters of linked accounts abstracted from the customer database. The cluster membership rules are based upon certain observed data patterns associated with potentially fraudulent activity. In one embodiment, account clusters are grouped around behavior patterns exhibited by imposters. The system then identifies those clusters exhibiting a high probability of fraud and builds cluster membership rules for identifying subsequent accounts that match those rules. The rules are designed to define the parameters of the identified clusters. When the rules are deployed in a transaction blocking system, when a rule pertaining to an identified fraudulent cluster is triggered, the transaction blocking system blocks the transaction with respect to new users who enter the website. | 02-12-2009 |
20090058859 | CONSTRUCTION OF DECISION LOGIC WITH GRAPHS - Data characterizing a plurality of related action graphs is received. Thereafter, the, plurality of related action graphs are transformed into a logically equivalent structure so that rendering of the logically equivalent structure can be initiated. Related interfaces, apparatus, systems, techniques and articles are also described. | 03-05-2009 |
20090063389 | Comparison of Decision Logic - A request to compare strategies is received. The first strategy can be graphically represented by a first set of linked nodes arranged in a first form of decision logic. The second strategy can be graphically represented by a second set of linked nodes arranged in a second form of decision logic. The first set of linked nodes can be converted to a first modified set of linked nodes arranged in a third form of decision logic. The second set of linked nodes can be converted to a second modified set of linked nodes arranged in the third form of decision logic. A visual representation of the first modified set of linked nodes and the second modified set of linked nodes can be provided to a user. Related apparatus, techniques, and articles are also described. | 03-05-2009 |
20100306167 | ARTICLE AND METHOD FOR FINDING A COMPACT REPRESENTATION TO VISUALIZE COMPLEX DECISION TREES - The invention comprises an article and method for transforming a complex or large decision tree having multiple variables; multiple values for each variable; and, multiple outcomes for each combination of variables and their associated values, into a compact, efficient graphical representation to provided enhanced ease of use and interaction by a human user. More particularly, the invention comprises a computationally efficient method for transforming an input decision tree into an optimal compact representation by computing a particular ordering of variables in the decision tree that first leads to a Directed Acyclic Graph, or “DAG,” with a minimum number of nodes. The method then converts the DAG into an exception-based DAG, or “EDAG,” with exactly one exception, having an optimal, minimum number of nodes with increased comprehensibility for a user. | 12-02-2010 |
20100332514 | DECISION LOGIC COMPARISON AND REVIEW - Techniques are described for logically comparing strategies. In one aspect the strategies can be compared by receiving a request to compare a first strategy to a second strategy, the first strategy graphically represented by a first set of linked nodes, the second strategy graphically represented by a second set of linked nodes, each set of linked nodes linking a root node to at least one action node; identifying a subset of linked nodes from at least one of the first set of linked nodes and the second set of linked nodes based on an equivalence of a first subset of the first set of linked nodes to a second subset of the second set of linked nodes; and, providing a visual depiction of the identified subset of the linked nodes to a user, the visual depiction corresponding to the equivalence of the first subset to the second subset. | 12-30-2010 |