Mancini, IT
Aldo Mancini, Naples IT
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20110091438 | RADIOPROTECTIVE SOD SOLUBLE ISOFORM AND USES THEREOF - The invention refers to a specific isoform of MnSOD (Mn-superoxide dismutase) and its uses for protecting and curing subjects exposed to radiations, specifically space radiations. | 04-21-2011 |
Aldo Mancini, Napoli IT
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20110111043 | PEPTIDES AND THEIR USE AS CARRIERS INTO CANCER CELLS - The use of a peptide is described as a carrier for the transport of molecules or radioisotopes into cancer cells; also described are modifications of said peptide and their use. | 05-12-2011 |
Alfredo Mancini, Spinadesco (cr) IT
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20120322996 | Novel Method for the Preparation of Stavudine Polymorphic Form I and Form II - A novel method for the preparation of stavudine polymorphic form I and form II is described. 5′-acetate-2′,3′-diacetyl-5-methyluridine is reacted with catalytic amounts of sodium methoxide in a C | 12-20-2012 |
Angelo Mancini, Ariccia IT
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20120250312 | LIGHTING DEVICE FOR RESCUE AND EMERGENCY PRIORITARY VEHICLES, HEAVY TRANSPORTS AND VEHICLES, AND WORK MACHINERY - A lighting device, in particular a light signaling supplementary device for rescue and emergency prioritary vehicles, heavy transports and vehicles, and work machinery is described. The lighting device has a light source placed on a disposition plane and a semi-parabolic reflector body for the conveying of the light within a predefined exit angular aperture of ±α of the light beam with respect to the disposition plane. A semi-parabolic reflector body of the lighting device can be rotated around a rotation axis that passes in correspondence of a center of said light source and is perpendicular to said disposition plane, in such a way to obtain a light beam which spans a predefined maximal angle around said light source. | 10-04-2012 |
Angelo Mancini, Ariccia - Rome IT
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20100214776 | LIGHTING DEVICE, IN PARTICULAR LIGHT SIGNALLING SUPPLEMENTARY DEVICE FOR RESCUE AND EMERGENCY PRIORITARY VEHICLES - The invention concerns a lighting device ( | 08-26-2010 |
Edo Mancini, Gemmano IT
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20130056953 | SUPPORT FOR BICYCLE SADDLE - The support for bicycle saddle comprises a support rod ( | 03-07-2013 |
Flavio Mancini, Brescia Bs IT
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20150090420 | METHOD AND PLANT FOR MANUFACTURING LIGHT ALLOY CASTINGS BY INJECTION DIE CASTING WITH NON-METALLIC CORES - A method for manufacturing light alloy castings by die casting with disposable cores, including a mold filling phase in which the parameters of pressure and speed of the molten alloy are controlled at levels tolerable by the cores until the cavities around the latter are filled by the molten alloy, and thereafter the pressure and speed parameters are controlled at levels suitable for completing and compacting the casting, the alloy being kept at a temperature close to its melting temperature throughout the whole path between the pump that pressurizes it and the entrance to the cavities around the cores. The invention relates also to a plant implementing said method by means of a pump connected to a mold through a duct that comes out within the casting envelope at a point close to the centroid of the cores. | 04-02-2015 |
20150151356 | INJECTION PUMP FOR THE HOT-CHAMBER DIE CASTING OF CORROSIVE LIGHT ALLOYS - An injection pump for the hot-chamber die casting of corrosive light alloys includes a body provided with an internal coaxial liner where an injector piston sealingly slides. The liner being made of a material resistant to the molten alloy and has a coefficient of thermal expansion different from the material of the body. Static sealing elements, made of a graphite-based non-metallic material that yields under compression, are arranged between the internal surface of the body and the external surface of the liner. The pump also has axial compression means arranged between a ring nut screwed into the body and the liner and the static sealing elements. | 06-04-2015 |
Francesca Mancini, Nettuno(roma) IT
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20160045485 | NEW USE OF 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 BETA INHIBITORS - The present invention relates to the new use of 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta (GSK-3β) inhibitors and to their use in the treatment of GSK-3β-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) substance abuse disorders; and (viii) epilepsies. | 02-18-2016 |
Francesca Mancini, Roma (rm) IT
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20130217634 | PEPTIDES ABLE TO INTERFERE WITH THE INHIBITING ACTIVITY OF MDM2/MDM4 HETERODIMER TOWARDS P53 AND USE THEREOF FOR CANCER TREATMENT - The present disclosure concerns peptides able to interfere and in particular impair the inhibiting activity of MDM2/MDM4 heterodimer towards p53 and maintain the association between MDM4 and p53 so to restore the p53 oncosuppressive function in cancer cells harboring wild type p53 protein, directing its function specifically towards an apoptotic outcome. | 08-22-2013 |
Francesca Mancini, Nettuno (roma) IT
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20140378455 | NEW USE OF 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 BETA INHIBITORS - 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors. The present invention relates to the 1H-indazole-3-carboxamide compounds for use as glycogen synthase kinase 3 beta (GSK-33) inhibitors and to their use in the treatment of GSK-3p-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) substance abuse disorders; and (viii) epilepsies. | 12-25-2014 |
20150057294 | 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 BETA INHIBITORS - The present invention relates to the 1H-indazole-3-carboxamide compounds having the following general formula (I) as glycogen synthase kinase 3 beta (GSK-3β) inhibitors and to their use in the treatment of GSK-3p-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) substance abuse disorders; (viii) epilepsies; and (ix) neuropathic pain. | 02-26-2015 |
Franco Mancini, Cremona IT
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20120322996 | Novel Method for the Preparation of Stavudine Polymorphic Form I and Form II - A novel method for the preparation of stavudine polymorphic form I and form II is described. 5′-acetate-2′,3′-diacetyl-5-methyluridine is reacted with catalytic amounts of sodium methoxide in a C | 12-20-2012 |
Gianni Mancini, Milan IT
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20140271959 | PROCESS AND APPARATUS FOR MOULDING AND CURING TYRES - An apparatus for moulding and curing a green tyre includes a curing mould that includes a first sidewall plate and a second sidewall plate, with a ring of circumferential sectors circumscribing a mould cavity. The first sidewall plate is capable of coming into contact with a first annular fixing structure of the green tyre when the green tyre is inserted into the mould. The apparatus also includes at least a first bead moulding ring movable from a first contracted operating position to a second extended operating position, a second bead moulding ring movable from a first contracted operating position to a second extended operating position, and an expandable bladder delimited by a membrane associated for operation with the mould to exert a pre-moulding pressure which is lower than a moulding pressure to bring the first annular fixing structure into contact with the first sidewall plate. | 09-18-2014 |
Ines Mancini, Povo-Trento IT
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20120123113 | DI-SUBSTITUTED PYRIDINUM POLYMERS AND SYNTHESIS THEREOF - A method of producing a di-substituted pyridinium polymer by microwave-assisted polymerisation of a 2, 3, or 4-substituted pyridine monomer of the formula NC | 05-17-2012 |
Luca Mancini, Budrio IT
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20080290194 | Outward opening fuel injector - A fuel injector provided with: an injection valve comprising an injection nozzle; a mobile needle for regulating the fuel flow through the injection valve and ending with a shutting head, which engages a valve seat of the injection valve, is arranged externally with respect to injection valve and presents a predetermined sealing diameter; an actuator for displacing the needle between a closing position and an opening position of the injection valve; a closing spring which tends to maintain the needle in the closing position of the injection valve pushing the shutting head against the valve seat itself in a sense contrary to the feeding sense of the fuel; and a supporting body having a tubular shape and presenting a feeding channel within which a needle is arranged; the needle, at an opposite end of the shutting head, is coupled to a balancing channel, which is at ambient pressure. | 11-27-2008 |
20100242922 | DIRECT-INJECTION SYSTEM FUEL PUMP WITH A MAXIMUM-PRESSURE VALVE - A direct-injection system fuel pump having: at least one pumping chamber; a piston mounted to slide inside the pumping chamber to cyclically alter the volume of the pumping chamber; an intake channel connected to the pumping chamber and regulated by an intake valve; a delivery channel connected to the pumping chamber and regulated by a one-way delivery valve that only permits fuel flow from the pumping chamber; and a drain channel regulated by a one-way, maximum-pressure valve, which opens when the fuel pressure in the drain channel exceeds a threshold value, and which has a shutter movable along the drain channel, a valve seat engaged in fluidtight manner by the shutter, and a spring calibrated to push the shutter into a position engaging the valve seat in fluidtight manner. | 09-30-2010 |
20110103985 | FUEL PUMP WITH AN IMPROVED DAMPING DEVICE FOR A DIRECT INJECTION SYSTEM - A fuel pump for a direct injection system having: at least one pumping chamber; a piston which is mounted sliding inside the pumping chamber in order to vary cyclically the volume of the pumping chamber; an intake duct connected to the pumping chamber and regulated by an inlet valve; a delivery duct connected to the pumping chamber and regulated by a one-way delivery valve which allows exclusively a fuel flow outgoing from the pumping chamber; and a damping device, which is placed along the intake duct upstream of the inlet valve, and comprises at least one elastically deformable damping body that has internally a closed chamber filled with pressurized gas and composed of two metal plates cup shaped and welded together at their annular edges by an annular weld without interruptions. | 05-05-2011 |
20110108007 | FUEL PUMP WITH REDUCED SEAL WEAR FOR A DIRECT INJECTION SYSTEM - A fuel pump for a direct injection system having: at least one pumping chamber, a piston which is slidingly mounted inside the pumping chamber in order to cyclically vary the volume of the pumping chamber, an intake duct connected to the pumping chamber and regulated by an inlet valve, a delivery duct connected to the pumping chamber and regulated by a one-way valve that only allows outgoing fuel flow from the pumping chamber, and an annular seal, which is placed in a seat made below the pumping chamber around a lower portion of the piston and has the function of preventing fuel leakage along the side wall of the piston. | 05-12-2011 |
20110163189 | OUTWARD OPENING FUEL INJECTOR - A fuel injector provided with: an injection valve comprising an injection nozzle; a mobile needle for regulating the fuel flow through the injection valve and ending with a shutting head, which engages a valve seat of the injection valve, is arranged externally with respect to injection valve and presents a predetermined sealing diameter; an actuator for displacing the needle between a closing position and an opening position of the injection valve; a closing spring which tends to maintain the needle in the closing position of the injection valve pushing the shutting head against the valve seat itself in a sense contrary to the feeding sense of the fuel; and a supporting body having a tubular shape and presenting a feeding channel within which a needle is arranged; the needle, at an opposite end of the shutting head, is coupled to a balancing channel, which is at ambient pressure. | 07-07-2011 |
20120255636 | SILENCED FUEL PUMP FOR A DIRECT INJECTION SYSTEM - A fuel pump for a direct-injection system provided with a common rail comprises a pumping chamber defined in a main body. A piston is mounted in a sliding manner inside the pumping chamber to cyclically vary volume of the pumping chamber. A suction channel is connected to the pumping chamber and regulated by a suction valve. A delivery channel is connected to the pumping chamber and regulated by a delivery valve. A flow-rate-adjustment device is mechanically coupled to the suction valve to keep, when necessary, the suction valve substantially open during pumping of the piston and includes a control rod that is coupled to the suction valve and an electromagnetic actuator that acts on the control rod and has a one-way hydraulic brake that is integral to and substantially slows movement of the control rod. | 10-11-2012 |
20150204286 | METHOD TO CONTROL AN ELECTROMAGNETIC ACTUATOR OF AN INTERNAL COMBUSTION ENGINE - Method to control an electromagnetic actuator of an internal combustion engine, in particular for a fuel pump of a direct-injection system; wherein the electromagnetic actuator is controlled by an electric current pulse of the Peak&Hold type, i.e. subdivided into a peak phase and a hold phase; the method includes acquiring the initial duration of the peak phase, during which a peak control current is to be supplied to the electromagnetic actuator to control the movement of a component of the electromagnetic actuator moving towards a position defined by a limit stop; and determining the duration of the peak phase by progressively decreasing the initial duration of the peak phase by a first change. | 07-23-2015 |
20160069313 | FUEL PUMP FOR A DIRECT INJECTION SYSTEM - Fuel pump for a direct injection system provided with a common rail; the fuel pump has: a pumping chamber defined in a main body; a piston which is mounted in a sliding manner inside the pumping chamber to cyclically vary the volume of the pumping chamber; an intake channel which originates from a wall of the pumping chamber; an intake valve which is coupled to the intake channel; a delivery channel which originates from a wall of the pumping chamber; a delivery valve which is coupled to the delivery channel; and an actuating spring which has a plurality of turns having a pitch between the turns being variable and coupled to the piston so as to push the piston towards a maximum volume or minimum volume position of the pumping chamber. | 03-10-2016 |
Manuela Mancini, Bologna IT
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20130203831 | NON PEPTIDIC 14-3-3 INHIBITORS AND THE USE THEREOF - The present invention refers to compounds with inhibitory activity against 14-3-3 proteins and their use in the treatment of tumors, in particular chronic myeloid leukemia. The invention also provides methods for the identification of 14-3-3 protein inhibitors. | 08-08-2013 |
Mauro Mancini, Fabriano IT
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20150191861 | WASHING MACHINE PROVIDED WITH A RECIRCULATION CIRCUIT - A washing machine comprising: a washing tub ( | 07-09-2015 |
Osvaldo Mancini, Pescara IT
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20090033716 | METHOD AND DEVICE FOR INK-JET PRINTING A MOVING WEB - A device for printing a web moving in a direction (Y | 02-05-2009 |
Rita Mancini, Rome IT
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20140017259 | IMMUNOTHERAPY AGAINST ERBB-3 RECEPTOR - The present invention describes methods and pharmaceutical compositions for the treatment of cancer in mammals, more particularly in human subjects. More specifically, the invention concerns anti-tumor vaccines based upon plasmid DNA and/or genetic vectors carrying a codon-usage optimized sequence and coding for a mutant form of the ErbB-3 receptor. Furthermore, the invention refers to monoclonal antibodies directed against the ErbB-3 receptor, obtained using these methods and capable to block its activity in cancer cells. | 01-16-2014 |
Rita Mancini, Sandigliano-Biella IT
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20120141047 | Bag made of recycled components - The invention relates to a bag ( | 06-07-2012 |
Stefano Mancini, Jesi IT
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20100287995 | WASHING MACHINE TANK PROVIDED WTIH EXTERNAL REINFORCING CAP ON BOTTOM WALL - The present invention relates to a washing machine tank ( | 11-18-2010 |
20110000265 | ANCHORING SYSTEM OF COUNTERWEIGHTS FOR WASHERS AND WASHER/DRYER COMBOS - The present invention relates to an anchoring system of counterweights for washers and washer/dryer combos based on the presence of a plurality of tubular divaricable pins ( | 01-06-2011 |
Stefano Mancini, Ravenna IT
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20110024194 | SYSTEM AND METHOD FOR ONE-TRIP HOLE ENLARGEMENT OPERATIONS - A drilling assembly for simultaneous hole enlargement operations comprises a drill bit, an adjustable diameter reamer, and a hole opener. The reamer is coupled with, and positioned uphole from the drill bit. The reamer is adjustable between a first diameter and a second diameter that is larger than the first diameter. The hole opener is coupled with, and positioned uphole from the reamer. | 02-03-2011 |
20110166837 | Reamer and Bit Interaction Model System and Method - Teachings of the disclosure are directed to a reamer and/or bit interaction model system and method. The method may include receiving performance data regarding a cutting structure, and calculating a characteristic curve, using the performance data. The characteristic curve may be weight-based and/or torque-based. The method may also include storing the characteristic curve. In particular embodiments, the characteristic curve may include either weight on cutting structure or torque on the cutting structure, as a function of the rate of penetration. | 07-07-2011 |
20150081221 | DRILLING SYSTEM FAILURE RISK ANALYSIS METHOD - There is disclosed a method for assessing risk associated with drilling a section of a wellbore in a formation using a drilling system, comprising: providing a probabilistic model for the risk of the drilling system triggering a failure mode during drilling; and assessing the risk of the drilling system triggering one of said failure modes during drilling of the section based on said model. A further such method comprises: defining the critical control parameters for the drilling system; and identifying one or more failure modes of the drilling system associated with each critical control parameter which may arise during drilling the section of the formation. | 03-19-2015 |
20150198014 | REAMER AND BIT INTERACTION MODEL SYSTEM AND METHOD - Teachings of the disclosure are directed to a reamer and/or bit interaction model system and method. The method may include receiving performance data regarding a cutting structure, and calculating a characteristic curve, using the performance data. The characteristic curve may be weight-based and/or torque-based. The method may also include storing the characteristic curve. In particular embodiments, the characteristic curve may include either weight on cutting structure or torque on the cutting structure, as a function of the rate of penetration. | 07-16-2015 |
Stefano Mancini, Jesi (an) IT
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20100175433 | Tub for washing machine or washer-drier - A tub for washing machine or washer-drier has a back and a front adapted to be mutually fixed to house a rotary drum where laundry is loaded. The front of the tub defines a loading mouth to provide access to the drum. The front of the tub has at least one stiffening structure, integrally obtained with the front, and adapted to avoid the deformation of the front of the tub and consequent ovalization of the loading mouth. | 07-15-2010 |