Patent application number | Description | Published |
20120263797 | IMPLANTABLE POLYMER FOR BONE AND VASCULAR LESIONS - A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures. | 10-18-2012 |
20130253661 | METHOD AND APPARATUS FOR TREATING BONE FRACTURES, AND/OR FOR FORTIFYING AND/OR AUGMENTING BONE, INCLUDING THE PROVISION AND USE OF COMPOSITE IMPLANTS - A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone. | 09-26-2013 |
20130309166 | Injection Molding of Poly-4-Hydroxybutyrate - Compositions of P4HB and processes to injection mold these compositions have been developed. These compositions are prepared from P4HB polymers and blends having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g, moisture contents of less than 0.5% by weight, and more preferably less than 0.05% by weight, and using a polymer melt temperature during molding of at least 150° C. A preferred embodiment comprises a P4HB molding with an intrinsic viscosity of less than 3.2 dl/g that degrades rapidly in vivo. | 11-21-2013 |
20130309275 | Resorbable Bioceramic Compositions of Poly-4-Hydroxybutyrate and Copolymers - Compositions for making implants comprising high levels of resorbable bioceramics have been developed. These compositions comprise P4HB and copolymers thereof filled with bioceramics, and can be prepared with high levels of bioceramic without the compositions becoming too brittle for the intended application. A preferred embodiment comprises P4HB filled with β-TCP. | 11-21-2013 |
20140178328 | IMPLANTABLE POLYMER FOR BONE AND VASCULAR LESIONS - A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures. | 06-26-2014 |
20140199409 | OXYGENATED DEMINERALIZED BONE MATRIX FOR BONE GROWTH - An improved composition for inducing bone growth is provided that is a mixture of DBM and a perfluorocarbon oxygen carrier. Injection/implantation of a composition of DBM and a perfluorocarbon results in enhancement of bone formation. | 07-17-2014 |
20140200667 | Implants for Soft and Hard Tissue Regeneration - Implants for osteo and osteochondral repair have been developed. These implants include a series of channels between the upper and lower surfaces of the implants, such that when implanted the lower surfaces are situated in an area rich in bone marrow and the channels provide a means for the bone marrow to migrate through the implant. Preferably the implants are made from resorbable polymer fibers, preferably arranged in braids that are knitted or woven together such that the braids are substantially parallel with each other. The implants may be rolled into a bundle of braids with the axis of the braids substantially parallel to the axis of the bundle, to provide channels along the axis of the bundle. A preferred embodiment includes P4HB fibers braided and knitted into a structure that is coated with a ceramic, preferably physiologic calcium phosphate. | 07-17-2014 |
20140314822 | DEMINERALIZED BONE FIBERS HAVING CONTROLLD GEOMETRY AND SHAPES AND METHODS THEREOF - A bone repair composition and methods thereof include elongated bone fibers made from cortical bone in which a plurality of approximately uniform bone fibers is made into various implant shapes conducive for various applications. The bone fiber compositions may be in the form of a cavity, ball, pellet, wrap, strip, cylinder, cone, putty, gel, or injectable slurry. | 10-23-2014 |
20150093429 | DEMINERALIZED BONE FIBERS HAVING CONTROLLED GEOMETRY AND SHAPES AND METHODS THEREOF - A bone repair composition and methods thereof include elongated bone fibers made from cortical bone in which a plurality of approximately uniform bone fibers is made into various implant shapes conducive for various applications. The bone fiber compositions may be in the form of a cavity, ball, pellet, wrap, strip, cylinder, cone, putty, gel, or injectable slurry. | 04-02-2015 |
20150343116 | OXYGENATED THREE-DIMENSIONAL MATRIX FOR BONE GROWTH - An encapsulated three-dimensional (3-D) bone matrix composition for inducing bone growth includes a 3-D bone matrix, an oxygen carrier incorporated into the 3-D bone matrix, and an encapsulation material which encapsulates the 3-D bone matrix incorporated with the oxygen carrier. Methods are disclosed for preparing an encapsulated 3-D bone matrix that can be maintained in packaging. | 12-03-2015 |
20150374878 | ANGIOGENIC DEVICES FOR WOUND CARE - Devices, such as dressing and implants, for treatment of chronic wounds comprising controlled delivery systems for butyric acid or salts, polymers, or derivatives thereof are provided. These devices are particularly useful when it is desirable to promote angiogenesis in a chronic wound. In the preferred embodiment, the implants are resorbable, provide a temporary scaffold for the in-growth of cells, tissues, and blood vessels to help regenerate the extracellular matrix, and deliver butyric acid to the chronic wound. The dressings and implants may also contain one or more antibiotics to treat or prevent infection in the wound, and/or inhibitors of proteases to modulate protease activity in the wound. | 12-31-2015 |
20160038639 | COMPOSITIONS OF AND METHODS FOR CANCELLOUS BONE MATRIX - A bone repair composition including a cancellous bone matrix with cortical and/or cancellous bone particles loaded therein; and a kit comprising the cancellous bone matrix and the cortical and/or cancellous bone particles. | 02-11-2016 |
Patent application number | Description | Published |
20110114427 | Shock energy absorber - A shock energy absorber includes, in one example, a cylinder having a closed end and an open end, a sleeve fixed about the open end of the cylinder, and a damping material in the form of an ultra high molecular weight polyethylene material in the cylinder. A plunger is positioned to be driven into the damping material via the sleeve. When the plunger is impacted and driven into the damping material, the damping material changes from a solid to a viscous fluid state thereby enabling absorption of a significant amount of energy. | 05-19-2011 |
20110233126 | Reverse Osmosis Pressure Vessel End Cap Assembly - A reverse osmosis pressure vessel end cap assembly includes a seal plate positioned within a pressure vessel shell, with one or more load plates positioned to retain the seal plate in position. A load ring is captured or expanded by the load plates to secure the load ring into a channel in the interior surface of the pressure vessel shell. The end cap assembly thus provides secure yet easily removable access to the pressure vessel, capable of withstanding the high pressures of a reverse osmosis filtration system. Various exemplary embodiments of the assembly are provided. | 09-29-2011 |
20120312497 | Fuel vapor reclamation system for diesel locomotives - An on-board vapor reclamation system and method includes an air inlet into an on-board diesel fuel tank and a fuel vapor/air mixture outlet from the fuel tank. A pump or a suction fan is operable to drive air from the air inlet through the tank and a fuel vapor/air mixture out the fuel vapor/air mixture outlet at a flow rate which maintains a fuel vapor concentration in the tank to less than a predetermined value corresponding to the lower explosive limit to reduce fire and explosive hazards and to reduce harmful emissions. A condenser subsystem is fluidly connected to the fuel vapor/air mixture tank outlet and is configured to condense fuel vapor in the fuel vapor/air mixture delivered to the condenser subsystem at the required flow rate. Condensed fuel vapor from the condenser subsystem is returned to the fuel tank to save fuel and increase mileage. | 12-13-2012 |
20140326553 | SHOCK ENERGY ABSORBER - A shock energy absorber includes, in one example, a cylinder having a closed end and an open end, a sleeve fixed about the open end of the cylinder, and a damping material in the form of an ultra high molecular weight polyethylene material in the cylinder. A plunger is positioned to be driven into the damping material via the sleeve. When the plunger is impacted and driven into the damping material, the damping material changes from a solid to a viscous fluid state thereby enabling absorption of a significant amount of energy. | 11-06-2014 |
Patent application number | Description | Published |
20090210748 | METHODS AND SYSTEMS TO TEST AIRLINE INFORMATION SYSTEMS - Methods and systems to simulated a plurality of airline information systems (AISs) to test an AIS under test (AISUT), including to send and receive messages between the simulated AISs, and to send messages to and receive messages from the AISUT, in accordance with communication parameters associated with the corresponding AISs and AISUT. The AISUT and/or the simulated AISs may be stimulated to cause interaction with the AISUT, and resultant messages and information may be recorded. Stimulation may include controlling a web browser to interact with a web application of the AISUT. AISs may be represented as travel system objects, which may be associated with corresponding AIS-specific message handling and reporting parameters. Message processing logic may be configured to process messages, such as booking request messages, directed to a plurality of the simulated AISs, and the travel systems and the message processing logic may be modifiable independent of one another. | 08-20-2009 |
20140214624 | Method And Interface For Comparing Costs Of Vacation Components - The disclosure generally describes computer-implemented methods, software, and systems for comparing costs of vacation components. One computer-implemented method includes determining a geographic origin for a received request, selecting a plurality of proposed vacation destinations and, for each proposed vacation destination, identifying vacation information, filtering the selected plurality of proposed vacation destinations based upon at least one filtering rule based at least in part upon the determined geographic origin to generate a set of filtered proposed vacation destinations, initiating a presentation of the vacation information for the set of filtered proposed vacation destinations, wherein each proposed vacation destination of the filtered proposed vacation destinations is associated with an interactive informational element representing the proposed vacation destination, receiving a hover event associated with a particular interactive informational element, and initiating a presentation of an interactive price-date summary graph for the proposed vacation destination associated with the particular interactive informational element. | 07-31-2014 |
Patent application number | Description | Published |
20100301647 | Blast mitigating seat - A blast mitigating seat features a base and a seat frame. The seat frame includes a pan and a backrest including an open area for gear worn by a user. A first damping subsystem between the base and the seat frame has a first force/stroke relationship and a second damping subsystem between the base and the seat frame has a second force/stroke relationship. | 12-02-2010 |
20140150632 | AMPHIBIOUS ARMOR - Buoyant armor for jacketed rounds includes an outer, laminate reinforced strike face having a hardness greater than 640 Brinell. The strike face is configured to strip the jacket off a projectile as it passes through the strike face and to rotate the projectile. An inner, laminate reinforced strike face is separated from the outer, laminate reinforced strike face by a spacer layer. Foam greater than 40 mm thick is disposed behind the inner strike face and is configured to disperse a round and/or its fragments and to provide buoyancy to the armor. | 06-05-2014 |
20150251509 | AMPHIBIOUS ARMOR - Buoyant armor for jacketed rounds includes an outer, laminate reinforced strike face having a hardness greater than 640 Brinell. The strike face is configured to strip the jacket off a projectile as it passes through the strike face and to rotate the projectile. An inner, laminate reinforced strike face is separated from the outer, laminate reinforced strike face by a spacer layer. Foam greater than 40 mm thick is disposed behind the inner strike face and is configured to disperse a round and/or its fragments and to provide buoyancy to the armor. | 09-10-2015 |
Patent application number | Description | Published |
20110142379 | THREE-DIMENSIONAL PLASTIC BAG AND PRODUCTION THEREOF - The present invention relates to an insert for reinforcement of bags made of plastic film, comprising a star-like plastic part having at least three jaws, wherein the insert is adapted for insertion and heat-sealing at a junction inside a three-dimensional bag where at least three plastic films meet, so that each jaw extends in a direction between two films. The invention also relates to a three dimensional bag incorporating such inserts and a method of producing such a bag. | 06-16-2011 |
20110151551 | BIOREACTORS - The present invention relates to improved single-use bioreactors comprising disposable plastic bags for cell cultivation. The invention provides an inflatable bioreactor bag for cell cultivation comprised of a top and a bottom sheet of polymer material that are joined along their edges to form a sealed bag, wherein two opposing edges are formed as clamping edges to allow clamping of the bioreactor bag to a rocker type bioreactor, and wherein the bioreactor bag is provided with a wrinkle preventing structure at each end of the clamping edges. The bag avoids formation of undesired wrinkles or creases which otherwise lead to fatigue of the plastic and eventually fracture. | 06-23-2011 |
20110151552 | BIOREACTORS - The present invention relates to improvements of bioreactor bags for cell cultivation. The invention provides an inflatable bioreactor bag for cell cultivation comprised of a top and a bottom sheet of polymer material that are joined along their edges to form a sealed bag, wherein two opposing edges are formed as clamping edges to allow clamping of the bioreactor bag to a rocker type bioreactor, wherein the top sheet is at least 5% longer than the bottom sheet between the clamping edges. The bioreactor bags provided by the invention avoid formation of undesired wrinkles or creases which otherwise may lead to fatigue of the plastic and eventually fracture. | 06-23-2011 |
Patent application number | Description | Published |
20100106502 | SPEAKER VERIFICATION METHODS AND APPARATUS - In one aspect, a method for determining validity of an identity asserted by a speaker using a voice print associated with a user whose identity the speaker is asserting, the voice print obtained from characteristic features of at least one first voice signal obtained from the user uttering at least one enrollment utterance including at least one enrollment word is provided. The method comprises acts of obtaining a second voice signal of the speaker uttering at least one challenge utterance, wherein the at least one challenge utterance includes at least one word that was not in the at least one enrollment utterance, obtaining at least one characteristic feature from the second voice signal, comparing the at least one characteristic feature with at least a portion of the voice print to determine a similarity between the at least one characteristic feature and the at least a portion of the voice print, and determining whether the speaker is the user based, at least in part, on the similarity between the at least one characteristic feature and the at least a portion of the voice print. | 04-29-2010 |
20100106503 | SPEAKER VERIFICATION METHODS AND APPARATUS - In one aspect, a method for determining a validity of an identity asserted by a speaker using a voice print that models speech of a user whose identity the speaker is asserting is provided. The method comprises acts of performing a first verification stage comprising acts of obtaining a first voice signal from the speaker uttering at least one first challenge utterance; and comparing at least one characteristic feature of the first voice signal with at least a portion of the voice print to assess whether the at least one characteristic feature of the first voice signal is similar enough to the at least a portion of the voice print to conclude that the first voice signal was obtained from an utterance by the user. The method further comprises performing a second verification stage if it is concluded in the first verification stage that the first voice signal was obtained from an utterance by the user, the second verification stage comprising acts of adapting at least one parameter of the voice print based, at least in part, on the first voice signal to obtain an adapted voice print, obtaining a second voice signal from the speaker uttering at least one second challenge utterance, and comparing at least one characteristic feature of the second voice signal with at least a portion of the adapted voice print to assess whether the at least one characteristic feature of the second voice signal is similar enough to the at least a portion of the adapted voice print to conclude that the second voice signal was obtained from an utterance by the user. | 04-29-2010 |
20120239398 | SPEAKER VERIFICATION METHODS AND APPARATUS - In one aspect, a method for determining a validity of an identity asserted by a speaker using a voice print is provided. The method comprises acts of performing a first verification stage comprising comparing a first voice signal from the speaker uttering at least one first challenge utterance-with at least a portion of the voice print and performing a second verification stage if it is concluded in the first verification stage that the first voice signal was obtained from an utterance by the user. The second verification stage comprises adapting at least one parameter of the voice print based, at least in part, on the first voice signal to obtain an adapted voice print, and comparing a second voice signal from the speaker uttering at least one second challenge utterance with at least a portion of the adapted voice print. | 09-20-2012 |
20130030809 | SPEAKER VERIFICATION METHODS AND APPARATUS - One aspect includes determining validity of an identity asserted by a speaker using a voice print associated with a user whose identity the speaker is asserting, the voice print obtained from characteristic features of at least one first voice signal obtained from the user uttering at least one enrollment utterance including at least one enrollment word by obtaining a second voice signal of the speaker uttering at least one challenge utterance that includes at least one word not in the at least one enrollment utterance, obtaining at least one characteristic feature from the second voice signal, comparing the at least one characteristic feature with at least a portion of the voice print to determine a similarity between the at least one characteristic feature and the at least a portion of the voice print, and determining whether the speaker is the user based, at least in part, on the similarity. | 01-31-2013 |
20140081640 | SPEAKER VERIFICATION METHODS AND APPARATUS - One aspect includes determining validity of an identity asserted by a speaker using a voice print associated with a user whose identity the speaker is asserting, the voice print obtained from characteristic features of at least one first voice signal obtained from the user uttering at least one enrollment utterance including at least one enrollment word by obtaining a second voice signal of the speaker uttering at least one challenge utterance that includes at least one word not in the at least one enrollment utterance, obtaining at least one characteristic feature from the second voice signal, comparing the at least one characteristic feature with at least a portion of the voice print to determine a similarity between the at least one characteristic feature and the at least a portion of the voice print, and determining whether the speaker is the user based, at least in part, on the similarity. | 03-20-2014 |
Patent application number | Description | Published |
20080249282 | POLYFLUORENE METHOD - A method of synthesizing a poly(9,9-disubstituted-fluorene) includes reacting a 9,9-disubstituted-fluorene with an alkyl lithium in the presence of a catalytic amount of a nickel amine complex. The 9,9-disubstituted-fluorene includes solubility-enhancing substituents in the 9-position and leaving groups in the 2-position and the 7-position. The product poly(9,9-disubstituted-fluorene)s are fluorescent conjugated polymers that are useful as, for example, blue light-emitting materials. | 10-09-2008 |
20090011141 | ARTICLE WITH PHEMA LIFT-OFF LAYER AND METHOD THEREFOR - A method of forming a patterned functional layer on a substrate using a poly(hydroxyethyl methacrylate) lift-off layer is described. The method can be used with substrates that would not tolerate the organic solvents required for processing of known poly(methyl methacrylate) lift-off layers. When used in combination with known nanoimprint lithography and step-and-flash imprint lithography techniques, the method can be used to generate patterned functional structures with dimensions as small as five nanometers. | 01-08-2009 |
20090264317 | Functionalized nanostructure, methods of manufacture thereof and articles comprising the same - Disclosed is a method comprising disposing a functionalized patternable material on a substrate, wherein the functionalized patternable material comprises a first click chemical moiety; patterning the functionalized patternable material; and reacting the first click chemical moiety with a complementary reactant to form an functionalized patterned surface, the complementary reactant comprising a second click chemical moiety that reacts with the first click chemical moiety; the complementary reactant comprising an functional group. | 10-22-2009 |
Patent application number | Description | Published |
20080311117 | Antibodies against PD-1 and uses therefor - This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders. | 12-18-2008 |
20100028330 | METHODS OF UPMODULATING ADAPTIVE IMMUNE RESPONSE USING ANTI-PD1 ANTIBODIES - This disclosure provides antibodies and antigen-binding fragments that can act as agonists and/or antagonists of PD-1 (Programmed Death 1), thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The disclosed compositions and methods may be used for example, in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders. | 02-04-2010 |
Patent application number | Description | Published |
20090215054 | PROGNOSIS INDICATORS FOR SOLID HUMAN TUMORS - The present teachings provide methods for predicting the clinical outcome of the treatment of human solid tumors. In some embodiments, the method includes measuring in the cells of a tumor the expression level of a set of genes whose change is related to chromosomal instability; taking a statistical measure of the expression level of the set of measured genes; and if the statistical measure of the expression level of the set of measured genes is elevated, determining that the prognosis is poor. Another aspect of the present teachings is the sets of genes, which are useful in predicting the outcome of treatment of solid tumors. | 08-27-2009 |
20110217701 | Prognostic Marker for Endometrial Carcinoma - The present invention relates to a method for diagnosis of different stages of endometrial cancer in an individual. Further, the present invention relates to a method for evaluating the probability of survival for an individual suffering from endometrial carcinoma. In another aspect, the present invention relates to the stratification of therapy regimen of endometrial tumor, ovarian cancer, breast cancer, non-small lung cancer or hormone refractory prostate cancer therapy in an individual or monitoring therapeutic efficacy in an individual suffering from the same based on the expression status of STMN1 gene or protein. Moreover, the present invention relates to a kit for use in any of the above referenced methods comprising a means for determining amplifications and deletions of chromosomal regions 3q26.32 and 12p12.1, determining alterations of the gene expression profile of the genes (gene signature): upregulation of the genes PLEKHK1, ATP10B, NMU, MMP1, ATAD2, NETO2, TNNI3, PHLDA2, OVOL1 and down-regulation of the genes: NDP, KIAA1434, MME, CFH, MOXD1, SLC47A1, RBP1, PDE8B, ASRGL1, ADAMTS19, EFHD1, ABCA5, NPAS3, SCML1, TNXB, ENTPD3, AMY1A, ENPP, RASL11B, PDZK3, or the expression status of the STMN1 gene or protein, respectively. Finally, the present invention provides a method for predicting the response to taxanes in an individual suffering from a disease treated with the taxanes based on the expression status of the STMN1 gene or protein. | 09-08-2011 |
20130338026 | Prognostic Marker for Endometrial Carcinoma - A method for diagnosis of different stages of endometrial cancer and for evaluating the probability of survival for an individual suffering from endometrial carcinoma, and for stratification of a therapy regimen for an endometrial tumor or monitoring therapeutic efficacy in an individual suffering considers the expression status of STMN1 gene or protein. A kit for use in the methods allows for determining amplifications and deletions of chromosomal regions 3q26.32 and 12p12.1, determining alterations of the gene expression profile of the genes (gene signature): upregulation of the genes PLEKHK1, ATP10B, NMU, MMP1, ATAD2, NETO2, TNNI3, PHLDA2, OVOL1 and down-regulation of the genes: NDP, KIAA1434, MME, CFH, MOXD1, SLC47A1, RBP1, PDE8B, ASRGL1, ADAMTS19, EFHD1, ABCA5, NPAS3, SCML1, TNXB, ENTPD3, AMY1A, ENPP, RASL11B, PDZK3, or the expression status of the STMN1 gene or protein. | 12-19-2013 |
20150197785 | METHODS AND APPARATUS FOR ANALYZING AND QUANTIFYING DNA ALTERATIONS IN CANCER - Methods and apparatus for inferring purity and ploidy from a sample of cells (e.g., a sample comprising cancer and normal cells) are described. Copy number per cell of interest (e.g., cancer cell) is determined by optimizing purity and ploidy for the sample based, at least in part, on relative copy number profile information. One or more likelihood fit scores are determined for each of a plurality of candidate solutions generated by the methods described herein. A solution is selected based, at least in part on the likelihood fit score(s) and the copy number per cancer cell is determined in accordance with the selected solution. | 07-16-2015 |
Patent application number | Description | Published |
20080312296 | Bifunctional synthetic molecules - The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three major classes of molecules are covalently joined as bifunctional substances; chemical vasodilators, passive dermal penetration enhancers and therapeutic or diagnostic drugs. Chemical vasodilators may be delivered into the skin to increasing the blood flow in a tissue that has compromised circulation or they may be used as part of a delivery vehicle to promote the delivery of the drug. Passive dermal penetration enhancers are those chemicals that promote the passive penetration of drugs and other chemicals through the stratum corneum and epidermis of the skin tissue. Drugs and diagnostic agents are the third group of chemicals that are candidates for the linkage of molecules. | 12-18-2008 |
20090214504 | Methods and Compositions for Topical Treatment of Medical Conditions Including Wounds and Inflammation - A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant. | 08-27-2009 |
20100003353 | Control of Blood Vessel Physiology to Treat Skin Disorders - In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing. | 01-07-2010 |
20100076035 | Transdermal Drug Delivery using an Osmolyte and Vasoactive Agent - A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient. | 03-25-2010 |
20100137443 | Ibuprofen for Topical Administration - Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl)propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide. | 06-03-2010 |
20100145256 | METHODS AND COMPOSITIONS FOR TATTOO REMOVAL - Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle. | 06-10-2010 |
20120329875 | Ibuprofen for Topical Administration - Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide. | 12-27-2012 |
20130245538 | Control of Blood Vessel Physiology To Treat Skin Disorders - In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing. | 09-19-2013 |
20130273019 | Compositions for Topical Treatment of Medical Conditions Including Wounds and Inflammation - A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant. | 10-17-2013 |
20160058725 | Topical Formulations and Methods for Drug Delivery - Disclosed are topical formulations for delivery of an active ingredient to a patient. The formulation comprises components including: an active ingredient; a vasoactive agent; and a chelator, wherein the components are selected so that none of the other components is sequestered by the chelator. In some embodiments, the formulation comprises an osmolarity that is greater than about 345 milliOsmoles/liter (345 mOsM). In some embodiments, the formulation further comprises an osmolyte, wherein the osmoyte does not include an ion with a valency higher than monovalency. In some embodiments, the osmolyte in the formulation comprises an osmolarity that is greater than about 290 milliOsmoles/liter (290 mOsM). Also disclosed are methods for using the formulations, and components thereof, kits comprising the components of the formulation, and methods for manufacturing a medicament comprising components of the formulations. | 03-03-2016 |
Patent application number | Description | Published |
20100047671 | HIGH ENERGY DENSITY REDOX FLOW DEVICE - Redox flow devices are described in which at least one of the positive electrode or negative electrode-active materials is a semi-solid or is a condensed ion-storing electroactive material, and in which at least one of the electrode-active materials is transported to and from an assembly at which the electrochemical reaction occurs, producing electrical energy. The electronic conductivity of the semi-solid is increased by the addition of conductive particle to suspensions and the surface modification of the solid in semi-solids: coating the solid with a more electron conductive coating material to increase the power of the device. High energy density and high power redox flow devices are disclosed. | 02-25-2010 |
20110200848 | HIGH ENERGY DENSITY REDOX FLOW DEVICE - Redox flow devices are described in which at least one of the positive electrode or negative electrode-active materials is a semi-solid or is a condensed ion-storing electroactive material, and in which at least one of the electrode-active materials is transported to and from an assembly at which the electrochemical reaction occurs, producing electrical energy. The electronic conductivity of the semi-solid is increased by the addition of conductive particles to suspensions and/or via the surface modification of the solid in semi-solids (e.g., by coating the solid with a more electron conductive coating material to increase the power of the device). High energy density and high power redox flow devices are disclosed. The redox flow devices described herein can also include one or more inventive design features. In addition, inventive chemistries for use in redox flow devices are also described. | 08-18-2011 |
20110274948 | ENERGY TRANSFER USING ELECTROCHEMICALLY ISOLATED FLUIDS - The present invention is related to energy generation using electrochemically isolated fluids, and articles, systems, and methods for achieving the same. The embodiments described herein can be used in electrochemical cells in which at least one electrode comprises an electrochemically active fluid (i.e., the electrochemical cell comprises at least one fluid comprising electrode active material that is flowable into and/or out of the electrode compartment in which the electrode active material is charged and/or discharged). | 11-10-2011 |
20120164499 | STATIONARY, FLUID REDOX ELECTRODE - The present invention is related to electrochemical energy generation devices including at least one electrode comprising an electrochemically active fluid that is enclosed within the cell, as well as related articles, systems, and methods. In some embodiments, the anode and/or cathode of the electrochemical energy generation devices described herein can be formed of an electrochemically active fluid, such as a semi-solid or a redox active ion-storing liquid. The electrochemical energy generation device can be configured such that the anode and/or cathode can be flowed into their respective electrode compartments, for example, during assembly. During operation, on the other hand, little or none of the electrochemically active fluid(s) are transported into or out of the energy generation device (e.g., out of the electrode compartments of the electrochemical energy generation device). | 06-28-2012 |
20130344367 | HIGH ENERGY DENSITY REDOX FLOW DEVICE - Redox flow devices are described in which at least one of the positive electrode or negative electrode-active materials is a semi-solid or is a condensed ion-storing electroactive material, and in which at least one of the electrode-active materials is transported to and from an assembly at which the electrochemical reaction occurs, producing electrical energy. The electronic conductivity of the semi-solid is increased by the addition of conductive particles to suspensions and/or via the surface modification of the solid in semi-solids (e.g., by coating the solid with a more electron conductive coating material to increase the power of the device). High energy density and high power redox flow devices are disclosed. The redox flow devices described herein can also include one or more inventive design features. In addition, inventive chemistries for use in redox flow devices are also described. | 12-26-2013 |
20140039710 | ENERGY STORAGE MODELING AND CONTROL - Systems and methods for optimal planning and real-time control of energy storage systems for multiple simultaneous applications are provided. Energy storage applications can be analyzed for relevant metrics such as profitability and impact on the functionality of the electric grid, subject to system-wide and energy storage hardware constraints. The optimal amount of storage capacity and the optimal operating strategy can then be derived for each application and be prioritized according to a dispatch stack, which can be statically or dynamically updated according to data forecasts. Embodiments can consist of both planning tools and real-time control algorithms. | 02-06-2014 |
20140154546 | High Energy Density Redox Flow Device - Redox flow devices are described including a positive electrode current collector, a negative electrode current collector, and an ion-permeable membrane separating said positive and negative current collectors, positioned and arranged to define a positive electroactive zone and a negative electroactive zone; wherein at least one of said positive and negative electroactive zone comprises a flowable semi-solid composition comprising ion storage compound particles capable of taking up or releasing said ions during operation of the cell, and wherein the ion storage compound particles have a polydisperse size distribution in which the finest particles present in at least 5 vol % of the total volume, is at least a factor of 5 smaller than the largest particles present in at least 5 vol % of the total volume. | 06-05-2014 |
20140248521 | HIGH ENERGY DENSITY REDOX FLOW DEVICE - Redox flow devices are described including a positive electrode current collector, a negative electrode current collector, and an ion-permeable membrane separating said positive and negative current collectors, positioned and arranged to define a positive electroactive zone and a negative electroactive zone; wherein at least one of said positive and negative electroactive zone comprises a flowable semi-solid composition comprising ion storage compound particles capable of taking up or releasing said ions during operation of the cell, and wherein the ion storage compound particles have a polydisperse size distribution in which the finest particles present in at least 5 vol % of the total volume, is at least a factor of 5 smaller than the largest particles present in at least 5 vol % of the total volume. | 09-04-2014 |
20150125764 | Flow Battery Using Non-Newtonian Fluids - Flow battery. The battery includes high energy density fluid electrodes having a selected non-Newtonian rheology and structure for providing intermittent flow pulses of controlled volume and duration of the fluid electrodes, the structure adapted to promote interfacial slip to improve flow uniformity. The battery disclosed herein provides a potential solution to large-scale electrical energy storage needs. | 05-07-2015 |
20150155585 | GRAVITY INDUCED FLOW CELL - Gravity induced flow cell. The flow cell includes first and second reservoirs having a selected volume containing a flowable redox electrode. A membrane separates charged and discharged material. An energy-extraction region includes electronically conductive porous current collectors through or adjacent to which the flowable redox electrodes flow and to which charge transfer occurs. Structure is provided for altering orientation of the flow cell whereby gravity induces flow of the flowable redox electrode between the first and second reservoirs to deliver power. By varying the angle of the cell, flow rate and power delivered on discharge or the charge rate on charge may be varied. | 06-04-2015 |