Lian, US
Aaron B. Lian, Portland, OR US
Patent application number | Description | Published |
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20080263913 | Lock assembly for securing a wear member to earth-working equipment - A locking assembly for retaining a wear member to excavating equipment has a locking element that is received into an opening in the assembly and is movable about a pivot axis in the opening between a hold position and a release position. The locking element has an outer edge that is generally opposite the pivot axis that opposes a base surface of the opening when the locking element is in the hold position. The outer edge is configured to pull away from the base surface when the locking element is rotated from the hold position toward the release position. | 10-30-2008 |
Bin Lian, Portland, OR US
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20120276541 | Microplates, Reaction Modules and Detection Systems - Microplates, reaction modules and optical detection systems for chemical and/or bio-chemical reactions including polymerase chain reactions. | 11-01-2012 |
Christine Guo Lian, Shrewsbury, MA US
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20140206757 | TREATMENT OF CANCER - This disclosure provides agents, compositions and methods of treating cancer by inhibiting histone lysine specific demethylase 1 (LSD1) and/or and a histone lysine specific demethylase 2 (LSD2). Agents and compositions comprise statins and/or inhibitors of LSD1/2. | 07-24-2014 |
20150285807 | SYSTEM AND METHOD FOR DETECTING CANCER - Disclosed herein are methods of detecting malignancy in a tumor of a subject comprising measuring the amount of 5-hmC in a tumor sample and comparing to a control to thereby detect a level of reduction of 5-hmC in the tumor, wherein the tumor is characterized as malignant if a threshold level of reduction is detected. The tumor may be a solid tumor such as a melanocytic lesion. Also disclosed are methods of determining the prognosis of a subject with a tumor by determination of the amount of 5-hmC in the tumor. Methods for treatment of a tumor with reduced 5-hmC are also disclosed. | 10-08-2015 |
Elizabeth H. Lian, Brookline, MA US
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20080288534 | CONTENT FEEDBACK IN A MULTIPLE-OWNER CONTENT MANAGEMENT SYSTEM - New functions for a contact center system include: testing user's comprehension of informational messages with a quiz; capturing insight of superior users having a KPI score above a threshold by having those users submit information on why they perform so well; dynamically ordering solutions to issues by re-ranking the solutions periodically based on recency and frequency; integrating information for use by a contact center representative while online with a customer and information for use when not online; storing content items in a telecommunications industry taxonomy; directing user feedback on a content item to the proper owner/manager of that content; communicating solution information using a solutions taxonomy; displaying a dual information system having a CRM application as well as reference material that is context-appropriate; enforcing completion of a group of templates when creating a content item to be published; ensuring a group of templates for a content item are complete before publishing them; and searching within a contact center system portal using a continuum of search functions. | 11-20-2008 |
20120150574 | CONTENT FEEDBACK IN A MULTIPLE-OWNER CONTENT MANAGEMENT SYSTEM - New functions for a contact center system include: testing user's comprehension of informational messages; capturing insight users having a KPI score above a threshold by having those users submit information on why they perform well; dynamically ordering solutions to issues by re-ranking the solutions periodically based on recency and frequency; integrating information for use by a contact center representative while online with a customer and information for use when not online; storing content items in a telecommunications industry taxonomy; directing user feedback on a content item to the proper owner/manager of that content; communicating solution information using a solutions taxonomy; displaying a dual information system having a CRM application and reference material that's context-appropriate; enforcing completion of a group of templates when creating a content item to be published; ensuring a group of templates for a content item are complete before publishing them; and searching within a contact center system. | 06-14-2012 |
Guoda Lian, Plano, TX US
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20110084209 | REPRODUCIBLE LATTICE STRAIN MEASUREMENT METHOD - Lattice strain is reproducibly measured using geometric phase analysis (GPA) of a high angle annular dark field mode scanning transmission electron microscope (HAADF-STEM). Errors caused by beam shift (also known as fly-back error) between scan lines are eliminated. | 04-14-2011 |
20120325009 | STRAIN MEASUREMENT TEST MODULE - A test structure for measuring strain in the channel of transistors. A method of correlating transistor performance with channel strain. | 12-27-2012 |
Hong Lian, Peoria, IL US
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20140286693 | Boot Seal For Machine System And Method - A machine system includes a first component, a second component, and a joint assembly pivotably connecting the first and second components in a finite angular pivoting range. A boot seal seals between the first and second components, and has a rest configuration where the boot seal has a curvilinear taper, and is deformable to a squished configuration forming a radially outward bulge. The radially outward bulge stores an energy of compression of the boot seal, to bias a sealing ring in the boot seal against the second component. | 09-25-2014 |
Hongbing Lian, Plano, TX US
Patent application number | Description | Published |
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20090103604 | Method and Apparatus for On-Chip Voltage Controlled Oscillator Function - This invention uses a flying adder frequency synthesis circuit to provide the required frequency adjustments to accommodate the varying encoding density of a MPEG2 video data stream. This invention adjusts the local clock based on the information extracted from the program clock reference signal in the incoming data. This invention replaces an external or internal voltage-controlled crystal oscillator using a phase locked loop circuit on the video processing integrated circuit. | 04-23-2009 |
20090161809 | Method and Apparatus for Variable Frame Rate - A method and apparatus for adjusting to a frame rate. The method displays the video frames with varying rates. The method comprising the steps of detecting a change in the frame rate, calculating the FREQ of the frame, adjusting the phase-locked loop utilizing the calculated FREQ, and utilizing the adjusted phase-locked loop output as the pixel clock to display the frame. | 06-25-2009 |
Jane B. Lian, Westborough, MA US
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20100159011 | Compositions For Biomedical Applications - The invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments. In further embodiments, the polymer matrix comprises biomolecules. | 06-24-2010 |
20150209477 | COMPOSITIONS FOR BIOMEDICAL APPLICATIONS - The invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments. In further embodiments, the polymer matrix comprises biomolecules. | 07-30-2015 |
Jianming Lian, Richland, WA US
Patent application number | Description | Published |
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20150379542 | TRANSACTIVE CONTROL FRAMEWORK FOR HETEROGENEOUS DEVICES - Various innovations for a transactive control framework with heterogeneous devices such as refrigerators, air conditioners, water heaters, and clothes dryers, or components of such systems/units, are presented. For example, an aggregator for the transactive control framework receives bids from device controllers for heterogeneous devices. Different bids can reflect different behaviors of heterogeneous devices under one transactive control framework, which allows the heterogeneous devices to participate in the same ancillary service market for power. The aggregator determines a cleared price value, then broadcasts the cleared price value and a regulation signal to the device controllers. The device controllers can use a stochastic decision-making process to regulate power utilization by the respective heterogeneous devices, such that the aggregate behavior of the controlled devices tracks the regulation signal. In many case, the transactive control framework helps the devices, collectively, provide a regulation service according to the regulation signal. | 12-31-2015 |
20160092978 | COORDINATION OF THERMOSTATICALLY CONTROLLED LOADS - Apparatus and methods for a market-based control framework to coordinate a group of autonomous thermostatically controlled loads (TCL) to achieve system-level objectives with pricing incentives is disclosed. In one example of the disclosed technology, a method of providing power to a load via a power grid by submitting bids to a coordinator includes determining an energy response relating price data for one or more energy prices to quantity data for power to be consumed by the load, sending a bid for power for a finite time period based on the energy response to the coordinator, and receiving a clearing price based on: the bid, on bids received from a plurality of additional loads, and a feeder power constraint. In some examples, the energy response is based at least in part on an equivalent thermal parameter model and a control policy indicating one or more power states for the load. | 03-31-2016 |
20160092986 | COORDINATION OF THERMOSTATICALLY CONTROLLED LOADS WITH UNKNOWN PARAMETERS - Apparatus and methods are disclosed for coordination of a population of Thermostatically Controlled Loads (TCLs) with unknown parameters to achieve group objectives including bidding and market clearing strategies designed to motivate self-interested users to realize efficient energy allocation subject to a peak power constraint. In one examples of the disclosed technology, a method of operating a load includes estimating a set of values for unmeasured parameters of the load's thermal environment based on output measurements of the thermal environment, determining an energy response based on the estimated set of values for the unmeasured parameters, and transmitting a bid for power for a finite time period based on the determined energy response to the coordinator. A clearing price is received from the coordinator responsive to the transmitted bid and power is sent to the load responsive to the received clearing price. | 03-31-2016 |
Jianyu Lian, Westford, MA US
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20110241812 | MAGNETIC FIELD GENERATOR BASED ON DUAL PERMANENT MAGNET RINGS - A magnet assembly primarily for use in MRI applications is disclosed comprising two main permanent magnet rings that are spaced-apart and arranged to be coaxially aligned with two easy-access openings. The magnetization direction in each magnet ring is substantially radially oriented and maintains an anti-parallel orientation with respect to each other. Together, these two magnet rings create a homogeneous and strong magnetic field in the central enclosure between them with two orthogonal access paths to the enclosure. Through one access pathway a patient can be inserted while through the other pathway a doctor can fully access the patient and perform interventional procedures during a real-time MRI scan. Embodiments of the system also have poles and yokes that shape the field and minimize fringe fields. Embodiments of this magnet assembly can achieve high magnetic fields for whole-body scanning without saturating the magnet pole and other structures. | 10-06-2011 |
20110248715 | Compact Inhomogeneous Permanent Magnetic Field Generator for Magnetic Resonance Imaging - A magnet assembly primarily for use in MRI applications is disclosed. The magnet assembly is composed of a single disk and ring permanent magnet set connected to a C-type magnet yoke and return fixture with asymmetrically arranged poles. Together, the permanent magnets create a strong magnetic field that has a large static gradient in the central enclosure. The magnet assembly is primarily designed for diffusion based MRI scanning but can perform routine MRI scanning as well. | 10-13-2011 |
20120240385 | Cylindrical Bi-Planar Gradient Coil for MRI - Cylindrical bi-planar gradient coil assemblies for use in open magnetic resonance imaging, wherein each of the coil assemblies contains in sequential order (i) a circular primary coil set placed flat above a cylindrical planar substrate, (ii) cooling means, (iii) 0th and 2nd order shims, (iv) shield layers, and (v) 1st order shims. In use the gradient coil assemblies are disposed symmetrically to each other about a plane of symmetry parallel to each. | 09-27-2012 |
Jianyu Lian, Quincy, MA US
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20090085700 | Open MRI Magnetic Field Generator - A magnet primarily for use in MRI applications comprises a pair of poles oriented about a plane of symmetry parallel to each therebetween defining an air gap region, magnetic field sources secured on the surfaces of the poles opposite the air gap that have yokes disposed on them, the yokes connected to each other by returns so that the entire magnet assembly can form a closed magnetic flux circuit to substantially confine the magnetic fields generated by the apparatus in the air gap where an imaging region is formed to place subjects for the purposes of examination. The main assembly being cylindrical in geometry has permanent magnets for magnetic field sources that are composed of two regions, a central disk-like portion magnetized substantially along the axial direction and an outer ring-like region magnetized substantially along the radial direction extending axially to form part of the pole together producing a very efficient and even flux distribution throughout the entire magnet assembly with minimal flux leakage. A further means of reducing flux leakage is incorporated in the yokes which have two sections, a disk-like region and an ring-like section to enclose the permanent magnets. The poles are made of multiple sections with a central disk-like region and an outer ring-like region that is a combination of permanent magnets and high permeability materials. This magnet assembly can achieve 1.0 Tesla or greater magnetic fields for whole-body scanning without saturating the magnet pole and other structures. | 04-02-2009 |
20090206837 | INTERVENTIONAL MRI MAGNETIC FIELD GENERATOR BASED ON PERMANENT MAGNETS - A magnet assembly primarily for use in MRI Interventional applications having an array of four mam permanent magnets that are spaced-apart and arranged into a ring-like geometry with six easy-access openings The magnetization direction in each permanent magnet is anti-parallel to any other adjacent permanent magnet in the πng assembly while it is parallel to any other permanent magnet in the array that is oppositely located just as in a quadrupolar system Such an arrangement has the advantage of concentrating the magnetic field inside the nng enclosure while minimizing magnetic field generated outside Together, these four spatially spaced-apart permanent magnets create a very homogeneous and strong magnetic field in the central enclosure with two orthogonal access paths and one parallel access path to the enclosure Through one access pathway a patient can be inserted while through the other pathways a doctor can fully access the patient. | 08-20-2009 |
Jie Lian US
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20110022438 | METHOD FOR OPTIMIZING RESOURCE ALLOCATION - Conventional resource allocation process has intrinsic inefficiency because of the resource fragmentation. A solution is provided to defragment the resource so that the customers' requests are better served and provider's resource utilization rate is improved. | 01-27-2011 |
20120016249 | METHOD AND DEVICE FOR NOISE DETECTION IN PHYSIOLOGICAL SIGNALS - A method for determining the signal quality of samples in a physiological signal, in particular an electrocardiogram (ECG) signal, is provided. A supra-threshold sample sum, a noise threshold crossing sum, or both are calculated in a noise detection window including the sample to be evaluated, and low signal quality is indicated if either or both of the sums exceed respective values. ECG beat detections can then be labeled as unreliable based on the determination of low signal quality for one or more samples between the detections. | 01-19-2012 |
20120179056 | APPARATUS AND METHOD FOR DETECTION OF LEAD FAILURE IN AN IMPLANTABLE MEDICAL DEVICE - A method for automatic threshold control and detection of lead failure in an implanted medical device obtains three sensing vectors for measurement of an electrocardiogram signal. A dynamic error signal is determined from the vectors, and may be used to set a detection threshold for insufficient ECG signals, and/or to passively monitor the device for indications of lead failure without performing an impedance measurement. Passive mode operation conserves battery power and enables continuous lead integrity checks. A quality factor may also be determined from the error signal, to indicate whether or not signal measurements are valid with respect to noise levels. If the detection threshold is allowed to decay between successive features of the electrocardiogram, the decay rate may be made adaptive such that it automatically adjusts to changes in heart rate or to changes in amplitude of the electrocardiogram features. | 07-12-2012 |
20120302904 | HEART STIMULATOR AND METHOD FOR A-V DELAY OPTIMIZATION - Exemplary methods and apparatuses are disclosed that provide for determination of an atrio-ventricular delay on a beat-to-beat basis by determining a P-wave duration from electric signals corresponding to electric potentials in a heart, and determining the atrio-ventricular delay on a beat-to-beat basis such that the atrio-ventricular delay for an individual heart cycle depends on the P-wave duration of a same or an immediately preceding heart cycle. | 11-29-2012 |
Jieni Lian, Pullman, WA US
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20100223839 | SYSTEMS AND PROCESSES FOR PRODUCING BIO-FUELS FROM LIGNOCELLULOSIC MATERIALS - A selective pyrolysis process for the production of bio-oils enriched in pyrolytic sugars and phenols and conversion of these compounds into second generation bio-fuels is disclosed herein. One embodiment of the process comprises pre-treating a biomass with superheated steam or gases in a selected range of temperatures, followed by fast pyrolysis using synthesis gas as a carrier, and a two-step condensation operation. The aqueous phase from the second condenser can then be reformed to produce hydrogen or can be gasified together with the charcoal to produce syngas. | 09-09-2010 |
Jiyong Lian, Austin, TX US
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20130250635 | CONTROL TECHNIQUES FOR PHOTOVOLTAIC POWER PLANTS - A photovoltaic power plant includes solar cells and inverters that convert direct current generated by the solar cells to alternating current. The reactive powers generated by the inverters are based on a reactive power generated by a virtual inverter. The virtual inverter has an equivalent impedance representing the impedances of the inverters in the photovoltaic power plant. The reactive power setpoints of the inverters may be received from a local interpreter. The local interpreter may generate the reactive power setpoints from a global reactive power setpoint generated by a grid controller. | 09-26-2013 |
20140078793 | MITIGATION OF ARC FLASH HAZARD IN PHOTOVOLTAIC POWER PLANTS - Arc flash mitigation devices are employed to protect personnel during maintenance of photovoltaic inverters. During normal operation, an alternating current (AC) output of a photovoltaic inverter is coupled to a low voltage winding of a step up transformer through a bus-bar (e.g., an electrically conductive interconnect), which has higher current rating than a fuse. During maintenance, the bus-bar is replaced with the fuse. The fuse may be employed in conjunction with a switch. The switch may be a disconnect switch that places the bus-bar in parallel with the fuse during normal operation, and decouples the bus-bar from the fuse during maintenance. The switch may also be a transfer switch that places either the bus-bar or the fuse in series with the AC output of the photovoltaic inverter and the low voltage winding of the step up transformer. | 03-20-2014 |
20160087425 | MITIGATION OF ARC FLASH HAZARD IN PHOTOVOLTAIC POWER PLANTS - Arc flash mitigation devices are employed to protect personnel during maintenance of photovoltaic inverters. During normal operation, an alternating current (AC) output of a photovoltaic inverter is coupled to a low voltage winding of a step up transformer through a bus-bar (e.g., an electrically conductive interconnect), which has higher current rating than a fuse. During maintenance, the bus-bar is replaced with the fuse. The fuse may be employed in conjunction with a switch. The switch may be a disconnect switch that places the bus-bar in parallel with the fuse during normal operation, and decouples the bus-bar from the fuse during maintenance. The switch may also be a transfer switch that places either the bus-bar or the fuse in series with the AC output of the photovoltaic inverter and the low voltage winding of the step up transformer. | 03-24-2016 |
Kun Lian, Baton Rouge, LA US
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20080227753 | Nano-sized Bagasse Fiber - A new composition of nanosized bagasse fibers has been made by a method which reduces the sugarcane bagasse fibers to nano-sized particles while retaining the natural components of the bagasse. The resulting bagasse particles were shown to be effective as a nutritional supplement in a mouse model to aid in glucose control and body weight. Using the bagasse nanofibers, the addition of 5 to 10% fiber did not change the color or texture of food products. Moreover, the bagasse powder has a natural color and absorbs color evenly so that it could be used as a natural foundation material for cosmetic products. | 09-18-2008 |
20090098033 | Carbon-Encased Metal Nanoparticles and Sponges, Methods of Synthesis, and Methods of Use - We disclose novel metallic nanoparticles coated with a thin protective carbon shell, and three-dimensional nano-metallic sponges; methods of preparation of the nanoparticles; and uses for these novel materials, including wood preservation, strengthening of polymer and fiber/polymer building materials, and catalysis. | 04-16-2009 |
20120021222 | Carbon-Encased Metal Nanoparticles and Sponges, Methods of Synthesis, and Methods of Use - We disclose novel metallic nanoparticles coated with a thin protective carbon shell, and three-dimensional nano-metallic sponges; methods of preparation of the nanoparticles; and uses for these novel materials, including wood preservation, strengthening of polymer and fiber/polymer building materials, and catalysis. | 01-26-2012 |
20140370422 | Nanoparticles, Nanosponges, Methods of Synthesis, and Methods of Use - We disclose novel metallic nanoparticles coated with a thin protective carbon shell, and three-dimensional nano-metallic sponges; methods of preparation of the nanoparticles; and uses for these novel materials, including wood preservation, strengthening of polymer and fiber/polymer building materials, and catalysis. | 12-18-2014 |
20150299954 | Nano-sized Bagasse Fiber - A new composition of nanosized bagasse fibers has been made by a method which reduces the sugarcane bagasse fibers to nano-sized particles while retaining the natural components of the bagasse. The resulting bagasse particles were shown to be effective as a nutritional supplement in a mouse model to aid in glucose control and body weight. Using the bagasse nanofibers, the addition of 5 to 10% fiber did not change the color or texture of food products. Moreover, the bagasse powder has a natural color and absorbs color evenly so that it could be used as a natural foundation material for cosmetic products. | 10-22-2015 |
Piezhi Lian, Sharon, MA US
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20100175441 | BIOPRODUCTION OF HYDROLYSATE FROM SQUID PROCESSING BYPRODUCTS FOR AQUACULTURE FEED INGREDIENT AND ORGANIC FERTILIZER - A bioproduction process of preparing an hydrolysate from squid processing byproducts. The process includes obtaining squid byproducts and hydrolyzing the byproducts. The hydrolyzed product are heated until the viscosity stabilizes. The hydrolyzed product is then filtered to form a filtrate and then concentrated to form the desired hydrolysate. | 07-15-2010 |
Robert Lian, Miami Beach, FL US
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20150374089 | LUGGAGE CARRYING DEVICE - A body removably attachable to belts for carrying a wheeled luggage includes an attachable element for attaching the body to a belt. The attachable element has an orifice and can include an elongated U-shaped member having a bottom, first and second side sections. The attachable element further includes a top section having first and second ends. The first end of the top section is hingedly connected to the first end of the first side section of the U-shaped member. A flap is hingedly connected to the second end of the top section. The flap and second side section of the U-shaped member are provided with a tongue and groove locking arrangement. The body further includes a reversed j-shaped utility element for holding a handle of a wheeled luggage. | 12-31-2015 |
20150374103 | LUGGAGE CARRYING DEVICE - A body removably attachable to a belt for carrying a wheeled luggage having a top part having a hooked element for receiving a belt; a bottom part having a second hooked element for holding a handle of a wheeled luggage; and a swivel device for swivelly connecting the top part with the bottom part. The swivel device comprises a first tube positioned on the top part of the body for receiving a first portion of an elongated cylindrical element and a second tube positioned on the bottom part of the body for receiving a second portion of an elongated cylindrical element. The cylindrical element includes a first collar proximate to a first end of the elongated cylindrical element and a second collar proximate to a second end of the elongated cylindrical element, wherein the first and second collars are positioned such that when the elongated element is received by the first and second tubes, the first collar is positioned in first cutout and the second collar is positioned in the second cutout. | 12-31-2015 |
Tianquan Lian, Tucker, GA US
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20130240349 | EFFICIENT SYSTEM FOR PHOTOGENERATION OF REDOX MEDIATOR RADICALS AND THEIR USE FOR SOLAR-TO-FUEL CONVERSION - This disclosure relates to compositions of nanoparticles and methods of their use related thereto such as for solar-to-fuel conversion. In general, the compositions include specific nanostructures that act as photosensitizers can help provide near quantum yield for light driven redox mediator reduction and hydrogen generation. In the presence of a catalyst and redox mediator, compositions described herein can efficiently convert sunlight to hydrogen, providing a versatile approach to solar-to-fuel conversion. | 09-19-2013 |
Wenlong Lian, Columbus, OH US
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20160115202 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES - Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 04-28-2016 |
Xiaojun Lian, Madison, WI US
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20110142935 | CARDIAC DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS UNDER DEFINED CONDITIONS USING MATRIX OVERLAY METHODS - Methods for culturing the pluripotent stem cells to undergo epithelial-to-mesenchymal transition and for generating high-yield, high-purity cardiomyocyte cultures from pluripotent stem cells are described. Pluripotent stem cells are cultured on a support with an overlaid matrix and, optionally, exposed to one or more factors to induce epithelial-to-mesenchymal transition and cardiogenesis. | 06-16-2011 |
20160068814 | CHEMICALLY DEFINED ALBUMIN-FREE CONDITIONS FOR CARDIOMYOCYTE DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS - Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/β-catenin signaling is first activated in pluripotent cells, by, for example, inhibiting Gsk-3 to obtain a first population of cells. Wnt/β-catenin signaling is then inhibited in the first cell population to induce cardiogenesis. One or more of these steps is performed under defined, albumin-free culture conditions. | 03-10-2016 |
Xiaojun Lian, Allston, MA US
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20150152389 | GENERATION OF CARDIOMYOCYTES FROM HUMAN PLURIPOTENT STEM CELLS - Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/β-catenin signaling is first activated in pluripotent cells, e.g., by inhibition of Gsk-3 to obtain a first population of cells. Wnt/β-catenin signaling is then inhibited in the first cell population to induce cardiogenesis under fully defined, growth factor free culture conditions. | 06-04-2015 |
Xiaojun Lance Lian, University Park, PA US
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20160108363 | USE OF LIFR OR FGFR3 AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS - The present invention provides LIFR and FGFR3 as cell surface markers for isolating human cardiomyogenic ventricular progenitor cells, in particular progenitor cells that preferentially differentiate into cardiac ventricular muscle cells. Thus, the invention provides human ventricular progenitor (HVP) cells. The invention provides in vitro methods of the separation of Islet 1+ LIFR+ ventricular progenitor cells and/or Islet 1+/FGFR3+ ventricular progenitor cells and/or Islet 1+/LIFR+/FGFR3+ ventricular progenitor cells, and the large scale expansion and propagation thereof. Large clonal populations of isolated LIFR+ and/or FGFR3+ ventricular progenitor cells are also provided. Methods of in vivo use of LIFR+ and/or FGFR3+ ventricular progenitor cells for cardiac repair or to improve cardiac function are also provided. Methods of using the LIFR+ and/or FGFR3+ ventricular progenitor cells for cardiac toxicity screening of test compounds are also provided. | 04-21-2016 |
Xiao Xiao Lian US
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20110060983 | PRODUCING A VISUAL SUMMARIZATION OF TEXT DOCUMENTS - A method and system of producing a visual text summarization. According to the method, a plurality of topics may be extracted from a collection of text documents, where each of the topics comprises a distribution of topic keywords. An importance ranking for each of the topics may be determined, and an importance ranking for each of the topic keywords of a topic may also be determined. A graph may be displayed having a plurality of stacked layers representing a group of topics selected from the plurality of topics based on the importance ranking of the topics. A keyword cloud within each layer of the graph may also be displayed, where the one keyword cloud is a group of topic keywords selected from the extracted topic keywords based on the importance ranking of the extracted topic keywords. | 03-10-2011 |
Xiao-Yuan Lian, Houston, TX US
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20100197610 | FRUCTOSE 1, 6 BISPHOSPHATE - A NOVEL ANTICONVULSANT DRUG - The present invention concerns methods and compositions for preventing one or more epileptic seizures in an individual by delivering fructose-1,6-bisphosphate to the individual. In certain cases, an additional therapy for epilepsy is provided to the individual. | 08-05-2010 |
Yachun Lian US
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20150193473 | Database Storage System based on Optical Disk and Method Using the System - A database storage system based on optical disk includes a database management system installed on a server, a magnetic disk storage device and an optical disk storage device connecting, via a data connection, to the server. The database management system processes database management and data management in response to data requests and a database is created in the magnetic disk storage device, and includes a field structure generation module, a record index generation module, a storage space allocation module, a storage space status module, a record linkage module, a record split module and a database creation on optical disk module. The integrity of data is maintained during a database backup process. The optical disk containing a subdatabase accepts the management of the database management system to serve as a normal data source. The databases are hierarchically stored using the storage devices. The methods for database backup and restoration are provided. | 07-09-2015 |
Yijian Lian, Lake Jackson, TX US
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20110241245 | AXIALLY ORIENTED CONFINED CRYSTALLIZATION MULTILAYER FILMS - A method of forming a confined crystallization multilayer film includes coextruding a plurality of first polymer layers and a plurality of second polymer layer to form a multilayer film wherein each first polymer layer is sandwiched between second polymer layers and axially orienting the multilayer film at a temperature below the melting temperature (T | 10-06-2011 |
Zenyu Lian, Northville, MI US
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20090278333 | INTEGRATED TOW HOOK AND BUMPER MOUNTING BRACKET - An integrated tow hook and vehicle bumper mounting bracket assembly including a mounting bracket including a frame mounting surface and a bumper mounting surface. A vehicle bumper assembly may be removably securable to the bumper mounting surface of the mounting bracket, and a tow hook may be removably securable to the frame mounting surface of the mounting bracket by one or more mechanical fasteners. The mechanical fastener used to secure the tow hook to the mounting bracket may further serve to secure the mounting bracket to a vehicle frame. | 11-12-2009 |
Zichuan Lian US
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20150193473 | Database Storage System based on Optical Disk and Method Using the System - A database storage system based on optical disk includes a database management system installed on a server, a magnetic disk storage device and an optical disk storage device connecting, via a data connection, to the server. The database management system processes database management and data management in response to data requests and a database is created in the magnetic disk storage device, and includes a field structure generation module, a record index generation module, a storage space allocation module, a storage space status module, a record linkage module, a record split module and a database creation on optical disk module. The integrity of data is maintained during a database backup process. The optical disk containing a subdatabase accepts the management of the database management system to serve as a normal data source. The databases are hierarchically stored using the storage devices. The methods for database backup and restoration are provided. | 07-09-2015 |