Patent application number | Description | Published |
20090094829 | Method for ultrasonic peening of gas turbine engine components without engine disassembly - A method for peening a component of a gas turbine engine, or a module of a gas turbine engine, without removing the component from the assembled gas turbine engine or module includes blending the damaged area of the component, determining parameters for peening the damaged component, and peening the damaged component without removing it from the engine. | 04-16-2009 |
20090320287 | Compressor blade flow form technique for repair - A method for repairing a turbine engine component is provided. The method broadly comprises the steps of providing a turbine engine component having an airfoil portion, applying a coating to the airfoil portion, and restoring a tip portion, a chord, and surfaces of the airfoil portion to original dimensions in a single operation. A system for repairing the turbine engine component is also described. | 12-31-2009 |
20110308290 | METHOD FOR ULTRASONIC PEENING OF GAS TURBINE ENGINE COMPONENTS WITHOUT ENGINE DISASSEMBLY - A method for peening a component of a gas turbine engine, or a module of a gas turbine engine, without removing the component from the assembled gas turbine engine or module includes blending the damaged area of the component, determining parameters for peening the damaged component, and peening the damaged component without removing it from the engine. | 12-22-2011 |
Patent application number | Description | Published |
20090240914 | RECYCLING LONG MULTI-OPERAND INSTRUCTIONS - A pipelined microprocessor configured for long operand instructions is disclosed. The microprocessor includes a memory unit and a load-store unit. The load store unit is coupled to the memory unit and includes a data formatter receiving information from the memory unit and including an operand selector and a shift register portion. The microprocessor also includes an execution unit coupled to the load-store unit and receiving operand information there from. The execution unit includes output latches coupled to a storage location within the execution unit for storing output information from the execution unit. | 09-24-2009 |
20090240918 | METHOD, COMPUTER PROGRAM PRODUCT, AND HARDWARE PRODUCT FOR ELIMINATING OR REDUCING OPERAND LINE CROSSING PENALTY - Eliminating or reducing an operand line crossing penalty by performing an initial fetch for an operand from a data cache of a processor. The initial fetch is performed by allowing or permitting the initial fetch to occur unaligned with reference to a quadword boundary. A plurality of subsequent fetches for a corresponding plurality of operands from the data cache are performed wherein each of the plurality of subsequent fetches is aligned to any of a plurality of quadword boundaries to prevent each of a plurality of individual fetch requests from spanning a plurality of lines in the data cache. A steady stream of data is maintained by placing an operand buffer at an output of the data cache to store and merge data from the initial fetch and the plurality of subsequent fetches, and to return the stored and merged data to the processor. | 09-24-2009 |
20090240922 | METHOD, SYSTEM, COMPUTER PROGRAM PRODUCT, AND HARDWARE PRODUCT FOR IMPLEMENTING RESULT FORWARDING BETWEEN DIFFERENTLY SIZED OPERANDS IN A SUPERSCALAR PROCESSOR - Result and operand forwarding is provided between differently sized operands in a superscalar processor by grouping a first set of instructions for operand forwarding, and grouping a second set of instructions for result forwarding, the first set of instructions comprising a first source instruction having a first operand and a first dependent instruction having a second operand, the first dependent instruction depending from the first source instruction; the second set of instructions comprising a second source instruction having a third operand and a second dependent instruction having a fourth operand, the second dependent instruction depending from the second source instruction, performing operand forwarding by forwarding the first operand, either whole or in part, as it is being read to the first dependent instruction prior to execution; performing result forwarding by forwarding a result of the second source instruction, either whole or in part, to the second dependent instruction, after execution; wherein the operand forwarding is performed by executing the first source instruction together with the first dependent instruction; and wherein the result forwarding is performed by executing the second source instruction together with the second dependent instruction. | 09-24-2009 |
20090241084 | METHOD, SYSTEM AND COMPUTER PROGRAM PRODUCT FOR EXPLOITING ORTHOGONAL CONTROL VECTORS IN TIMING DRIVEN SYSTEMS - Systems, methods and computer program products for exploiting orthogonal control vectors in timing driven systems. An exemplary embodiment includes running an initial logic synthesis run on the system, identifying critical inputs to a logic cone related to the run, identifying orthogonal vectors in the logic cone, adding vectors to the logic cone, obtaining logical solutions and selecting a solution from the logical solutions. | 09-24-2009 |
20130339666 | SPECIAL CASE REGISTER UPDATE WITHOUT EXECUTION - A method of changing a value of associated with a logical address in a computing device. The method includes: receiving an instruction at an instruction decoder, the instruction including a target register expressed as a logical value; determining at an instruction decoder that a result of the instruction is to set the target register to a constant value, the target register being in a physical register file associated with an execution unit; and mapping, in a register mapper, the logical address to a location represented by a special register tag. | 12-19-2013 |
Patent application number | Description | Published |
20080269499 | CRYSTALLINE FORMS AND PROCESS FOR PREPARING SPIRO-HYDANTOIN COMPOUNDS - A process is provided for preparing spiro-hydantoin compounds of the formula II | 10-30-2008 |
20090054303 | CRYSTAL FORMS OF SAXAGLIPTIN AND PROCESSES FOR PREPARING SAME - Physical crystal structures of a compound of the formula I: | 02-26-2009 |
20090203630 | PROCESS FOR PREPARING ATAZANAVIR BISULFATE AND NOVEL FORMS - A process is provided for preparing the HIV protease inhibitor atazanavir bisulfate wherein a solution of atazanavir free base is reacted with concentrated sulfuric acid in an amount to react with less than about 15% by weight of the free base, seeds of Form A crystals of atazanavir bisulfate are added to the reaction mixture, and as crystals of the bisulfate form, additional concentrated sulfuric acid is added in multiple stages at increasing rates according to a cubic equation, to effect formation of Form A crystals of atazanavir bisulfate. | 08-13-2009 |
20090312331 | PROCESS FOR PREPARING SALTS OF 4-[[5-[(CYCLOPROPYLAMINO)CARBONYL]-2-METHYLPHENYL]AMINO]-5-METHYL-N-PROPY- LPYRROLO[2,1-f][1,2,4]TRIAZINE-6-CARBOXAMIDE AND NOVEL STABLE FORMS PRODUCED THEREIN - Processes are provided for selectively preparing novel stable crystalline salt forms, selectively and consistently, namely, preparing Form N-1 of the methanesulfonic acid salt, and Form N-1 and Form N-4 of the hydrochloric acid salt of the p38 kinase inhibitor 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide. The processes preferably employ solvent systems including formic acid/acetone and formic acid/methylethyl ketone which produce crystals having suitable flow properties and desired particle size, and solvents such as N,N-dimethylformamide and N,N-dimethylacetamide may be employed as well. | 12-17-2009 |
20100004293 | CRYSTALLINE FORMS OF ARYL-SUBSTITUTED PYRAZOLE-AMIDE COMPOUNDS - The present invention provides novel crystals of Compound I, pharmaceutical compositions containing such novel form and a method of treating p38 kinase associated conditions, including rheumatoid arthritis, using such novel form. | 01-07-2010 |
20110124689 | PROCESS FOR PREPARING ATAZANAVIR BISULFATE AND NOVEL FORMS - A process is provided for preparing the HIV protease inhibitor atazanavir bisulfate wherein a solution of atazanavir free base is reacted with concentrated sulfuric acid in an amount to react with less than about 15% by weight of the free base, seeds of Form A crystals of atazanavir bisulfate are added to the reaction mixture, and as crystals of the bisulfate form, additional concentrated sulfuric acid is added in multiple stages at increasing rates according to a cubic equation, to effect formation of Form A crystals of atazanavir bisulfate. | 05-26-2011 |
20120108594 | PROCESS FOR PREPARING SALTS OF 4-[[5-[(CYCLOPROPYLAMINO)CARBONYL]-2-METHYLPHENYL]AMINO]-5-METHYL-N-PROPY- LPYRROLO[2,1-f][1,2,4]TRIAZINE-6-CARBOXAMIDE AND NOVEL STABLE FORMS PRODUCED THEREIN - Processes are provided for selectively preparing novel stable crystalline salt forms, selectively and consistently, namely, preparing Form N-1 of the methanesulfonic acid salt, and Form N-1 and Form N-4 of the hydrochloric acid salt of the p38 kinase inhibitor 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide. The processes preferably employ solvent systems including formic acid/acetone and formic acid/methylethyl ketone which produce crystals having suitable flow properties and desired particle size, and solvents such as N,N-dimethylformamide and N,N-dimethylacetamide may be employed as well. | 05-03-2012 |
Patent application number | Description | Published |
20110020386 | VACCINES AND COMPOSITIONS AGAINST STREPTOCOCCUS PNEUMONIAE - is a major health concern, especially in very young, elderly, or immunocompromised patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in | 01-27-2011 |
20110159040 | NOVEL IMMUNOGENS AND METHODS FOR DISCOVERY AND SCREENING THEREOF - An aspect of the present invention provides for methods for identifying novel immunogens that when administered as vaccines elicit a cellular or humoral immunogenic response. In a particular embodiment, a method identified pneumococcal T-cell immunogens that elicit systemic IL-17A responses, and reduce or protect against pneumococcal colonization. | 06-30-2011 |
20110206716 | SYNERGISTIC IMMUNOGENIC FUSION PROTEIN-POLYSACCHARIDE CONJUGATE - An immunogenic composition comprising a fusion protein-polysaccharide conjugate consisting of a polysaccharide (PS) or pneumococcal bacterial cell wall polysaccharide (CWPS) conjugated to X:PdT where PdT represents the nonhemolytic variant of pneumolysin and X represents an antigenic peptide or protein of interest is provided. The immunity to X is synergistically enhanced by the fusion conjugate. Methods of protecting a subject from pneumococcal colonization or disease by administering an immunogenic composition including a fusion protein (PsaA:PdT) containing truncated PsaA and the nonhemolytic variant of pneumolysin (PdT) conjugated with CWPS (PsaA:PdT-CWPS) is also provided. | 08-25-2011 |
20120189649 | Vaccines and Compositions Against Streptococcus Pneumoniae - is a major health concern, especially in very young, elderly, or immunocompromised patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in | 07-26-2012 |
20120251577 | SELECTIVELY DISRUPTED WHOLE-CELL VACCINE - The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell | 10-04-2012 |
20130039947 | NOVEL IMMUNOGENS AND METHODS FOR DISCOVERY AND SCREENING THEREOF - The present application is generally directed to methods for identifying immunogens from organisms and pathogens, and in particular for identifying immunogens which when administered as vaccines elicit a cellular and/or humoral immune response. The present application is also directed to pneumococcal T-cell immunogens, and vaccine compositions comprising one or a combination of pneumococcal immunogens and methods for treating or preventing pneumococcal infections using the vaccines thereof. The present invention also encompasses use of the pneumococcal immunogens for diagnostic purposes to identify a subject with a pneumococcal infection. | 02-14-2013 |
20140154286 | MODIFIED BIOTIN-BINDING PROTEIN, FUSION PROTEINS THEREOF AND APPLICATIONS - The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from | 06-05-2014 |
20140154287 | MULTIPLE ANTIGEN PRESENTING IMMUNOGENIC COMPOSITION, AND METHODS AND USES THEREOF - The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time. | 06-05-2014 |
20150056239 | FUSED ANTIGEN VACCINES AND COMPOSITIONS AGAINST STREPTOCOCCUS PNEUMONIAE - is a major health concern, especially in very young, elderly, or immunocompromised patients. The present disclosure provides, inter alia, certain highly effective vaccines and pharmaceutical compositions in | 02-26-2015 |