Patent application number | Description | Published |
20140135275 | MITOCHONDRIAL TARGETING AND THERAPEUTIC USE THEREOF - The present invention provides, among other things, compositions and methods for treatment of Friedrich's Ataxia based on effective targeting of a therapeutic moiety to mitochondria that can substitute for natural FXN protein activity or rescue one or more phenotypes or symptoms associated with frataxin-deficiency. In some embodiments, the present invention provides a targeted therapeutic comprising a therapeutic moiety, which is a polypeptide having an N-terminus and a C-terminus, a mitochondrial targeting sequence associated with the therapeutic moiety at the N-terminus, and a mitochondrial membrane-penetrating peptide associated with the therapeutic moiety at the C-terminus, wherein the therapeutic moiety is targeted to mitochondria upon cellular entry. | 05-15-2014 |
20140275222 | ANTISENSE OLIGONUCLEOTIDE MODULATORS OF SEROTONIN RECEPTOR 2C AND USES THEREOF - The present invention provides, among other things, oligonucleotide modulators of human 5′-HT2C receptor (HTR2C) and improved methods and composition for treating HTR2C-related diseases, disorders or conditions based on such modulators. In particular, oligonucleotides modulators according to the invention target specific regions in the Exon V/Intron V junction of the human HTR2C pre-mRNA and drive expression of HTR2C Vb splice isoform, leading to increased generation of non-edited strong HTR2C receptor and enhanced serotonin receptor activity. | 09-18-2014 |
Patent application number | Description | Published |
20110021879 | SURGICAL ACCESS DEVICE COMPRISING INTERNAL RETRACTOR - Devices, methods, and systems provide a surgical access device comprising an internal retractor device integrated with or coupled to a body wall or wound retractor. The wound retractor retracts an opening in a body wall into a body cavity, while the internal retractor permits a user to control the positions of internal structures within the body cavity, thereby permitting a user to define a surgical field. Embodiments of the internal retractor are adjustable. | 01-27-2011 |
20130296655 | SURGICAL ACCESS DEVICE COMPRISING INTERNAL RETRACTOR - Devices, methods, and systems provide a surgical access device comprising an internal retractor device integrated with or coupled to a body wall or wound retractor. The wound retractor retracts an opening in a body wall into a body cavity, while the internal retractor permits a user to control the positions of internal structures within the body cavity, thereby permitting a user to define a surgical field. Embodiments of the internal retractor are adjustable. | 11-07-2013 |
20140087345 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A surgical training model that includes a simulated tissue having a tubular shape that is connected to a tissue holder is provided. A portion of the simulated tissue overhangs the distal end of the tissue holder to simulate a cuff-like entry to the vaginal vault or resected intestine suitable for practicing laparoscopic closure of the vaginal vault, intestine or other organ via suturing or stapling. Two concentric tubular structures are also arranged over the same tissue holder. A second model includes two portions of simulated tissue that are held by two holders such that the simulated tissues are adjacent making the model suitable for practicing different types of anastomosis procedures. A third model includes two holders with a single or double tubular simulated tissue structure connected to and spanning a gap between the holders. The model isolates the step of closing a cylindrical opening for the purpose of repeated practice. | 03-27-2014 |
20140087346 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A surgical training model that includes a simulated tissue having a tubular shape that is connected to a tissue holder is provided. A portion of the simulated tissue overhangs the distal end of the tissue holder to simulate a cuff-like entry to the vaginal vault or resected intestine suitable for practicing laparoscopic closure of the vaginal vault, intestine or other organ via suturing or stapling. Two concentric tubular structures are also arranged over the same tissue holder. A second model includes two portions of simulated tissue that are held by two holders such that the simulated tissues are adjacent making the model suitable for practicing different types of anastomosis procedures. A third model includes two holders with a single or double tubular simulated tissue structure connected to and spanning a gap between the holders. The model isolates the step of closing a cylindrical opening for the purpose of repeated practice. | 03-27-2014 |
20140087347 | SURGICAL TRAINING MODEL FOR LAPAROSCOPIC PROCEDURES - A surgical training device includes a model comprising a simulated tissue portion mounted in selectable tension onto a plurality of posts connected to a base. Each post includes at least one notch configured for retaining the simulated tissue portion. Mounting the simulated tissue portion that is in the form of a sheet in notches of different heights creates an angled installation of simulated tissue upon which surgical techniques such as cutting and suturing can be practiced in a simulated laparoscopic environment. More than one sheet can be mounted and each sheet can be mounted with selectable tension by pulling the sheet more or less as desired onto the posts. One variation includes a simulated tumor disposed between sheets, angled or wobbly posts and textured and imprinted simulated tissue surfaces to provide various levels of dynamism and difficulty for surgical skills training in a laparoscopic environment. | 03-27-2014 |
20140207115 | MEDICAL TUBING HAVING VARIABLE CHARACTERISTCS AND METHOD OF MAKING SAME - The invention primarily is directed to a medical tubing adapted for insertion into a body tissue or cavity and method of manufacturing different variations of the tubing along a length of the tubing. The tubing comprises a plurality of individual, discrete, generally ring-shaped elements arranged in series and fused or bonded together forming a continuous tubular structure. The ring-shaped elements may include a combination of flexible and rigid ring-shaped elements assembled along different portions or sections of the tubular structure. In another aspect of the invention, the medical tubing may further comprise a secondary lumen and a pull wire to control the tubular structure. In another aspect of the invention, the ring-shaped elements may vary in diameter and/or composition in different portions or sections of the tubular structure. | 07-24-2014 |
20150187229 | ADVANCED FIRST ENTRY MODEL FOR SURGICAL SIMULATION - The present invention provides a surgical training device for training laparoscopic first entry surgical techniques. The training device includes a simulated abdominal wall that is penetrable with an optical trocar. A receptacle containing a tissue simulation is located inside the receptacle. The tissue simulation is observable via scope placed inside the optical trocar. Upon penetration of the one or more of the simulated abdominal wall and receptacle, the tissue simulation appears to translate distally relative to the simulated abdominal wall. The distal translation is effected by a variety of ways including the release of negative pressure inside the receptacle upon penetration and the expansion of an elastic wall of the receptacle with the introduction of fluid under pressure into the receptacle. | 07-02-2015 |