Patent application number | Description | Published |
20090068700 | Device and methods for monitoring the status of at least one cell - A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate having a first surface and an opposite second surface, a second substrate supported by the first substrate, the second substrate having a first surface, an opposite second surface, a body portion between the first surface and the second surface, a first side surface and an opposite second side surface, wherein the body portion defines a first passage between the first side surface and the second side surface and an opening on the first surface of the second substrate and in fluid communication with the first passage, and sidewalls positioned above the first surface of the second substrate. In one operation mode, when a first medium is introduced into the first passage, the intracellular space of the cell is in fluid communication with the first passage with the first medium, a sensor measures the response of the cell to the first medium. | 03-12-2009 |
20090215654 | Capillary Perfused Bioreactors with Multiple Chambers - A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel. | 08-27-2009 |
20090305319 | Apparatus and methods for monitoring the status of a metabolically active cell - An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the status of the cell from the measured intracellular or extracellular signaling of the cell. | 12-10-2009 |
20110294202 | BIOREACTORS WITH MULTIPLE CHAMBERS - A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further has a barrier dividing the chamber into a first subchamber and a second subchamber, wherein the barrier has a porosity to allow the first subchamber and the second subchamber in fluid communication and allow at least one predetermined type of cells to permeate between the first subchamber and the second subchamber. | 12-01-2011 |
20120003729 | CAPILLARY PERFUSED BIOREACTORS WITH MULTIPLE CHAMBERS - A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel. | 01-05-2012 |
20120156763 | Apparatus and Methods for Using Biological Material to Discriminate an Agent - An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of a physical quantity related to at least one of the cellular physiological activities of the cell, and identifying the agent from the measured response. The method further includes the step of quantifying the agent from the measured response. | 06-21-2012 |
Patent application number | Description | Published |
20110067671 | Non-soot emitting fuel combustion chamber - An embodiment of the invention provides a combustion chamber for non-soot emitting fuel. The combustion chamber includes a piston bowl, and a fuel injector mounted through a cylinder wall of a cylinder with the piston bowl, wherein the fuel injector injects fuel against a wall of the piston bowl in at least a substantially tangential manner. | 03-24-2011 |
20110068188 | Fuel injector for permitting efficient combustion - An embodiment of the invention provides an apparatus for fuel injection that permits efficient combustion. In one embodiment, the apparatus includes: a fuel injector including an injector needle; a fuel injection passage having a fuel injection passage inlet connected to the injector needle and a fuel injection passage outlet; and an air passage having an air passage outlet that is connected to the fuel injection passage and that is located between the fuel injection passage inlet and the fuel injection passage outlet, wherein the air passage provides air that mixes with the fuel in the fuel injection passage so that the fuel will have an increased fuel plume angle as the fuel exits from the fuel injection passage outlet. | 03-24-2011 |
20110241473 | Electric Motor Rotor - A rotor of an electric machine is disclosed that resists expansion of the rotor components even at high rotational speed. The rotor includes first and second pluralities of laminations having slots to accept rotor bars. A support disk, also having slots, is placed between the laminations. The support disk, into which the rotor bars are slid, restrains the rotor bars from bending outwardly at high rotational speeds of the rotor. The rotor bars are further restrained at the ends by end rings, which have apertures into which ends of the rotor bars are placed. In some embodiments, containment rings are placed over axial extension of the end rings to prevent outward bowing at high speeds. In some embodiments, the rotor includes a stiffener sleeve to provide additional resistance to expansion during high rotational speeds. | 10-06-2011 |
20130008403 | SYMMETRIC EXTENDED PORTING - A cylinder of an externally fired, two-stroke engine has at least two exhaust channels. At least the inflow openings of the exhaust channels are located or formed symmetrical in relation to a plane of symmetry containing a longitudinal center axis of the cylinder. The inflow openings of the exhaust channels lying above each other in the cylinder wall surface and spaced apart by wall webs lie distributed over a peripheral region of the cylinder wall surface which in relation to the longitudinal center axis corresponds to a central angle Z of 175°≦Z≦280°, preferably 180°≦Z≦265°. | 01-10-2013 |
20130186365 | PISTON, CYLINDER AND ENGINE WITH CROWN PRECISION COOLING - An engine piston has a connecting rod connected rigidly to the piston. At least one cavity is formed in the piston head, the cavity communicating in the region thereof close to the piston longitudinal axis with an oil supply line running through the connecting rod. The cavity is formed by a number of channels which run, preferably radially, in the piston head and are connected to one another in the circumferential region of the piston via an annular space or an annular line, and wherein a return line leading to the connecting rod is connected to the annular space or the annular line. The cavity or the channels forming the cavity and/or the return line are inclined at an angle of 1° to 4°, preferably 1° to 3°, to a plane perpendicular to the piston longitudinal axis. | 07-25-2013 |
20130186367 | METHOD, CYLINDER, AND ENGINE WITH CENTRAL IGNITION SPARK POSITION - A method for the combustion of a fuel-air mixture present in the combustion chamber of an engine cylinder. At least a part of the fuel, in particular all of the fuel, is introduced immediately prior to the ignition time with a mean fuel droplet size of ≦20 μm, preferably ≦10 μm, as defined by the mean Sauter diameter, in the direction of at least one ignition path situated in the central region of the piston crown ( | 07-25-2013 |
20130220040 | VIBRATION-FREE OPPOSED PISTON ENGINE - An engine has a cylinder, in which two pistons are mounted which are driven in opposite directions. Each piston drives, via a crankshaft, a toothed disk which is attached on the crankshaft. The two toothed disks are coupled to one another with regard to their rotational movement, or the toothed disks that are attached to the two crankshafts are in meshing engagement with one another. The crankshafts are driven by the pistons to produce a rotational movement in opposite directions. The toothed disks have the same diameter and are in direct engagement with one another by way of teeth which are arranged or formed along their circumference. | 08-29-2013 |
20130220246 | W6-MOTOR - A W6 engine has two W3 engine units disposed juxtaposed on a common crankshaft. Exhaust pipes of the cylinders containing the pistons driving the common crankshaft are guided to an exhaust. Each cylinder has at least one intake valve and at least one exhaust valve. The intake valves for the individual cylinders are disposed in wall portions of the respective cylinders oriented in the same circumferential direction about the crankshaft or lateral portions of their cylinder head. The exhaust valves for the individual cylinders are disposed in opposite circumferential direction. Each exhaust valve closes an exhaust pipe, which is led from the valve seat of the exhaust valve to the outer surface of the W3 engine unit in which the cylinder with the exhaust valve is disposed. | 08-29-2013 |
20130220264 | ENGINE AND CYLINDER WITH GAS EXCHANGE THROUGH THE CYLINDER WALL - An engine cylinder with a piston and at least one, preferably two or four, cam-operated valves leading to the combustion chamber. A valve seat of the valve is formed in the cylinder wall immediately laterally adjacent to the cylinder bore or to the cylinder chamber. The valve axis and the cylinder axis enclose an acute angle A of 5°≦A≦25°, preferably 10°≦A≦20°. The axis of the inlet channel or the outlet channel leading to the valve seat in a plane defined by the valve axis and the cylinder axis is inclined at an angle B of 25°≦B≦65°, preferably 40°≦B≦50° to the valve axis. | 08-29-2013 |
20130220267 | BEARING CONNECTION, ENGINE CYLINDER, AND ENGINE WITH THE BEARING CONNECTION - A bearing connection having a connecting rod connected rigidly to a piston and a crankshaft driven by the connecting rod. The connecting rod is connected on the crankshaft side to a transverse bearing for a sliding block, the sliding block being mounted such that it can move to and fro in the transverse bearing and a rolling contact bearing being arranged in the sliding block in order to receive the crank pin of a crankshaft. At least one cavity is formed in the piston crown and, in the area thereof close to the piston longitudinal axis, is connected to an oil feed line running through the connecting rod and that the oil feed line in the connecting rod is led or extended to the end region thereof remote from the piston and, from there, is led onward into the interior of the transverse bearing via a transfer channel. | 08-29-2013 |
20130220281 | METHOD, ENGINE CYLINDER, AND ENGINE WITH OPPOSED SEMI-LOOP SCAVENGING - A method for the reverse scavenging of an engine cylinder and for the introduction of fresh gas into the cylinder and for the discharge of exhaust gas out of the cylinder. The cylinder has oppositely disposed and opposingly driven pistons. In the region of the respective bottom dead center (BDC) of the two pistons, there are formed in the cylinder wall in each case one outlet region for the exhaust gas and in each case one, in particular circumferentially opposite flow transfer region for pre-compressed fresh gas which has been admitted from the crankcase. The fresh gas supplied through the respective flow transfer region is expelled in the direction of the wall region which is situated on that side of the cylinder inner wall and which adjoins the flow transfer region in the cylinder longitudinal direction. | 08-29-2013 |
20150114358 | Master and Slave Pullrods - Master and slave pullrods are disclosed in which a master pullrod is coupled to a journal of a crankshaft. The slave pullrod indirectly couples to the crankshaft by coupling to the master pullrod. Such a configuration allows two connecting rods to be coupled to the journal of the crankshaft inline with each other. | 04-30-2015 |