Alfredo Martinez
Alfredo Martinez, Chihuahua MX
Patent application number | Description | Published |
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20110031765 | HOLD OPEN LEVER INTEGRATED TO LATCH HOUSING - A compartment latch is shown. It includes a fork bolt that moves between an open position and a closed position and a first detent lever that that cooperates with the fork bolt and that moves between a latched position and a released position. A support for holding the fork bolt and the detent lever is also provided. A second detent lever for biasing against the first detent lever when the first detent lever is in the released position is provided. The second detent lever is connected to the support at a hinge. | 02-10-2011 |
20150028603 | APPARATUS AND METHOD FOR HOLD OPEN FEATURE IN A LATCH - A latch is disclosed herein. The latch having: a fork bolt movably mounted to the latch for movement between an open position and a closed position; a detent lever movably mounted to the latch for movement between a latched position and a released position, wherein the detent lever prevents the fork bolt from moving from the closed position to the open position when the detent lever is in the latched position; a bellcrank lever movably mounted to the latch for movement between a first position and a second position, wherein the bellcrank lever moves the detent lever from the latched position to the released position as the bellcrank lever moves from the first position to the second position; and a hold open feature movably mounted to the latch for movement between a first position and a second position, wherein the hold open feature is configured to engage and retain the bellcrank lever in the second position when the hold open feature is in the first position and wherein the hold open feature allows the bell crank lever to travel from the second position to the first position when the hold open feature is in the second position. | 01-29-2015 |
Alfredo Martinez, Cd. Juarez Chihuahua MX
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20100127511 | VEHICLE DOOR LATCH HAVING A POWER LOCK-UNLOCK MECHANISM - A door latch having a forkbolt that moves between a latched position and an unlatched position is provided. It includes a detent for holding the forkbolt in the latched position, and a power operated lock mechanism for moving the door latch to an unlock or lock position. It further comprises a first rotatable locking lever moveable between an unlocked and locked position and in operable communication with the detent through an intermittent lever; a second rotatable locking lever in operable communication with the first rotatable locking lever; a motor driven actuator engaging the second rotatable locking lever; and an actuator pin disposed between the motor driven actuator and the second rotatable locking lever for rotating the second rotatable locking lever. | 05-27-2010 |
20100127512 | VEHICLE DOOR LATCH - A door latch comprising a forkbolt that has a movement between a latched position and an unlatched position is provided. A detent is included that has movement on a travel path between a first position and a second position, the detent engaging and holding the forkbolt in the latched position when the detent is in the first position. The detent releases the forkbolt for movement to the unlatched position when the detent moves to the second position. A detent spring eccentrically engages the detent relative to the detent travel path and biases the detent toward the first position. A release mechanism is also included for moving the detent against the bias of the detent spring to the second position, thus releasing the forkbolt and producing a non-linear torque on the detent. | 05-27-2010 |
Alfredo Martinez, Mclean, VA US
Patent application number | Description | Published |
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20090053734 | DETERMINATION OF AM-BINDING PROTEINS AND THE ASSOCIATION OF ADRENOMEDULLIN (AM) THEREWITH - The present invention provides methods for the isolation, identification, and purification of adrenomedullin (AM)-binding proteins. Also, provided are methods for utilizing the purified AM-binding proteins, or functional portions thereof, to diagnose, treat, and monitor AM-related diseases, for example, diseases or disorders associated with abnormally elevated AM levels. In addition, the present invention provides a newly identified complex between AM and a specific AM-binding protein 1 (AMBP-1); which has been isolated and identified herein as factor H (fH). The invention also provides AM/AMBP complexes, particularly AM/FH complexes, and antibodies specifically reactive with this complexes. Further provided are methods for identifying and purifying complexes of AM and an AM binding protein using anti-AM/fH antibodies, and methods for treating conditions such as cancer or diabetes utilizing compositions comprising these antibodies. The present invention additionally provides methods for identifying antagonists agents that inhibit the function of AM, factor H, or the AM/factor H complex. The invention also provides methods for treating conditions such as cancer or diabetes using these antagonist agents. | 02-26-2009 |
20100021469 | FUNCTIONAL ROLE OF ADRENOMEDULLIN (AM) AND THE GENE RELATED PRODUCT (PAMP) IN HUMAN PATHOLOGY AND PHYSIOLOGY - The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was show by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM. | 01-28-2010 |
20100098703 | DETERMINATION OF AM-BINDING PROTEINS AND THE ASSOCIATION OF ADRENOMEDULLIN (AM) THEREWITH - The present invention provides methods for the isolation, identification, and purification of adrenomedullin (AM)-binding proteins. Also, provided are methods for utilizing the purified AM-binding proteins, or functional portions thereof, to diagnose, treat, and monitor AM-related diseases, for example, diseases or disorders associated with abnormally elevated AM levels. In addition, the present invention provides a newly identified complex between AM and a specific AM-binding protein 1 (AMBP-1); which has been isolated and identified herein as factor H (fH). The invention also provides AM/AMBP complexes, particularly AM/FH complexes, and antibodies specifically reactive with this complexes. Further provided are methods for identifying and purifying complexes of AM and an AM binding protein using anti-AM/fH antibodies, and methods for treating conditions such as cancer or diabetes utilizing compositions comprising these antibodies. The present invention additionally provides methods for identifying antagonists agents that inhibit the function of AM, factor H, or the AM/factor H complex. The invention also provides methods for treating conditions such as cancer or diabetes using these antagonist agents. | 04-22-2010 |
Alfredo Martinez, Bethesda, MD US
Patent application number | Description | Published |
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20080249115 | Non Peptide Agonists and Antagonists of Adrenomedullin and Gastric Releasing Peptide - This invention relates, e.g., to methods for inhibiting or stimulating an activity of an adrenomedullin (AM) or gastrin releasing peptide (GRP) peptide hormone, comprising contacting the peptide with a small molecule, non-peptide, modulatory agent of the invention. Complexes of these modulatory agents with other components, such as the peptides or blocking antibodies specific for the peptides, are also described, as are pharmaceutical compositions comprising the modulatory agents, and methods for using the modulatory agents to diagnose or treat patients. | 10-09-2008 |
20090048170 | TARGET FOR ANTI-ANGIOGENESIS THERAPY - The present disclosure concerns the use of peptides and compositions, such as pharmaceutical compositions, to influence angiogenesis. Particular methods are useful for promoting angiogenesis, while others are particularly useful for inhibiting angiogenesis. | 02-19-2009 |
20120232107 | NON-PEPTIDE ANTAGONISTS OF GASTRIN RELEASING PEPTIDE - This invention relates, e.g., to methods for inhibiting or stimulating an activity of an adrenomedullin (AM) or gastrin releasing peptide (GRP) peptide hormone, comprising contacting the peptide with a small molecule, non-peptide, modulatory agent of the invention. Complexes of these modulatory agents with other components, such as the peptides or blocking antibodies specific for the peptides, are also described, as are pharmaceutical compositions comprising the modulatory agents, and methods for using the modulatory agents to diagnose or treat patients. | 09-13-2012 |
Alfredo Martinez, Cd. Juarez MX
Patent application number | Description | Published |
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20120175896 | VEHICLE DOOR LATCH - A vehicle door latch assembly is disclosed herein, the vehicle latch assembly having: a fork bolt movably secured to the latch assembly, the fork bolt being capable of movement between a latched position and an unlatched position; a detent lever movably secured to the latch assembly, the detent lever being capable of movement between an engaged position and a disengaged position, the detent lever retains the fork bolt in the latched position when the detent lever is in the engaged position and an engagement surface of the detent lever contacts an engagement surface of the fork bolt; and an inertia block out assembly for preventing the detent lever from moving into the disengaged position until a predetermined force is applied to the detent lever to move it to the disengaged position when the fork bolt is in the latched position. | 07-12-2012 |
20140292000 | APPARATUS AND METHOD FOR PREVENTING UNDESIRED ENGAGEMENT OF HOLD OPEN LEVER IN A LATCH - A latch is disclosed herein. The latch having: a fork bolt movably mounted to the latch for movement between an open position and a closed position; a detent lever movably mounted to the latch for movement between a latched position and a released position, wherein the detent lever prevents the fork bolt from moving from the closed position to the open position when the detent lever is in the latched position; a hold open lever configured to engage and retain the detent lever when it moves from the latched position to the released position; and wherein the fork bolt is configured to disengage the hold open lever from the detent lever when the fork bolt travels away from the closed position. | 10-02-2014 |
Alfredo Martinez, Galilea ES
Patent application number | Description | Published |
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20140100163 | NON-PEPTIDE AGONISTS AND ANTAGONISTS OF ADRENOMEDULLIN AND GASTRIN RELEASING PEPTIDE - This invention relates, e.g., to methods for inhibiting or stimulating an activity of an adrenomedullin (AM) or gastrin releasing peptide (GRP) peptide hormone, comprising contacting the peptide with a small molecule, non-peptide, modulatory agent of the invention. Complexes of these modulatory agents with other components, such as the peptides or blocking antibodies specific for the peptides, are also described, as are pharmaceutical compositions comprising the modulatory agents, and methods for using the modulatory agents to diagnose or treat patients. | 04-10-2014 |