Patent application number | Description | Published |
20090275485 | Reversible Natural Product Glycosyltransferase-Catalyzed Reactions, Compounds and Related Methods - The present invention relates to methods of use of glycosyltransferases and related novel compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomolecules and numerous one-pot reactions for generation of new biomolecules having varied backbones such as enediynes, vancomycins, bleomycins, anthracyclines, macrolides, pluramycins, aureolic acids, indolocarbazoles, aminglycosides, glycopeptides, polyenes, coumarins, benzoisochromanequinones, calicheamicins, erythromycin, avermectins, ivermectins, angucyclines, cardiac glycosides, steroids or flavinoids. In preferred embodiments, the invention specifically relates to biosynthesis of anticancer (the enediyne calicheamicin, CLM), anthelmintic agents (the macrolides avermectin, ivermectin and erythromycin) and antibiotic (the glycopeptide vancomycin, VCM) natural product-based drugs developed by reversible, bidirectional glycosyltransferase-catalyzed reactions. | 11-05-2009 |
Patent application number | Description | Published |
20150141294 | REVERSIBLE NATURAL PRODUCT GLYCOSYLTRANSFERASE-CATALYZED REACTIONS, COMPOUNDS AND RELATED METHODS - The present invention relates to methods of use of glycosyltransferases and related novel compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomolecules and numerous one-pot reactions for generation of new biomolecules having varied backbones such as enediynes, vancomycins, bleomycins, anthracyclines, macrolides, pluramycins, aureolic acids, indolocarbazoles, aminglycosides, glycopeptides, polyenes, coumarins, benzoisochromanequinones, calicheamicins, erythromycin, avermectins, ivermectins, angucyclines, cardiac glycosides, steroids or flavinoids. In preferred embodiments, the invention specifically relates to biosynthesis of anticancer (the enediyne calicheamicin, CLM), anthelmintic agents (the macrolides avermectin, ivermectin and erythromycin) and antibiotic (the glycopeptide vancomycin, VCM) natural product-based drugs developed by reversible, bidirectional glycosyltransferase-catalyzed reactions. | 05-21-2015 |
Patent application number | Description | Published |
20100245766 | SYSTEMS AND METHODS FOR PHOTOACOUSTIC OPTHALMOSCOPY - Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser ophthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes. | 09-30-2010 |
20100245769 | SYSTEMS AND METHODS FOR PHOTOACOUSTIC OPTHALMOSCOPY - Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser opthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes. | 09-30-2010 |
20100245770 | SYSTEMS AND METHODS FOR PHOTOACOUSTIC OPTHALMOSCOPY - Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser opthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes. | 09-30-2010 |
20100249562 | ULTRASONIC IMAGING DEVICE - Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser opthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes. | 09-30-2010 |
Patent application number | Description | Published |
20090088583 | Organosilicon Amine-Based Electrolytes - Disclosed are electrolytes that are organosilicon amine-based, and supercapacitors which incorporate them. These electrolytes are quaternary ammonium salts with an organosilicon moiety. They appear particularly suitable for use at high voltages in applications such as electric and hybrid electric vehicles. | 04-02-2009 |
20090314998 | SYNTHESIS OF POLYMER NANOSTRUCTURES WITH CONDUCTANCE SWITCHING PROPERTIES - The present invention is directed to crystalline organic polymer nanoparticles comprising a conductive organic polymer; wherein the crystalline organic polymer nanoparticles have a size of from 10 nm to 200 nm and exhibits two current-voltage states: (1) a high resistance current-voltage state, and (2) a low resistance current-voltage state, wherein when a first positive threshold voltage (V | 12-24-2009 |
20100029970 | Organosilicon Phosphorus-Based Electrolytes - Disclosed are electrolytes that are organosilicon phosphorus-based, and supercapacitors which incorporate them. These electrolytes are cationic salts with a phosphorous containing organosilicon moiety. They appear particularly suitable for use in applications such as electric and hybrid electric vehicles. | 02-04-2010 |
20100149726 | Organosilicon Amine-Based Electrolytes - Disclosed are electrochemical double-layer capacitors having an electrode with a substrate and an electrolyte/quaternary ammonium salt capable of penetrating the substrate. Such salts have a moiety of the following formula: | 06-17-2010 |
Patent application number | Description | Published |
20110034536 | CONTROLLING THE POTENTIAL OF PRIMATE NEURAL STEM CELLS BY REGULATING PAX6 - A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed. | 02-10-2011 |
20120040393 | Directed Differentiation of Primate Pluripotent Stem Cells Into Functional Basal Forebrain Cholinergic Neurons (BFCNs) and Medium Spiny Gabaergic Projection Neurons - Methods of efficiently converting primate pluripotent stem cells to GABA neurons or cholinergic neurons, as well as applications thereof, are disclosed. | 02-16-2012 |
20140248696 | METHODS OF MAINTAINING, EXPANDING, AND DIFFRENTIATING NEURONAL SUBTYPE SPECIFIC PROGENITORS - Methods for expanding proliferating populations of neuronal subtype-specific progenitors are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors. | 09-04-2014 |
20150285822 | THERAPEUTIC AND DIAGNOSTIC METHODS AND COMPOSITIONS FOR NEURODEGENERATIVE DISEASES - Methods and compositions relating to motor neurons derived from induced pluripotent stem cells of subjects having a neurodegenerative disease, where the motor neurons exhibit phenotypes characteristic of the neurodegenerative disease, are provided herein. In particular, the present invention provides methods for screening putative therapeutic agents and methods for diagnosing living subjects as having a neurodegenerative disease. In addition, the present invention provides therapeutic gene transfer methods for treating or preventing a neurodegenerative disease in a subject in need thereof. | 10-08-2015 |
Patent application number | Description | Published |
20080206865 | Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells - A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1 | 08-28-2008 |
20080227137 | METHOD OF IN VITRO DIFFERENTIATION OF NEURAL STEM CELLS, MOTOR NEURONS AND DOPAMINE NEURONS FROM PRIMATE EMBRYONIC STEM CELLS - A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1 | 09-18-2008 |
20090239305 | Gene recombination exchange system for stable gene modification in human ES cells - A method of creating a human pluripotent transgenic stem cell, wherein heterologous DNA is inserted into specific “hot-spots” in the genome where stable and high gene expression may occur, is disclosed. In one embodiment, the method comprises the steps of: (a) selecting a pluripotent stem cell line, and (b) inserting heterologous DNA at an insertion site selected from the group consisting of insertion site one and insertion site two to form a transgenic cell line. In another embodiment, the heterologous DNA is an exchange cassette and the transgenic cell line formed is a master cell line. | 09-24-2009 |
20100159595 | METHOD OF GENERATING MYELINATING OLIGODENDROCYTES - A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFRα+. | 06-24-2010 |
20110275152 | Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells - A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1 | 11-10-2011 |
20120157510 | Controlling The Potential Of Primate Neural Stem Cells By Regulating Pax6 - A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed. | 06-21-2012 |
20120184032 | Method of In Vitro Differentiation of Neural Stem Cells, Motor Neurons and Dopamine Neurons From Primate Embryonic Stem Cells - A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1 | 07-19-2012 |
20130011917 | METHOD OF GENERATING MYELINATING OLIGODENDROCYTES - A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFRα+. | 01-10-2013 |
Patent application number | Description | Published |
20090290686 | ARTIFACT REDUCTION SYSTEM AND METHOD FOR RADIOLOGICAL IMAGING SYSTEM - The effects of electromagnetic interference (EMI) on X-ray image data is corrected by characterizing the EMI and processing the image data to subtract the EMI effects from the image data. The X-ray image data, along with offset data, are collected in a conventional manner, affected by EMI if present, and EMI-characterizing data is immediately collected thereafter by disabling rows of a digital detector (FET off). The EMI-characterizing data, then, is not affected by the presence of image data, and can be used to characterize the amplitude and frequency of the EMI. The EMI-characterizing data is assured of being in phase with the collected image and offset data due to its collection in the same image acquisition sequence immediately following the collection of image and offset data. Artifacts due to the presence of EMI are thus eliminated from reconstructed images based upon the corrected data. | 11-26-2009 |
20100290707 | IMAGE ACQUISITION METHOD, DEVICE AND RADIOGRAPHY SYSTEM - An image acquisition method includes determining the starting position, the ending position of a region of interest, and the value of overlap of the region of interest in the two adjacent sub-images, calculating the number of the sub-images required to be captured, the component of field of view at the direction of tube movement and the positions of the tube and the detector corresponding to each sub-image based on the starting position and the ending position of a region of interest and the value of the overlap. The method also includes moving the tube and the detector to each position and capturing the region of interest to obtain sub-images at the positions, and pasting the several sub-images together to form an image of the said region of interest. | 11-18-2010 |
Patent application number | Description | Published |
20100114050 | ABSORBENT MATERIALS AND ABSORBENT ARTICLES INCORPORATING SUCH ABSORBENT MATERIALS - An absorbent material formed at least in part of a crosslinked polymer. The absorbent material has a centrifuge retention capacity as determined by a Centrifuge Retention Capacity Test of at least about 20 g/g and a gel bed permeability under load as determined by a Gel Bed Permeability Under Load Test of at least about 300×10 | 05-06-2010 |
20120225773 | LOW-DENSITY, OPEN-CELL, SOFT, FLEXIBLE, THERMOPLASTIC ABSORBENT FOAM AND METHOD OF MAKING FOAM - A soft, flexible, low-density, open-cell, thermoplastic, absorbent foam formed from a foam polymer formula including a balanced amount of a plasticizing agent and a surfactant in combination with a base resin. Thermoplastic elastomers can be added to the foam polymer formula to improve softness, flexibility, elasticity, and resiliency of the resulting foam. The surfactant may be either a single surfactant or a multi-surfactant system. The foam possesses a number of qualities, such as softness and strength, which render the foam particularly suitable for use in a variety of personal care products, medical products, and the like. | 09-06-2012 |
Patent application number | Description | Published |
20090269002 | SYSTEMS AND METHODS FOR SENSING PROPERTIES OF A WORKPIECE AND EMBEDDING A PHOTONIC SENSOR IN METAL - Systems and methods for sensing properties of a workpiece and embedding a photonic sensor in metal are disclosed herein. In some embodiments, systems for sensing properties of a workpiece include an optical input, a photonic device, an optical detector, and a digital processing device. The optical input provides an optical signal at an output of the optical input. The photonic device is coupled to the workpiece and to the output of the optical input. The photonic device generates an output signal in response to the optical signal, wherein at least one of an intensity of the output signal and a wavelength of the output signal depends on at least one of thermal characteristics and mechanical characteristics of the workpiece. The optical detector receives the output signal from the photonic device and is configured to generate a corresponding electronic signal. The digital processing device is coupled to the optical detector and determines at least one of the thermal characteristics and mechanical the characteristics of the workpiece based on the electronic signal. | 10-29-2009 |
20120015235 | BATTERY MODULE HAVING ELECTROCHEMICAL CELLS WITH INTEGRALLY FORMED TERMINALS - An electrochemical cell includes a housing and a lid coupled to the housing. The electrochemical cell also includes a first member conductively coupled to the housing and configured to act as a first terminal for the electrochemical cell. The electrochemical cell further includes a second member electrically insulated from the lid and configured to act as a second terminal for the electrochemical cell. A first portion of the second member extends through the lid and a second portion of the second member extends in a direction generally perpendicular to the first portion. | 01-19-2012 |
20120244404 | PRISMATIC CELL SYSTEM WITH THERMAL MANAGEMENT FEATURES - A battery module includes a plurality of electrochemical cells provided side-by-side one another and a thermal management feature extending substantially the length of the battery module. The thermal management feature is coupled to a first side of each of the electrochemical cells and includes a passage though which a thermal management fluid may pass and a heat sink provided within the passage to transfer heat between the electrochemical cells and the thermal management fluid. | 09-27-2012 |
20130004807 | ELECTROCHEMICAL CELL HAVING RELEASABLE SUPPRESSANT - An electrochemical cell is provided. The electrochemical cell includes, but is not limited to, a can, a cell element within the can, electrolyte within the can, and a first suppressant container including suppressant and disposed within a void defined within the can. The suppressant is separated from the electrolyte by the first suppressant container. | 01-03-2013 |
20130136964 | ELECTROCHEMICAL CELL HAVING A SAFETY DEVICE - An electrochemical cell is provided including, but not limited to, a can, an output terminal for outputting current generated within the can, an electrode assembly connected with the output terminal and which comprises a positive electrode and a negative electrode, electrolyte within the can, and a safety device provided within the can. The safety device is configured to interrupt or reduce electric current passing from the electrode assembly to the output terminal when temperature inside the can exceeds a predetermined temperature. | 05-30-2013 |
20130216872 | PRISMATIC ELECTROCHEMICAL CELL - Systems are disclosed for battery modules having a plurality of electrochemical cells and cooling systems. According to one embodiment, a battery system includes a plurality of battery modules. Each battery module includes a plurality of electrochemical cells in thermal contact with a heat sink. The heat sink may utilize a plurality of fins and a fluid (e.g., air) to cool or heat the electrochemical cells. The electrochemical cells each have a positive terminal blade and a negative terminal blade that function as external terminals for the cell. The negative terminal blade is electrically isolated from the cover of the cell and is configured to be coupled to an internal negative terminal of the cell. | 08-22-2013 |
20140065451 | SYSTEM AND METHOD FOR CLOSING A BATTERY FILL HOLE - A battery module includes a hermetically sealed battery cell assembly. The battery cell assembly includes a housing and an electrochemical cell disposed in the housing, wherein the housing includes a fill hole configured to receive electrolyte into the battery cell assembly. The battery cell assembly also includes a seal disposed over the fill hole and ultrasonically welded to an annular portion of the housing around the fill hole. | 03-06-2014 |
20150188198 | BATTERY WITH LIFE ESTIMATION - A battery module includes a housing. The battery module also includes a cell stack disposed in the housing and including a battery cell. The battery module also includes a force gauge in mechanical communication with the cell stack and configured to measure a force generated by a swelling of the cell stack. The battery module also includes a control module configured to receive data indicative of the force and to estimate a remaining usable life of the battery module based on the data. | 07-02-2015 |
20160036032 | OVERCHARGE PROTECTION DEVICE FOR A BATTERY MODULE - The present disclosure includes a battery module having a plurality of battery cells disposed in a housing. Each of the plurality of battery cells has a positive terminal, a negative terminal, an overcharge protection assembly, and a casing having an electrically conductive material. The overcharge protection assembly includes a vent, a first spring component, a second spring component, and an insulative component. The first spring component is coupled to the positive terminal, the second spring component is coupled to the negative terminal, the insulative component is between the first spring component and a conductive piece and between the second spring component and the conductive piece, and the vent is configured to drive the insulative component from between the first and second spring components and the conductive piece, such that the first and second spring components contact the conductive piece, when a pressure in the casing exceeds a threshold. | 02-04-2016 |
20160049703 | BATTERY MODULE WITH RESTRAINED BATTERY CELLS UTILIZING A HEAT EXCHANGER - A battery module includes a battery module housing, a heat exchanger including a plurality of fins disposed in the housing, a first lithium ion battery cell and a second lithium ion battery cell disposed within the battery module housing. The first lithium ion battery cell and the second lithium ion battery cell are separated by a fin of the plurality of fins. The module includes a temperature sensing component coupled to the fin separating the first and second battery cells. Filler material is disposed within the housing and between the battery cells and the fins to mechanically restrain the battery cells within the battery module housing. The filler materials conduct thermal energy between the battery cells and the fin. The filler material covers a free end of the fin and the temperature sensing component. The temperature sensing component is coupled to a conductor extending out of the filler material. | 02-18-2016 |
Patent application number | Description | Published |
20160035163 | LOCATION TRACKING FOR LOCKING DEVICE - Disclosed are methods, systems, and computer-readable media for tracking location of locking devices. One locking device includes a wireless transceiver, a memory, an electronically controllable locking mechanism, a processor, and a location determination circuit configured to determine a location of the electronic locking device. The processor is configured to receive one or more location data items indicating the location of the electronic locking device at one or more times, to store the one or more location data items in the memory, and to transmit the one or more location data items from the memory to a mobile device via the wireless transceiver. | 02-04-2016 |
20160036594 | WIRELESS KEY MANAGEMENT FOR AUTHENTICATION - Disclosed are methods, systems, and computer-readable media for wireless key management for authentication. Authentication includes transmitting a request to a locking device, transmitting a security challenge to the mobile device, and transmitting a response to the challenge and an encrypted user profile for the locking device. The response includes data generated with an access key that is stored by both the mobile device and the locking device, and the user profile is encrypted by a server using a secret key that is stored by the server and the locking device. Authentication further includes verifying the response to the challenge, where the response is verified using the access key, and validating additional data from the mobile device. An action of the locking device may be initiated as specified by the request. | 02-04-2016 |
20160036788 | WIRELESS KEY MANAGEMENT FOR AUTHENTICATION - Disclosed are methods, and devices for wireless key management for authentication. One method includes receiving a lock identifier from a locking device; determining that the lock identifier is associated with a user profile, wherein a user profile is authenticated and encrypted by a server using a lock key that is stored by the server and the locking device, and wherein the user profile comprises a user key; transmitting the user profile; decrypting the user profile using the lock key; transmitting a security code; generating an encrypted command comprising the security code and encrypted using the user key; transmitting the command; validating the command. Validating the command can include decrypting using the user key; determining whether the security code is valid; and authenticating using the user key; and initiating, in response to validating, an action of the locking device as specified by the command. | 02-04-2016 |
20160036814 | WIRELESS FIRMWARE UPDATES - Disclosed are methods and devices for securely updating firmware of locking devices. One method includes receiving a lock identifier from a locking device; determining that the lock identifier is associated with a user profile by comparing the lock identifier to a set of lock identifiers; receiving a firmware update packet from a server, wherein the firmware packet is encrypted by a lock key; transmitting the firmware update packet to the lock; decrypting the firmware update using the lock key; validating the encrypted firmware update; and installing the firmware update. | 02-04-2016 |
Patent application number | Description | Published |
20140186723 | SYSTEMS AND METHODS FOR WIDE TEMPERATURE OPERATION FOR LITHIUM-ION BATTERY CELLS - The present disclosure relates generally to the field of batteries and battery modules. More specifically, the present disclosure relates to battery cells that may be used in vehicular contexts, as well as other energy storage/expending applications. An electrolyte solution includes at least one ester solvent and a plurality of additives. In particular, the plurality of additives includes a cyclic carbonate-based additive, a sultone-based additive, and either a borate-based additive or an imide-based additive. The presently disclosed electrolyte solutions enable the manufacture of battery cells having a wide operating temperature range (e.g., between approximately −30° C. and approximately 60° C.). | 07-03-2014 |
20150188188 | COMBINATORIAL CHEMISTRIES FOR MATCHING MULTIPLE BATTERIES - A micro-hybrid battery system includes a lithium ion battery module configured to be coupled to an electrical load. The lithium ion battery module includes a housing. The lithium ion battery module also includes a first lithium ion battery cell disposed in the housing and having a first active material chemistry including a first cathode active material and a first anode active material. The lithium ion battery module also includes a second lithium ion battery cell electrically connected to the first lithium ion battery cell and disposed in the housing. The second lithium ion battery cell has a second active material chemistry including a second cathode active material and a second anode active material. The first and second active material chemistries are different such that the first and second lithium ion battery cells have different open circuit voltages. | 07-02-2015 |
20160107526 | COOLING STRATEGY FOR BATTERY SYSTEMS - Embodiments describe a battery system that includes a first battery module coupled to a regenerative braking system and a control module that controls operation of the battery system by: determining a predicted driving pattern over a prediction horizon using a driving pattern recognition model based in part on a battery current and a previous driving pattern; determining a predicted battery resistance of the first battery module over the prediction horizon using a recursive battery model based in part on the predicted driving pattern, the battery current, a present bus voltage, and a previous bus voltage; determining a target trajectory of a battery temperature of the first battery module over a control horizon using an objective function; and controlling magnitude and duration of electrical power supplied from the regenerative such that a predicted trajectory of the battery temperature is guided toward the target trajectory of the battery temperature during the control horizon. | 04-21-2016 |