Patent application number | Description | Published |
20140074663 | INTEGRATING PURCHASE HISTORY AND METADATA ACROSS DEVICES - The technology relates to synchronizing purchase information and metadata across devices. The system maintains a server listing of items purchased from an online store and associated with a user account, each item in the server listing of items being associated with a respective first hash value. Then, the system receives, from a client device, a client listing of items purchased from the online store representing a last known listing of items purchased from the online store and associated with the user account, each item in the client listing of items being associated with a respective second hash value. Next, the system determines a difference between the respective first hash value and the respective second hash value. Based on the difference, the system sends, to the client device, metadata identifying items present in the server listing of items that are not in the client listing of items. | 03-13-2014 |
20140074783 | SYNCHRONIZING METADATA ACROSS DEVICES - The technology relates to synchronizing user metadata across devices. The system maintains a collection of incremental metadata changes for a collection of media items, for each media item represented in the collection, storing a media item identifier and a value, wherein the value is an incremental user metadata change for a respective media item. Next, the system receives, from a client device, a request for a metadata sync, the request comprising a last metadata version update number indicative of a last metadata sync received by the client device. The system then sends, to the client device, a metadata update associated with a version update number subsequent to the last metadata version update number indicative of the last metadata sync received by the client device. | 03-13-2014 |
Patent application number | Description | Published |
20090041800 | Methods for Treating Dependence - Provided are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance with Compound A. Also provided are methods of treating at least one phase of substance dependence on at least one substance in patients and certain methods of treating at least one phase of cocaine dependence in patients. | 02-12-2009 |
20100324286 | BENZOTHIAZOLE DERIVATIVES - Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance. | 12-23-2010 |
20120065403 | Benzothiazole Derivatives - Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance. | 03-15-2012 |
20130317219 | Benzothiazole Derivatives - Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance. | 11-28-2013 |
20140099336 | Methods for Treating Dependence - Provided are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance with Compound A. Also provided are methods of treating at least one phase of substance dependence on at least one substance in patients and certain methods of treating at least one phase of cocaine dependence in patients. | 04-10-2014 |
Patent application number | Description | Published |
20080255248 | Prodrug compounds with isoleucine - The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by an enzyme associated with the target cell. Methods of making and using the compounds are also disclosed. | 10-16-2008 |
20090110753 | Enzyme-cleavable prodrug compounds - The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention. | 04-30-2009 |
20090136980 | CD10-activated prodrug compounds - The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing the prodrug are also disclosed. | 05-28-2009 |
20110165158 | METHODS FOR THE THERAPY OF INFLAMMATORY BOWEL DISEASE USING A TYPE-1 INTERFERON ANTAGONIST - Compositions and methods for the therapy of Inflammatory Bowel Disease (IBD), including Celiac Disease, Crohn's Disease, and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more anti-type 1 interferon antagonists, such as anti-type 1 interferon receptor antibody antagonists and fragments thereof, as well as polypeptides and small molecules that inhibit the interaction of type 1 interferon with its receptor (IFNAR). | 07-07-2011 |
Patent application number | Description | Published |
20130259638 | TURBOMACHINE THERMAL MANAGEMENT - An example turbomachine assembly includes, among other things, a nose cone of a turbomachine, and a pump at least partially within an interior of the nose cone. The pump is selectively rotated by a motor to communicate air to the interior. | 10-03-2013 |
20130259639 | TURBOMACHINE THERMAL MANAGEMENT - An example turbomachine assembly includes, among other things, a nose cone of a turbomachine, and a pump that is selectively driven by a motor or a shaft to communicate air to an interior of the nose cone. The pump shaft is driven by a dedicated geared architecture. | 10-03-2013 |
20130259687 | TURBOMACHINE THERMAL MANAGEMENT - An example turbomachine assembly includes, among other things, a nose cone of a turbomachine. The nose cone provides an aperture that communicates air to an interior of the nose cone. | 10-03-2013 |
20140010639 | GAS TURBINE ENGINE OIL TANK WITH INTEGRATED PACKAGING CONFIGURATION - A gas turbine engine includes a fan case radially outwardly of a core compartment. A compressor section is located within an engine core compartment and includes a front mount flange and an aft mount flange. An oil tank is mounted to at least one of the fan case or the front and aft mount flanges. The oil tank has a cooling structure integrated into an outer surface such that the oil tank is subjected to cooling air flow from a plurality of air sources. | 01-09-2014 |
20140096534 | Low Profile Compressor Bleed Air-Oil Coolers - An air-oil cooler (AOC) for a gas turbine engine is disclosed. The AOC may comprise an oil inlet, an oil outlet, and heat exchange elements between the oil inlet and the oil outlet. The AOC may be longitudinally positioned between a fan and a V-groove of the engine and radially spaced between a low pressure compressor and a low pressure compressor panel. A gas turbine engine comprising an AOC is disclosed. The AOC of the engine may comprise an oil inlet, an oil outlet, and heat exchange elements between the oil inlet and the oil outlet. The AOC of the engine may be longitudinally positioned between a fan and a V-groove of the engine and radially spaced between a low pressure compressor and a low pressure compressor panel. A method of operating an AOC for use on a gas turbine engine is also disclosed. | 04-10-2014 |